LOCUS       NP_536327                594 aa            linear   ROD 03-APR-2024
DEFINITION  tyrosine-protein kinase RYK precursor [Rattus norvegicus].
ACCESSION   NP_536327 XP_343459
VERSION     NP_536327.1
DBSOURCE    REFSEQ: accession NM_080402.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 594)
  AUTHORS   Yang,Q.O., Yang,W.J., Li,J., Liu,F.T., Yuan,H. and Ou Yang,Y.P.
  TITLE     Ryk receptors on unmyelinated nerve fibers mediate excitatory
            synaptic transmission and CCL2 release during neuropathic pain
            induced by peripheral nerve injury
  JOURNAL   Mol Pain 13, 1744806917709372 (2017)
   PUBMED   28565999
  REMARK    GeneRIF: These studies demonstrate the existence of critical
            crosstalk between astrocytes and unmyelinated fibers, which
            indicate the presynaptic mechanism of Ryk in cytokine transmission
            of neuropathic pain and the therapeutic potential for Wnt/Ryk
            signaling pathway in the treatment of neuropathic pain.
REFERENCE   2  (residues 1 to 594)
  AUTHORS   Rao,K.S., Aronshtam,A., McElory-Yaggy,K.L., Bakondi,B.,
            VanBuren,P., Sobel,B.E. and Spees,J.L.
  TITLE     Human epicardial cell-conditioned medium contains HGF/IgG complexes
            that phosphorylate RYK and protect against vascular injury
  JOURNAL   Cardiovasc Res 107 (2), 277-286 (2015)
   PUBMED   26025956
  REMARK    GeneRIF: Early treatment with HGF/IgG complexes after myocardial
            ischaemia with reperfusion may rescue tissue through vasoprotection
REFERENCE   3  (residues 1 to 594)
  AUTHORS   Blakely,B.D., Bye,C.R., Fernando,C.V., Prasad,A.A.,
            Pasterkamp,R.J., Macheda,M.L., Stacker,S.A. and Parish,C.L.
  TITLE     Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon
            morphogenesis of ventral midbrain dopaminergic neurons
  JOURNAL   Stem Cells Dev 22 (15), 2132-2144 (2013)
   PUBMED   23517308
REFERENCE   4  (residues 1 to 594)
  AUTHORS   Gonzalez,P., Fernandez-Martos,C.M., Arenas,E. and Rodriguez,F.J.
  TITLE     The Ryk receptor is expressed in glial and fibronectin-expressing
            cells after spinal cord injury
  JOURNAL   J Neurotrauma 30 (10), 806-817 (2013)
   PUBMED   23320533
  REMARK    GeneRIF: we demonstrate that Ryk is expressed in the unlesioned
            spinal cord and that, after spinal cord injury, its spatiotemporal
            and cellular expression pattern changed dramatically, being
            expressed in cells involved in the spinal cord response to damage.
REFERENCE   5  (residues 1 to 594)
  AUTHORS   Lyu,J., Yamamoto,V. and Lu,W.
  TITLE     Cleavage of the Wnt receptor Ryk regulates neuronal differentiation
            during cortical neurogenesis
  JOURNAL   Dev Cell 15 (5), 773-780 (2008)
   PUBMED   19000841
REFERENCE   6  (residues 1 to 594)
  AUTHORS   Kamitori,K., Machide,M., Osumi,N. and Kohsaka,S.
  TITLE     Expression of receptor tyrosine kinase RYK in developing rat
            central nervous system
  JOURNAL   Brain Res Dev Brain Res 114 (1), 149-160 (1999)
   PUBMED   10209253
REFERENCE   7  (residues 1 to 594)
  AUTHORS   Serfas,M.S. and Tyner,A.L.
  TITLE     Ryk is expressed in a differentiation-specific manner in epithelial
            tissues and is strongly induced in decidualizing uterine stroma
  JOURNAL   Oncogene 17 (26), 3435-3444 (1998)
   PUBMED   10030667
REFERENCE   8  (residues 1 to 594)
  AUTHORS   Simoneaux,D.K., Fletcher,F.A., Jurecic,R., Shilling,H.G., Van,N.T.,
            Patel,P. and Belmont,J.W.
  TITLE     The receptor tyrosine kinase-related gene (ryk) demonstrates
            lineage and stage-specific expression in hematopoietic cells
  JOURNAL   J Immunol 154 (3), 1157-1166 (1995)
   PUBMED   7822791
REFERENCE   9  (residues 1 to 594)
  AUTHORS   Yee,K., Bishop,T.R., Mather,C. and Zon,L.I.
  TITLE     Isolation of a novel receptor tyrosine kinase cDNA expressed by
            developing erythroid progenitors
  JOURNAL   Blood 82 (4), 1335-1343 (1993)
   PUBMED   8394755
REFERENCE   10 (residues 1 to 594)
  AUTHORS   Hovens,C.M., Stacker,S.A., Andres,A.C., Harpur,A.G., Ziemiecki,A.
            and Wilks,A.F.
  TITLE     RYK, a receptor tyrosine kinase-related molecule with unusual
            kinase domain motifs
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 11818-11822 (1992)
   PUBMED   1334548
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Apr 19, 2005 this sequence version replaced XP_343459.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY669340.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..594
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     Protein         1..594
                     /product="tyrosine-protein kinase RYK precursor"
                     /EC_number="2.7.10.1"
                     /note="tyrosine-protein kinase RYK"
                     /calculated_mol_wt=62350
     sig_peptide     1..40
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3899
     Region          47..180
                     /region_name="WIF"
                     /note="Wnt-inhibitory factor-1 like domain; smart00469"
                     /db_xref="CDD:128745"
     Region          310..590
                     /region_name="PTK_Ryk"
                     /note="Pseudokinase domain of Ryk (Receptor related to
                     tyrosine kinase); cd05043"
                     /db_xref="CDD:270639"
     CDS             1..594
                     /gene="Ryk"
                     /coded_by="NM_080402.3:162..1946"
                     /db_xref="GeneID:140585"
                     /db_xref="RGD:620549"
ORIGIN      
        1 mragrggvpg tgglrapppp llllllamlp aaaprspala aapagpsvsl ylsedevrrl
       61 lgldaelyyv rndlishyal sfnllvpset nflhftwhak skveyklgfq vdnfvamgmp
      121 qvnisaqgev prtlsvfrve lsctgkvdse vmilmqlnlt vnssknftvl nfkrrkmcyk
      181 kleevktsal dkntsrtiyd pvhaapttst rvfyisvgvc caviflvaii lavlhlhsmk
      241 rielddsisa ssssqglsqp stqttqylra dtpnnatpvt sssgyptlri ekndlrsvtl
      301 leakakvkdi aisrervtlk dvlqegtfgr ifhgilvdek dpnkekqtfv ktvkdqasev
      361 qvtmmltesc klrglhhrnl lpithvciee gekpmvispy mnwgnlklfl rqcklveann
      421 pqaisqqdlv hmaiqiacgm sylarrevih kdlaarncvi ddtlqvkitd nalsrdlfpm
      481 dyhclgdnen rpvrwmales lvnnefssas dvwafgvtlw elmtlgqtpy vdidpfemaa
      541 ylkdgyriaq pincpdelfa vmaccwaldp eerpkfqqlv qcltefhaal gayv
//
