LOCUS       NM_001024759            1442 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus ribitol xylosyltransferase 1 (Rxylt1), mRNA.
ACCESSION   NM_001024759 XM_006241397 XM_216904
VERSION     NM_001024759.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1442)
  AUTHORS   Manya,H., Yamaguchi,Y., Kanagawa,M., Kobayashi,K., Tajiri,M.,
            Akasaka-Manya,K., Kawakami,H., Mizuno,M., Wada,Y., Toda,T. and
            Endo,T.
  TITLE     The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol
            beta1,4-Xylosyltransferase Required for the Functional
            Glycosylation of Dystroglycan
  JOURNAL   J Biol Chem 291 (47), 24618-24627 (2016)
   PUBMED   27733679
REFERENCE   2  (bases 1 to 1442)
  AUTHORS   Praissman,J.L., Willer,T., Sheikh,M.O., Toi,A., Chitayat,D.,
            Lin,Y.Y., Lee,H., Stalnaker,S.H., Wang,S., Prabhakar,P.K.,
            Nelson,S.F., Stemple,D.L., Moore,S.A., Moremen,K.W., Campbell,K.P.
            and Wells,L.
  TITLE     The functional O-mannose glycan on alpha-dystroglycan contains a
            phospho-ribitol primed for matriglycan addition
  JOURNAL   Elife 5, e14473 (2016)
   PUBMED   27130732
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1442)
  AUTHORS   Willer,T., Inamori,K., Venzke,D., Harvey,C., Morgensen,G., Hara,Y.,
            Beltran Valero de Bernabe,D., Yu,L., Wright,K.M. and Campbell,K.P.
  TITLE     The glucuronyltransferase B4GAT1 is required for initiation of
            LARGE-mediated alpha-dystroglycan functional glycosylation
  JOURNAL   Elife 3, e03941 (2014)
   PUBMED   25279699
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Jul 2, 2021 this sequence version replaced
            XM_006241397.4, NM_001024759.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR23984936.42160.1,
                                           SRR26643295.28194.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JAXUCZ010000007.1  59667704-59667972   c
            270-425             JAXUCZ010000007.1  59666712-59666867   c
            426-528             JAXUCZ010000007.1  59665314-59665416   c
            529-843             JAXUCZ010000007.1  59659510-59659824   c
            844-1014            JAXUCZ010000007.1  59657524-59657694   c
            1015-1442           JAXUCZ010000007.1  59656274-59656701   c
FEATURES             Location/Qualifiers
     source          1..1442
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1442
                     /gene="Rxylt1"
                     /gene_synonym="Tmem5"
                     /note="ribitol xylosyltransferase 1"
                     /db_xref="GeneID:299841"
                     /db_xref="RGD:1309356"
     exon            1..269
                     /gene="Rxylt1"
                     /gene_synonym="Tmem5"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1432
                     /gene="Rxylt1"
                     /gene_synonym="Tmem5"
                     /EC_number="2.4.2.61"
                     /note="transmembrane protein 5"
                     /codon_start=1
                     /product="ribitol-5-phosphate xylosyltransferase 1"
                     /protein_id="NP_001019930.2"
                     /db_xref="GeneID:299841"
                     /db_xref="RGD:1309356"
                     /translation="MRLTRTRLCSLLVALYCLFSIYAAYHVFFGRRRRPPGATSRGSR
                     KTAAQAKERRGREQSALESEEWNPWEGDEKNEQQHRIKTGLQILNKSTKEKIEHRVQI
                     WGKAAIGLYLWEHVFEGTLAPADVTAQWREGQSVVGRTHYSFITGPAVVPGYFSIDVD
                     NVVLVLNGREKAKIFHATQWLTYAQNLIQTQKLQHLAVVLLGDEHCDNDWIMQFLRRN
                     GGFVDLLFITYDSPWINGADVLQWPLGVATYRKFPVVEASWSMLHDERPYICNFLGTI
                     YENSSRQALMNILKQDGNDKLCWVSAREQWQPQETNESLKNYQDALLHSDLTLCPVGV
                     NTECYRIYEACSFGSIPVVEDVMTAGHCGNTSSQHSAPLQLLKAMGAPFIFIKNWKEL
                     PAILEKEKTIILQEKIQRRKMLLHWYQHFKTELKWKFTKILESSFFMNNKG"
     exon            270..425
                     /gene="Rxylt1"
                     /gene_synonym="Tmem5"
                     /inference="alignment:Splign:2.1.0"
     exon            426..528
                     /gene="Rxylt1"
                     /gene_synonym="Tmem5"
                     /inference="alignment:Splign:2.1.0"
     exon            529..843
                     /gene="Rxylt1"
                     /gene_synonym="Tmem5"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1014
                     /gene="Rxylt1"
                     /gene_synonym="Tmem5"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1442
                     /gene="Rxylt1"
                     /gene_synonym="Tmem5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcccggctt agcccacagg gagggcggca accctggacc aaagcttttc ctcacgccta
       61 aggtggaagc gaggacgcgg agccgggaag ccgcggtggg atgcggctga cgcggacccg
      121 gctctgctcg ctcctcgtcg ccctgtactg cctcttctcc atctacgccg cctaccacgt
      181 cttcttcggg cgccgccgcc ggccgccggg cgcgacctct cggggctcca ggaagacagc
      241 ggcgcaagcg aaggagaggc gcggccgaga gcagtccgcg ttggagagtg aagaatggaa
      301 tccttgggaa ggagatgaaa aaaacgagca gcaacacaga attaaaactg gcctgcaaat
      361 cttaaacaaa tccacaaaag aaaaaataga gcatcgtgtg caaatctggg gcaaagctgc
      421 catcggtctc tatctctggg aacatgtttt tgaaggcact ctcgctcctg ctgatgtgac
      481 tgctcagtgg agggaaggac agtcagttgt aggaagaaca cattacagct tcatcactgg
      541 cccagctgta gttcccgggt acttctccat agatgtggac aatgtggtcc ttgttttaaa
      601 tggaagagaa aaagcaaaga tcttccatgc cacccagtgg ttaacttatg cccagaattt
      661 aatacaaacc caaaaactgc agcatctggc tgttgtcttg cttggagatg agcactgtga
      721 taatgactgg ataatgcagt tcctcagaag aaatggaggc ttcgtggacc tacttttcat
      781 aacatatgac agcccttgga ttaatggtgc agatgtcctc cagtggccgt taggtgtagc
      841 aacatacagg aagtttcctg tggttgaagc cagctggtcc atgctgcatg atgagagacc
      901 ctatatatgt aatttcttag ggactatcta tgaaaattca tcaagacaag cactaatgaa
      961 cattttgaaa caagatggaa atgataaact ttgttgggtt tctgcaagag aacagtggca
     1021 gcctcaggag acaaatgaaa gccttaaaaa ttaccaagat gctttgcttc atagtgacct
     1081 cacattgtgc cctgtaggag tgaacactga atgttacagg atctatgagg cctgctcctt
     1141 tggctccatt cctgtggtag aagacgtgat gacagctggc cactgtggaa acacatccag
     1201 tcagcacagc gctcctctgc agttactcaa ggccatgggg gcccccttca tcttcatcaa
     1261 gaactggaag gagctccctg ctattttaga aaaggaaaaa actataatct tacaagaaaa
     1321 gattcaaaga agaaaaatgt tacttcattg gtaccaacat ttcaaaacag aactaaagtg
     1381 gaaatttact aaaattttag aaagttcatt ttttatgaat aataaaggtt aattatatct
     1441 ag
//
