LOCUS       NM_206849               2481 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus retinoid X receptor beta (Rxrb), mRNA.
ACCESSION   NM_206849 XM_342095
VERSION     NM_206849.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2481)
  AUTHORS   Cheng,B., Al-Shammari,F.H., Ghader,I.A., Sequeira,F., Thakkar,J.
            and Mathew,T.C.
  TITLE     Fundamental studies of adrenal retinoid-X-receptor: Protein
            isoform, tissue expression, subcellular distribution, and ligand
            availability
  JOURNAL   J Steroid Biochem Mol Biol 171, 110-120 (2017)
   PUBMED   28267642
  REMARK    GeneRIF: Data suggest cells of the adrenal gland that contain
            RXRalpha are primarily localized in zona fasciculata and adrenal
            medulla with RXRalpha almost exclusively localized in cell nucleus;
            cells that contain RXRbeta are primarily localized in zona
            fasciculata. RXR ligands, such as all-trans-retinoic acid and
            long-chain polyunsaturated fatty acids, are also present in the
            adrenal gland.
REFERENCE   2  (bases 1 to 2481)
  AUTHORS   Gong,M., Bi,Y., Jiang,W., Zhang,Y., Chen,L., Hou,N., Chen,J. and
            Li,T.
  TITLE     Retinoic acid receptor beta mediates all-trans retinoic acid
            facilitation of mesenchymal stem cells neuronal differentiation
  JOURNAL   Int J Biochem Cell Biol 45 (4), 866-875 (2013)
   PUBMED   23318218
  REMARK    GeneRIF: all-trans retinoic acid pre-induction facilitates the
            neuronal differentiation of mesenchymal stem cells
REFERENCE   3  (bases 1 to 2481)
  AUTHORS   Arfaoui,A., Lobo,M.V., Boulbaroud,S., Ouichou,A., Mesfioui,A. and
            Arenas,M.I.
  TITLE     Expression of retinoic acid receptors and retinoid X receptors in
            normal and vitamin A deficient adult rat brain
  JOURNAL   Ann Anat 195 (2), 111-121 (2013)
   PUBMED   23017197
  REMARK    GeneRIF: RARalpha and beta isotypes were detected in practically
            all the male rat brain areas whereas immunostaining was weak or
            absent in the female brain except RARalpha.
REFERENCE   4  (bases 1 to 2481)
  AUTHORS   Feng,Y., Yu,Y.M., Yin,M.Z., Hong,L. and Cai,W.
  TITLE     Ectopic expression of retinoic acid receptors and change of
            myocardial structure in the offspring heart with vitamin A
            deficiency
  JOURNAL   J Nutr Sci Vitaminol (Tokyo) 58 (5), 309-318 (2012)
   PUBMED   23327965
  REMARK    GeneRIF: We showed that the embryo hearts from vitamin A
            insufficient groups exhibited ultrastructural changes and
            significantly lowe expression of GATA-4, RARalpha and gamma, and
            higher expression of RXRalpha and beta.
REFERENCE   5  (bases 1 to 2481)
  AUTHORS   Latasa,M.J., Ituero,M., Moran-Gonzalez,A., Aranda,A. and
            Cosgaya,J.M.
  TITLE     Retinoic acid regulates myelin formation in the peripheral nervous
            system
  JOURNAL   Glia 58 (12), 1451-1464 (2010)
   PUBMED   20648638
REFERENCE   6  (bases 1 to 2481)
  AUTHORS   Ben-Shushan,E., Sharir,H., Pikarsky,E. and Bergman,Y.
  TITLE     A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and
            retinoic acid receptor:retinoid X receptor heterodimers regulates
            Oct-3/4 expression in embryonal carcinoma cells
  JOURNAL   Mol Cell Biol 15 (2), 1034-1048 (1995)
   PUBMED   7823919
REFERENCE   7  (bases 1 to 2481)
  AUTHORS   Chen,H. and Privalsky,M.L.
  TITLE     Cooperative formation of high-order oligomers by retinoid X
            receptors: an unexpected mode of DNA recognition
  JOURNAL   Proc Natl Acad Sci U S A 92 (2), 422-426 (1995)
   PUBMED   7831303
REFERENCE   8  (bases 1 to 2481)
  AUTHORS   Mangelsdorf,D.J., Borgmeyer,U., Heyman,R.A., Zhou,J.Y., Ong,E.S.,
            Oro,A.E., Kakizuka,A. and Evans,R.M.
  TITLE     Characterization of three RXR genes that mediate the action of
            9-cis retinoic acid
  JOURNAL   Genes Dev 6 (3), 329-344 (1992)
   PUBMED   1312497
REFERENCE   9  (bases 1 to 2481)
  AUTHORS   Yu,V.C., Delsert,C., Andersen,B., Holloway,J.M., Devary,O.V.,
            Naar,A.M., Kim,S.Y., Boutin,J.M., Glass,C.K. and Rosenfeld,M.G.
  TITLE     RXR beta: a coregulator that enhances binding of retinoic acid,
            thyroid hormone, and vitamin D receptors to their cognate response
            elements
  JOURNAL   Cell 67 (6), 1251-1266 (1991)
   PUBMED   1662118
REFERENCE   10 (bases 1 to 2481)
  AUTHORS   Hamada,K., Gleason,S.L., Levi,B.Z., Hirschfeld,S., Appella,E. and
            Ozato,K.
  TITLE     H-2RIIBP, a member of the nuclear hormone receptor superfamily that
            binds to both the regulatory element of major histocompatibility
            class I genes and the estrogen response element
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8289-8293 (1989)
   PUBMED   2554307
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 25, 2008 this sequence version replaced NM_206849.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099776.1, SRR26643429.57000.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               JAXUCZ010000020.1  4824440-4824659     c
            221-438             JAXUCZ010000020.1  4823616-4823833     c
            439-595             JAXUCZ010000020.1  4822869-4823025     c
            596-775             JAXUCZ010000020.1  4822390-4822569     c
            776-948             JAXUCZ010000020.1  4821281-4821453     c
            949-1078            JAXUCZ010000020.1  4820674-4820803     c
            1079-1211           JAXUCZ010000020.1  4820368-4820500     c
            1212-1303           JAXUCZ010000020.1  4820161-4820252     c
            1304-1409           JAXUCZ010000020.1  4819881-4819986     c
            1410-2481           JAXUCZ010000020.1  4818709-4819780     c
FEATURES             Location/Qualifiers
     source          1..2481
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2481
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /note="retinoid X receptor beta"
                     /db_xref="GeneID:361801"
                     /db_xref="RGD:3611"
     CDS             1..1557
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /note="retinoic acid receptor, beta; nuclear receptor
                     co-regulator 1; nuclear receptor coregulator 1; nuclear
                     receptor subfamily 2 group B member 2"
                     /codon_start=1
                     /product="retinoic acid receptor RXR-beta"
                     /protein_id="NP_996731.2"
                     /db_xref="GeneID:361801"
                     /db_xref="RGD:3611"
                     /translation="MSWATRPPFLPPRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLD
                     PAAAAAGEQQTLEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLSQGIPPSSPPGPPHTP
                     SAPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGP
                     PEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTI
                     RKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGDG
                     AGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFT
                     LVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNS
                     AHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPGEVEILRE
                     KVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLM
                     EMLEAPHQLA"
     exon            1..220
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            221..438
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            439..595
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            596..775
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            776..948
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1078
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1211
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1303
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1409
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..2481
                     /gene="Rxrb"
                     /gene_synonym="RXR-beta"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcttggg ccactcgtcc gcccttcctc ccgccgcggc atgccgcggg gcagtgtggg
       61 ccggtggggg tgagaaaaga gatgcattgt ggggtcgcgt cccggtggcg gcggcggcgg
      121 ccctggctgg atcccgcggc ggcggcggcc ggagagcagc aaaccctgga gccggagccg
      181 ggggaggctg gccgggacgg gatgggcgac agcgggcggg attcccgaag cccagacagc
      241 tcctccccaa atcccctttc ccaggggatc cctccctctt ctcctcccgg tccacctcac
      301 accccttcag cacctccacc tccaatgcca ccccctccac tgggctcccc cttcccagtc
      361 atcagttctt ccatggggtc tcctggcttg ccccctccgg ctcccccagg attctccggg
      421 cctgtcagca gccctcagat taactccaca gtgtcgctcc ctgggggtgg gtctggcccc
      481 cctgaagatg tgaagccacc agtcttaggg gtccggggcc tgcactgtcc accccctcca
      541 ggtggccctg gggctggcaa acgactttgt gcaatctgcg gggaccgaag ctcaggcaag
      601 cactatgggg tttacagctg cgagggctgc aagggtttct tcaagcgcac cattcggaag
      661 gacctgacct actcatgccg agataacaaa gactgcacag tggacaagcg ccagcggaat
      721 cgctgtcagt actgtcgata tcagaagtgc ctggccaccg gcatgaaaag ggaggcggta
      781 caggaggagc gacaacgggg gaaggacaaa gacggggatg gggatggggc tgggggagcc
      841 cccgaggaga tgccggtgga caggatcctg gaggcagagc ttgctgtgga acagaagagc
      901 gaccaaggcg ttgagggccc tgggggcacc ggggggagtg gcagcagccc caatgaccca
      961 gtgactaaca tctgccaggc ggctgacaag cagctgttca cactcgtgga gtgggccaag
     1021 aggatcccgc acttttcctc cctacctctg gacgaccagg tcatactgct gcgggcaggc
     1081 tggaatgagc tcctcattgc gtccttctcc catcggtcca tcgatgtccg agatggcatc
     1141 ctcctggcca cgggtcttca tgtgcacaga aactcagccc attctgcagg cgtgggagcc
     1201 atctttgatc gggtgctgac agagctagtg tccaaaatgc gtgacatgag gatggacaag
     1261 acggagcttg gctgcctgcg ggcaatcata ctgtttaacc cagacgccaa gggcctctcc
     1321 aaccctggag aggtggagat ccttcgggag aaggtgtatg cctcactgga gacctactgc
     1381 aagcagaagt atcctgagca gcagggccgg tttgccaagc tgctactacg tcttcctgcc
     1441 ctgcgctcca tcggcctcaa gtgtctggag cacctgttct tcttcaagct cattggcgac
     1501 acccccattg acaccttcct catggagatg cttgaggctc cccaccagct agcctgagtc
     1561 cggatgcaca cggagggaga gtgtcgctga ggaggacttg agccgggcgg gggcgagagc
     1621 catgggacag gtgcagagca ggaggggact tgcccatcct gccaggggtc tggcaacact
     1681 taacagggtt tgcgtggtcc ccaagtcaga gcagagggga ccccagatcc ctgtgacgac
     1741 tacatgtcta ccttcagtgg ccttgagtct ctgaatttgt cggggtctcc catggtgcgg
     1801 gtgactcctc atcctgactc cccagcacca agccctgccc tgctcccggg accctgcccc
     1861 cttctcatta gcctcactcc cttctgaaga gtggaacgga gctccccaga aaggggtgtt
     1921 gtggggcagg cccccaagcc ggtggtcttg ggagggagca gggctcggac agcccttcag
     1981 cctcccaggc tcggcaggtg gggcagagga gggcctgcct ctgtcctgtc agccctttcc
     2041 acagtacctg ctgcagtcag actgaagaac aaagaggctg tgaaggggcc gctgaggagg
     2101 aggccattgc tatttttaat ttcctgtgag gagagactgg gagttagact caaagaagaa
     2161 gtactgtaca tccccaggtt gacttaaatg tcagggctgg aggtggcatg tgggcaagga
     2221 ggcccctcag gtggtctgtc ctggagctgt ctgggctctg ccttcctcat cttccctgca
     2281 gctctggact gagaggcggt ggcccctcct tgccccgctc ttccctaatc ctcagcgcag
     2341 ctagtctggg aacagggaga atgtggggtg gccagcctgc agagatgggt gctgggctgc
     2401 atggtttttg ccctggatct cttttggggg ggggttccct cccatctttc acttgcacat
     2461 aaagtcgctt tccagttaaa a
//
