LOCUS       NM_012805               2042 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus retinoid X receptor alpha (Rxra), mRNA.
ACCESSION   NM_012805
VERSION     NM_012805.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   Yu,P., Yang,K. and Jiang,M.
  TITLE     RXRalpha Blocks Nerve Regeneration after Spinal Cord Injury by
            Targeting p66shc
  JOURNAL   Oxid Med Cell Longev 2021, 8253742 (2021)
   PUBMED   33628383
  REMARK    GeneRIF: RXRalpha Blocks Nerve Regeneration after Spinal Cord
            Injury by Targeting p66shc.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Luo,Y., Liang,C., Liu,Y., Liu,X. and Xu,Y.
  TITLE     RXRalpha and MRTF-A have a synergistic effect in the retinoic
            acid-induced neural-like differentiation of adult bone
            marrow-derived mesenchymal stem cells
  JOURNAL   Cell Biol Int 44 (6), 1373-1381 (2020)
   PUBMED   32125053
  REMARK    GeneRIF: RXRalpha and MRTF-A have a synergistic effect in the
            retinoic acid-induced neural-like differentiation of adult bone
            marrow-derived mesenchymal stem cells.
REFERENCE   3  (bases 1 to 2042)
  AUTHORS   Mukwaya,A., Lennikov,A., Xeroudaki,M., Mirabelli,P., Lachota,M.,
            Jensen,L., Peebo,B. and Lagali,N.
  TITLE     Time-dependent LXR/RXR pathway modulation characterizes capillary
            remodeling in inflammatory corneal neovascularization
  JOURNAL   Angiogenesis 21 (2), 395-413 (2018)
   PUBMED   29445990
  REMARK    GeneRIF: A complex and coordinated time-dependent interplay between
            pro- and anti-inflammatory signaling pathways highlights a
            potential anti-inflammatory role of LXR/RXR, PPARalpha/RXRalpha and
            STAT3 signaling pathways in resolving inflammatory corneal
            angiogenesis.
REFERENCE   4  (bases 1 to 2042)
  AUTHORS   Cheng,B., Al-Shammari,F.H., Ghader,I.A., Sequeira,F., Thakkar,J.
            and Mathew,T.C.
  TITLE     Fundamental studies of adrenal retinoid-X-receptor: Protein
            isoform, tissue expression, subcellular distribution, and ligand
            availability
  JOURNAL   J Steroid Biochem Mol Biol 171, 110-120 (2017)
   PUBMED   28267642
  REMARK    GeneRIF: Data suggest cells of the adrenal gland that contain
            RXRalpha are primarily localized in zona fasciculata and adrenal
            medulla with RXRalpha almost exclusively localized in cell nucleus;
            cells that contain RXRbeta are primarily localized in zona
            fasciculata. RXR ligands, such as all-trans-retinoic acid and
            long-chain polyunsaturated fatty acids, are also present in the
            adrenal gland.
REFERENCE   5  (bases 1 to 2042)
  AUTHORS   Senol,S.P., Temiz,M., Guden,D.S., Cecen,P., Sari,A.N.,
            Sahan-Firat,S., Falck,J.R., Dakarapu,R., Malik,K.U. and Tunctan,B.
  TITLE     Contribution of PPARalpha/beta/gamma, AP-1, importin-alpha3, and
            RXRalpha to the protective effect of 5,14-HEDGE, a 20-HETE mimetic,
            against hypotension, tachycardia, and inflammation in a rat model
            of septic shock
  JOURNAL   Inflamm Res 65 (5), 367-387 (2016)
   PUBMED   26875149
  REMARK    GeneRIF: The results suggest that an increase in the expression of
            PPARalpha/beta/gamma and RXRalpha as well as a decrease in AP-1 and
            importin-alpha3 expression/activity participates in the protective
            effect of 5,14-HEDGE against hypotension, tachycardia, and
            inflammation during endotoxemia and thus have a beneficial effect
            in septic shock treatment
REFERENCE   6  (bases 1 to 2042)
  AUTHORS   Le Douarin,B., Zechel,C., Garnier,J.M., Lutz,Y., Tora,L.,
            Pierrat,P., Heery,D., Gronemeyer,H., Chambon,P. and Losson,R.
  TITLE     The N-terminal part of TIF1, a putative mediator of the
            ligand-dependent activation function (AF-2) of nuclear receptors,
            is fused to B-raf in the oncogenic protein T18
  JOURNAL   EMBO J 14 (9), 2020-2033 (1995)
   PUBMED   7744009
REFERENCE   7  (bases 1 to 2042)
  AUTHORS   Ben-Shushan,E., Sharir,H., Pikarsky,E. and Bergman,Y.
  TITLE     A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and
            retinoic acid receptor:retinoid X receptor heterodimers regulates
            Oct-3/4 expression in embryonal carcinoma cells
  JOURNAL   Mol Cell Biol 15 (2), 1034-1048 (1995)
   PUBMED   7823919
REFERENCE   8  (bases 1 to 2042)
  AUTHORS   Chen,H. and Privalsky,M.L.
  TITLE     Cooperative formation of high-order oligomers by retinoid X
            receptors: an unexpected mode of DNA recognition
  JOURNAL   Proc Natl Acad Sci U S A 92 (2), 422-426 (1995)
   PUBMED   7831303
REFERENCE   9  (bases 1 to 2042)
  AUTHORS   Seol,W., Choi,H.S. and Moore,D.D.
  TITLE     Isolation of proteins that interact specifically with the retinoid
            X receptor: two novel orphan receptors
  JOURNAL   Mol Endocrinol 9 (1), 72-85 (1995)
   PUBMED   7760852
REFERENCE   10 (bases 1 to 2042)
  AUTHORS   Mangelsdorf,D.J., Borgmeyer,U., Heyman,R.A., Zhou,J.Y., Ong,E.S.,
            Oro,A.E., Kakizuka,A. and Evans,R.M.
  TITLE     Characterization of three RXR genes that mediate the action of
            9-cis retinoic acid
  JOURNAL   Genes Dev 6 (3), 329-344 (1992)
   PUBMED   1312497
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 24, 2020 this sequence version replaced NM_012805.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM295013.1, AM295012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               JAXUCZ010000003.1  31387892-31388003
            113-378             JAXUCZ010000003.1  31448400-31448665
            379-529             JAXUCZ010000003.1  31452327-31452477
            530-709             JAXUCZ010000003.1  31453023-31453202
            710-879             JAXUCZ010000003.1  31460127-31460296
            880-1009            JAXUCZ010000003.1  31463971-31464100
            1010-1142           JAXUCZ010000003.1  31465831-31465963
            1143-1234           JAXUCZ010000003.1  31467824-31467915
            1235-1340           JAXUCZ010000003.1  31469284-31469389
            1341-2042           JAXUCZ010000003.1  31471064-31471765
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p12"
     gene            1..2042
                     /gene="Rxra"
                     /note="retinoid X receptor alpha"
                     /db_xref="GeneID:25271"
                     /db_xref="RGD:3610"
     exon            1..112
                     /gene="Rxra"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1488
                     /gene="Rxra"
                     /note="nuclear receptor subfamily 2 group B member 1"
                     /codon_start=1
                     /product="retinoic acid receptor RXR-alpha"
                     /protein_id="NP_036937.2"
                     /db_xref="GeneID:25271"
                     /db_xref="RGD:3610"
                     /translation="MDTKHFLPLDFSTQVNSSSLSSPTGRGSMAAPSLHPSLGPGLGS
                     PLGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFGTGSPQLNSP
                     MNPVSSSEDIKPPLGLNGVLKVPAHPSGNMSSFTKHICAICGDRSSGKHYGVYSCEGC
                     KGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGK
                     DRNENEVESTSSANEDMPVEKILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQA
                     ADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATG
                     LHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPA
                     EVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDT
                     PIDTFLMEMLEAPHQTT"
     exon            113..378
                     /gene="Rxra"
                     /inference="alignment:Splign:2.1.0"
     exon            379..529
                     /gene="Rxra"
                     /inference="alignment:Splign:2.1.0"
     exon            530..709
                     /gene="Rxra"
                     /inference="alignment:Splign:2.1.0"
     exon            710..879
                     /gene="Rxra"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1009
                     /gene="Rxra"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1142
                     /gene="Rxra"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1234
                     /gene="Rxra"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1340
                     /gene="Rxra"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..2042
                     /gene="Rxra"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggccccgg gcgggccgcg ccgggggccg ccgcgctgcc gccctgctgc tccgccgccg
       61 gctgggcatg agttagtagc agacatggac accaaacatt tcctgccgct cgacttctct
      121 acccaggtga actcttcatc cctgagctct ccaacgggtc gaggctccat ggctgccccc
      181 tcgctgcacc cttccctggg tccaggactc ggctctcctc tgggctcccc tgggcagctg
      241 cactcgccta tcagcaccct gagttctccc atcaatggca tgggcccacc cttctcggtc
      301 atcagctccc cgatgggccc gcactccatg tcggtaccca ccacacccac actgggcttc
      361 gggactggca gcccccagct caactcaccc atgaaccccg tgagcagcag tgaggatatc
      421 aaaccccctc taggcctcaa tggcgtcctc aaggttcctg cccacccctc aggaaatatg
      481 tcatccttca ccaagcacat ctgcgctatc tgtggggacc gctcctcagg caaacactat
      541 ggggtctaca gctgtgaggg ctgcaagggc ttcttcaaga ggacagtacg caaagacctg
      601 acctacacct gccgtgacaa caaggactgc ctgatcgaca agagacagcg gaaccggtgt
      661 cagtactgcc gataccagaa gtgcctggcc atgggcatga agcgggaagc cgtgcaggag
      721 gagcggcagc gaggcaagga ccggaacgag aatgaggtgg agtccaccag cagtgccaac
      781 gaggacatgc ctgtagagaa gattctggaa gctgagctcg ctgttgagcc caagactgag
      841 acatacgtgg aggcaaacat ggggctgaac cccagctcac caaatgaccc tgttaccaac
      901 atctgtcaag cagcagacaa gcagctcttc actcttgtgg agtgggccaa gaggatccca
      961 cacttttctg agctgcccct ggacgaccag gtcatcctcc tccgggcagg ctggaacgag
     1021 ctgctgattg cctccttctc ccaccgctcc atagctgtga aagacggcat cctcctggcc
     1081 accggcctgc acgtacacag gaacagcgct cacagtgctg gggtgggcgc catctttgac
     1141 agggtgctaa cggagctggt gtcgaagatg cgtgacatgc agatggacaa gacggagctg
     1201 ggctgcttgc gcgccattgt cctcttcaac cctgactcta aggggctctc aaaccctgct
     1261 gaggtggagg cgctgaggga gaaggtgtat gcatcactag aagcgtactg caaacacaag
     1321 taccctgagc agccgggcag gtttgccaag ctgctgctcc ggctgcctgc actgcgatcc
     1381 attgggctca agtgcctgga gcacctgttc ttcttcaagc tcatcgggga tacacccatc
     1441 gacactttcc tcatggagat gctggaggcc ccacatcaaa ccacctaggc cccgtcaccc
     1501 atgtgccggt cccttgcccc gcctggacac agctgctcag ctccagccct gtccctgccc
     1561 tttctgatgg cctgtgtgga tctttggggt gcagcgtccc catggtccca aaagatgcat
     1621 caccatcctc gccatcatca ttaatgcttg cctttggccc agggccgtgg cagagctggc
     1681 gtgacaccta cccagccccc tgccctacac caggctctaa ggctggtcac cctgagggtc
     1741 ttggggtact tcgtggggtc ttcagcacct ggagctgcag gagctgggag aggggcttgt
     1801 tctggttgct ggttgctgtc gctggttctc gacatgcccg cgtggcacct ctgtttggag
     1861 taccccatct ttgcccgtgc agagtcctgg tacccagcta agggtgggaa agggagcagg
     1921 tggggcaggt catatcctcc tggatcatag ctaaccttta agcctgtttc caaagatacc
     1981 ctgggctatc accccgagca ggattctggg accacctcaa ggccgcgtgg gctggaggtc
     2041 cg
//
