LOCUS       NM_001008310            1431 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Rattus norvegicus relaxin family peptide receptor 3 (Rxfp3), mRNA.
ACCESSION   NM_001008310 XM_226835
VERSION     NM_001008310.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1431)
  AUTHORS   Golyszny,M., Zielinski,M. and Obuchowicz,E.
  TITLE     Acute Stress Affects the Relaxin/Insulin-Like Family Peptide
            Receptor 3 mRNA Expression in Brain of Pubertal Male Wistar Rats
  JOURNAL   Dev Psychobiol 66 (6), e22523 (2024)
   PUBMED   38970242
  REMARK    GeneRIF: Acute Stress Affects the Relaxin/Insulin-Like Family
            Peptide Receptor 3 mRNA Expression in Brain of Pubertal Male Wistar
            Rats.
REFERENCE   2  (bases 1 to 1431)
  AUTHORS   Vafaei,Z., Khodagholi,F., Nategh,M., Nikseresht,S.,
            Hashemirad,S.R., Raise-Abdullahi,P., Vafaei,A.A. and Motamedi,F.
  TITLE     Involvement of relaxin-family peptide-3 receptor (RXFP3) in the
            ventral dentate gyrus of the hippocampus in spatial and fear memory
            in rats
  JOURNAL   Peptides 178, 171244 (2024)
   PUBMED   38788901
  REMARK    GeneRIF: Involvement of relaxin-family peptide-3 receptor (RXFP3)
            in the ventral dentate gyrus of the hippocampus in spatial and fear
            memory in rats.
REFERENCE   3  (bases 1 to 1431)
  AUTHORS   Kania,A., Szlaga,A., Sambak,P., Gugula,A., Blasiak,E., Micioni Di
            Bonaventura,M.V., Hossain,M.A., Cifani,C., Hess,G., Gundlach,A.L.
            and Blasiak,A.
  TITLE     RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular Neurons via
            M-like Current Activation and Contributes to Binge Eating Behavior
  JOURNAL   J Neurosci 40 (28), 5362-5375 (2020)
   PUBMED   32532885
  REMARK    GeneRIF: RLN3/RXFP3 Signaling in the PVN Inhibits Magnocellular
            Neurons via M-like Current Activation and Contributes to Binge
            Eating Behavior.
REFERENCE   4  (bases 1 to 1431)
  AUTHORS   Furuya,W.I., Dhingra,R.R., Gundlach,A.L., Hossain,M.A. and
            Dutschmann,M.
  TITLE     Relaxin-3 receptor (RXFP3) activation in the nucleus of the
            solitary tract modulates respiratory rate and the arterial
            chemoreceptor reflex in rat
  JOURNAL   Respir Physiol Neurobiol 271, 103310 (2020)
   PUBMED   31568840
  REMARK    GeneRIF: Activation of RXFP3 in the nucleus of the solitary tract
            selectively modulates respiration.
REFERENCE   5  (bases 1 to 1431)
  AUTHORS   Zhang,X., Pan,L., Yang,K., Fu,Y., Liu,Y., Chen,W., Ma,X. and Yin,X.
  TITLE     Alterations of relaxin and its receptor system components in
            experimental diabetic cardiomyopathy rats
  JOURNAL   Cell Tissue Res 370 (2), 297-304 (2017)
   PUBMED   28776188
  REMARK    GeneRIF: Relaxin-1 mRNA in the hearts of diabetic rats was
            significantly increased and that relaxin-3 mRNA expression at
            different time points was decreased. In addition, significant
            down-regulation of the mRNA expression of RXFP1 and RXFP3 was
            observed at 4 weeks after Streptozocin.
REFERENCE   6  (bases 1 to 1431)
  AUTHORS   Ma,S., Bonaventure,P., Ferraro,T., Shen,P.J., Burazin,T.C.,
            Bathgate,R.A., Liu,C., Tregear,G.W., Sutton,S.W. and Gundlach,A.L.
  TITLE     Relaxin-3 in GABA projection neurons of nucleus incertus suggests
            widespread influence on forebrain circuits via G-protein-coupled
            receptor-135 in the rat
  JOURNAL   Neuroscience 144 (1), 165-190 (2007)
   PUBMED   17071007
  REMARK    GeneRIF: RLX3 is the endogenous ligand for GPCR135 in rat brain
REFERENCE   7  (bases 1 to 1431)
  AUTHORS   McGowan,B.M., Stanley,S.A., Smith,K.L., Minnion,J.S., Donovan,J.,
            Thompson,E.L., Patterson,M., Connolly,M.M., Abbott,C.R.,
            Small,C.J., Gardiner,J.V., Ghatei,M.A. and Bloom,S.R.
  TITLE     Effects of acute and chronic relaxin-3 on food intake and energy
            expenditure in rats
  JOURNAL   Regul Pept 136 (1-3), 72-77 (2006)
   PUBMED   16764952
  REMARK    GeneRIF: relaxin-3 and GPCR153 have roles in food intake and energy
            expenditure in rats
REFERENCE   8  (bases 1 to 1431)
  AUTHORS   Susens,U., Hermans-Borgmeyer,I., Urny,J. and Schaller,H.C.
  TITLE     Characterisation and differential expression of two very closely
            related G-protein-coupled receptors, GPR139 and GPR142, in mouse
            tissue and during mouse development
  JOURNAL   Neuropharmacology 50 (4), 512-520 (2006)
   PUBMED   16378626
REFERENCE   9  (bases 1 to 1431)
  AUTHORS   Tanaka,M., Iijima,N., Miyamoto,Y., Fukusumi,S., Itoh,Y., Ozawa,H.
            and Ibata,Y.
  TITLE     Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond
            to stress
  JOURNAL   Eur J Neurosci 21 (6), 1659-1670 (2005)
   PUBMED   15845093
  REMARK    GeneRIF: We then confirmed that c-Fos was induced in 60% of relaxin
            3 neurons in the nucleus incertus (NI) and the expression of
            relaxin 3 mRNA increased significantly in the NI after
            water-restraint stress.
REFERENCE   10 (bases 1 to 1431)
  AUTHORS   Chen,J., Kuei,C., Sutton,S.W., Bonaventure,P., Nepomuceno,D.,
            Eriste,E., Sillard,R., Lovenberg,T.W. and Liu,C.
  TITLE     Pharmacological characterization of relaxin-3/INSL7 receptors
            GPCR135 and GPCR142 from different mammalian species
  JOURNAL   J Pharmacol Exp Ther 312 (1), 83-95 (2005)
   PUBMED   15367576
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY633764.1.
            
            On Dec 16, 2004 this sequence version replaced XM_226835.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY633764.1, AY633763.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1431
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="relaxin family peptide receptor 3"
                     /db_xref="GeneID:294807"
                     /db_xref="RGD:1311550"
     CDS             1..1431
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /note="relaxin-3/INSL7 receptor 1; G-protein coupled
                     receptor SALPR; relaxin/insulin-like family peptide
                     receptor 3"
                     /codon_start=1
                     /product="relaxin-3 receptor 1"
                     /protein_id="NP_001008311.1"
                     /db_xref="GeneID:294807"
                     /db_xref="RGD:1311550"
                     /translation="MPKAHLSMQVASATTAAPMSKAAAGDELSGFFGLIPDLLEVANR
                     SSNASLQLQDLWWELGLELPDGAAPGHPPGSGGAESADTEARVRILISAVYWVVCALG
                     LAGNLLVLYLMKSKQGWRKSSINLFVTNLALTDFQFVLTLPFWAVENALDFKWPFGKA
                     MCKIVSMVTSMNMYASVFFLTAMSVARYHSVASALKSHRTRGHGRGDCCGQSLGESCC
                     FSAKVLCGLIWASAAIASLPNVIFSTTINVLGEELCLMHFPDKLLGWDRQFWLGLYHL
                     QKVLLGFLLPLSIISLCYLLLVRFISDRRVVGTTDGATAPGGSLSTAGARRRSKVTKS
                     VTIVVLSFFLCWLPNQALTTWSILIKFNVVPFSQEYFQCQVYAFPVSVCLAHSNSCLN
                     PILYCLVRREFRKALKNLLWRIASPSLTSMRPFTATTKPEPEDHGLQALAPLNATAEP
                     DLIYYPPGVVVYSGGRYDLLPSSSAY"
     exon            1..1431
                     /gene="Rxfp3"
                     /gene_synonym="GPCR135; RGD1311550; Rln3r1; Salpr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcccaaag cgcacctgag catgcaagtg gcttctgcaa ccaccgcagc ccccatgagt
       61 aaggcagctg cgggtgatga gctctccgga ttcttcggcc tgatcccaga cttgctggag
      121 gttgccaaca ggagcagcaa tgcgtcgctg cagcttcagg acttgtggtg ggagctgggg
      181 ctggagttgc ccgacggtgc ggcgcctggg catcccccgg gcagcggtgg ggcagagagc
      241 gcggacacag aggccagggt acggatcctc atcagcgccg tttactgggt ggtttgtgcc
      301 ctgggactgg ctggcaacct gctggttctc tacctgatga agagcaaaca gggctggcgc
      361 aaatcctcca ttaacctctt tgtcactaac ctggcgctga ctgactttca gtttgtgctc
      421 actctgccct tctgggcggt ggagaacgca ctagatttca agtggccctt tggcaaggcc
      481 atgtgtaaga tcgtatctat ggtgacatcc atgaacatgt atgccagcgt cttctttctc
      541 actgctatga gtgtggcgcg ctaccactcg gtggcctcag ctctcaagag ccatcggacc
      601 cgcgggcatg gccgtggcga ctgctgcggc cagagcttgg gggagagctg ctgtttctca
      661 gccaaggtgc tgtgtggatt gatctgggct tctgccgcga tagcttcgct gcccaatgtc
      721 attttttcta ccaccatcaa tgtgttgggc gaggagctgt gcctcatgca ctttccggac
      781 aagctcctgg gttgggaccg gcagttctgg ctgggtttgt accacctgca gaaggtgctg
      841 ctgggcttcc tgctgccgct gagcatcatc agtttgtgtt acctgttgct cgtgcgcttc
      901 atctccgacc gccgcgtagt ggggacaacg gatggagcaa cagcgcctgg ggggagcctg
      961 agtacagccg gcgctcggag acgctccaag gtcaccaagt cggtgaccat cgtagtcctt
     1021 tccttcttct tatgttggct gcccaaccaa gcgctcacca cctggagcat cctcatcaag
     1081 ttcaacgtag tgcccttcag tcaggagtac tttcagtgcc aagtgtacgc gttcccagtc
     1141 agcgtgtgcc tggcacactc caacagctgc ctcaacccca tcctctactg cttagtgcgc
     1201 cgcgagttcc gcaaggcgct caagaacctg ctgtggcgta tagcatcgcc ttcgctcacc
     1261 agcatgcgcc ccttcaccgc caccaccaag ccagaacctg aagatcacgg gctgcaggcc
     1321 ctggcgccac ttaatgctac tgcagagcct gacctgatct actatccacc cggtgtggtg
     1381 gtctacagcg gaggtcgcta cgaccttctc cctagcagct ctgcctactg a
//
