LOCUS       NM_001128152            1044 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus RWD domain containing 3 (Rwdd3), mRNA.
ACCESSION   NM_001128152 XM_342332
VERSION     NM_001128152.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1044)
  AUTHORS   Gerez,J., Fuertes,M., Tedesco,L., Silberstein,S., Sevlever,G.,
            Paez-Pereda,M., Holsboer,F., Turjanski,A.G. and Arzt,E.
  TITLE     In silico structural and functional characterization of the RSUME
            splice variants
  JOURNAL   PLoS One 8 (2), e57795 (2013)
   PUBMED   23469069
REFERENCE   2  (bases 1 to 1044)
  AUTHORS   Shan,B., Gerez,J., Haedo,M., Fuertes,M., Theodoropoulou,M.,
            Buchfelder,M., Losa,M., Stalla,G.K., Arzt,E. and Renner,U.
  TITLE     RSUME is implicated in HIF-1-induced VEGF-A production in pituitary
            tumour cells
  JOURNAL   Endocr Relat Cancer 19 (1), 13-27 (2012)
   PUBMED   22009797
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1044)
  AUTHORS   Carbia-Nagashima,A., Gerez,J., Perez-Castro,C., Paez-Pereda,M.,
            Silberstein,S., Stalla,G.K., Holsboer,F. and Arzt,E.
  TITLE     RSUME, a small RWD-containing protein, enhances SUMO conjugation
            and stabilizes HIF-1alpha during hypoxia
  JOURNAL   Cell 131 (2), 309-323 (2007)
   PUBMED   17956732
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jun 6, 2008 this sequence version replaced XM_342332.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.981823.1,
                                           SRR26360186.1740532.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000002.1  211933488-211933592 c
            106-593             JAXUCZ010000002.1  211920895-211921382 c
            594-709             JAXUCZ010000002.1  211918925-211919040 c
            710-825             JAXUCZ010000002.1  211918711-211918826 c
            826-1044            JAXUCZ010000002.1  211918361-211918579 c
FEATURES             Location/Qualifiers
     source          1..1044
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q42"
     gene            1..1044
                     /gene="Rwdd3"
                     /gene_synonym="Rsume; X2cr1"
                     /note="RWD domain containing 3"
                     /db_xref="GeneID:65026"
                     /db_xref="RGD:620472"
     exon            1..105
                     /gene="Rwdd3"
                     /gene_synonym="Rsume; X2cr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..824
                     /gene="Rwdd3"
                     /gene_synonym="Rsume; X2cr1"
                     /note="pituitary tumor X2CR1 protein; RWD-containing
                     sumoylation enhancer; RWD domain-containing sumoylation
                     enhancer"
                     /codon_start=1
                     /product="RWD domain-containing protein 3"
                     /protein_id="NP_001121624.1"
                     /db_xref="GeneID:65026"
                     /db_xref="RGD:620472"
                     /translation="MAEEMRQELSALAAIFCGPHEWEMLSCSETDGAVFRIHTTAEGL
                     AGEDVPLELAFHLPAGYPSCLPGISVNSERLTRAQCVTVKEKLLGEARRLLSEPMVHE
                     LVLWTQQNLRHILSQTETESSNGTCTLPESSTVDGGLWMTLLRLDHMRARTKYVKVVE
                     KWASELRLTGRLMFMGKMILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISV
                     LSETKVQTEHKRFLAFEVKEYSTLEELQKEFETAGLQELFSECVLGLVK"
     exon            106..593
                     /gene="Rwdd3"
                     /gene_synonym="Rsume; X2cr1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..709
                     /gene="Rwdd3"
                     /gene_synonym="Rsume; X2cr1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..825
                     /gene="Rwdd3"
                     /gene_synonym="Rsume; X2cr1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..1044
                     /gene="Rwdd3"
                     /gene_synonym="Rsume; X2cr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggattctgg tcacgcggaa atggcggagg agatgaggca ggaactctcg gcgctggccg
       61 cgatcttctg cgggccccac gagtgggaga tgttgagctg ttcagagaca gatggggctg
      121 tctttagaat tcacacaaca gctgaaggac ttgcgggtga ggatgtgccc ttagagttgg
      181 cgttccactt accagccggt tacccatcgt gtctacccgg catttcggtt aactcggaac
      241 gtctgaccag ggcccagtgt gttaccgtga aggagaaact actcggagaa gccaggaggc
      301 ttctgtcaga accgatggtt cacgagctgg ttctttggac tcagcagaat ctcagacaca
      361 tcctcagcca gacagagaca gagagcagca atgggacgtg tactctgcca gaaagctcga
      421 ctgtggacgg cggactgtgg atgactcttt tgcgtttaga tcacatgaga gcgaggacta
      481 aatatgtgaa agttgtggag aagtgggctt cagagttaag gctgacagga agactgatgt
      541 tcatgggtaa aatgatactg attttactac aaggagacag aagcaacatc aaggagtacc
      601 tgattcttca gaaaacctcc aaagtagatg tggactcaag tggaaagaaa tgcaaagaga
      661 aaatgattag tgtactgtct gaaacaaaag tacaaacgga acacaaaagg tttctggcgt
      721 ttgaagtcaa agagtattca acactggagg agttacaaaa ggaatttgaa actgcaggac
      781 ttcaggagct cttctcagag tgtgtacttg ggctggtgaa atgaggaaga aaagtgagtc
      841 ctgttttatg gaatattaaa catgaaaaga tcccatatat tctaacgttt gccagaagag
      901 actaggttca atcgacggga ttgtctggag gagaaataaa aacccatgac tgtaaaggag
      961 ctgttgtctt tatgtagaca atttgtttgg gagtctgcaa tttccaggct aattttctcg
     1021 taattaaatg atttcttaaa gtga
//
