LOCUS       NM_001411778            3727 bp    mRNA    linear   ROD 28-DEC-2023
DEFINITION  Rattus norvegicus RUNX family transcription factor 3 (Runx3),
            transcript variant 2, mRNA.
ACCESSION   NM_001411778
VERSION     NM_001411778.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3727)
  AUTHORS   Wu Q, Xie J, Zhu X and He J.
  TITLE     Runt-related transcription factor 3, mediated by
            DNA-methyltransferase 1, regulated Schwann cell proliferation and
            myelination during peripheral nerve regeneration via JAK/STAT
            signaling pathway
  JOURNAL   Neurosci Res 192, 1-10 (2023)
   PUBMED   36690210
  REMARK    GeneRIF: Runt-related transcription factor 3, mediated by
            DNA-methyltransferase 1, regulated Schwann cell proliferation and
            myelination during peripheral nerve regeneration via JAK/STAT
            signaling pathway.
REFERENCE   2  (bases 1 to 3727)
  AUTHORS   Liu Y, Qu HQ, Chang X, Qu J, Mentch FD, Nguyen K, Tian L, Glessner
            J, Sleiman PMA and Hakonarson H.
  TITLE     Mutation burden analysis of six common mental disorders in African
            Americans by whole genome sequencing
  JOURNAL   Hum Mol Genet 31 (22), 3769-3776 (2022)
   PUBMED   35642741
REFERENCE   3  (bases 1 to 3727)
  AUTHORS   Shi L, Liu BY, Wang X, Zhu MJ, Chen L, Zhou MY, Gu YJ, Cheng L and
            Wang Y.
  TITLE     RUNX3-dependent oxidative epithelial-to-mesenchymal transition in
            methamphetamine-induced chronic lung injury
  JOURNAL   Cell Stress Chaperones 25 (5), 793-802 (2020)
   PUBMED   32681471
  REMARK    GeneRIF: RUNX3-dependent oxidative epithelial-to-mesenchymal
            transition in methamphetamine-induced chronic lung injury.
REFERENCE   4  (bases 1 to 3727)
  AUTHORS   Li Y, Li H and Han J.
  TITLE     Sphingosine-1-phosphate receptor 2 modulates pain sensitivity by
            suppressing the ROS-RUNX3 pathway in a rat model of neuropathy
  JOURNAL   J Cell Physiol 235 (4), 3864-3873 (2020)
   PUBMED   31603252
  REMARK    GeneRIF: Sphingosine-1-phosphate receptor 2 modulates pain
            sensitivity by suppressing the ROS-RUNX3 pathway in a rat model of
            neuropathy.
REFERENCE   5  (bases 1 to 3727)
  AUTHORS   Li S, Cui HZ, Xu CM, Sun ZW, Tang ZK and Chen HL.
  TITLE     RUNX3 protects against acute lung injury by inhibiting the
            JAK2/STAT3 pathway in rats with severe acute pancreatitis
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (12), 5382-5391 (2019)
   PUBMED   31298391
  REMARK    GeneRIF: RUNX3 protects against acute lung injury by inhibiting the
            JAK2/STAT3 pathway in rats with severe acute pancreatitis.
REFERENCE   6  (bases 1 to 3727)
  AUTHORS   Yoshida CA, Yamamoto H, Fujita T, Furuichi T, Ito K, Inoue K,
            Yamana K, Zanma A, Takada K, Ito Y and Komori T.
  TITLE     Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2
            regulates limb growth through induction of Indian hedgehog
  JOURNAL   Genes Dev 18 (8), 952-963 (2004)
   PUBMED   15107406
REFERENCE   7  (bases 1 to 3727)
  AUTHORS   Zhang L, Li Z, Yan J, Pradhan P, Corpora T, Cheney MD, Bravo J,
            Warren AJ, Bushweller JH and Speck NA.
  TITLE     Mutagenesis of the Runt domain defines two energetic hot spots for
            heterodimerization with the core binding factor beta subunit
  JOURNAL   J Biol Chem 278 (35), 33097-33104 (2003)
   PUBMED   12807883
REFERENCE   8  (bases 1 to 3727)
  AUTHORS   Taniuchi I, Osato M, Egawa T, Sunshine MJ, Bae SC, Komori T, Ito Y
            and Littman DR.
  TITLE     Differential requirements for Runx proteins in CD4 repression and
            epigenetic silencing during T lymphocyte development
  JOURNAL   Cell 111 (5), 621-633 (2002)
   PUBMED   12464175
REFERENCE   9  (bases 1 to 3727)
  AUTHORS   Inoue K, Ozaki S, Shiga T, Ito K, Masuda T, Okado N, Iseda T,
            Kawaguchi S, Ogawa M, Bae SC, Yamashita N, Itohara S, Kudo N and
            Ito Y.
  TITLE     Runx3 controls the axonal projection of proprioceptive dorsal root
            ganglion neurons
  JOURNAL   Nat Neurosci 5 (10), 946-954 (2002)
   PUBMED   12352981
REFERENCE   10 (bases 1 to 3727)
  AUTHORS   Li QL, Ito K, Sakakura C, Fukamachi H, Inoue Ki, Chi XZ, Lee KY,
            Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N,
            Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi
            H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC and Ito Y.
  TITLE     Causal relationship between the loss of RUNX3 expression and
            gastric cancer
  JOURNAL   Cell 109 (1), 113-124 (2002)
   PUBMED   11955451
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000162.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001411778.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06680422,
                              SAMN06680423 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-556               JACYVU010000162.1  61909886-61910441
            557-825             JACYVU010000162.1  61943496-61943764
            826-982             JACYVU010000162.1  61945927-61946083
            983-1087            JACYVU010000162.1  61954037-61954141
            1088-1237           JACYVU010000162.1  61962101-61962250
            1238-3727           JACYVU010000162.1  61965971-61968460
FEATURES             Location/Qualifiers
     source          1..3727
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3727
                     /gene="Runx3"
                     /note="RUNX family transcription factor 3"
                     /db_xref="GeneID:156726"
                     /db_xref="RGD:620082"
     exon            1..556
                     /gene="Runx3"
                     /inference="alignment:Splign:2.1.0"
     CDS             499..1770
                     /gene="Runx3"
                     /note="isoform 2 is encoded by transcript variant 2; Runt
                     related transcription factor 3; runt-related transcription
                     factor 3"
                     /codon_start=1
                     /product="runt-related transcription factor 3 isoform 2"
                     /protein_id="NP_001398707.1"
                     /db_xref="GeneID:156726"
                     /db_xref="RGD:620082"
                     /translation="MASNSIFDSFPNYTPTFIRDPSTSRRFTPPSTAFPCGGGGGGKM
                     GENSGALSAQAAAGPGGRTRPEVRSMVDVLADHAGELVRTDSPNFLCSVLPSHWRCNK
                     TLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSG
                     RGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRHRQKIEDQTKAFPDRFGDLRM
                     RVTPSTPSPRGSLSTTSHFSSQAQTPIQGSSDLNPFSDPRQFDRSFPTLQSLTESRFP
                     DPRMHYPGAMSAAFPYSATPSGTSLGGLSVAGMPASSRFHHTYLPPPYPGAPQSQSGP
                     FQANPAPYHLFYGTSSGSYQFSMAAAGGGERSPTRMLTSCPTGASVSAGNLMNPSLGQ
                     ADGVEADGSHSNSPTALSTPGRMDEAVWRPY"
     exon            557..825
                     /gene="Runx3"
                     /inference="alignment:Splign:2.1.0"
     exon            826..982
                     /gene="Runx3"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1087
                     /gene="Runx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1237
                     /gene="Runx3"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..3727
                     /gene="Runx3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcattcat tcatccgggc tgctgagtct ggtctcgccg ccgcagccct gggctcctcc
       61 gccctggctg ctccgagccc cttcccacca tttaatgata ctctgcacat agcgctgttg
      121 agaatttgtg gctagacatt cctgtgggac tgggaggcca aattcttggg tacaaaccga
      181 aactttcttt ccttggagat tttcttctct ctcgcccaca gataactctc gcgttctttc
      241 ccccattttt ttctttcttt ctttttcctc tttttttttt cttttttgta gcagcagggg
      301 gaggaaaaaa aaaaagaaac caaactttaa aaaaaaaaaa aaaggcaaca cctcccctcc
      361 cttttttttt tttttttttt tttttttttt tttttgaaag caacttgaaa aaaatatata
      421 acaaaacagc agccaaccaa gcgggtccga acccgacccc ctgaggccga cgagtccttg
      481 cctctgtcag cgtgggatat ggcctccaac agcatcttcg attccttccc caactacacg
      541 ccaaccttca tacgagaccc gagcaccagc cgccgcttca ctcccccctc cacggccttc
      601 ccctgcggcg gcggcggcgg cggcaagatg ggcgagaaca gcggcgcgct gagcgcgcag
      661 gcggccgcgg gccccggcgg ccgcacccgg cccgaagtgc gctcgatggt ggacgtgctg
      721 gccgaccacg cgggagagct cgtgcgcacc gacagcccca acttcctctg ctccgtgctg
      781 ccctcgcact ggcgctgcaa caagacgctg ccggtcgcct tcaaggtggt ggcactgggg
      841 gatgttcctg atggaacggt ggtgaccgtg atggcgggca atgacgagaa ttactccgcc
      901 gagctgcgca acgcttccgc tgtcatgaag aaccaagtgg cccggttcaa cgacctccgc
      961 ttcgtgggcc gcagcgggcg agggaagagc ttcacgctca caatcaccgt gttcaccaac
     1021 cctacccaag tggccaccta ccaccgagcc atcaaggtta ctgtggatgg accccgggaa
     1081 ccccgacggc accggcagaa gatagaggac cagaccaaag ccttccccga ccgcttcgga
     1141 gacctgcgca tgcgtgtaac accaagcaca cccagccccc gtggctctct cagcaccacg
     1201 agccacttca gcagccaggc ccagacccca atccaaggct cctcagacct gaaccccttc
     1261 tcggaccccc gccagtttga tcgctccttc cctacgctgc aaagcctcac agagagccgc
     1321 ttcccggacc caaggatgca ctacccggga gccatgtctg ccgccttccc ctacagtgcc
     1381 acaccatcgg gaaccagcct gggcggcctg agcgtggccg gcatgccggc cagcagccgc
     1441 ttccaccaca cctacctccc tccgccctac ccgggggccc cgcagagtca gagcgggccc
     1501 tttcaggcca accctgcgcc ctaccacctc ttctatggca cctcctccgg ctcctaccag
     1561 ttctccatgg cagctgccgg aggtggcgag cgctcgccca cccgcatgct gacctcctgc
     1621 cccaccggcg cttcggtgtc agcaggcaat ctcatgaacc ccagcctggg ccaggctgat
     1681 ggcgtggaag ccgacggcag tcacagcaac tcgcccacgg ccctgagcac accgggccgc
     1741 atggacgagg ccgtgtggcg gccctactga gcaccctagg gactctcggg tcagcagaat
     1801 ctgtccctcc agcccgaggc tacaagaaaa aaaaacaaac tttggcttgg tcccaggggc
     1861 cagagctggc tatggctcct agagctctgt ccagccacaa gttttgaaca gaggaagtgg
     1921 ggagctccca caggacactg cgccggccca aatcaatgtc ctctctccct gtgcatccca
     1981 aacccacctc tgttgtcttc agccatgccc aggattaatt ccggaatcgg aggctacccc
     2041 tgcccatgag gcaagagaaa ctcaggctca aagatgtctg gacttcctct caccctgcac
     2101 cctggggacc aaccctctct ctgcatccat acttgtcaac tggaaactcc aacccctgag
     2161 atggtttctt gtgtgactcg tggaggagcc acgacacaca cacaagagtc cccagctgga
     2221 cttccccata actccaggca agaagcccct gatcaggtct agcttacctg aaaacaccag
     2281 gccccagagc agactcatct ccagtggcag gtccctaaaa acaaggatgg cctcaacact
     2341 gtccagcaca ctccagcctg agttgcctac tggcagaaag tcttaaacct tggggatcta
     2401 tagggtggtt agccctgctc agtaggtcca gccaaggctg ctctgggcct ggcctcccag
     2461 ctcccactcc cactcccaac ttgtttgtac ctagaggcaa acaaccttga aaaaaaagaa
     2521 aggtgactcc ttcaagcatc taaaacctct ggcaggtggc cgtccctgtg tatgaaagcc
     2581 caaccccttg ctagtgtgat gtcattagga tcctgccacc tccataccac acattcctca
     2641 cagaggggga ccagatactc caggcggcca tatggagtct ctggcgaggt gtgcagcagc
     2701 agagcggtgt ccaagcagag gtcagatgtc atcttagatc tgtgggagat ggtgcgtggg
     2761 ataggttaaa aagttgttac cagagctggc ccacggctgt tttttttttt tcaaactcag
     2821 tgaggcacgt actctgtggc cattgaaatg tcctttacaa ggctccttag tgagggtctc
     2881 tggcaggtgc ttggcttgcc ccattgcctg ggcctgacgg ccacgaatgc actctagcag
     2941 gccagggggt cccgggggtc cccacaatcc tgagcaaatg cctctggttg cagtttctct
     3001 tgtcccattc ttactggagg aaaagaaaat tctatctctt ggaagtagct ggggtaacct
     3061 tttagctccc tgcacccaga ggggccttct cacctcttct caggaagcag ctaagaccca
     3121 ttgtcctcct actcgcttcg ctactggtcc atggtgcaga ctgtcccaaa tcaccaagaa
     3181 aggtactttc aggatcccag cacctagcac tgtgtaagcc atcccagaca actacccttc
     3241 ctgatacccc aaaatgtgtg cggagataga aaagtcgccc tgcccccaaa actcctttct
     3301 catccctgat taacagtgaa ggccgagtct gtcgtggatc ctacagtagg ctcaggcagc
     3361 ctagaggggt ttaaaaaccg gtggttccta tttgcaaggc tactttaaag tgctacttga
     3421 aaagcactgg ctacaaagaa agaaagcaca agaacctgaa aggctgatac gatgttgctc
     3481 taagtgtgtg ggtgggtacc gatccttaag gtatcctgcc tgctgtgggc aggtcttcct
     3541 gaagtggtct ccaaactgag ggacagggga gggcctgctt tgcactatag gctgcttgtg
     3601 tgtttgtttg tttgttgttt ttagcacaac gtgcttgtac agaccaactg cccgtcttgg
     3661 gtactattta actgtaagag aaaagctgta tttgttacaa taatataaca gatctgtgga
     3721 ggaccga
//
