LOCUS       NM_001415755            5668 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus RUNX family transcription factor 2 (Runx2),
            transcript variant 3, mRNA.
ACCESSION   NM_001415755
VERSION     NM_001415755.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5668)
  AUTHORS   Gopinathan,G., Luan,X. and Diekwisch,T.G.H.
  TITLE     Epigenetic Repression of RUNX2 and OSX Promoters Controls the
            Nonmineralized State of the Periodontal Ligament
  JOURNAL   Genes (Basel) 14 (1), 201 (2023)
   PUBMED   36672941
  REMARK    GeneRIF: Epigenetic Repression of RUNX2 and OSX Promoters Controls
            the Nonmineralized State of the Periodontal Ligament.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5668)
  AUTHORS   Xie,S., Chen,M., Fang,W., Liu,S., Wu,Q., Liu,C., Xing,Y., Shi,W.,
            Xu,M., Zhang,M., Chen,S., Zeng,X., Wang,S., Deng,W. and Tang,Q.
  TITLE     Diminished arachidonate 5-lipoxygenase perturbs phase separation
            and transcriptional response of Runx2 to reverse pathological
            ventricular remodeling
  JOURNAL   EBioMedicine 86, 104359 (2022)
   PUBMED   36395739
  REMARK    GeneRIF: Diminished arachidonate 5-lipoxygenase perturbs phase
            separation and transcriptional response of Runx2 to reverse
            pathological ventricular remodeling.
REFERENCE   3  (bases 1 to 5668)
  AUTHORS   Zhou,W., Feng,Q., Cheng,M., Zhang,D., Jin,J., Zhang,S., Bai,Y. and
            Xu,J.
  TITLE     LncRNA H19 sponges miR-103-3p to promote the high
            phosphorus-induced osteoblast phenotypic transition of vascular
            smooth muscle cells by upregulating Runx2
  JOURNAL   Cell Signal 91, 110220 (2022)
   PUBMED   34923106
  REMARK    GeneRIF: LncRNA H19 sponges miR-103-3p to promote the high
            phosphorus-induced osteoblast phenotypic transition of vascular
            smooth muscle cells by upregulating Runx2.
REFERENCE   4  (bases 1 to 5668)
  AUTHORS   Samanta,J., Mondal,A., Das,S., Chakraborty,S. and Sengupta,A.
  TITLE     Induction of cardiomyocyte calcification is dependent on
            FoxO1/NFATc3/Runx2 signaling
  JOURNAL   In Vitro Cell Dev Biol Anim 57 (10), 973-986 (2021)
   PUBMED   34845564
  REMARK    GeneRIF: Induction of cardiomyocyte calcification is dependent on
            FoxO1/NFATc3/Runx2 signaling.
REFERENCE   5  (bases 1 to 5668)
  AUTHORS   Gomathi,K., Rohini,M., Partridge,N.C. and Selvamurugan,N.
  TITLE     Regulation of transforming growth factor-beta1-stimulation of Runx2
            acetylation for matrix metalloproteinase 13 expression in
            osteoblastic cells
  JOURNAL   Biol Chem 403 (3), 305-315 (2021)
   PUBMED   34643076
  REMARK    GeneRIF: Regulation of transforming growth factor-beta1-stimulation
            of Runx2 acetylation for matrix metalloproteinase 13 expression in
            osteoblastic cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5668)
  AUTHORS   Xiao,Z.S., Thomas,R., Hinson,T.K. and Quarles,L.D.
  TITLE     Genomic structure and isoform expression of the mouse, rat and
            human Cbfa1/Osf2 transcription factor
  JOURNAL   Gene 214 (1-2), 187-197 (1998)
   PUBMED   9651525
REFERENCE   7  (bases 1 to 5668)
  AUTHORS   Thirunavukkarasu,K., Mahajan,M., McLarren,K.W., Stifani,S. and
            Karsenty,G.
  TITLE     Two domains unique to osteoblast-specific transcription factor
            Osf2/Cbfa1 contribute to its transactivation function and its
            inability to heterodimerize with Cbfbeta
  JOURNAL   Mol Cell Biol 18 (7), 4197-4208 (1998)
   PUBMED   9632804
REFERENCE   8  (bases 1 to 5668)
  AUTHORS   Mundlos,S., Otto,F., Mundlos,C., Mulliken,J.B., Aylsworth,A.S.,
            Albright,S., Lindhout,D., Cole,W.G., Henn,W., Knoll,J.H.,
            Owen,M.J., Mertelsmann,R., Zabel,B.U. and Olsen,B.R.
  TITLE     Mutations involving the transcription factor CBFA1 cause
            cleidocranial dysplasia
  JOURNAL   Cell 89 (5), 773-779 (1997)
   PUBMED   9182765
REFERENCE   9  (bases 1 to 5668)
  AUTHORS   Ducy,P., Zhang,R., Geoffroy,V., Ridall,A.L. and Karsenty,G.
  TITLE     Osf2/Cbfa1: a transcriptional activator of osteoblast
            differentiation
  JOURNAL   Cell 89 (5), 747-754 (1997)
   PUBMED   9182762
REFERENCE   10 (bases 1 to 5668)
  AUTHORS   Satake,M., Nomura,S., Yamaguchi-Iwai,Y., Takahama,Y., Hashimoto,Y.,
            Niki,M., Kitamura,Y. and Ito,Y.
  TITLE     Expression of the Runt domain-encoding PEBP2 alpha genes in T cells
            during thymic development
  JOURNAL   Mol Cell Biol 15 (3), 1662-1670 (1995)
   PUBMED   7862157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.49329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-175               JAXUCZ010000009.1  23665058-23665232
            176-299             JAXUCZ010000009.1  23665397-23665520
            300-688             JAXUCZ010000009.1  23743281-23743669
            689-845             JAXUCZ010000009.1  23753580-23753736
            846-950             JAXUCZ010000009.1  23760516-23760620
            951-1124            JAXUCZ010000009.1  23818195-23818368
            1125-1286           JAXUCZ010000009.1  23837869-23838030
            1287-1352           JAXUCZ010000009.1  23867080-23867145
            1353-5668           JAXUCZ010000009.1  23868867-23873182
FEATURES             Location/Qualifiers
     source          1..5668
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q13"
     gene            1..5668
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="RUNX family transcription factor 2"
                     /db_xref="GeneID:367218"
                     /db_xref="RGD:2282"
     exon            1..175
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            176..299
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1831
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     core-binding factor subunit alpha-1; osteoblast-specific
                     transcription factor 2; runt-related transcription factor
                     2"
                     /codon_start=1
                     /product="runt-related transcription factor 2 isoform 1"
                     /protein_id="NP_001402684.1"
                     /db_xref="GeneID:367218"
                     /db_xref="RGD:2282"
                     /translation="MASNSLFSAVTPCQQNFFWDPSTSRRFSPPSSSLQPGKMSDVSP
                     VVAAQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQEAAAAAAAAAAAAAAAAAVPRLR
                     PPHDNRTMVEIIADHPAELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGEVPDGT
                     VVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQV
                     ATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRP
                     SLNSAPSPFNPQGQSQITDPRQTQSSPPWSYDQSYPSYLSQMTSPSIHSTTPLSSTRG
                     TGLPAITDVPRRISDDDTATSDFCLWPSSLSKKSQAGASELGPFSDPRQFPGISSLTE
                     SRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQSQSGPFQTSST
                     PYLYYGTSSASYQFPMVPGGDRSPSRMVPPCTTTSNGSTLLNPNLPNQNDGVDADGSH
                     SSSPTVLNSSGRMDESVWRPY"
     exon            300..688
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..845
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            846..950
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1124
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1286
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1352
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..5668
                     /gene="Runx2"
                     /gene_synonym="CBF-alpha-1; Cbfa1; OSF-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaatgctt cattcgcctc acaaacaacc acagaaccac aagtgcggtg caaactttct
       61 ccaggaggac agcaaggagg ccctggtgtt taaatggtta atctctgcag gtcactacca
      121 gccaccgaga ccaaccgagt cagtgagtgc tctgagcaca gtccatgcag taatatttaa
      181 ggctgcaagc agtatttaca acagagggca caagttctat ctggaaaaaa aaggagggac
      241 tatggcgtca aacagcctct tcagtgcagt gacaccgtgt cagcaaaact tcttttggga
      301 tccgagcacc agccggcgct tcagcccccc ctccagcagc ctgcagcccg gcaagatgag
      361 cgacgtgagc ccggtagtgg ctgctcagca gcagcagcag cagcagcagc agcagcagca
      421 gcagcaacag cagcaacagc agcagcagca gcagcaacag cagcagcagc agcagcagga
      481 ggcggccgca gcagcagcag cggcagcggc ggcggcagca gcggcggcag ccgtgccccg
      541 gttgaggccg ccgcacgaca accgcaccat ggtggagatc atcgcggacc acccggccga
      601 actggtccgc accgacagcc ccaacttcct gtgctccgtg ctgccctcgc actggcggtg
      661 caacaagacc ctgcccgtgg ccttcaaggt tgtagccctc ggagaggtac ccgatgggac
      721 cgtggttacc gtcatggccg ggaatgatga gaactactct gccgagctac gaaatgcctc
      781 tgctgttatg aaaaaccaag tggccaggtt caacgatctg agatttgtag gccggagcgg
      841 acgaggcaag agtttcactt tgaccataac ggtcttcaca aatcctcccc aagtggccac
      901 ttaccacaga gctattaaag tgacagtgga cggtccccgg gaaccaagaa ggcacagaca
      961 gaagcttgat gactctaaac ctagtttgtt ctctgaccgc ctcagtgatt tagggcgcat
     1021 tcctcatccc agtatgagag taggtgtccc gcctcagaac ccacggccct ccctgaactc
     1081 agcaccaagt ccttttaatc cacaaggaca gagtcagatt acagatccca ggcagacaca
     1141 atcctcccca ccgtggtcct atgaccagtc ttacccctct tatctgagcc agatgacgtc
     1201 cccatccatc cattccacca cgccgctgtc ttccacacgg ggcactgggc tgccagccat
     1261 caccgacgta cccaggcgta tttcagatga tgacactgcc acctctgact tctgcctctg
     1321 gccttcctct ctcagtaaga agagccaggc aggtgcttca gaactgggcc ctttttcaga
     1381 ccccaggcag ttcccaggca tttcatccct cactgagagc cgcttctcca acccacgaat
     1441 gcactatcca gccaccttca cttacacccc gccagtcacg tcaggcatgt ccctgggcat
     1501 gtccgccacc actcactacc acacgtacct gccaccaccc taccccggct cttcccaaag
     1561 ccagagcgga cccttccaga ccagcagcac tccatatctc tactatggta cttcgtcagc
     1621 gtcctatcag ttcccaatgg tccccggggg agaccggtct ccttccagga tggtcccacc
     1681 gtgcacgacc acctcgaatg gcagcacgct attaaatcca aatttgccta accagaatga
     1741 tggtgttgac gctgatggaa gccacagcag ctccccaacc gttttgaatt ctagcggcag
     1801 aatggatgag tctgtctggc gaccctattg aagtctgtca accgtgcatg gcccagtggc
     1861 atgcagtggc cacgtcccac atgtgttaat atatacatat ataaagagag tgcctatata
     1921 tgtatattga ttagctatct agaagatttc tcattcactc cccagttgtg atctggcaac
     1981 cctaagagtg tggggacagt cattactggg tttcatattg tttactattt aagatgtctc
     2041 ctctaccaag gagcagaccg tcaaaggtgt tatctggtct ggtttcgtaa gtgacctgtt
     2101 cccacaacaa ttcagagagg tggactctgg gtccgggagg aagaacggcc acttcctccc
     2161 tgtgctttgc aaccaaatca aggcctctgc tgtgtggagg cctgtgcact ctgcagacca
     2221 gcttacaaag ctgtggtgca ctcggaaagg gacgagaggc agcgtggctg cttcccctac
     2281 cgtccactct gaatacctgt tccaaagctt cccttcagac ttgatgcagg tatgcgtttg
     2341 aacttttgag ttcactcttt tttttttttt ttttctattc taagaaagtg acttcaaaaa
     2401 tactgatcag gacagattat tttattttac ttttttaaaa tattccctca cttcccccat
     2461 ttaaccaaaa aataagtccc attcccctcc cccgtgcctc ctgcttctcc ctttatgcaa
     2521 aactgaaaat ggcaatatct tattatagcc ataatgatat agtgtttgag ttggctgtgt
     2581 gttgtttgtt tttactttct ttttttcctt ttttaagtta tgaatatgtg taaaatctga
     2641 agtaacttgc taacgtgaat ggtcatataa ctttaaagat atatttataa ttatttaatg
     2701 acatttggac atttggaaca tttcttagtg taatggtctg ttgacttcgg tctctaaaag
     2761 tgcttcttct taaataacaa gtttcttcag tgggctagag ccatatcgga aatattgcta
     2821 agcaatttca attccttcag gcataatgtg attttttttt tttatgataa ctcccatttc
     2881 caaatatttt agttgtagtt ttgtttccat gatgtatgaa ggaaatgcta tgcttctttc
     2941 tttcaggtgt ttgattgcct ctgacacggc tttacctgtt aaagcaataa ttagggatta
     3001 aaaaacaaaa caaaacaaaa caaaaaccac ctataaccct gcagcccttt gacgcttaat
     3061 gcggcctctt tgctagcatt gaaatgctgg agacatgtgg tttcctaatt tcttcatttt
     3121 tggggggtgg ggggttggcc attatgagtc ttgtcatatt aaaaagccaa gcacaagtga
     3181 ttggccgaac tgcagaaaag tgttctgtgg tctcagagtt gagcagaact ctaaattgca
     3241 ggcttcgtgg ttgagggcct aggcagctga aagccacacg tgtagtaaag gctcaaccat
     3301 gacacgtaca gcctaggaac acagatgcat taggagtctg cacccccccc ccagccttac
     3361 cacacagcca ttcaggggaa cccaaaagtg ccttacccaa ggagccccca cccccaacag
     3421 cagctttgca ggaagtggaa tgaagtcaat gtcctagggg agctggtcag ctgaagtagt
     3481 agctgatgtc agtagacaca gagcctgtgg ggacctccag gaagcctttg atactcaagg
     3541 ctctcactag ggagggccgt agagagcagg gaagacaatg tatgtagcag ttggtgtctg
     3601 ccatcgtgtg tgaacataag atccagccct cctaggagga cgtactgtga tcattcctgg
     3661 caccttgtgg ccaatccctg agtgtgactc cctaatccaa gccagagatc attcagtgac
     3721 accaccaggc aagtgctagc attcctcctg cacaaagtgt gtttgttggg ggttggggtt
     3781 gggggccacc ttcctttgaa tccagagcca ttctaagagt ccttcaggct tttgccttta
     3841 gcccctacac ccccttgctc tctgttcctt ctcaggttga cctttgtccc aatgtgggac
     3901 agtccagggg cagatgggga acttatgtgt gcctccaacc tgtgttttcc ctcaggattc
     3961 atcctgactc cttctgacac aaattgaggg ggaaagaaac ccacccagta gcaaaccgaa
     4021 acactttgcc ttctaaaggt tgtgtaccaa gtatgcacag atagatggtc aggccacctt
     4081 tgtgtttctt gagatggaat ttgtagctga tgctatttat tgtctgtgtg tggtagcttg
     4141 aagcacacca cggtccgtgt gtttgtctga tgcctatttc agcagcattt acaaaagtca
     4201 gtgtctggtt acacttttta gttttcatta atcgacatgg aaatgttacc accggtgcca
     4261 gctgcaccct atttaacttc ttttcaaagg cactatattt gtacattatt atttttttct
     4321 ttaacgttaa agggcttctt aaagtttaca atacagttat taagggacta gaggggatgc
     4381 cttagtgccc aaatgttatt acagtggctg caggcagcaa cccagaaaca tttttgaaaa
     4441 caggttgttt ccctccatcc tcccttattt gggaaaaatt caagtgcttt cttcaccctt
     4501 cagccacctc acagggtgac tcccgttaca acagtctccc ccattccccc actatgtttt
     4561 aaattttccc cttcccctcc ctttatctct taaactcttc atttgcactg ggtcacatgt
     4621 atgatttgtg gttttaagac caaagcaatg tcttaatact ctcctgggac tgttttcgtg
     4681 tacaaacttc cctgggctta gatggacatg gttctcgaag gagcacaaac atggctgaga
     4741 tttgcagtgg gaccgacaca gccatataaa aaaaaatgct cttcagttat ctcagaattt
     4801 taacctaggc cacagttcct aacgggcacc atggctttgg tttcaggtta gggaatgagg
     4861 cgcacccagc ccataataga aagacttacc agatttaact agttggctct catccttccc
     4921 tccgagaccc taagaaaacg aacagagcaa catctccaca tcattagaga ctgtccacag
     4981 taggttcaga agggagcagc catgttgggg gttctccttg ctccaaggaa aggcactgac
     5041 tgacctagtt ttagagaaca gtagcgggag catttgcatc cacagtgttt gagagggtaa
     5101 taaacaataa aagatgattc tcccagcctt tgaattcatt gttcttaaag atgatgatgc
     5161 atctaaaaca aagatttttt ttttctcctc ctatgtggga actttcttcg ttgtctgttt
     5221 acttcatgtt tacaaataat tgtttgcttt ttaatgcagt actttaaaaa tatatcagcc
     5281 aaaaccataa cgtacagtaa tttcttaggt attctgaata aaattccatg tctttcgata
     5341 tgcctactgt tcttaggttt ctgcggaaca acaacaacaa caacaacaaa aaaattgtag
     5401 cattttgtgt aaataacagc tttcgttctt atttttttat ttctctgatt gctattgccc
     5461 aagatttgct ttccatgcac atattgtaca aattctgctt tgtaccacac aggtcacgat
     5521 tgtggatgag tttactctga acttcaaagg gactatttgt attgtatgtt gcaactgtaa
     5581 attgaattat ttggcatttt ctcccctcat gattgtaata ttaatttgaa gtttgaattt
     5641 aattttcaat aaaaaggctt tttttttc
//
