LOCUS       NM_001108657            3364 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus RUNX1 partner transcriptional co-repressor 1
            (Runx1t1), mRNA.
ACCESSION   NM_001108657 XM_001053893 XM_342808
VERSION     NM_001108657.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3364)
  AUTHORS   Indjeian,V.B., Kingman,G.A., Jones,F.C., Guenther,C.A.,
            Grimwood,J., Schmutz,J., Myers,R.M. and Kingsley,D.M.
  TITLE     Evolving New Skeletal Traits by cis-Regulatory Changes in Bone
            Morphogenetic Proteins
  JOURNAL   Cell 164 (1-2), 45-56 (2016)
   PUBMED   26774823
REFERENCE   2  (bases 1 to 3364)
  AUTHORS   Linqing,Z., Guohua,J., Haoming,L., Xuelei,T., Jianbing,Q. and
            Meiling,T.
  TITLE     Runx1t1 regulates the neuronal differentiation of radial glial
            cells from the rat hippocampus
  JOURNAL   Stem Cells Transl Med 4 (1), 110-116 (2015)
   PUBMED   25473084
  REMARK    GeneRIF: We have concluded that Runx1t1 could be involved in the
            process through which radial glial cells differentiate into neurons
REFERENCE   3  (bases 1 to 3364)
  AUTHORS   Barrett,C.W., Smith,J.J., Lu,L.C., Markham,N., Stengel,K.R.,
            Short,S.P., Zhang,B., Hunt,A.A., Fingleton,B.M., Carnahan,R.H.,
            Engel,M.E., Chen,X., Beauchamp,R.D., Wilson,K.T., Hiebert,S.W.,
            Reynolds,A.B. and Williams,C.S.
  TITLE     Kaiso directs the transcriptional corepressor MTG16 to the Kaiso
            binding site in target promoters
  JOURNAL   PLoS One 7 (12), e51205 (2012)
   PUBMED   23251453
REFERENCE   4  (bases 1 to 3364)
  AUTHORS   Kim,Y.R., Kim,M.S., Lee,S.H. and Yoo,N.J.
  TITLE     Mutational analysis of RUNX1T1 gene in acute leukemias, breast and
            lung carcinomas
  JOURNAL   Leuk Res 35 (9), e157-e158 (2011)
   PUBMED   21571369
REFERENCE   5  (bases 1 to 3364)
  AUTHORS   Rochford,J.J., Semple,R.K., Laudes,M., Boyle,K.B.,
            Christodoulides,C., Mulligan,C., Lelliott,C.J., Schinner,S.,
            Hadaschik,D., Mahadevan,M., Sethi,J.K., Vidal-Puig,A. and
            O'Rahilly,S.
  TITLE     ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of
            early adipogenesis
  JOURNAL   Mol Cell Biol 24 (22), 9863-9872 (2004)
   PUBMED   15509789
REFERENCE   6  (bases 1 to 3364)
  AUTHORS   Wood,J.D., Nucifora,F.C. Jr., Duan,K., Zhang,C., Wang,J., Kim,Y.,
            Schilling,G., Sacchi,N., Liu,J.M. and Ross,C.A.
  TITLE     Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene
            product, interacts with ETO/MTG8 in the nuclear matrix and
            represses transcription
  JOURNAL   J Cell Biol 150 (5), 939-948 (2000)
   PUBMED   10973986
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001053893.1, XM_342808.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3364
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q13"
     gene            1..3364
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="RUNX1 partner transcriptional co-repressor 1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
     exon            1..360
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..2087
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /note="CBFA2T1 identified gene homolog; core-binding
                     factor, runt domain, alpha subunit 2; translocated to, 1;
                     cyclin D-related; RUNX1 translocation partner 1; acute
                     myelogenous leukemia 1 translocation 1 protein;
                     core-binding factor, runt domain, alpha subunit 2,
                     translocated to, 1; runt-related transcription factor 1;
                     translocated to, 1 (cyclin D-related)"
                     /codon_start=1
                     /product="protein CBFA2T1"
                     /protein_id="NP_001102127.1"
                     /db_xref="GeneID:362489"
                     /db_xref="RGD:1305490"
                     /translation="MPDRTEKHSTMPDSPVDVKTQSRLTPPAMPPPPTTQGAPRTSSF
                     TPTTLTNGTSHSPTALNGAPSPPNGFSNGPSSSSSSSLANQQLPPACGARQLSKLKRF
                     LTTLQQFGNDISPEIGERVRTLVLGLVNSTLTIEEFHSKLQEATNFPLRPFVIPFLKA
                     NLPLLQRELLHCARLAKQNPAQYLAQHEQLLLDASTTSPVDSSELLLDVNENGKRRTP
                     DRTKENGFDREPLHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLD
                     DMAIAHHYRDSYRHPSHRDLRDRNRPMGLHGTRQEEMIDHRLTDREWAEEWKHLDHLL
                     NCIMDMVEKTRRSLTVLRRCQEADREELNYWIRRYSDAEDLKKGGSGSSSHSRQQSPV
                     NPDPVALDAHREFLHRPASGYVPEEIWKKAEEAVNEVKRQAMTELQKAVSEAERKAHD
                     MITTERAKMERTVAEAKRQAAEDALAVINQQEDSSESCWNCGRKASETCSGCNTARYC
                     GSFCQHKDWEKHHHICGQTLQAPQQGETPAVSSSVTPSSGAGSPMDTPPAATPRSTTP
                     GTPSTIETTPR"
     exon            361..498
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..740
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..830
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..1012
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1263
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1349
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1551
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1620
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1811
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..3364
                     /gene="Runx1t1"
                     /gene_synonym="Cbfa2t1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggaactgg ggcaggagga agagtggaga aagggagaca ggagttgtga tactttgtac
       61 acacgtccct gtccttgttc tgcctgaaga gacagggctg ggttcaaggc cacatgtgtt
      121 cctgtcatcc tgcacatttc tgctccaagt gcaatcccga gtgtcagttc tccatctgtc
      181 tctgcctggc aggcgcacgc gcccagcacc ctgcctcggg ccatgccgcc ccagcccctc
      241 tgatggccct cctctccacc gccccgcaca ttccagaaca ggaggcatga gcccgcatcg
      301 cgcgccctct taacacagac ttgctttcac tgtgttacag gctggattcc gggatgcctg
      361 atcgtaccga gaagcactcc acgatgccag actcacctgt ggatgtgaag acgcagtcta
      421 ggctgactcc cccagcaatg ccgcctcctc cgaccactca aggagccccg agaaccagtt
      481 cgtttacgcc aacgacatta acgaatggca ccagccattc acccacggcc ttgaatggcg
      541 ccccctcacc gcctaatggc tttagcaacg ggccttcctc ttcctcttcc tcttctctgg
      601 ctaatcaaca gctgccccca gcctgtggtg ctagacaact gagcaagctg aagcgatttc
      661 ttactaccct gcagcagttt ggcaatgaca tttcaccaga gattggagaa agagttcgca
      721 ctcttgtact aggactggtg aactctactt tgacaattga agaatttcat tccaaacttc
      781 aagaagctac taacttccca ctgagacctt ttgtcatccc gtttttgaag gccaacctgc
      841 ccctgctaca gcgtgaactc ctccactgcg caaggctagc caaacagaac cctgcccagt
      901 acctcgctca gcacgaacag ctgcttctgg atgccagcac cacctcccct gtcgactcct
      961 cagagctgct tctcgatgtg aacgaaaacg ggaagaggcg aactccagac agaaccaaag
     1021 aaaatggctt tgacagagag cctttgcact cagaacatcc aagcaagcga ccatgcacta
     1081 ttagcccagg ccagcggtac agtccaaata atggcttatc ctaccagcca aatggcctgc
     1141 ctcaccccac cccacctcca cctcagcatt accgtttgga tgatatggcc attgcccacc
     1201 actacaggga ctcctatcga caccccagcc acagggacct cagggacaga aatagaccta
     1261 tggggttaca tggcacacgt caagaagaaa tgattgacca cagactaaca gacagagaat
     1321 gggcagaaga gtggaagcat ctcgatcatc tgttaaactg cataatggac atggtagaga
     1381 agacgaggcg atccctcact gtactaagac gatgtcagga agcagaccgg gaagaactga
     1441 attactggat ccggaggtac agtgatgctg aggacttgaa aaagggcggc agcggtagca
     1501 gcagccactc caggcaacag agccccgtca atccggaccc agtcgcatta gatgcacatc
     1561 gggaattcct tcacaggcct gcgtctggat acgtgccaga ggagatctgg aagaaagctg
     1621 aggaggctgt gaatgaggtg aagcgacagg caatgacgga gctgcagaaa gccgtgtctg
     1681 aagccgagag gaaagcccat gacatgatca ccacagagcg agccaaaatg gaacgcacgg
     1741 tggctgaagc caagcggcag gccgcagagg atgctctggc agtcatcaac cagcaggaag
     1801 actccagtga gagttgctgg aactgtggcc ggaaagcaag tgagacctgc agcggctgta
     1861 acacggcccg atactgtggc tctttttgcc agcataaaga ctgggagaag catcaccaca
     1921 tctgtggaca gaccctgcag gccccacagc agggagaaac gcctgctgtc agctcctcag
     1981 tcacgcccag cagtggggct gggagcccaa tggacacacc accagcagcc actccgaggt
     2041 ctaccacccc cggaaccccc tccaccatag agacgacgcc tcgctagacc taaactcaga
     2101 ctgtcagagg aaagacacca caaccaacac gaaagcaatt cctcatcctc agatgctcaa
     2161 agtccctttt ctgtttgttt gtttatagat gaactatcta tcttatttca gtacttcggc
     2221 aagagagaac ctaactgtat ctttgaggcg atagtaaaac acagaggcca gtaacgggtc
     2281 gtaatgactt actgtggaaa acaaagatat cttttcttta gagaactgaa aagagaggaa
     2341 agaatataac gtgaaatgct agatttgacc tcctccctgt tattttcaag tagctgggat
     2401 tttaaactag atgacctcat taaccaatgc tttaccaaac agcaaaccaa gagattgcta
     2461 attgctgttg aaagcaaaaa tgctaatatt aaaagtcaca gtgttcttta tatacaataa
     2521 tggaaagaaa aaaaaaaaag aggcaattcc tcaagggcac gagcgttgga tacagcagta
     2581 gacattttaa caagaagatg aatggcgtct gtgggttgct aactgaactt tgaagaccgg
     2641 ctgcaaaacg cacagatgtg cagcagattg gaaggagaca cagatgttcg ttttttttcc
     2701 cccgtttctg aaaaagaaat aataatatcc aggtcaacag aatgaaaaat gaaagatgat
     2761 ttccagtggg gtgtatgact acagcagcaa gaaaaaaaaa attgccataa tacaaaggct
     2821 cctttttata tcacacacac acacacacac acacacacac acacacacac acacacacac
     2881 actcactctc tctctccctc tctctctctc ttaagagact cagcctgcag ttaattagca
     2941 ttctggcagc ttccaagtca gccagctgcc ctaaataacc cttcaacgtt tcttcacttt
     3001 tgcaaggttc cacagagtaa gacattgaat ctattccagc ttattcattt tatatcgaaa
     3061 aaccaatttt tttaaaaaaa aaaatggcgg cttcagctcc agcccctttc caaaattttt
     3121 caaccccacc ctgtttgggt ttttaattaa aatctagtag ttctcttggt attaaaacac
     3181 ttctgtcctg tgaggttttc ccaatggtgt ttttcttgta aatgtgttgg acaaatgtga
     3241 agatgcgttg tagttgatcc atatgcccac atttagtctc tttattccta gttggtgaga
     3301 gaaaccagta tctttctatg ctgcttttat atctgtatgt attagtgata tttctctagt
     3361 agtt
//
