LOCUS       NM_017325               2135 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RUNX family transcription factor 1 (Runx1), mRNA.
ACCESSION   NM_017325
VERSION     NM_017325.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Xiao,C., Liu,J., Cheng,Y., Wu,Y., Li,Q., Chen,X., Yuan,J., Dong,Q.,
            Li,L., Liu,Y. and Shen,F.
  TITLE     RUNX1 targeting AKT3 promotes alveolar hypercoagulation and
            fibrinolytic inhibition in LPS induced ARDS
  JOURNAL   Respir Res 25 (1), 54 (2024)
   PUBMED   38267920
  REMARK    GeneRIF: RUNX1 targeting AKT3 promotes alveolar hypercoagulation
            and fibrinolytic inhibition in LPS induced ARDS.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Suzuki,S., Tanaka,S., Kametani,Y., Umeda,A., Nishinaka,K.,
            Egawa,K., Okada,Y., Obana,M. and Fujio,Y.
  TITLE     Runx1 is upregulated by STAT3 and promotes proliferation of
            neonatal rat cardiomyocytes
  JOURNAL   Physiol Rep 11 (23), e15872 (2023)
   PUBMED   38040660
  REMARK    GeneRIF: Runx1 is upregulated by STAT3 and promotes proliferation
            of neonatal rat cardiomyocytes.
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Song,J., Zhang,X., Lv,S., Liu,M., Hua,X., Yue,L., Wang,S. and He,W.
  TITLE     Age-related promoter-switch regulates Runx1 expression in adult rat
            hearts
  JOURNAL   BMC Cardiovasc Disord 23 (1), 541 (2023)
   PUBMED   37936072
  REMARK    GeneRIF: Age-related promoter-switch regulates Runx1 expression in
            adult rat hearts.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Xiao,C., Li,Q., Xiao,J., Chen,X., Yuan,J., Li,S., Li,W., Gao,D.,
            Li,L., Liu,Y. and Shen,F.
  TITLE     miR-9 targeting RUNX1 improves LPS-induced alveolar
            hypercoagulation and fibrinolysis inhibition through NF-kappaB
            inactivation in ARDS
  JOURNAL   Int Immunopharmacol 120, 110318 (2023)
   PUBMED   37201407
  REMARK    GeneRIF: miR-9 targeting RUNX1 improves LPS-induced alveolar
            hypercoagulation and fibrinolysis inhibition through NF-kappaB
            inactivation in ARDS.
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Zhang,Y., Huang,H., Liu,W., Liu,S., Wang,X.Y., Diao,Z.L.,
            Zhang,A.H., Guo,W., Han,X., Dong,X. and Katilov,O.
  TITLE     Endothelial progenitor cells-derived exosomal microRNA-21-5p
            alleviates sepsis-induced acute kidney injury by inhibiting RUNX1
            expression
  JOURNAL   Cell Death Dis 12 (4), 335 (2021)
   PUBMED   33785732
  REMARK    GeneRIF: Endothelial progenitor cells-derived exosomal
            microRNA-21-5p alleviates sepsis-induced acute kidney injury by
            inhibiting RUNX1 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Zhang,Y.W., Bae,S.C., Huang,G., Fu,Y.X., Lu,J., Ahn,M.Y., Kanno,Y.,
            Kanno,T. and Ito,Y.
  TITLE     A novel transcript encoding an N-terminally truncated AML1/PEBP2
            alphaB protein interferes with transactivation and blocks
            granulocytic differentiation of 32Dcl3 myeloid cells
  JOURNAL   Mol Cell Biol 17 (7), 4133-4145 (1997)
   PUBMED   9199349
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   Giese,K., Kingsley,C., Kirshner,J.R. and Grosschedl,R.
  TITLE     Assembly and function of a TCR alpha enhancer complex is dependent
            on LEF-1-induced DNA bending and multiple protein-protein
            interactions
  JOURNAL   Genes Dev 9 (8), 995-1008 (1995)
   PUBMED   7774816
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Lu,J., Maruyama,M., Satake,M., Bae,S.C., Ogawa,E., Kagoshima,H.,
            Shigesada,K. and Ito,Y.
  TITLE     Subcellular localization of the alpha and beta subunits of the
            acute myeloid leukemia-linked transcription factor PEBP2/CBF
  JOURNAL   Mol Cell Biol 15 (3), 1651-1661 (1995)
   PUBMED   7862156
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Zhu,X., Yeadon,J.E. and Burden,S.J.
  TITLE     AML1 is expressed in skeletal muscle and is regulated by
            innervation
  JOURNAL   Mol Cell Biol 14 (12), 8051-8057 (1994)
   PUBMED   7969143
  REMARK    Erratum:[Mol Cell Biol 1995 Feb;15(2):1136]
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   Meyers,S., Downing,J.R. and Hiebert,S.W.
  TITLE     Identification of AML-1 and the (8;21) translocation protein
            (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt
            homology domain is required for DNA binding and protein-protein
            interactions
  JOURNAL   Mol Cell Biol 13 (10), 6336-6345 (1993)
   PUBMED   8413232
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jun 11, 2015 this sequence version replaced NM_017325.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L35271.1, SRR26643429.40770.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-669               JAXUCZ010000011.1  45420657-45421325   c
            670-826             JAXUCZ010000011.1  45414819-45414975   c
            827-931             JAXUCZ010000011.1  45394767-45394871   c
            932-1123            JAXUCZ010000011.1  45368175-45368366   c
            1124-1282           JAXUCZ010000011.1  45337718-45337876   c
            1283-2135           JAXUCZ010000011.1  45329662-45330514   c
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q11"
     gene            1..2135
                     /gene="Runx1"
                     /gene_synonym="Aml1; CBF-alpha-2; Cbfa2; PEA2-alpha;
                     PEBP2-alpha"
                     /note="RUNX family transcription factor 1"
                     /db_xref="GeneID:50662"
                     /db_xref="RGD:2283"
     exon            1..669
                     /gene="Runx1"
                     /gene_synonym="Aml1; CBF-alpha-2; Cbfa2; PEA2-alpha;
                     PEBP2-alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..1752
                     /gene="Runx1"
                     /gene_synonym="Aml1; CBF-alpha-2; Cbfa2; PEA2-alpha;
                     PEBP2-alpha"
                     /note="core-binding factor runt domain alpha subunit 2
                     (acute myeloid leukemia 1 oncogene); oncogene AML-1; acute
                     myeloid leukemia 1 protein; core-binding factor subunit
                     alpha-2; polyomavirus enhancer-binding protein 2 alpha B
                     subunit; PEA2-alpha B; PEBP2-alpha B"
                     /codon_start=1
                     /product="runt-related transcription factor 1"
                     /protein_id="NP_059021.1"
                     /db_xref="GeneID:50662"
                     /db_xref="RGD:2283"
                     /translation="MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDGGAALASKL
                     RSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTL
                     VTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVA
                     TYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAP
                     TPNPRASLNHSTAFNPQPQSQMQDARQIQPSPPWSYDQSYQYLGSITSSVHPATPISP
                     GRASGMTSLSAELSSRLSTAPDLTAFGDPRQFPTLPSISDPRMHYPGAFTYSPPVTSG
                     IGIGMSAMSSTSRYHTYLPPPYPGSSQAQAGPFQTGSPSYHLYYGTSAGSYQFSMVGG
                     ERSPPRILPPCTNASTGAALLNPSLPSQSDVVETEGSHSNSPTNMPPARLEEAVWRPY
                     "
     exon            670..826
                     /gene="Runx1"
                     /gene_synonym="Aml1; CBF-alpha-2; Cbfa2; PEA2-alpha;
                     PEBP2-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            827..931
                     /gene="Runx1"
                     /gene_synonym="Aml1; CBF-alpha-2; Cbfa2; PEA2-alpha;
                     PEBP2-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1123
                     /gene="Runx1"
                     /gene_synonym="Aml1; CBF-alpha-2; Cbfa2; PEA2-alpha;
                     PEBP2-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1282
                     /gene="Runx1"
                     /gene_synonym="Aml1; CBF-alpha-2; Cbfa2; PEA2-alpha;
                     PEBP2-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..2135
                     /gene="Runx1"
                     /gene_synonym="Aml1; CBF-alpha-2; Cbfa2; PEA2-alpha;
                     PEBP2-alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccaaatcta gtttgttttt tttttttttc tggtcatttt ttttaattct gcgcataaat
       61 attttaggac gcatacggga attttgcctc cgggaccgtt tgtaatagcc aaagactgaa
      121 ctccaaactc tgaaagcgag gctccttggg gcatttgact ttgaattctg ggttgcccac
      181 ttttcaatgc actaagcggc cagttgctaa ccctgcctgg gtgtaaggcc gatccgcgta
      241 actagatctc agtcctgcta cccccacaac cctccggtag taataaaggc tcctgaactt
      301 gtatgttggt ctcccgggag cagcttgcag aagatccgag tccctgtcgc cgtctagtag
      361 gagctgtttt cagggtcctt actcaatcgg cttgttgtga tgcgtatccc cgtagatgcc
      421 agcacgagcc gccgcttcac gccgccttcc accgcgctga gccccggcaa gatgagcgag
      481 gcgctgccgc tgggcgcccc ggatggcggc gccgccctgg ccagcaagct gaggagcggc
      541 gaccgcagca tggtggaggt actagctgac caccccggcg agctagtccg caccgacagc
      601 cccaacttcc tctgctccgt gctgcccact cactggcgct gcaacaagac cctgcccatc
      661 gctttcaagg tggtagcgct gggcgacgtt ccggatggca ctctggtcac cgtcatggcg
      721 ggcaatgacg aaaactactc ggcggagctg agaaacgcca ccgcggccat gaagaaccaa
      781 gtggcgagat tcaacgacct caggtttgtc ggtcggagcg gcagaggcaa gagcttcact
      841 ctgaccatca ccgtctttac aaacccccca caagttgcca cctaccatag agccatcaaa
      901 atcacagtgg acggcccccg agaaccccga agacatcggc agaaactaga tgatcagacc
      961 aagcccggga gtttgtcctt ttccgagcgg ctcagtgaac tggagcagct gcggcgcacg
     1021 gccatgaggg tcagcccgca tcacccagcc cccacgccca accctcgggc ctccttgaac
     1081 cactccactg cctttaaccc tcagcctcaa agtcagatgc aggatgccag gcagatccag
     1141 ccgtccccac cgtggtccta tgaccagtct taccagtacc tggggtccat cacctcttct
     1201 gtgcacccgg cgacacccat ttctcccggc cgagccagtg gcatgaccag cctctcagcg
     1261 gaactttcca gtcgactctc aacagccccg gacctgacag ccttcggcga cccgcgccag
     1321 ttccccacgc tgccgtccat ctccgacccg cgcatgcact acccaggcgc cttcacctac
     1381 tcgcctcctg tcacatcggg catcggcatt ggcatgtcag ccatgagctc gacctctcgc
     1441 taccacacct acctgccgcc gccctaccca ggctcctcgc aggcgcaggc cgggcccttc
     1501 cagaccggct cgccctccta ccacctgtac tacggcacct cggcaggctc ctaccaattc
     1561 tccatggtgg gcggcgagcg atcacccccg cgcatcctgc cgccctgcac caacgcgtcc
     1621 accggagccg cgctgctcaa ccccagcctc cccagccaga gcgacgtggt ggaaaccgag
     1681 ggcagccata gcaactcgcc caccaacatg ccacccgcgc gcctggagga ggctgtctgg
     1741 cggccctact gagcgccttc gggggactga gcccgccgtc catgcacaga ccccgccagg
     1801 agagcccttg gaggccaaca ggagggaaac tgtgaatgct tctgatttag taatgctgtg
     1861 aataaaagaa agattttata cccttgactt cactttttaa ccacgttgtt tattccaaag
     1921 agtgtggaat gttttcggtt ccgggtgggg aagacgcagc ccatcctgtt tggcatctat
     1981 ttcttttccg caccttattg attgcaaaaa aaaaaaaaaa aaaaaaaatg cctgtttgca
     2041 tctgggtggt cgttattttt aaatatgtat agatttgagc ttgctttttt ccttcctttg
     2101 accaactcaa agaaataaaa ttcccttctc tgtaa
//
