LOCUS       NM_001401613            3344 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus RUN and FYVE domain containing 3 (Rufy3),
            transcript variant 1, mRNA.
ACCESSION   NM_001401613 XM_008770045
VERSION     NM_001401613.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3344)
  AUTHORS   Wang,G., Zhang,Q., Song,Y., Wang,X., Guo,Q., Zhang,J., Li,J.,
            Han,Y., Miao,Z. and Li,F.
  TITLE     PAK1 regulates RUFY3-mediated gastric cancer cell migration and
            invasion
  JOURNAL   Cell Death Dis 6 (3), e1682 (2015)
   PUBMED   25766321
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3344)
  AUTHORS   Wei,Z., Sun,M., Liu,X., Zhang,J. and Jin,Y.
  TITLE     Rufy3, a protein specifically expressed in neurons, interacts with
            actin-bundling protein Fascin to control the growth of axons
  JOURNAL   J Neurochem 130 (5), 678-692 (2014)
   PUBMED   24720729
REFERENCE   3  (bases 1 to 3344)
  AUTHORS   Meregalli,M., Farini,A., Belicchi,M., Parolini,D., Cassinelli,L.,
            Razini,P., Sitzia,C. and Torrente,Y.
  TITLE     Perspectives of stem cell therapy in Duchenne muscular dystrophy
  JOURNAL   FEBS J 280 (17), 4251-4262 (2013)
   PUBMED   23206279
  REMARK    Review article
REFERENCE   4  (bases 1 to 3344)
  AUTHORS   Mori,T., Wada,T., Suzuki,T., Kubota,Y. and Inagaki,N.
  TITLE     Singar1, a novel RUN domain-containing protein, suppresses
            formation of surplus axons for neuronal polarity
  JOURNAL   J Biol Chem 282 (27), 19884-19893 (2007)
   PUBMED   17439943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Feb 16, 2022 this sequence version replaced XM_008770045.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.32886.1,
                                           SRR26643288.51287.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               JAXUCZ010000014.1  19790082-19790530   c
            450-623             JAXUCZ010000014.1  19749388-19749561   c
            624-741             JAXUCZ010000014.1  19747678-19747795   c
            742-843             JAXUCZ010000014.1  19746803-19746904   c
            844-967             JAXUCZ010000014.1  19743296-19743419   c
            968-1029            JAXUCZ010000014.1  19740519-19740580   c
            1030-1095           JAXUCZ010000014.1  19739459-19739524   c
            1096-1165           JAXUCZ010000014.1  19736896-19736965   c
            1166-1258           JAXUCZ010000014.1  19734764-19734856   c
            1259-1342           JAXUCZ010000014.1  19732650-19732733   c
            1343-1510           JAXUCZ010000014.1  19730425-19730592   c
            1511-1608           JAXUCZ010000014.1  19729137-19729234   c
            1609-1728           JAXUCZ010000014.1  19725231-19725350   c
            1729-1825           JAXUCZ010000014.1  19723824-19723920   c
            1826-1890           JAXUCZ010000014.1  19722414-19722478   c
            1891-1918           JAXUCZ010000014.1  19719848-19719875   c
            1919-1987           JAXUCZ010000014.1  19718763-19718831   c
            1988-3344           JAXUCZ010000014.1  19715593-19716949   c
FEATURES             Location/Qualifiers
     source          1..3344
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..3344
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /note="RUN and FYVE domain containing 3"
                     /db_xref="GeneID:360921"
                     /db_xref="RGD:1565242"
     exon            1..449
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2131
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein RUFY3; singar2; rap2-interacting protein x; single
                     axon-regulated protein; RUN and FYVE domain-containing
                     protein 3"
                     /codon_start=1
                     /product="protein RUFY3 isoform 1"
                     /protein_id="NP_001388542.1"
                     /db_xref="GeneID:360921"
                     /db_xref="RGD:1565242"
                     /translation="MAESPPPGAAAESCGQDTERGGERRPEEPLEPRGAAARGADPED
                     EAGPSEPDSPVAAPFFLLYPGDGGAGFAARPPPQRSWRTPPSPGSPLPFLLLSYPSGG
                     SGGGGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEH
                     CLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLR
                     LALMQKKLSEYMKALINKKELLSEFYEANALMMEEEGAIIAGLLVGLNVIDANFCMKG
                     EDLDSQVGVIDFSMYLKDGNSSKGSEGDGQITAILDQKNYVEELNRHLNATVNNLQAK
                     VDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYLLESNRKGPKQDRTAEGQAL
                     SEARKHLKEETQLRLDVEKELELQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDD
                     LRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERGRQSAE
                     LDNRLFKQDFGDKINSLQLEVEALTRQRTQLELELKQEKEKKSQNRAAPGKVTQKPEP
                     RMDGKHRIQEDSVTLKKPLEEGPGLLTHPAEEQGQPSGSEKAQVCQLCREDESLTKNT
                     CKHCRGTFCNACMTNELPLPSSIKPELVCNPCHEQLIKQYSTSPS"
     exon            450..623
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..741
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..843
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..967
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1029
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1095
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1165
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1258
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1342
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1510
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1608
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1728
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..1825
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1890
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1918
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..1987
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..3344
                     /gene="Rufy3"
                     /gene_synonym="Ripx; Singar1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggcggcagc gaacggcgga cggcggcggc ggctgcgcgg gcacggcggg gcatccgatc
       61 ctcgccgtga gcctcgggct cgggcctgga gaggcggctg caccgcgaag ccaccagcga
      121 gatggcagag tccccgccgc ccggcgcggc tgctgaaagt tgcggccagg acacggagag
      181 gggcggggag cggcgccccg aggagccgct ggaaccgcgc ggtgcggccg ctcgcggcgc
      241 ggacccggag gacgaggcgg ggccctcgga gccggactcg ccggtggccg cccccttctt
      301 cctgctgtac ccgggagatg gaggagccgg cttcgctgcg cgcccgccac cgcagcgctc
      361 ctggaggacc ccgccgtcgc ccggctcccc gttgcccttc ctgctactga gctacccgag
      421 cggcggcagc ggtggcggag gcaagcacca tcctaattat ctcatggcta acgagcgcat
      481 gaacctgatg aacatggcga agctgagcat caagggcttg attgagtcgg ctctgaacct
      541 ggggcggacc ctggactctg actacgcacc tctccagcag ttcttcgtgg tgatggaaca
      601 ctgcctgaaa catggcttga aagccaagaa aacttttctt ggacaaaata agtccttctg
      661 gggtcctcta gagctggtag aaaagcttgt tccagaagct gcagagataa cagcaagtgt
      721 aaaagatctc ccaggactca agacaccagt tggcagagga agagcctggc ttcggttggc
      781 attaatgcaa aagaagcttt ctgagtacat gaaggccttg atcaataaga aggaacttct
      841 cagtgagttc tatgaagcca atgctctcat gatggaagaa gaaggcgcaa ttattgctgg
      901 cctcctggtc ggtctgaatg tcatcgatgc caatttctgc atgaaaggag aagacctgga
      961 ctctcaggtt ggcgttatag acttttcaat gtatctcaaa gatgggaaca gcagtaaagg
     1021 cagtgaaggg gatggacaga ttactgcgat tctggaccag aaaaactatg tagaagaact
     1081 caacagacat ctgaatgcta ctgtaaacaa ccttcaggca aaagtagatg cgttagaaaa
     1141 atccaacacg aaattgacag aggaacttgc cgtcgccaac aacagaatta ttaccttaca
     1201 agaagaaatg gaacgggtta aagaagaaag ttcctatcta ctggaatcca atcggaaggg
     1261 tcctaagcaa gacagaactg cagaagggca agcgctgagc gaagccagaa agcatctaaa
     1321 ggaggagaca cagttacgat tggacgttga aaaggagctg gagctgcaga tcagcatgag
     1381 gcaggagatg gaactggcta tgaagatgct ggagaaggat gtctgtgaga agcaggatgc
     1441 cctggtgtcc ctgcggcagc agctggatga tctccgagct cttaaacacg agcttgcctt
     1501 taagctgcag agttcagacc taggagtgaa acagaaaagt gaattaaaca gtcgcttgga
     1561 agagaagacc aatcagatgg ctgccaccat taaacagctg gagcaaagat tgcgccaggc
     1621 tgagcgaggc cgccagtctg ccgagctgga caaccggctc ttcaaacagg acttcggaga
     1681 caagatcaac agcctgcagc tggaggtgga ggcgctcacc aggcagcgga ctcagctgga
     1741 gttagaacta aaacaagaaa aggagaagaa gtcacaaaac agggccgccc cggggaaggt
     1801 gacccagaag ccggagcccc gaatggatgg gaagcacaga attcaagagg acagcgttac
     1861 actaaagaag ccactggaag aaggccccgg gctgctgact catcctgcag aggaacaggg
     1921 tcagccttca ggctctgaaa aggctcaggt gtgtcagctg tgccgggagg atgagagcct
     1981 gacaaagaac acatgtaaac actgccgagg gaccttctgt aatgcctgca tgacaaatga
     2041 actgcctctc ccttcgagca tcaagcctga gctggtgtgc aacccttgtc acgagcagtt
     2101 gataaagcag tattccacca gcccatccta agactggagc cagggccagg ctacggggtt
     2161 tatgccgggc atcggcagag ttagacgcaa gacgccctgg aacccagacc ttaggaccaa
     2221 ccatagttgg taggaaaggg agacgtaaac caggtcgatg tctgagggga aggcagagct
     2281 tggggtgctc tgacctttgc tcatcttctc aatgagtgtg taaataaaag ttgccgagcc
     2341 tctcccttca acacctaaac cagcccactt tggagacttt ataagcgtat ctttgggcat
     2401 ttttatttct atgaagtggt aaagccaggc tgtggccacg tggagaagcg cggctgagcc
     2461 agtgtgcggc ccctcttttt actgcagcac tgctgtccac aaagcagcac tgcatctgca
     2521 ccgaggggca acctgacaag tgccgctctg gcactgttgc tttcctctca gctcccagga
     2581 cctacctcta ccaaactgtg aacccaagct cagggaaagg aatcaagagt aatataaatt
     2641 ctgaatgtac tgataacagt accataatac agaacctcag aaccagatga ttttttttcc
     2701 tttggtcgta actacaagag ttttctttct gtgaaccaca acatcagttg cttcccacca
     2761 gacggctcca gaagtaagta tgtgcacttt tcaggatcct cccagggcaa gccgagtgtc
     2821 ctgcccagtc cctcccccct gagtcataaa ggacagtaag actttcaaag acagggtttg
     2881 cctgtcttgc aagtagaaga ttaaagctaa gtcaggtaca cagaacatca actctgattt
     2941 gttaatggct gaggacagtt agcacagcac tcactaaact gtttatttga tgagaagtcc
     3001 atattctgaa ctacagatca gaagcagcag gcagggttct aggaaaagac aatttcaaac
     3061 atctctttgt gacaaacgct tgtggaaaag tgggagtaca ctgaataaaa gatggaaaga
     3121 aatggcttag ttacaatgac tgtgttgtat agttgtatat ctgaattgat tccaattaag
     3181 atttgggaaa acatgattct atgtaggttt ggatttctga ggtaaaaatg gcgacagctc
     3241 ctgaaaaggg gtaaaacccg ggaaggcatt attatttcag aaatctgacc tgctggggaa
     3301 gctgaagtta aaacattagg ggaaaataaa attagtaact ctaa
//
