LOCUS       NM_181380               1304 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus reticulon 4 receptor-like 2 (Rtn4rl2), mRNA.
ACCESSION   NM_181380
VERSION     NM_181380.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1304)
  AUTHORS   Zhao,H., Liu,Z.D., Zhang,Y.B., Gao,X.Y., Wang,C., Liu,Y. and
            Wang,X.F.
  TITLE     NEP1-40 promotes myelin regeneration via upregulation of GAP-43 and
            MAP-2 expression after focal cerebral ischemia in rats
  JOURNAL   Mol Med Rep 24 (6) (2021)
   PUBMED   34643252
  REMARK    GeneRIF: NEP140 promotes myelin regeneration via upregulation of
            GAP43 and MAP2 expression after focal cerebral ischemia in rats.
            Erratum:[Mol Med Rep. 2023 Mar;27(3):58. doi:
            10.3892/mmr.2023.12945.. PMID: 36695184]
REFERENCE   2  (bases 1 to 1304)
  AUTHORS   Zhang,B., Wang,D., Li,X., Yang,S. and Yuan,H.
  TITLE     NEP1-40-overexpressing Neural Stem Cells Enhance Axon Regeneration
            by Inhibiting Nogo-A/NgR1 Signaling Pathway
  JOURNAL   Curr Neurovasc Res 18 (3), 271-278 (2021)
   PUBMED   34544340
  REMARK    GeneRIF: NEP1-40-overexpressing Neural Stem Cells Enhance Axon
            Regeneration by Inhibiting Nogo-A/NgR1 Signaling Pathway.
REFERENCE   3  (bases 1 to 1304)
  AUTHORS   Yoo,S.W., Motari,M.G. and Schnaar,R.L.
  TITLE     Agenesis of the corpus callosum in Nogo receptor deficient mice
  JOURNAL   J Comp Neurol 525 (2), 291-301 (2017)
   PUBMED   27339102
REFERENCE   4  (bases 1 to 1304)
  AUTHORS   Dickendesher,T.L., Baldwin,K.T., Mironova,Y.A., Koriyama,Y.,
            Raiker,S.J., Askew,K.L., Wood,A., Geoffroy,C.G., Zheng,B.,
            Liepmann,C.D., Katagiri,Y., Benowitz,L.I., Geller,H.M. and
            Giger,R.J.
  TITLE     NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans
  JOURNAL   Nat Neurosci 15 (5), 703-712 (2012)
   PUBMED   22406547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1304)
  AUTHORS   Semavina,M., Saha,N., Kolev,M.V., Goldgur,Y., Giger,R.J.,
            Himanen,J.P. and Nikolov,D.B.
  TITLE     Crystal structure of the Nogo-receptor-2
  JOURNAL   Protein Sci 20 (4), 684-689 (2011)
   PUBMED   21308849
  REMARK    GeneRIF: crystal structure of the leucine-rich repeat region and
            part of the stalk regions of NgR2 and comparison to the previously
            reported NgR1 structure with respect to the distinct signaling
            properties of the two receptor isoforms
REFERENCE   6  (bases 1 to 1304)
  AUTHORS   Richard,M., Sacquet,J., Jourdan,F. and Pellier-Monnin,V.
  TITLE     Spatio-temporal expression pattern of receptors for
            myelin-associated inhibitors in the developing rat olfactory system
  JOURNAL   Brain Res 1252, 52-65 (2009)
   PUBMED   19063867
  REMARK    GeneRIF: spatio-temporal expression pattern of NgR1, NgR2 & NgR3
            mRNAs & corresponding proteins in developing olfactory system; data
            suggest, in non-pathological conditions, NgR1 & homologs may play a
            role in axon outgrowth in the olfactory system.
REFERENCE   7  (bases 1 to 1304)
  AUTHORS   Cao,Y., Shumsky,J.S., Sabol,M.A., Kushner,R.A., Strittmatter,S.,
            Hamers,F.P., Lee,D.H., Rabacchi,S.A. and Murray,M.
  TITLE     Nogo-66 receptor antagonist peptide (NEP1-40) administration
            promotes functional recovery and axonal growth after lateral
            funiculus injury in the adult rat
  JOURNAL   Neurorehabil Neural Repair 22 (3), 262-278 (2008)
   PUBMED   18056009
  REMARK    GeneRIF: The authors' results indicate that severed rubrospinal
            axons respond to NEP1-40 treatment but less robustly than
            corticospinal, raphe-spinal, or dorsal root axons.
REFERENCE   8  (bases 1 to 1304)
  AUTHORS   Venkatesh,K., Chivatakarn,O., Lee,H., Joshi,P.S., Kantor,D.B.,
            Newman,B.A., Mage,R., Rader,C. and Giger,R.J.
  TITLE     The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent
            receptor selective for myelin-associated glycoprotein
  JOURNAL   J Neurosci 25 (4), 808-822 (2005)
   PUBMED   15673660
REFERENCE   9  (bases 1 to 1304)
  AUTHORS   Pignot,V., Hein,A.E., Barske,C., Wiessner,C., Walmsley,A.R.,
            Kaupmann,K., Mayeur,H., Sommer,B., Mir,A.K. and Frentzel,S.
  TITLE     Characterization of two novel proteins, NgRH1 and NgRH2,
            structurally and biochemically homologous to the Nogo-66 receptor
  JOURNAL   J Neurochem 85 (3), 717-728 (2003)
   PUBMED   12694398
REFERENCE   10 (bases 1 to 1304)
  AUTHORS   Josephson,A., Trifunovski,A., Scheele,C., Widenfalk,J.,
            Wahlestedt,C., Brene,S., Olson,L. and Spenger,C.
  TITLE     Activity-induced and developmental downregulation of the Nogo
            receptor
  JOURNAL   Cell Tissue Res 311 (3), 333-342 (2003)
   PUBMED   12658441
  REMARK    GeneRIF: Downregulation of Nogo receptor(NgR) after kainic acid or
            wheel-running in cortex and hippocampus suggests a role for NgR and
            Nogo-A in plasticity, learning and memory.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF532860.1.
            
            On Jun 3, 2003 this sequence version replaced NM_181380.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF532860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1304
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q24"
     gene            1..1304
                     /gene="Rtn4rl2"
                     /gene_synonym="Ngrh1"
                     /note="reticulon 4 receptor-like 2"
                     /db_xref="GeneID:311169"
                     /db_xref="RGD:727797"
     exon            1..49
                     /gene="Rtn4rl2"
                     /gene_synonym="Ngrh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1281
                     /gene="Rtn4rl2"
                     /gene_synonym="Ngrh1"
                     /note="ngR2; nogo receptor-like 3; nogo-66
                     receptor-related protein 2; Nogo-66 receptor homolog 1"
                     /codon_start=1
                     /product="reticulon-4 receptor-like 2 precursor"
                     /protein_id="NP_852045.1"
                     /db_xref="GeneID:311169"
                     /db_xref="RGD:727797"
                     /translation="MLPGLRRLLQGPASACLLLTLLALPPVTPSCPMLCTCYSSPPTV
                     SCQANNFSSVPLSLPPSTQRLFLQNNLIRSLRPGTFGPNLLTLWLFSNNLSTIYPGTF
                     RHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYL
                     YLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGV
                     HRAAFHGLSRLTILYLFNNSLASLPGEALADLPALEFLRLNANPWACDCRARPLWAWF
                     QRARVSSSDVTCATPPERQGRDLRTLRDTDFQACPPPTPTRPGSRARGNSSSNHLYGV
                     AEAGAPPADPSTLYRDLPAEDSRGRQGGDAPTEDDYWGGYGGEDQRGEQTCPGAACQA
                     PADSRGPVLSAGLRTPLLCLLLLAPHHL"
     exon            50..531
                     /gene="Rtn4rl2"
                     /gene_synonym="Ngrh1"
                     /inference="alignment:Splign:2.1.0"
     exon            532..1304
                     /gene="Rtn4rl2"
                     /gene_synonym="Ngrh1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgagcatc gagacaagat gctgcccggg ctccggcgcc tgctgcaagg tcctgcctca
       61 gcctgcctcc tgctgacact cctggccctc cctcctgtga cccccagctg ccctatgctc
      121 tgcacctgct actcctctcc gcccacagtg agctgccagg ccaacaactt ctcctcggtg
      181 ccgctgtcct tgccacccag tacacagcga ctcttcttgc agaacaacct cattcgctca
      241 ctgcggccag gaacttttgg gcccaacctg ctcaccctgt ggctcttctc caacaacctc
      301 tccaccatct accctggcac cttccgccat ctgcaggccc tagaggaact ggacctcggt
      361 gacaatcggc acctgcgctc cctggagcct gacaccttcc agggcctgga gaggctgcag
      421 tcactacatc tgtaccggtg ccagctcagc agtctgcctg gcaacatctt ccgaggcctg
      481 gtcagcctac agtacctcta cctccaggag aacagcctgc tccacctaca ggatgacttg
      541 ttcgccgacc tggccaacct gagccacctt ttcctccacg ggaaccgcct gcggctgctc
      601 acggagcacg tgttccgcgg cttgggcagc ctggaccggc tgctgctgca cgggaaccgg
      661 ctgcagggcg tacaccgcgc agccttccac ggtctcagcc gcctcaccat cctttacctg
      721 ttcaacaaca gcctggcctc gctgccggga gaggcgctgg ctgacctgcc agcgctcgag
      781 ttcctgcggc tcaacgccaa cccctgggcg tgcgactgcc gcgctcggcc gctctgggct
      841 tggttccagc gcgcgcgggt gtccagctcc gacgtgacct gcgccacccc gcccgagcgc
      901 cagggccggg acctgcgcac gctgcgcgac accgatttcc aagcgtgccc gccgcccaca
      961 cccacgcggc cgggcagccg cgcccgcggc aacagctctt ccaaccacct gtacggcgtg
     1021 gccgaggcgg gcgctccccc cgcagaccca tccacgctct accgagacct gcccgccgag
     1081 gactcgcggg ggcgtcaggg cggggacgcg cccactgagg acgactactg ggggggctac
     1141 ggcggcgagg accagcgagg cgagcagacg tgtcccgggg ccgcgtgcca ggcgcccgcg
     1201 gactcgcgtg gccccgtgct ctcggccggg ctgcgcaccc ctctgctctg cctcttgctc
     1261 ctggctcccc atcacctctg actgcggtgc tccgatggaa gaga
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