LOCUS       NM_031831               4662 bp    mRNA    linear   ROD 12-AUG-2024
DEFINITION  Rattus norvegicus reticulon 4 (Rtn4), mRNA.
ACCESSION   NM_031831 XM_001065481
VERSION     NM_031831.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4662)
  AUTHORS   Ruknudin,P., Nazari,A.R., Wirth,M., Lahaie,I., Bajon,E., Rivard,A.,
            Chemtob,S. and Desjarlais,M.
  TITLE     Novel Function of Nogo-A as Negative Regulator of Endothelial
            Progenitor Cell Angiogenic Activity: Impact in Oxygen-Induced
            Retinopathy
  JOURNAL   Int J Mol Sci 24 (17), 13185 (2023)
   PUBMED   37685993
  REMARK    GeneRIF: Novel Function of Nogo-A as Negative Regulator of
            Endothelial Progenitor Cell Angiogenic Activity: Impact in
            Oxygen-Induced Retinopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4662)
  AUTHORS   Xiao,P., Gu,J., Xu,W., Niu,X., Zhang,J., Li,J., Chen,Y., Pei,Z.,
            Zeng,J. and Xing,S.
  TITLE     RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary
            neural repair through enhancing vascular autophagy in the thalamus
            after cerebral cortical infarction
  JOURNAL   Autophagy 18 (11), 2711-2730 (2022)
   PUBMED   35263212
  REMARK    GeneRIF: RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and
            secondary neural repair through enhancing vascular autophagy in the
            thalamus after cerebral cortical infarction.
REFERENCE   3  (bases 1 to 4662)
  AUTHORS   Chen,L., Hu,Q., Liu,H., Zhao,Y., Chan,S.O. and Wang,J.
  TITLE     Nogo-A Induced Polymerization of Microtubule Is Involved in the
            Inflammatory Heat Hyperalgesia in Rat Dorsal Root Ganglion Neurons
  JOURNAL   Int J Mol Sci 22 (19), 10360 (2021)
   PUBMED   34638704
  REMARK    GeneRIF: Nogo-A Induced Polymerization of Microtubule Is Involved
            in the Inflammatory Heat Hyperalgesia in Rat Dorsal Root Ganglion
            Neurons.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4662)
  AUTHORS   Wang,J.L., Chen,W.G., Zhang,J.J. and Xu,C.J.
  TITLE     Nogo-A-Delta20/EphA4 interaction antagonizes apoptosis of neural
            stem cells by integrating p38 and JNK MAPK signaling
  JOURNAL   J Mol Histol 52 (3), 521-537 (2021)
   PUBMED   33555537
  REMARK    GeneRIF: Nogo-A-Delta20/EphA4 interaction antagonizes apoptosis of
            neural stem cells by integrating p38 and JNK MAPK signaling.
REFERENCE   5  (bases 1 to 4662)
  AUTHORS   Stehle,J.H., Sheng,Z., Hausmann,L., Bechstein,P., Weinmann,O.,
            Hernesniemi,J., Neimat,J.S., Schwab,M.E. and Zemmar,A.
  TITLE     Exercise-induced Nogo-A influences rodent motor learning in a
            time-dependent manner
  JOURNAL   PLoS One 16 (5), e0250743 (2021)
   PUBMED   33951058
  REMARK    GeneRIF: Exercise-induced Nogo-A influences rodent motor learning
            in a time-dependent manner.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4662)
  AUTHORS   GrandPre,T., Li,S. and Strittmatter,S.M.
  TITLE     Nogo-66 receptor antagonist peptide promotes axonal regeneration
  JOURNAL   Nature 417 (6888), 547-551 (2002)
   PUBMED   12037567
REFERENCE   7  (bases 1 to 4662)
  AUTHORS   Tagami,S., Eguchi,Y., Kinoshita,M., Takeda,M. and Tsujimoto,Y.
  TITLE     A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on
            endoplasmic reticulum and reduces their anti-apoptotic activity
  JOURNAL   Oncogene 19 (50), 5736-5746 (2000)
   PUBMED   11126360
REFERENCE   8  (bases 1 to 4662)
  AUTHORS   GrandPre,T., Nakamura,F., Vartanian,T. and Strittmatter,S.M.
  TITLE     Identification of the Nogo inhibitor of axon regeneration as a
            Reticulon protein
  JOURNAL   Nature 403 (6768), 439-444 (2000)
   PUBMED   10667797
REFERENCE   9  (bases 1 to 4662)
  AUTHORS   Chen,M.S., Huber,A.B., van der Haar,M.E., Frank,M., Schnell,L.,
            Spillmann,A.A., Christ,F. and Schwab,M.E.
  TITLE     Nogo-A is a myelin-associated neurite outgrowth inhibitor and an
            antigen for monoclonal antibody IN-1
  JOURNAL   Nature 403 (6768), 434-439 (2000)
   PUBMED   10667796
REFERENCE   10 (bases 1 to 4662)
  AUTHORS   Morris,N.J., Ross,S.A., Neveu,J.M., Lane,W.S. and Lienhard,G.E.
  TITLE     Cloning and characterization of a 22 kDa protein from rat
            adipocytes: a new member of the reticulon family
  JOURNAL   Biochim Biophys Acta 1450 (1), 68-76 (1999)
   PUBMED   10231557
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031831.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ242961.1, SRR26643298.56024.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-769               JAXUCZ010000014.1  107651117-107651885
            770-826             JAXUCZ010000014.1  107663567-107663623
            827-3178            JAXUCZ010000014.1  107664480-107666831
            3179-3386           JAXUCZ010000014.1  107691290-107691497
            3387-3525           JAXUCZ010000014.1  107694043-107694181
            3526-3595           JAXUCZ010000014.1  107696670-107696739
            3596-3642           JAXUCZ010000014.1  107697127-107697173
            3643-3701           JAXUCZ010000014.1  107697331-107697389
            3702-4662           JAXUCZ010000014.1  107697646-107698606
FEATURES             Location/Qualifiers
     source          1..4662
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..4662
                     /gene="Rtn4"
                     /gene_synonym="NI-250; Nogo; Nogo-A; rat N; rat NogoA;
                     Vp20"
                     /note="reticulon 4"
                     /db_xref="GeneID:83765"
                     /db_xref="RGD:620989"
     exon            1..769
                     /gene="Rtn4"
                     /gene_synonym="NI-250; Nogo; Nogo-A; rat N; rat NogoA;
                     Vp20"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..3744
                     /gene="Rtn4"
                     /gene_synonym="NI-250; Nogo; Nogo-A; rat N; rat NogoA;
                     Vp20"
                     /note="foocen; neurite outgrowth inhibitor; GLUT4 vesicle
                     20kDa protein; glut4 vesicle 20 kDa protein; NI-220/250"
                     /codon_start=1
                     /product="reticulon-4"
                     /protein_id="NP_114019.2"
                     /db_xref="GeneID:83765"
                     /db_xref="RGD:620989"
                     /translation="MEDIDQSSLVSSSTDSPPRPPPAFKYQFVTEPEDEEDEEEEEDE
                     EEDDEDLEELEVLERKPAAGLSAAAVPPAAAAPLLDFSSDSVPPAPRGPLPAAPPAAP
                     ERQPSWERSPAAPAPSLPPAAAVLPSKLPEDDEPPARPPPPPPAGASPLAEPAAPPST
                     PAAPKRRGSGSVDETLFALPAASEPVIPSSAEKIMDLMEQPGNTVSSGQEDFPSVLLE
                     TAASLPSLSPLSTVSFKEHGYLGNLSAVSSSEGTIEETLNEASKELPERATNPFVNRD
                     LAEFSELEYSEMGSSFKGSPKGESAILVENTKEEVIVRSKDKEDLVCSAALHSPQESP
                     VGKEDRVVSPEKTMDIFNEMQMSVVAPVREEYADFKPFEQAWEVKDTYEGSRDVLAAR
                     ANVESKVDRKCLEDSLEQKSLGKDSEGRNEDASFPSTPEPVKDSSRAYITCASFTSAT
                     ESTTANTFPLLEDHTSENKTDEKKIEERKAQIITEKTSPKTSNPFLVAVQDSEADYVT
                     TDTLSKVTEAAVSNMPEGLTPDLVQEACESELNEATGTKIAYETKVDLVQTSEAIQES
                     LYPTAQLCPSFEEAEATPSPVLPDIVMEAPLNSLLPSAGASVVQPSVSPLEAPPPLSY
                     DSIKLEPENPPPYEEAMNVALKALGTKEGIKEPESFNAAVQETEAPYISIACDLIKET
                     KLSTEPSPDFSNYSEIAKFEKSVPEHAELVEDSSPESEPVDLFSDDSIPEVPQTQEEA
                     VMLMKESLTEVSETVAQHKEERLSASPQELGKPYLESFQPNLHSTKDAASNDIPTLTK
                     KEKISLQMEEFNTAIYSNDDLLSSKEDKIKESETFSDSSPIEIIDEFPTFVSAKDDSP
                     KLAKEYTDLEVSDKSEIANIQSGADSLPCLELPCDLSFKNIYPKDEVHVSDEFSENRS
                     SVSKASISPSNVSALEPQTEMGSIVKSKSLTKEAEKKLPSDTEKEDRSLSAVLSAELS
                     KTSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKG
                     VIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNSTIKELRRLFLVDDLVD
                     SLKFAVLMWVFTYVGALFNGLTLLILALISLFSIPVIYERHQVQIDHYLGLANKSVKD
                     AMAKIQAKIPGLKRKAD"
     exon            770..826
                     /gene="Rtn4"
                     /gene_synonym="NI-250; Nogo; Nogo-A; rat N; rat NogoA;
                     Vp20"
                     /inference="alignment:Splign:2.1.0"
     exon            827..3178
                     /gene="Rtn4"
                     /gene_synonym="NI-250; Nogo; Nogo-A; rat N; rat NogoA;
                     Vp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3179..3386
                     /gene="Rtn4"
                     /gene_synonym="NI-250; Nogo; Nogo-A; rat N; rat NogoA;
                     Vp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3387..3525
                     /gene="Rtn4"
                     /gene_synonym="NI-250; Nogo; Nogo-A; rat N; rat NogoA;
                     Vp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3526..3595
                     /gene="Rtn4"
                     /gene_synonym="NI-250; Nogo; Nogo-A; rat N; rat NogoA;
                     Vp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3596..3642
                     /gene="Rtn4"
                     /gene_synonym="NI-250; Nogo; Nogo-A; rat N; rat NogoA;
                     Vp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3701
                     /gene="Rtn4"
                     /gene_synonym="NI-250; Nogo; Nogo-A; rat N; rat NogoA;
                     Vp20"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..4662
                     /gene="Rtn4"
                     /gene_synonym="NI-250; Nogo; Nogo-A; rat N; rat NogoA;
                     Vp20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgctcgtc tgggcggcgg cggcggctgc agcctgggac agggcgggtg gcacatctcg
       61 atcgcgaagg caggagaagc agtctcattg ttccgggagc cgtcgcctct gcaggttctt
      121 cggctcggct cggcacgact cggcctgcct ggcccctgcc agtcttgccc aacccccaca
      181 accgcccgcg actctgagga gaagcggccc tgcggcggct gtagctgcag catcgtcggc
      241 gacccgccag ccatggaaga catagaccag tcgtcgctgg tctcctcgtc cacggacagc
      301 ccgccccggc ctccgcccgc cttcaagtac cagttcgtga cggagcccga ggacgaggag
      361 gacgaggagg aggaggagga cgaggaggag gacgacgagg acctagagga actggaggtg
      421 ctggagagga agcccgcagc cgggctgtcc gcagctgcgg tgccgcccgc cgccgccgcg
      481 ccgctgctgg acttcagcag cgactcggtg ccccccgcgc cccgcgggcc gctgccggcc
      541 gcgccccctg ccgctcctga gaggcagcca tcctgggaac gcagccccgc ggcgcccgcg
      601 ccatccctgc cgcccgctgc cgcagtcctg ccctccaagc tcccagagga cgacgagcct
      661 ccggcgaggc ccccgcctcc gccgccagcc ggcgcgagcc ccctggcgga gcccgccgcg
      721 cccccttcca cgccggccgc gcccaagcgc aggggctccg gctcagtgga tgagaccctt
      781 tttgctcttc ctgctgcatc tgagcctgtg ataccctcct ctgcagaaaa aattatggat
      841 ttgatggagc agccaggtaa cactgtttcg tctggtcaag aggatttccc atctgtcctg
      901 cttgaaactg ctgcctctct tccttctcta tctcctctct caactgtttc ttttaaagaa
      961 catggatacc ttggtaactt atcagcagtg tcatcctcag aaggaacaat tgaagaaact
     1021 ttaaatgaag cttctaaaga gttgccagag agggcaacaa atccatttgt aaatagagat
     1081 ttagcagaat tttcagaatt agaatattca gaaatgggat catcttttaa aggctcccca
     1141 aaaggagagt cagccatatt agtagaaaac actaaggaag aagtaattgt gaggagtaaa
     1201 gacaaagagg atttagtttg tagtgcagcc cttcacagtc cacaagaatc acctgtgggt
     1261 aaagaagaca gagttgtgtc tccagaaaag acaatggaca tttttaatga aatgcagatg
     1321 tcagtagtag cacctgtgag ggaagagtat gcagacttta agccatttga acaagcatgg
     1381 gaagtgaaag atacttatga gggaagtagg gatgtgctgg ctgctagagc taatgtggaa
     1441 agtaaagtgg acagaaaatg cttggaagat agcctggagc aaaaaagtct tgggaaggat
     1501 agtgaaggca gaaatgagga tgcttctttc cccagtaccc cagaacctgt gaaggacagc
     1561 tccagagcat atattacctg tgcttccttt acctcagcaa ccgaaagcac cacagcaaac
     1621 actttccctt tgttagaaga tcatacttca gaaaataaaa cagatgaaaa aaaaatagaa
     1681 gaaaggaagg cccaaattat aacagagaag actagcccca aaacgtcaaa tcctttcctt
     1741 gtagcagtac aggattctga ggcagattat gttacaacag ataccttatc aaaggtgact
     1801 gaggcagcag tgtcaaacat gcctgaaggt ctgacgccag atttagttca ggaagcatgt
     1861 gaaagtgaac tgaatgaagc cacaggtaca aagattgctt atgaaacaaa agtggacttg
     1921 gtccaaacat cagaagctat acaagaatca ctttacccca cagcacagct ttgcccatca
     1981 tttgaggaag ctgaagcaac tccgtcacca gttttgcctg atattgttat ggaagcacca
     2041 ttaaattctc tccttccaag cgctggtgct tctgtagtgc agcccagtgt atccccactg
     2101 gaagcacctc ctccacttag ttatgacagt ataaagcttg agcctgaaaa ccccccacca
     2161 tatgaagaag ccatgaacgt agcactaaaa gctttgggaa caaaggaagg aataaaagag
     2221 cctgaaagtt ttaatgcagc tgttcaggaa acagaagctc cttatatatc cattgcgtgt
     2281 gatttaatta aagaaacaaa gctctccact gagccaagtc cagatttctc taattattca
     2341 gaaatagcaa aattcgagaa gtcggtgccc gaacacgctg agctagtgga ggattcctca
     2401 cctgaatctg aaccagttga cttatttagt gatgattcga ttcctgaagt cccacaaaca
     2461 caagaggagg ctgtgatgct catgaaggag agtctcactg aagtgtctga gacagtagcc
     2521 cagcacaaag aggagagact tagtgcctca cctcaggagc taggaaagcc atatttagag
     2581 tcttttcagc ccaatttaca tagtacaaaa gatgctgcat ctaatgacat tccaacattg
     2641 accaaaaagg agaaaatttc tttgcaaatg gaagagttta atactgcaat ttattcaaat
     2701 gatgacttac tttcttctaa ggaagacaaa ataaaagaaa gtgaaacatt ttcagattca
     2761 tctccgattg agataataga tgaatttccc acgtttgtca gtgctaaaga tgattctcct
     2821 aaattagcca aggagtacac tgatctagaa gtatccgaca aaagtgaaat tgctaatatc
     2881 caaagcgggg cagattcatt gccttgctta gaattgccct gtgacctttc tttcaagaat
     2941 atatatccta aagatgaagt acatgtttca gatgaattct ccgaaaatag gtccagtgta
     3001 tctaaggcat ccatatcgcc ttcaaatgtc tctgctttgg aacctcagac agaaatgggc
     3061 agcatagtta aatccaaatc acttacgaaa gaagcagaga aaaaacttcc ttctgacaca
     3121 gagaaagagg acagatccct gtcagctgta ttgtcagcag agctgagtaa aacttcagtt
     3181 gttgacctcc tctactggag agacattaag aagactggag tggtgtttgg tgccagctta
     3241 ttcctgctgc tgtctctgac agtgttcagc attgtcagtg taacggccta cattgccttg
     3301 gccctgctct cggtgactat cagctttagg atatataagg gcgtgatcca ggctatccag
     3361 aaatcagatg aaggccaccc attcagggca tatttagaat ctgaagttgc tatatcagag
     3421 gaattggttc agaaatacag taattctgct cttggtcatg tgaacagcac aataaaagaa
     3481 ctgaggcggc ttttcttagt tgatgattta gttgattccc tgaagtttgc agtgttgatg
     3541 tgggtgttta cttatgttgg tgccttgttc aatggtctga cactactgat tttagctctg
     3601 atctcactct tcagtattcc tgttatttat gaacggcatc aggtgcagat agatcattat
     3661 ctaggacttg caaacaagag tgttaaggat gccatggcca aaatccaagc aaaaatccct
     3721 ggattgaagc gcaaagcaga ttgaaaaagc cccaaacaga agttcatctt taaaggggac
     3781 actcacttga ttacgggggt gggagggtca ggggtgagcc cttggtggcc gtgcggtttc
     3841 agctctttat ttttagcagt gcactgtttg aggaaaaatt acctgtcttg acttcctgtg
     3901 tttatcatct taagtattgt aagctgctgt gtatggatct cattgtagtc acacttgtct
     3961 tccccaatga ggcgcctggt gaataaagga ctcggggaaa gctgtgcatt gtatctgctg
     4021 cagggtagtc tagctgtatg cagagagttg taaagaaggc aaatctgggg gcagggaaaa
     4081 cccttttcac agtgtactgt gtttggtcag tgtaaaactg atgcagattt ttctgaaatg
     4141 aaatgtttag atgagagcat actactaaag cagagtggaa aactctgtct ttatggtgtg
     4201 ttctaggtgt attgtgaatt tactgttata ttgccaatat aagtaaatat agacctaatc
     4261 tatatatagt gtttcacaaa gcttagatct ttaaccttgc agctgcccca cagtgcttga
     4321 cctctgagtc attggttatg cagtgtagtc ccaagcacat aaactaggaa gagaaatgta
     4381 tttgtaggag tgctacctac cacctgtttt caagaaaata tagaactcca acaaaaatat
     4441 agaatgtcat ttcaaagact tactgtatgt atagttaatt ttgtcacaga ctctgaaatt
     4501 ctatggactg aatttcatgc ttccaaatgt ttgcagttat caaacattgt tatgcaagaa
     4561 atcataaaat gaagacttat accattgtgg tttaagccgt actgaattat ctgtggaatg
     4621 cattgtgaac tgtaaaagca aagtatcaat aaagcttata ga
//
