LOCUS       NM_080909               4926 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus reticulon 3 (Rtn3), transcript variant 1, mRNA.
ACCESSION   NM_080909 XM_342010
VERSION     NM_080909.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4926)
  AUTHORS   Chen,Y.J., Knupp,J., Arunagiri,A., Haataja,L., Arvan,P. and Tsai,B.
  TITLE     PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic
            clearance of mutant prohormones
  JOURNAL   Nat Commun 12 (1), 5991 (2021)
   PUBMED   34645803
  REMARK    GeneRIF: PGRMC1 acts as a size-selective cargo receptor to drive
            ER-phagic clearance of mutant prohormones.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4926)
  AUTHORS   Alhajlah,S., Thompson,A.M. and Ahmed,Z.
  TITLE     Overexpression of Reticulon 3 Enhances CNS Axon Regeneration and
            Functional Recovery after Traumatic Injury
  JOURNAL   Cells 10 (8), 2015 (2021)
   PUBMED   34440784
  REMARK    GeneRIF: Overexpression of Reticulon 3 Enhances CNS Axon
            Regeneration and Functional Recovery after Traumatic Injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4926)
  AUTHORS   Siddiqi,S., Zhelyabovska,O. and Siddiqi,S.A.
  TITLE     Reticulon 3 regulates very low density lipoprotein secretion by
            controlling very low density lipoprotein transport vesicle
            biogenesis
  JOURNAL   Can J Physiol Pharmacol 96 (7), 668-675 (2018)
   PUBMED   29756473
  REMARK    GeneRIF: RTN3 regulates very low density lipoprotein (VLDL)
            secretion by controlling VLDL transport vesicle-mediated
            endoplasmic reticulum-to-Golgi transport of nascent VLDL.
REFERENCE   4  (bases 1 to 4926)
  AUTHORS   Urade,T., Yamamoto,Y., Zhang,X., Ku,Y. and Sakisaka,T.
  TITLE     Identification and characterization of TMEM33 as a
            reticulon-binding protein
  JOURNAL   Kobe J Med Sci 60 (3), E57-E65 (2014)
   PUBMED   25612671
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4926)
  AUTHORS   Yamamoto,Y., Yoshida,A., Miyazaki,N., Iwasaki,K. and Sakisaka,T.
  TITLE     Arl6IP1 has the ability to shape the mammalian ER membrane in a
            reticulon-like fashion
  JOURNAL   Biochem J 458 (1), 69-79 (2014)
   PUBMED   24262037
REFERENCE   6  (bases 1 to 4926)
  AUTHORS   Chang,K., Seabold,G.K., Wang,C.Y. and Wenthold,R.J.
  TITLE     Reticulon 3 is an interacting partner of the SALM family of
            adhesion molecules
  JOURNAL   J Neurosci Res 88 (2), 266-274 (2010)
   PUBMED   19681166
  REMARK    GeneRIF: results show that reticulon 3 may play a role in the
            trafficking of the synaptic adhesion-like molecules family of
            adhesion molecules
REFERENCE   7  (bases 1 to 4926)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   8  (bases 1 to 4926)
  AUTHORS   Cai,Y., Saiyin,H., Lin,Q., Zhang,P., Tang,L., Pan,X. and Yu,L.
  TITLE     Identification of a new RTN3 transcript, RTN3-A1, and its
            distribution in adult mouse brain
  JOURNAL   Brain Res Mol Brain Res 138 (2), 236-243 (2005)
   PUBMED   15946766
REFERENCE   9  (bases 1 to 4926)
  AUTHORS   Kumamaru,E., Kuo,C.H., Fujimoto,T., Kohama,K., Zeng,L.H., Taira,E.,
            Tanaka,H., Toyoda,T. and Miki,N.
  TITLE     Reticulon3 expression in rat optic and olfactory systems
  JOURNAL   Neurosci Lett 356 (1), 17-20 (2004)
   PUBMED   14746891
  REMARK    GeneRIF: RTN3 may play an important role in developing axons and
            also in some glial cells such as Muller cells.
REFERENCE   10 (bases 1 to 4926)
  AUTHORS   Oertle,T., Klinger,M., Stuermer,C.A. and Schwab,M.E.
  TITLE     A reticular rhapsody: phylogenic evolution and nomenclature of the
            RTN/Nogo gene family
  JOURNAL   FASEB J 17 (10), 1238-1247 (2003)
   PUBMED   12832288
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from JAXUCZ010000001.1 and
            AY496443.1.
            
            On Mar 30, 2015 this sequence version replaced NM_080909.2.
            
            Summary: This gene encodes a member of the reticulon family, a
            large group of membrane-bound proteins that primarily localize to
            the endoplasmic reticulum with a small subpopulation at the cell
            surface. These proteins play roles in endocytosis, exocytosis,
            trafficking and neuronal outgrowth. Proteins belonging to this
            family are characterized by a carboxy-terminal reticulon homology
            domain that consists of a small hydrophilic loop flanked by
            hydrophobic regions. In rat, this protein has been shown to
            interact with two members of the synaptic adhesion-like molecule
            family, suggesting that it may function in trafficking of these
            proteins. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY496443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                JAXUCZ010000001.1  214098346-214098360 c
            16-4920             AY496443.1         1-4905
            4921-4926           JAXUCZ010000001.1  214041838-214041843 c
FEATURES             Location/Qualifiers
     source          1..4926
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..4926
                     /gene="Rtn3"
                     /note="reticulon 3"
                     /db_xref="GeneID:140945"
                     /db_xref="RGD:620988"
     exon            1..346
                     /gene="Rtn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..3024
                     /gene="Rtn3"
                     /note="isoform A is encoded by transcript variant 1"
                     /codon_start=1
                     /product="reticulon-3 isoform A"
                     /protein_id="NP_543185.2"
                     /db_xref="GeneID:140945"
                     /db_xref="RGD:620988"
                     /translation="MAESSAATQSPSVSSSSSGAEPSTLGGGGGSPGACPALGAKSCG
                     SSCAVGLSSLCSDEPPSKIMTSSFLSSSEIYNPDPTTPLGSETLGSHLVAKDGKDPLV
                     LLDKKTLDSPQGTNKDRVDTPVSLAADIPCSHPSIPDSFPEQPTFLSKETDPTEEWVV
                     KNQEPKNPSEVPSGEDRSALDLGQRKAEHICTHSLSPSEPAVASVEKDSPESPFEVII
                     DKATFDREFKDLYKESTDDLGGWAAHGDRESPADLLEMNDKVFPLRNKEAGRYPSSAL
                     LGRQFSHTTAALEEVSRCVNDMHNFTNEILTWDLDPQAKQQADKSPCTTESTGLDRSE
                     HRSEIPVINLKTSPQQKMPVCSFNGSTPITRSTGDWTETFTEGKPVKGYLSSTKEAGG
                     KGVPDSSQPISGSGAATVEVTLPDLRGTWPNSVLGEVTEVDSSGESDDTVIEDTTENP
                     SVKNNKVLPEKSDSLPSAAVKTSERENKETTSHETVRSEMYENSEQQQAHAETPTQRS
                     LEGQMSPQVPNMLNEVIPENLAMTDTTRVCSAAPPSVLSETGFSLTVPASAKSESLLG
                     KNVEDTDGSSPEDLMAALTGTEEKGTVDKEKGDVLEAVLEKIANVKNTLPVELLHENK
                     LSSSETKNTKSKYSEHSRETNGGAPKVSSDLEQEQLTIRAIKELGAKQVQAERMSPGG
                     KLKRTFDPQSGPQNSSDILEHTDITTGSDLGIPKKPTIIKDTRIDSISSLTKTETVNK
                     HVLARLLSDFPVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVT
                     ISFRVYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHSYMNAAMVHVNKALKLIIRL
                     FLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLVFSVPIVYEKYKTQIDHYVG
                     IARDQTKSIVEKIQAKLPGIAKKKAE"
     exon            347..2455
                     /gene="Rtn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2663
                     /gene="Rtn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2802
                     /gene="Rtn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..2872
                     /gene="Rtn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..2919
                     /gene="Rtn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..2978
                     /gene="Rtn3"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..4926
                     /gene="Rtn3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttaggctc tttatgcgca tgcgcgcccg tactcttctc cctgcggagc acggctgagt
       61 cagtcagtct gtcggagtca gtcttccgaa caggctacgc cggctacttc ggagaactag
      121 ctgctggatt attctgtgtc ccctcccact ctcccgcccc aagtctctct tcacccttct
      181 cccgcccttg ctcgtgcagc catggcggag tcatcggcgg ccactcagtc tccgtcagtc
      241 tcctcgtcgt cctccggggc cgagccgtca acgcttggcg gcggcggcgg gagccctgga
      301 gcctgccccg ccctgggggc gaagagctgc ggctcctcct gtgcggtggg attgagctct
      361 ctttgctctg atgagccacc atcaaaaatt atgacttcct cctttctttc atcttctgaa
      421 atatataacc ctgaccctac aacaccactt ggaagtgaaa cattaggcag ccatcttgta
      481 gctaaagacg gaaaagatcc cttggttctt ctagataaga aaactctgga ctcacctcag
      541 gggaccaaca aggacagagt agacactccg gtttctcttg cagctgacat tccttgcagc
      601 cacccttcta ttccagacag tttcccagaa caacctactt ttctttcaaa ggaaactgat
      661 ccaacagaag agtgggtagt taaaaaccaa gaacccaaga acccaagtga agttccaagt
      721 ggagaggaca gaagtgcact ggatcttggg cagcgtaagg cagaacacat ttgtacacat
      781 tccttgtctc catctgaacc tgcagtagcc agtgtagaaa aagattctcc tgagtcacca
      841 tttgaagtaa ttattgacaa agcaacattt gacagagaat ttaaagattt gtataaggaa
      901 agcacagatg atttgggtgg ctgggcagct cacggtgaca gagaatcccc agcagattta
      961 ttggaaatga atgacaaagt gtttccactg agaaataaag aggcagggcg ttacccatcc
     1021 tctgcactgc tcggtagaca attctcacac actacagcag cactggaaga agtgtctaga
     1081 tgtgtgaatg atatgcataa ctttactaat gaaatactga cttgggactt agatccccaa
     1141 gcaaaacaac aggcggacaa atcaccttgc accacagaaa gtacaggact agacaggagt
     1201 gaacatcgct cagaaattcc agttataaat cttaaaacaa gccctcaaca gaaaatgcct
     1261 gtatgttctt ttaatgggag cactcccatt actagatcca caggtgactg gacagaaaca
     1321 tttacagaag gaaaacctgt aaaaggctac ctcagctcca caaaagaagc tggtggcaaa
     1381 ggtgtaccag acagttctca gcctatctca ggctctggag cagccacagt ggaagtgact
     1441 ttacctgacc tgaggggtac ctggcctaac tctgtgctag gggaagtcac agaggttgat
     1501 agttctgggg aatctgatga cacagtaata gaggacacca cagaaaatcc ctcagttaag
     1561 aacaacaaag ttttgccaga aaaatctgac tcccttccaa gtgctgctgt aaaaacaagt
     1621 gaaagggaaa acaaagagac taccagtcat gaaactgtga ggagtgaaat gtatgaaaac
     1681 tctgagcagc agcaggccca tgcagaaact cctactcaga ggagtctgga aggtcagatg
     1741 tctccacaag tacctaatat gctgaatgaa gtcatacctg aaaatcttgc tatgactgac
     1801 acaaccagag tttgctcagc agcacctcca agtgttctta gtgagactgg attctcacta
     1861 actgtgccag cttctgccaa gtcagaatct ttgcttggaa aaaatgttga agatacagat
     1921 ggttcctctc cagaggactt gatggctgcc ctcacaggaa ctgaggagaa ggggacagtg
     1981 gataaagaga aaggtgatgt tttggaagca gtgttagaga agatagcaaa cgttaaaaac
     2041 actttgcctg tggaactctt gcatgaaaat aagctaagta gttctgaaac caaaaatact
     2101 aaaagcaaat acagtgaaca cagcagagaa acaaatggag gtgcccccaa ggtgtcttcc
     2161 gacttagagc aggagcagct caccattaga gccattaaag aattaggggc taagcaggtg
     2221 caggctgaaa gaatgtctcc tggaggaaaa ctcaagcgaa cctttgatcc acagtctggg
     2281 ccacagaatt catctgacat cctagaacac acagatatca caactggatc tgatcttggg
     2341 attcccaaaa agcctactat catcaaagac actagaatag attctatttc cagccttacc
     2401 aagactgaaa cagttaacaa gcatgttcta gcaagacttc tcagtgattt cccagtgcat
     2461 gatctgattt tctggcgaga tgtgaagaag actgggtttg tctttggcac cacgctgatc
     2521 atgctgctct ctctggcagc tttcagtgtt atcagtgtgg tctcttacct catcctggct
     2581 ctactctctg tcaccatcag cttcagagtc tacaagtctg tcatccaagc tgtgcagaag
     2641 tcagaagaag gacatccatt caaggcctac ctggatgtgg acattacact gtcctcagaa
     2701 gctttccaca gctacatgaa tgctgcaatg gtgcatgtca acaaggccct caaactcatt
     2761 attcgtctct ttctggtaga agacttggtt gactccttga agctggctgt cttcatgtgg
     2821 ctgatgacct acgtcggtgc tgtttttaac ggaattaccc ttctgattct cgccgagctg
     2881 ctggttttca gcgtcccaat tgtctatgag aagtataaga cacagattga ccactatgtt
     2941 gggattgccc gggatcagac caagtcaatt gttgaaaaga tccaagcaaa gcttcctgga
     3001 atcgccaaaa aaaaggcaga ataaacacat ggaagccaga agtgcaacag ttactaaaac
     3061 gccatttaat agttataaca tcgtcacttg tactatgaag gaacttgctc agtgtcagct
     3121 agagtttggt tccaagttgt ttgttctttt taatttggtg ttctctccca tcctctccct
     3181 ttaccctcag taccaagcac aagatgtgtt agactgaaaa aaagaactga tctcttagaa
     3241 ccctaaagaa taaggattga atcagattga tagaattaat cagaccatag tggttgtggg
     3301 gctttacgtg tactctaaag gaaaagaaaa acgtgtctag gtcctctctc cagtttcaag
     3361 gactgttaca gctcccattt ataattgtgc ccttattttt aagtcaggaa ataatgatta
     3421 acttatgagt aaatagtctg gggcaagagt gggatttctt cagtcccacc ctcctgcctt
     3481 acacataagc agctactctt cctgctcctc ttcgtcctta atgaaagaac ttacaggcga
     3541 gaggtgattc cctattccca gaatgccacc tgagaagtgc caggggtaag gggacagtgg
     3601 ggggagcagt cagagggagg gcagcagcag ccaccctctg ctgctcttcc tagggaagga
     3661 agggctctgc cagctgggag ggcagtgccc aagccattgg tctgggatac cagtgtgagt
     3721 gttggtttga gaaatcattc cagaatgtgc ttttccctct tttccctgcc caccttacct
     3781 caagtttaat aaatatggtt gtacttttct tattatgaag taaatgtctg taactgctgt
     3841 acactgctat aaacttgtta aagaaaaata atctgcatgt gggctctccg ccttgagtta
     3901 ttgtaatcct atctcagtct gtgggtaatg aggtacaagg acatgaaaag ccttccttct
     3961 ctgtcttccc tgctgcttcc acctgtgctg tgcagtgctt tagcctgagg accactgagc
     4021 cccactgcct gccagtcatg tgtctgttgt agtccagagg ccgtggctga tagaggaggt
     4081 acatttctag aagcatggca tgcagctgct tggagtcagt gcaatctgaa aggatctcca
     4141 ttctcaaaca tagtgatgaa atagttccta ccatgatcca cagtgctctc tggagagggc
     4201 tttccagaag ttttaggttg tgggtggcca agcaagccca ggtgatactg ctaagacaac
     4261 tgagcttaca gtggcatccg tggggtgtcc aggggtctta gtttctatcc gagaccttgc
     4321 atctcccctt cagcatggaa acccagtcag cttgaaaact ggcatccaag attccttcag
     4381 ttctcagctc tgccctattg taaggaagta ggagctgggg acttcaaggt gttcaatggt
     4441 cccaaagttc tgactgtaaa attaggaatg ggtcctcttc ccaatccttt tgggaaatga
     4501 cttacagatt tccatagata gaatgcctta ctccattttc ttaagtttct ttgcccctgt
     4561 acattttgaa tccttggttt ccactgtaga caacactcca tcaccatcct ctgccctccc
     4621 agaaagtaaa tacaccgatg gtctttgggg tctcccaacc agggacccca ttctgcactg
     4681 gaagcctcca caccttgctc ttttctctgt tgctgctgtg ttaaagtaat gggaaagatt
     4741 tctgtgtcac atgagttttt tttttttttt aaagaaaagt gtagagatga gaaactacta
     4801 atgatattgt gtgcgtgtct gtgcgtgcaa cataaaatac ggtagtaccg aggagctctc
     4861 tggtccctgt aaaactgcaa atcgatgtat taattataaa taaaaaacac agtgactgtc
     4921 tcatca
//
