LOCUS       NM_201562               1892 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Rattus norvegicus reticulon 2 (Rtn2), mRNA.
ACCESSION   NM_201562 XM_218418
VERSION     NM_201562.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1892)
  AUTHORS   Montenegro,G., Rebelo,A.P., Connell,J., Allison,R., Babalini,C.,
            D'Aloia,M., Montieri,P., Schule,R., Ishiura,H., Price,J.,
            Strickland,A., Gonzalez,M.A., Baumbach-Reardon,L., Deconinck,T.,
            Huang,J., Bernardi,G., Vance,J.M., Rogers,M.T., Tsuji,S., De
            Jonghe,P., Pericak-Vance,M.A., Schols,L., Orlacchio,A., Reid,E. and
            Zuchner,S.
  TITLE     Mutations in the ER-shaping protein reticulon 2 cause the
            axon-degenerative disorder hereditary spastic paraplegia type 12
  JOURNAL   J Clin Invest 122 (2), 538-544 (2012)
   PUBMED   22232211
REFERENCE   2  (bases 1 to 1892)
  AUTHORS   Ikemoto,T., Hosoya,T., Takata,K., Aoyama,H., Hiramatsu,T., Onoe,H.,
            Suzuki,M. and Endo,M.
  TITLE     Functional role of neuroendocrine-specific protein-like 1 in
            membrane translocation of GLUT4
  JOURNAL   Diabetes 58 (12), 2802-2812 (2009)
   PUBMED   19720795
REFERENCE   3  (bases 1 to 1892)
  AUTHORS   Liu,Y., Vidensky,S., Ruggiero,A.M., Maier,S., Sitte,H.H. and
            Rothstein,J.D.
  TITLE     Reticulon RTN2B regulates trafficking and function of neuronal
            glutamate transporter EAAC1
  JOURNAL   J Biol Chem 283 (10), 6561-6571 (2008)
   PUBMED   18096700
  REMARK    GeneRIF: RTN2B functions as a positive regulator in the delivery of
            EAAC1 from the ER to the cell surface.
REFERENCE   4  (bases 1 to 1892)
  AUTHORS   Oertle,T., Klinger,M., Stuermer,C.A. and Schwab,M.E.
  TITLE     A reticular rhapsody: phylogenic evolution and nomenclature of the
            RTN/Nogo gene family
  JOURNAL   FASEB J 17 (10), 1238-1247 (2003)
   PUBMED   12832288
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY279211.1.
            
            On Jun 3, 2007 this sequence version replaced NM_201562.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY279211.1, BK001788.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1892
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /note="reticulon 2"
                     /db_xref="GeneID:308410"
                     /db_xref="RGD:1303245"
     CDS             1..1410
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /note="reticulon 2 (Z-band associated protein); NSP-like
                     1; formerly RTN2w; NSP-like protein 1; NSP-like protein I;
                     neuroendocrine-specific protein-like 1;
                     neuroendocrine-specific protein-like I"
                     /codon_start=1
                     /product="reticulon-2"
                     /protein_id="NP_963856.1"
                     /db_xref="GeneID:308410"
                     /db_xref="RGD:1303245"
                     /translation="MGQVLPVFAHCKEAPSTASSTPDSTEGGNDDSDFRELHTAREFS
                     EDEEEETTSQDWGTPRELTFSYIAFDGVVGSGGRRDSVVRRPRPQGRSVSEPRDPPPQ
                     PSLGDSLESIPSLSQSPEPGRRGDPDTVPPAERPLEELRLRLDQLGWAVRSAGSGEDS
                     ATSSSTPLENEEPDGLEASEAGETNLELRLAQPLHLQFEGLTPQLSPSSGIPQAHTPS
                     PQRSQDLNTGPDEPLPNGEGEHWRLLEQEPITAQCLNSTDQSEFTLEPLLLVADLLYW
                     KDTRTSGAIFTGLMASLLCLLHFSIVSVAAHLALLGLCATISLRVYRKVLQAVHRGDG
                     TNPFQAYLDMDLTLTREQTERLSQQIASHVVSTATQLRHFFLVEDLVDSLKLALLFYI
                     LTFVGAIFNGLTLVILGVVALFTVPLLYRQHQAQIDQYVGLVTSQLSHIKAKIRAKIP
                     GTGTLAPAASVSGSKAKAE"
     exon            1..34
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /inference="alignment:Splign:2.1.0"
     exon            35..79
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /inference="alignment:Splign:2.1.0"
     exon            80..547
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /inference="alignment:Splign:2.1.0"
     exon            548..808
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1016
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1155
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1225
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1272
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1331
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1874
                     /gene="Rtn2"
                     /gene_synonym="NSPLI; RTN2-B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggggcagg tcctgccggt cttcgcccac tgcaaagaag ctccatctac agcctcttct
       61 acccccgatt ccacggaagg agggaatgac gactcggatt ttcgggagct gcacacagcc
      121 cgggaattct cggaggacga agaggaggag actacatcgc aggactgggg cacccccagg
      181 gagctgacct tttcctacat tgccttcgac ggcgtggtgg gctctggggg ccgtagggat
      241 tcagttgttc gtcgtcccag gccccaggga cgttcagtct cagaaccaag ggacccaccc
      301 ccacagccca gcctgggtga cagcttggag agtatcccta gtctgagcca gtccccagag
      361 ccggggcgtc gcggtgaccc agacactgta cctccagctg agcgcccgct ggaggaactg
      421 aggcttcggc tggaccagct tggctgggct gtccggagtg cgggatctgg ggaggattcg
      481 gccaccagca gctctacccc gctggaaaat gaggagccgg atggattgga ggccagcgag
      541 gctggagaga cgaatctgga actccgactt gctcagcctc tacatttgca atttgagggc
      601 ttgactcctc agcttagccc gagctccggg attccccagg cgcatacccc atccccacag
      661 agatctcaag atttgaacac cggtcctgat gagccgctgc cgaatgggga aggagaacat
      721 tggcggctgc tggagcagga gccaatcacg gcccagtgcc tcaatagcac agaccaatca
      781 gaattcacgt tggagccgct ccttctagtg gcagacctgt tgtactggaa ggacaccagg
      841 acgtcgggag ccatcttcac gggcctcatg gcctctctcc tctgcctcct gcactttagc
      901 atcgtgtccg tggctgcgca cctggccctg ctgggtctct gcgccaccat ctctctcagg
      961 gtttaccgca aagtgctgca ggccgtgcac cggggcgacg gcaccaaccc tttccaggct
     1021 tacctggaca tggacctgac cctgactcgg gagcagacag aacgtttgtc ccagcagatt
     1081 gcctcccacg tggtctccac ggccacacag ctgcggcatt tcttcctcgt agaagacctg
     1141 gtggattctc tcaagctggc tcttctcttc tacatcttga ccttcgtggg agccatcttt
     1201 aacggcttga ctcttgtcat cttgggagtg gttgctttgt tcaccgtccc ccttctgtac
     1261 agacaacatc aggcccagat tgaccagtat gtggggttgg tgaccagcca gttgagccac
     1321 atcaaagcta agatccgagc taagatcccg gggaccggaa cccttgcccc agcagcatca
     1381 gtctccggat ccaaagccaa agccgaatga gaagggtgtc tttgcccgag ggacgcctgc
     1441 cacaccccag cagccctctt ccctttcatt tcccgtgcat ccacaccctc tcccactcgg
     1501 ccgagccatt tcccagtggg aagtgcctga gcgacccaga ctacatttcc taagaggctc
     1561 tgctctaaga gtccaggaaa agaccatgct ccttggccgc ggagcctgct gggacttgta
     1621 gttgaatagt gaggacgctg ctctgcactt ccgtgacccg ccgctggagg cgccgtgagg
     1681 ggttggtgtc tctgaggcca ccaacccctg tgctggggct ttgcatgggg cccaggcgag
     1741 ccttgagctt ggatttacac tgtaataaag attcctgtgg aaaattcact gccttctatg
     1801 ctttaaagtc ctttcactta caccttccta cattgaaaaa aattaaaaca aacaaataaa
     1861 aacgtaaaaa acctaaaaaa aaaaaaaaaa aa
//
