LOCUS       NM_053865               3501 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus reticulon 1 (Rtn1), mRNA.
ACCESSION   NM_053865 XM_346763
VERSION     NM_053865.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3501)
  AUTHORS   Ling,J., Cai,H., Lin,M., Qi,S., Du,J. and Chen,L.
  TITLE     RTN1-C mediates cerebral ischemia/reperfusion injury via modulating
            autophagy
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (2), 170-178 (2021)
   PUBMED   33372676
  REMARK    GeneRIF: RTN1-C mediates cerebral ischemia/reperfusion injury via
            modulating autophagy.
REFERENCE   2  (bases 1 to 3501)
  AUTHORS   Lin,M., Ling,J., Geng,X., Zhang,J., Du,J. and Chen,L.
  TITLE     RTN1-C is involved in high glucose-aggravated neuronal cell
            subjected to oxygen-glucose deprivation and reoxygenation injury
            via endoplasmic reticulum stress
  JOURNAL   Brain Res Bull 149, 129-136 (2019)
   PUBMED   31002913
  REMARK    GeneRIF: High glucose significantly increases RTN1-C expression in
            OGD/R-treated cells. RTN1-C affects high glucose-treated OGD/R
            cells by exacerbating ER stress.
REFERENCE   3  (bases 1 to 3501)
  AUTHORS   Fan,X.X., Hao,Y.Y., Guo,S.W., Zhao,X.P., Xiang,Y., Feng,F.X.,
            Liang,G.T. and Dong,Y.W.
  TITLE     Knockdown of RTN1-C attenuates traumatic neuronal injury through
            regulating intracellular Ca2+ homeostasis
  JOURNAL   Neurochem Int 121, 19-25 (2018)
   PUBMED   30352262
  REMARK    GeneRIF: Knock-down of RTN1-c protected neurons against traumatic
            neuronal injury via preservation of calcium homeostasis.
REFERENCE   4  (bases 1 to 3501)
  AUTHORS   Gong,L., Tang,Y., An,R., Lin,M., Chen,L. and Du,J.
  TITLE     RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress
            and mitochondria-associated apoptosis pathways
  JOURNAL   Cell Death Dis 8 (10), e3080 (2017)
   PUBMED   28981095
  REMARK    GeneRIF: Collectively, these data support for the first time that
            RTN1-C may represent a novel candidate for therapies against
            cerebral ischemia/reperfusion injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3501)
  AUTHORS   Herlan,L., Schulz,A., Schulte,L., Schulz,H., Hubner,N. and
            Kreutz,R.
  TITLE     Novel candidate genes for impaired nephron development in a rat
            model with inherited nephron deficit and albuminuria
  JOURNAL   Clin Exp Pharmacol Physiol 42 (10), 1051-1058 (2015)
   PUBMED   26192016
REFERENCE   6  (bases 1 to 3501)
  AUTHORS   Yang,J. and Zoeller,R.T.
  TITLE     Differential display identifies neuroendocrine-specific protein-A
            (NSP-A) and interferon-inducible protein 10 (IP-10) as
            ethanol-responsive genes in the fetal rat brain
  JOURNAL   Brain Res Dev Brain Res 138 (2), 117-133 (2002)
   PUBMED   12354640
  REMARK    GeneRIF: neuroendocrine-specific protein-A (NSP-A) as
            ethanol-responsive gene in the fetal rat brain
REFERENCE   7  (bases 1 to 3501)
  AUTHORS   Hirata,T., Nomura,T., Takagi,Y., Sato,Y., Tomioka,N., Fujisawa,H.
            and Osumi,N.
  TITLE     Mosaic development of the olfactory cortex with Pax6-dependent and
            -independent components
  JOURNAL   Brain Res Dev Brain Res 136 (1), 17-26 (2002)
   PUBMED   12036513
REFERENCE   8  (bases 1 to 3501)
  AUTHORS   Hens,J., Nuydens,R., Geerts,H., Senden,N.H., Van de Ven,W.J.,
            Roebroek,A.J., van de Velde,H.J., Ramaekers,F.C. and Broers,J.L.
  TITLE     Neuronal differentiation is accompanied by NSP-C expression
  JOURNAL   Cell Tissue Res 292 (2), 229-237 (1998)
   PUBMED   9560466
REFERENCE   9  (bases 1 to 3501)
  AUTHORS   Ninkina,N.N., Baka,I.D. and Buchman,V.L.
  TITLE     Rat and chicken s-rex/NSP mRNA: nucleotide sequence of main
            transcripts and expression of splice variants in rat tissues
  JOURNAL   Gene 184 (2), 205-210 (1997)
   PUBMED   9031629
REFERENCE   10 (bases 1 to 3501)
  AUTHORS   Baka,I.D., Ninkina,N.N., Pinon,L.G., Adu,J., Davies,A.M.,
            Georgiev,G.P. and Buchman,V.L.
  TITLE     Intracellular compartmentalization of two differentially spliced
            s-rex/NSP mRNAs in neurons
  JOURNAL   Mol Cell Neurosci 7 (4), 289-303 (1996)
   PUBMED   8793864
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 2, 2021 this sequence version replaced NM_053865.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U17604.1, SRR26360176.2271200.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-645               JAXUCZ010000006.1  96718696-96719340   c
            646-1419            JAXUCZ010000006.1  96608298-96609071   c
            1420-2178           JAXUCZ010000006.1  96602363-96603121   c
            2179-2386           JAXUCZ010000006.1  96514159-96514366   c
            2387-2525           JAXUCZ010000006.1  96509682-96509820   c
            2526-2595           JAXUCZ010000006.1  96507318-96507387   c
            2596-2642           JAXUCZ010000006.1  96506809-96506855   c
            2643-2701           JAXUCZ010000006.1  96506665-96506723   c
            2702-3501           JAXUCZ010000006.1  96499137-96499936   c
FEATURES             Location/Qualifiers
     source          1..3501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..3501
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /note="reticulon 1"
                     /db_xref="GeneID:116644"
                     /db_xref="RGD:620986"
     exon            1..645
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     CDS             405..2744
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /note="S-rex; neuroendocrine-specific protein"
                     /codon_start=1
                     /product="reticulon-1"
                     /protein_id="NP_446317.2"
                     /db_xref="GeneID:116644"
                     /db_xref="RGD:620986"
                     /translation="MAAPPDLQDEPLSPANPGSQLFGGRGEGEDEEATPKGARPAQQD
                     GEPAWGSGAGAGVVSSRELCSGPARSPPVAMETASTGVAAVPDALDHSSSPTLKDGEG
                     ACYTSLISDICYPPREDSAYFTGILQKENGHITTSESPEELGTPGPSLPEVPGTEPHG
                     LLSSDSGIEMTPAESTEVNKILADPLDQMKAEACKYIDITRPQEAKGQEEQSPGLEDK
                     DLDFKDKDSEVSTKPEGVHAPNQPSPVEGKLIKDNLFEESTFAPYIDELSDEQHRMSL
                     VTAPVKITLTEIGPPVMTATHETIPEKQDLCLKPSPDTVPTVTVSEPEDDSPGSVTPP
                     SSGTEPSAAESQGKGSVSEDELIAAIKEAKGLSYETTESPRPVGQAADRPKVKARSGL
                     PTIPSSLDQEASSAESGDSEIELVSEDPMASEDALPSGYVSFGHVSGPPPSPASPSIQ
                     YSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPGVLDAIREETSSRATE
                     ERAPSHQGPVEPDPMLSFTPVTLQSRPEPSSGDGAPVPEPPKSQQQKPEEEAVSSSQS
                     PAATEIPGPLGSDLVPPLPFFNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVV
                     SVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCL
                     QLYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPV
                     VYVKHQAQVDQYLGLVRTHINTVVAKIQAKIPGAKRHAE"
     exon            646..1419
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            1420..2178
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2386
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2525
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2595
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2642
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2701
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..3501
                     /gene="Rtn1"
                     /gene_synonym="Nsp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacatccct taatcagagc ctgccattag caggcccggg gctgacgtgc tttagggagg
       61 actcggacca agcaggccat tttcacctgc gtaataacag gcttgggagt agcgaagcag
      121 cgcaggcaca gcgagctgcc tctggagcag gggaggagcg caggcggcag ccgccccggg
      181 gccccggagg aagaggaggg ggagaaggag gagccgaagc gcccagaaca gcagcagcgt
      241 ctcggcctga gttgcagaaa aagcagcgac ggtggcgcgg agactctgca gcctcctgga
      301 gcccggagtc ccggtaggga cagcagcagg gagcgtccgc gtccctagcc accgcacccg
      361 ggccttgcca agctacagtc gcccagcctg gggcatagcc agtcatggcc gcaccgccgg
      421 atctgcaaga tgagccactg tctccggcta accccgggtc ccagttgttc gggggccggg
      481 gggaggggga agacgaagaa gcgacgccga agggggccag accagcgcag caggatgggg
      541 agcccgcttg ggggtccggc gctggagctg gggtagtgtc gtcgcgggaa ctgtgctccg
      601 gccccgcccg gtcgcctccc gtcgccatgg aaactgcatc cacaggtgtg gcagctgttc
      661 ctgatgccct cgatcactct tcctctccaa cactaaaaga tggggaaggg gcatgttaca
      721 catccctgat ttctgacatc tgttatccac ctcgagagga ctctgcatac tttactggaa
      781 ttcttcagaa agaaaatggt cacatcacca cttccgagag tcctgaggag ctggggaccc
      841 ccggaccctc tttaccagaa gtgcctggga cggagccaca tggcttattg agttctgatt
      901 ctggaataga gatgactcct gctgagtcca ctgaggtgaa caagatccta gctgaccccc
      961 tagaccagat gaaagcagag gcctgtaaat atattgacat aaccaggcca caggaggcaa
     1021 aaggccagga ggagcaatcc cctgggctag aagacaaaga cttggacttt aaagacaagg
     1081 actctgaagt ctccacaaaa ccagaagggg tccatgcacc taaccagcca tctcctgtgg
     1141 aggggaagct catcaaggac aacttatttg aagaatctac ctttgctcct tacatagatg
     1201 agctttctga tgagcaacac aggatgtctc tggtcactgc ccctgtcaag atcacactga
     1261 cggaaatcgg acctcctgtc atgactgcca cacacgagac aatccctgag aagcaagacc
     1321 tgtgtctaaa gccaagtcct gacacagttc ccactgtgac tgtctcagag cctgaagatg
     1381 acagcccagg atctgtcact cctccatctt ctggaacaga accatctgct gcagagtccc
     1441 aggggaaagg cagcgtctcc gaggatgagt tgattgctgc cattaaagaa gcaaaggggt
     1501 tatcatatga aacaaccgag agtccaaggc cagtgggcca ggcggccgac agacccaaag
     1561 tcaaggccag gtccgggctg cccacaatcc ccagctccct ggaccaggag gccagcagtg
     1621 cggagtccgg agactcagaa attgaactgg tgtcagagga ccccatggcc tctgaggatg
     1681 cgctaccctc tggctatgtg agcttcggcc acgtgtcggg cccgcctccc tctcctgcct
     1741 ctccatctat ccagtacagc atcctgcggg aggagcggga ggccgagctg gacagcgagc
     1801 tcatcatcga gtcctgcgat gcctcctcgg cctcagagga gagccccaag cgcgagcagg
     1861 actcgccccc gatgaaaccg ggcgtcctgg atgccatccg cgaagagaca agctctcggg
     1921 ccaccgaaga gcgagcgccc agccaccaag gccctgtgga acctgacccg atgctcagct
     1981 tcacccctgt caccctccag tcccgcccag agccatcatc aggtgatgga gccccggtcc
     2041 cagagccgcc caagtcacag cagcagaagc ctgaagagga agctgtgagt tccagccaaa
     2101 gtcccgcggc caccgaaatt cctggaccac ttggttctga cctcgtgccc cctctgcctt
     2161 tcttcaacaa gcaaaaagct attgaccttc tgtactggcg ggacatcaag cagacgggga
     2221 ttgtgttcgg gagcttcctg ctgctgctct tctccctgac ccagttcagc gttgtgagcg
     2281 tcgtcgccta cctggccctg gctgccctct ctgccaccat cagcttccgc atctacaagt
     2341 ccgttctaca agctgtgcag aaaacagatg agggtcaccc tttcaaggcc tacctggagc
     2401 tggagatcac cctgtcccag gagcagatcc agaagtacac agactgcctg cagctatacg
     2461 tgaacagcac tctgaaggag ctacggaggc tcttcctggt ccaggacctg gtggattcct
     2521 taaaatttgc agtcctcatg tggctcctga cctacgttgg cgcactcttc aatggcctga
     2581 ccctgctgct tatggctgtg gtttcgatgt ttactctacc tgtggtatat gttaagcacc
     2641 aggcacaggt tgaccaatat ctgggacttg tgaggactca cataaacacc gttgtggcaa
     2701 agatccaggc taaaatcccc ggcgccaaga ggcacgctga gtagatggtt gccccaggag
     2761 aagccggaca tgaatggggg tgtctggagt ggtaacagct ctctccttcc tcgttactgc
     2821 gaattgattg tttcccttcc ccagtaccat aatcttagag gcaaacttcg agacaggtgt
     2881 tttcaggctt ttcctgtact cttaggatat ttgagtcccc ccgccccttg tcaagcacta
     2941 aagtatagag tgtgttagat gtggttttta attttgtgtt gctaaaaaaa aaagtgcatg
     3001 atggtgagag ctcacgttct ccttcgtccc ttgctgtcct ccccctgcaa tgcttctgtg
     3061 gcttctactg tccctgtggc taggcccttc ttgccaagtg cgctgacaca tagtgggtcg
     3121 cttatcatgt ccttgggttg ctggttggat tcatctctaa taacactata tagaatcgta
     3181 ggccaatgtt ttagcatttt acccccccac acacagaaca taaaaattaa tataaaacag
     3241 ttgaccgtgt atatggtgat ccgttttgta taactaagaa tgatcgaatt aaagaataaa
     3301 tccaaaaatg aacgcacagt acttttattg tatgggatgc ctgggctgat ttacatgtat
     3361 ggtaactaaa gtgccagcat gttgacttta ttacgatttg tatttcttcc tctgtagttc
     3421 ctaacggact caatcacaga ctctgggtat ttgcacttat gtacttgata ctgaatgcat
     3481 caataaatgt gactcaatgt a
//
