LOCUS       NM_001107625            6161 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus rhotekin 2 (Rtkn2), mRNA.
ACCESSION   NM_001107625 XM_001080372 XM_228115
VERSION     NM_001107625.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6161)
  AUTHORS   Collier FM, Loving A, Baker AJ, McLeod J, Walder K and Kirkland MA.
  TITLE     RTKN2 Induces NF-KappaB Dependent Resistance to Intrinsic Apoptosis
            in HEK Cells and Regulates BCL-2 Genes in Human CD4(+) Lymphocytes
  JOURNAL   J Cell Death 2, 9-23 (2009)
   PUBMED   26124677
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6161)
  AUTHORS   Collier FM, Gregorio-King CC, Gough TJ, Talbot CD, Walder K and
            Kirkland MA.
  TITLE     Identification and characterization of a lymphocytic Rho-GTPase
            effector: rhotekin-2
  JOURNAL   Biochem Biophys Res Commun 324 (4), 1360-1369 (2004)
   PUBMED   15504364
REFERENCE   3  (bases 1 to 6161)
  AUTHORS   Tulin EE, Onoda N, Hasegawa M, Nosaka T, Nomura H and Kitamura T.
  TITLE     Genetic approach and phenotype-based complementation screening for
            identification of stroma cell-derived proteins involved in cell
            proliferation
  JOURNAL   Exp Cell Res 272 (1), 23-31 (2002)
   PUBMED   11740862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000324.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001107625.3.
            
            On Apr 13, 2021 this sequence version replaced NM_001107625.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN16676786 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               JACYVU010000324.1  16333586-16333829   c
            245-447             JACYVU010000324.1  16326657-16326859   c
            448-506             JACYVU010000324.1  16316435-16316493   c
            507-560             JACYVU010000324.1  16312318-16312371   c
            561-678             JACYVU010000324.1  16311033-16311150   c
            679-873             JACYVU010000324.1  16307591-16307785   c
            874-968             JACYVU010000324.1  16289389-16289483   c
            969-1075            JACYVU010000324.1  16282381-16282487   c
            1076-1207           JACYVU010000324.1  16281283-16281414   c
            1208-1370           JACYVU010000324.1  16271212-16271374   c
            1371-1478           JACYVU010000324.1  16266598-16266705   c
            1479-6161           JACYVU010000324.1  16260506-16265188   c
FEATURES             Location/Qualifiers
     source          1..6161
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p11"
     gene            1..6161
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /note="rhotekin 2"
                     /db_xref="GeneID:309729"
                     /db_xref="RGD:1304834"
     exon            1..244
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2011
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /note="pleckstrin homology domain containing, family K
                     member 1"
                     /codon_start=1
                     /product="rhotekin-2"
                     /protein_id="NP_001101095.2"
                     /db_xref="GeneID:309729"
                     /db_xref="RGD:1304834"
                     /translation="MEGQLLRGLAAQQDCSIQEKIDLEIRMREGIWKLLSLSKKKDQV
                     LHAVKNLMVCNARMQVYTAELQKLEETASQTGRRLVLDASLETKEQEPCRGKIALSDI
                     RIPLMWKDSDHFGHKECTQRFAIFCLFRMGTQVFDTDMMIVDQTVTDICFENVTIFNE
                     AGPDFRVKIEVYSSSAEESSITNTPKKLAKKLKTSISKATGRKISAVLQEEDQEASLL
                     VSSVAGAKYHLLAHTTLTLENAGDCFKTHNLSVHGDEECSFWLPLYGNLCCRLVAQPA
                     CMAEDAFAGFLNEQQTGKGLVGWRRLYCALRGGKLRCFYGPEEIEAKVEPTLVIPVDK
                     ETRIQAMEKDSKKMHCFSVLTTAAGRAVSHIFAADGLGDFQEWMDAFRQHRFDLSHWK
                     HCCEELMRIEIMSPRKPPLFLAKEATSVYHDMSIDSPVKLESVTDIIQKKIGETNGQF
                     LIGREEESTTPPWASVFDGSHEMVIQKKVLSPAGKPAPDGKRKKRRAPLPPMDQPPFS
                     VKTQGSMGQSKDSEAQVGVSGAPSSDRRLSPPTHHLQKPVAAPRKLLPTRKSSSEDSG
                     PTDAKTSLDGKPVPAPRQKSIRDILDPRSWLQAQV"
     exon            245..447
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..506
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..560
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..678
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
     exon            679..873
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..968
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1075
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1207
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1370
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1478
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..6161
                     /gene="Rtkn2"
                     /gene_synonym="Plekhk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcttaaggc cggctgtagc agagggtctg tgcagagtcc tcgggtctcg tgctgttcta
       61 gagacggagc ggaccctagt gcgcttgcgc ggcgtcgtgg gccgggttcc cctgcagctc
      121 ggacttggta cggccgagcg gttggtgcgg tctgcagctg cagccccggg gcgcgctttt
      181 caaatcgtgg ttgacgtgcg ccgaaatgga agggcagctg ctgaggggcc tcgccgcgca
      241 gcaggactgc agcatccaag agaaaataga cttagagatc cgaatgcgag aaggaatatg
      301 gaaactgctc tccctgagta aaaaaaaaga ccaggttttg cacgcagtta agaacctcat
      361 ggtctgcaat gctcggatgc aggtgtacac ggcggagctg cagaagttag aagagactgc
      421 aagtcaaacc ggaagacggt tagtgctgga tgcgagttta gaaactaaag aacaagaacc
      481 ctgcagaggg aagatcgctc tgtcagatat tcgaataccg ttaatgtgga aagactccga
      541 tcacttcggt cataaggaat gcacacagcg ctttgccatc ttttgcttat tcaggatggg
      601 aacccaagtg tttgacaccg acatgatgat tgtggaccag accgtcacag atatatgttt
      661 tgaaaacgtc accatattca acgaagcagg accagacttc cgggtaaaga tagaggtcta
      721 cagcagcagc gcagaggaat cttccataac caacaccccc aaaaagctgg ctaaaaagct
      781 gaagacgtcc atcagcaaag ctacgggaag gaagataagt gctgtgctgc aggaggagga
      841 ccaggaggcg agcctgcttg tcagctccgt ggcgggagca aagtaccatt tactagctca
      901 caccaccctg accttggaaa atgccggaga ctgcttcaag acccataacc tgtcggttca
      961 cggagatgag gagtgttcct tttggcttcc cttgtatggc aacctatgct gtcggctagt
     1021 ggcccagcca gcctgcatgg ctgaagacgc atttgcagga ttccttaatg agcagcaaac
     1081 aggaaaaggt ttggttggct ggagaaggtt gtactgtgct ctgagagggg gtaaactccg
     1141 ctgtttttat ggtccagaag aaattgaagc caaagtggaa ccgactctgg tgattcctgt
     1201 tgacaaggaa accaggatcc aggccatgga aaaggattca aagaaaatgc actgcttctc
     1261 cgtcctcacc acggctgctg ggcgagcagt gagtcacatc tttgcggctg acggcctagg
     1321 agactttcaa gaatggatgg acgctttccg gcagcaccgc tttgatctca gccactggaa
     1381 gcattgttgt gaagaactta tgagaattga gattatgtca ccacggaaac cacctttgtt
     1441 cctggcaaag gaggcgactt cagtgtatca cgatatgagc attgattcac ctgtgaaact
     1501 cgaaagcgtg acggacataa tacaaaaaaa aatcggagag accaatggac agttcctcat
     1561 tggtcgggag gaggaatcca caacaccccc gtgggcctca gtgtttgatg gcagccatga
     1621 gatggtcatc cagaagaaag tcttgtcccc agcaggcaaa ccagcaccgg atgggaaaag
     1681 gaaaaagaga cgtgctcccc tccctcctat ggatcagcct cccttcagtg taaagacaca
     1741 aggtagcatg ggtcagtcca aggacagcga agcccaggtc ggtgtctctg gggccccatc
     1801 ttcagatcgc agactgtcac cgcctacgca tcacctccag aaaccggtgg ctgcccctcg
     1861 caaacttctc cccaccagga aaagcagttc agaggacagc gggcccacag atgctaaaac
     1921 cagtttggac gggaagccag tgccagctcc aaggcagaaa tccatcagag acattctgga
     1981 ccctcgatcg tggctccaag cacaagtgta ggaagcctgt actgtgtaaa tccagctgta
     2041 aggctcggtc agaggcattg tgagtgtaat gttagataat tgtagaggta aagaccagag
     2101 cagtttccgg aagccattaa taagtggtta gatacagaaa agcaccttta aatagagaat
     2161 tggatttccc ctttacttct cctttccaga atatcaatgg tttctcccca cggaacaaaa
     2221 gaggaaattt ctagacaata tcttactcgt tggaagggtt aatttattcc taattttgta
     2281 gcaggcagtg gacaggcagc aggcattaaa agcattgatt tttttttggg gggggggtaa
     2341 aatgtcttca atacaagcca cattctcatt gtgagaactt taatacttaa cggagtgctt
     2401 caaaggtttt actcaaacca caaattacag aatccaccca aggaaatgtg tccggtcagc
     2461 tttctgggat tctcatctaa cagtcctctg gatccctccc ctctgttgtt taactcaatg
     2521 atctataggg ttgacctttt taaattcctg ggatacattt tcgaatatta aaccctttat
     2581 ctttaaaggg aatttgtaat ctgctattca aagtcatttc tttgatgagc cctgaaatcc
     2641 tgttgacttc accgcttgca gtgaggccca cccttcttag ggagtgaagt ggatgtgaaa
     2701 tgtccccctt cgtcctgctt gccataggat gctaatctcc gtttgtggcc tctggaattc
     2761 agggagacaa gtcgctgact aatgccttaa atttttactt aatactttaa aagcagatgg
     2821 cagattcaaa aaattatcag gaaggttgac cgcagtaatc ttcagaatta atcctttttc
     2881 aattttttaa ttagattttc cttttttttt ttttttttga gtaaggactg atgtctgtta
     2941 ttgatattgt ctgatattgt gttactgata ttcattcagt aatcacattg gcgtcatttc
     3001 cataggaggt aatttccata gcaactaatc acagtgaccc aaacaggatt ataaattgaa
     3061 tggggggata aatagcaaga ggatgaatat cttaaacgga caaaaagaaa aatccacttt
     3121 ttataataac cccttttgta aacaagagta gcggaacagt tttaaaatgt catcagaatt
     3181 tccaagcaaa cttcccagag ggtatttgca ccagttctga aaagtccagg acctcccacg
     3241 ccctaacggg taccataatc catcacgctg aaggaatgag ttctgtcaat ctggatggga
     3301 actacgccca cgtaaaatgg ccaaccgagg tattgatggg accaaccatt caccgttttt
     3361 agatagcaga ggggaatagt tcgtctgtct gttgcttgcc caggaacccc cagtaaaaag
     3421 gggaacccgg gtccagtgac acacagccct tgtgaaggtc gagactccta cgcccatgga
     3481 aacccgaaga atagatgggt gtggttttgt ttttgtttta atctaactga aagggtctgg
     3541 gaagttttgg tggtaattac catttctttg ctttcttttt atacttattt tatgtatatg
     3601 agtacactgt ggctgtcttc agacacacca gaagagggca tcagatccta ccatgtgggt
     3661 actgggactt gaactcagca cctctggaag agcagtctct tagccgctca gccagctctc
     3721 cagccccagt aattgccctt tcaatacatc aaagtacgtt gttttattgc ttaaaaaatg
     3781 cctctgttag cccttggcga catcttcaac aattcttatg aactgttgat ggaacctctt
     3841 ttttgtttgt ttgtctaagt tagaaagtgc tgctggcaaa attgtttctg atccctggca
     3901 cccaagtgcc cctacctcga gcccctgtgc ccctcacttg ctgcgttcct ctattcaagc
     3961 cttccgattt cttgtacaaa ttacagctgg aagaatttaa ggtgtgtgcg tgcgtgcatg
     4021 catgcgtgtg tgcctgtgcc tgtgcctgtg cctgtgcctg tgcctgtgcc tgtgcctgtg
     4081 cctgtgtctc ttcctggaaa cattctgaag gagttgtgtt cttagcaggc agctttgaac
     4141 catgtctgaa atcagcctcc ttccttcttg gtgggtgaaa ttctgcccaa tccccaccag
     4201 ttaaaggagg tccccctctg taccactctg ctcatcaaat actaggccac actcgcccta
     4261 cacaacaaaa gagaagctgt cctctctttt actcctccct cctaactctt cccaccttcc
     4321 ttcctcctct tctctcattc cgtcacaact taaaagtgct gagatactga ctggtggagg
     4381 gatgcatcac gtgatagaag aggtgcggca gcttcgtgtg tgtccttccg attcgtttct
     4441 ttgctatcag atcttgataa cattataatt ggaggaactt aattatggtg ctttcgagga
     4501 tgcaaagata acgtcttggg cagttgcatc tacatctcaa ggtctgtgct ataaattaca
     4561 caaattataa aataagtttc cttattttga catctttcga agaggaagaa caccctttta
     4621 aacataaata cgcacatctc aaggtaaaat ccaccaaaac accaaacatg gatctcacca
     4681 ctccataaac aacttttaaa cagatatggc tacgtgtgtg gaaaactata cattccttac
     4741 caatatttgt ccctgccttt taggagaaaa tgtccctcac ctagcactgt tcattaaaaa
     4801 tcagtaggag cttagagacc accagtgcaa ggtaggcagg ccatgctggc cagtcttcct
     4861 ttcaggtacc tcagacctac tgtgaagtta attaattcag ttcaaaatga aattataggg
     4921 gcatttggtg gagtttgtat tcagtggcca tttaaatgca atcgcctgta caactcagca
     4981 ggggcagcca tgttagagat gcagcagatg cgggggcggg ggggtaggta caggtgtgct
     5041 tcttgtggtg aattgtatct cctgaccaga actttccaga actcacggat acactcaaga
     5101 gggagttggt gggtagcagt taaggtgcaa ttaatgacca tttgcattct ggcagttgtc
     5161 ttctccgccc tgttatgttt caatagcatt tctagacagg cggggggggg ggggtgcttc
     5221 cctttagtct cagtggcagg gaggcagagg caggcagatc tctgagttcg aggccagcct
     5281 gctctatgga ctgagttcca ggatagctac actaagaaac cctgtcttga aaaaccaaaa
     5341 ggaaaaagca tttctatttt aaatttttta tcgagatatt tctctctctc tttctctctc
     5401 tctctctctc tctctctctc tctctctctc tctctctgtg tgtgtatgtg tatgtgcgtg
     5461 catgtacatg catgcaaaca tgtgcgccca tggaggccag aagaggtcct tggacctcgt
     5521 ggaaccgaat cacaggtgag cctctctcag tatggctgcg aaagaactcc tgcgggaaga
     5581 gcaagttctc gtaacgtctg taccatcatc tatccagccc aaaacgtgtg ttaactactt
     5641 tgttattgtt aataacagtt ccacgaacac tgttgttata cattgtgtat ctcatcaacc
     5701 ctgggtgaaa atagcacttt tgagtttttt ttaaatggac tttttttttc tttttaaaac
     5761 gttatttatt tgtttacgta ttagctgtat gtgtctccga ccacaaagga agccaggtga
     5821 caacctgcgg gagtcagttc tctcagttct ctccttctat caagtgggtc cttccaatgg
     5881 aacccaattc ctgtgtttag tggcaagcgt ctttatccac tgagccatcg gccagccccc
     5941 atctttgact ttttaaatgg cagaatttca tttgaaagta gattgtattc tttttctaac
     6001 ttgttgaact gtgttccttt aaccatatgt ggatcaaatg tttggattaa aaaatagtac
     6061 ttctatcaga ctttttgtta atgatcaaag gtacttgagt gtaatctaag tcacataatt
     6121 aaaacctgtg tagtaattaa aggacttgat tcgtgaagac a
//
