LOCUS       NM_184046               2621 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus rhotekin (Rtkn), transcript variant 1, mRNA.
ACCESSION   NM_184046
VERSION     NM_184046.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2621)
  AUTHORS   Zhou,J., Zhang,Y., Qi,Y., Yu,D., Shao,Q. and Liang,J.
  TITLE     MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN
            in hepatocellular carcinoma
  JOURNAL   Oncol Rep 37 (2), 1227-1234 (2017)
   PUBMED   27922690
REFERENCE   2  (bases 1 to 2621)
  AUTHORS   Iwai,T., Saitoh,A., Yamada,M., Takahashi,K., Hashimoto,E., Ukai,W.,
            Saito,T. and Yamada,M.
  TITLE     Rhotekin modulates differentiation of cultured neural stem cells to
            neurons
  JOURNAL   J Neurosci Res 90 (7), 1359-1366 (2012)
   PUBMED   22411704
  REMARK    GeneRIF: Rhotekin is required for maintenance and survival of
            neurons and positively regulates differentiation and neurite
            outgrowth.
REFERENCE   3  (bases 1 to 2621)
  AUTHORS   Sudo,K., Ito,H., Iwamoto,I., Morishita,R., Asano,T. and Nagata,K.
  TITLE     SEPT9 sequence alternations causing hereditary neuralgic amyotrophy
            are associated with altered interactions with SEPT4/SEPT11 and
            resistance to Rho/Rhotekin-signaling
  JOURNAL   Hum Mutat 28 (10), 1005-1013 (2007)
   PUBMED   17546647
  REMARK    GeneRIF: SEPT9 sequence alternations causing hereditary neuralgic
            amyotrophy are associated with altered interactions with
            SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling
REFERENCE   4  (bases 1 to 2621)
  AUTHORS   Ryan,X.P., Alldritt,J., Svenningsson,P., Allen,P.B., Wu,G.Y.,
            Nairn,A.C. and Greengard,P.
  TITLE     The Rho-specific GEF Lfc interacts with neurabin and spinophilin to
            regulate dendritic spine morphology
  JOURNAL   Neuron 47 (1), 85-100 (2005)
   PUBMED   15996550
REFERENCE   5  (bases 1 to 2621)
  AUTHORS   Liu,C.A., Wang,M.J., Chi,C.W., Wu,C.W. and Chen,J.Y.
  TITLE     Rho/Rhotekin-mediated NF-kappaB activation confers resistance to
            apoptosis
  JOURNAL   Oncogene 23 (54), 8731-8742 (2004)
   PUBMED   15480428
REFERENCE   6  (bases 1 to 2621)
  AUTHORS   Reynaud,C., Fabre,S. and Jalinot,P.
  TITLE     The PDZ protein TIP-1 interacts with the Rho effector rhotekin and
            is involved in Rho signaling to the serum response element
  JOURNAL   J Biol Chem 275 (43), 33962-33968 (2000)
   PUBMED   10940294
REFERENCE   7  (bases 1 to 2621)
  AUTHORS   Reid,T., Furuyashiki,T., Ishizaki,T., Watanabe,G., Watanabe,N.,
            Fujisawa,K., Morii,N., Madaule,P. and Narumiya,S.
  TITLE     Rhotekin, a new putative target for Rho bearing homology to a
            serine/threonine kinase, PKN, and rhophilin in the rho-binding
            domain
  JOURNAL   J Biol Chem 271 (23), 13556-13560 (1996)
   PUBMED   8662891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000148.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_184046.3.
            
            On Jan 4, 2023 this sequence version replaced NM_184046.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY348867.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132291, SAMD00132292
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-415               JACYVU010000148.1  12972264-12972678
            416-701             JACYVU010000148.1  12973180-12973465
            702-901             JACYVU010000148.1  12980842-12981041
            902-963             JACYVU010000148.1  12982477-12982538
            964-1017            JACYVU010000148.1  12982654-12982707
            1018-1135           JACYVU010000148.1  12982827-12982944
            1136-1345           JACYVU010000148.1  12983156-12983365
            1346-1440           JACYVU010000148.1  12985067-12985161
            1441-1547           JACYVU010000148.1  12985310-12985416
            1548-1676           JACYVU010000148.1  12985597-12985725
            1677-1845           JACYVU010000148.1  12986346-12986514
            1846-1950           JACYVU010000148.1  12986643-12986747
            1951-2621           JACYVU010000148.1  12987284-12987954
FEATURES             Location/Qualifiers
     source          1..2621
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2621
                     /gene="Rtkn"
                     /note="rhotekin"
                     /db_xref="GeneID:297383"
                     /db_xref="RGD:727874"
     exon            1..415
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            416..701
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     CDS             630..2276
                     /gene="Rtkn"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="rhotekin isoform 1"
                     /protein_id="NP_908935.1"
                     /db_xref="GeneID:297383"
                     /db_xref="RGD:727874"
                     /translation="MQDRLRILEDLNMLYIRQMALSLEDTELQRKLDHEIRMREGACK
                     LLAACSQREQALEATKSLLVCNSRILSYMGELQRRKEAQVLGKTGRRPSDSVQPPERS
                     PCRGRVCISDLRIPLMWKDTEYFKNKGDLHRWAVFLLLQLGEQIQDTEMVLVDRTLTD
                     ISFQNNAIFAEAGPDFELRLELYGACVEEEGALAGAPKRLATKLSSSLGRSSGKRVRA
                     SLDSAGGSGNSPILLPTPAVGGPRYHLLAHTTLTLAAVQDGFRTHDLTLTSHEENPAW
                     LPLYGSMCCRLVAQPLCMTQPTASGTLRVQQAGELQSGTLVHGVLKGTNLFCYWRSED
                     ADSGQEPLFTILINKETRVRAGELEQAPEWPFTLSISNRYGDDEVTNTLQVQSRDALQ
                     SWMEALWQLFLDMSQWKHCCDEVMKIETPAPRKPPQALAKQGSLYHEMAIEPLEDIAA
                     VTDILAQREGTRLEPPPPWLAMFTDQPALRSSCSPASVPTWTQPLPWGRPRTFSLDAV
                     PADHSLGPSRSVAPLPPQRSPQSRGFYSKSQLSTWLQSPV"
     exon            702..901
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            902..963
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1017
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1135
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1345
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1440
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1547
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1676
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1845
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1950
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2621
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcccaggct ttctctgagt cagaagcgag tggagagctt ttgtcctcct cccgccccag
       61 caacttagac ccaaggaacc cgcgcgtagc cagcgtcgga gaaacggggg gcgaggttgg
      121 ggacctggag gagggcctgt gctcctaagc cttgctagga tatgccaggc cttgggggcc
      181 atagctgagg agtcggggcg gagccgcagg gccaagcctg ccgcccggtt gagtgtgact
      241 ccacggtccc ggggtagggg gtggggtggg ggacaaccct gcagctggct gggacccggg
      301 gctggtttcc tgtctggaag ggaaggggcc cgcagagggg atcagggcca gcagcagcca
      361 ggcacacccc tgactttctc cctctctttc tcctcccttc tgctggaaaa gcgaggtctt
      421 ggaacagcag taggagagaa aattttgtca aagaagccag agtggtctaa caggactgca
      481 gagggacagg gacagattct gcattctgtc ccagagctgg acacctctct caagcccagg
      541 gagcagtggg aggagaaact gtgggacagc gtggtgccta cctggcctct ctctgggcag
      601 caagggaagg ggctctaggg gacacagaga tgcaggacag attgcgaatc ctggaggacc
      661 tcaatatgct ctacatccgg cagatggcac tcagcctgga ggacacagag ttgcagagga
      721 aactagatca tgagatccgg atgagggaag gggcctgcaa gctgttggcg gcctgctccc
      781 agcgagagca ggctctggaa gccaccaaga gcctgctggt gtgcaatagc cggattctca
      841 gctacatggg cgagctgcag cggcgcaagg aggcccaggt gctgggaaag acaggccggc
      901 gaccttccga cagtgtgcag ccccctgagc gctctccttg ccgaggccgg gtctgcatct
      961 ctgacctccg gatcccactc atgtggaagg acacagagta tttcaagaac aaaggcgatc
     1021 tgcaccgctg ggctgtgttt ctactgctgc agcttgggga acagattcag gatactgaga
     1081 tggtcctggt ggacaggacc ctcacagaca tctcctttca gaacaatgcg atttttgctg
     1141 aggcagggcc tgactttgaa ttgcggctgg agctgtatgg ggcctgtgtg gaagaggagg
     1201 gagccctagc tggtgccccc aagaggcttg ccaccaaact cagtagctcc ctgggccggt
     1261 cctcagggaa gcgtgtcaga gcatcactgg acagtgctgg gggctccggg aacagtccca
     1321 tcctgctccc taccccagct gtgggaggtc ctcgatacca cctcttggcc cacaccactc
     1381 tcactctagc ggcagtgcaa gatggattcc gtacacatga cctcactctc accagtcatg
     1441 aggagaaccc tgcctggctg cccctttatg gtagcatgtg ttgccgcctg gtggctcagc
     1501 ctctctgcat gactcagcct actgcaagtg gtaccctcag ggtgcagcaa gccggggagc
     1561 tccagagtgg gacacttgta catggagtcc tgaaaggcac aaacctcttt tgctactgga
     1621 gatctgagga tgcagattct gggcaggagc cactgttcac tatcctcatc aacaaggaga
     1681 ctagggtccg ggcaggggag ttggagcagg ccccggagtg gcctttcacc ctcagtatca
     1741 gcaaccggta tggagatgat gaggtgacaa acacgctcca ggtgcagagc agggatgccc
     1801 tgcagagctg gatggaggcg ctgtggcagc tgttccttga catgagccag tggaaacact
     1861 gttgtgatga agttatgaag atcgaaactc ctgctccccg gaaaccaccc caagcactgg
     1921 ccaagcaggg gtccttatac cacgagatgg ccattgagcc actagaggac atcgcagcag
     1981 tgacagacat cctggcccag cgggagggca caaggctgga gccgccccca ccctggctag
     2041 caatgtttac cgaccagcct gccttgcgta gctcctgctc gcctgcctca gtcccaacct
     2101 ggacgcaacc cctgccctgg ggaagacccc gcaccttttc cctggatgct gtccctgcag
     2161 accactccct tgggccttct cgctcggttg caccccttcc cccacagcga tccccacaat
     2221 ccagaggttt ctacagcaaa agtcagctca gcacatggct ccagtcccca gtgtgagagg
     2281 caccagcaag aggatggcca agagagaaaa tgacccaagg acaactggac tctagggcca
     2341 gctggccagc ttgggctcct cttcctccac tggacaagga cagaaggctg gggaggggtg
     2401 acacaaaccc ttcttaagtt gtggttagat ggtactgagg ggaccattcc cggagctggc
     2461 taggaccccc cccccccaag cgcttcctgg gagaaaactg gaacaactct gccctacctc
     2521 cctacactaa ccagcctcca gggctgcact ggagagcgga gaggaaagca cctcccttgt
     2581 gacccctaca tcaaccatta aaagttattt aacagctcga a
//
