LOCUS       NM_001415852            2140 bp    mRNA    linear   ROD 18-FEB-2024
DEFINITION  Rattus norvegicus rhotekin (Rtkn), transcript variant 3, mRNA.
ACCESSION   NM_001415852 XM_008763035
VERSION     NM_001415852.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2140)
  AUTHORS   Zhou,J., Zhang,Y., Qi,Y., Yu,D., Shao,Q. and Liang,J.
  TITLE     MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN
            in hepatocellular carcinoma
  JOURNAL   Oncol Rep 37 (2), 1227-1234 (2017)
   PUBMED   27922690
REFERENCE   2  (bases 1 to 2140)
  AUTHORS   Iwai,T., Saitoh,A., Yamada,M., Takahashi,K., Hashimoto,E., Ukai,W.,
            Saito,T. and Yamada,M.
  TITLE     Rhotekin modulates differentiation of cultured neural stem cells to
            neurons
  JOURNAL   J Neurosci Res 90 (7), 1359-1366 (2012)
   PUBMED   22411704
  REMARK    GeneRIF: Rhotekin is required for maintenance and survival of
            neurons and positively regulates differentiation and neurite
            outgrowth.
REFERENCE   3  (bases 1 to 2140)
  AUTHORS   Sudo,K., Ito,H., Iwamoto,I., Morishita,R., Asano,T. and Nagata,K.
  TITLE     SEPT9 sequence alternations causing hereditary neuralgic amyotrophy
            are associated with altered interactions with SEPT4/SEPT11 and
            resistance to Rho/Rhotekin-signaling
  JOURNAL   Hum Mutat 28 (10), 1005-1013 (2007)
   PUBMED   17546647
  REMARK    GeneRIF: SEPT9 sequence alternations causing hereditary neuralgic
            amyotrophy are associated with altered interactions with
            SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling
REFERENCE   4  (bases 1 to 2140)
  AUTHORS   Ryan,X.P., Alldritt,J., Svenningsson,P., Allen,P.B., Wu,G.Y.,
            Nairn,A.C. and Greengard,P.
  TITLE     The Rho-specific GEF Lfc interacts with neurabin and spinophilin to
            regulate dendritic spine morphology
  JOURNAL   Neuron 47 (1), 85-100 (2005)
   PUBMED   15996550
REFERENCE   5  (bases 1 to 2140)
  AUTHORS   Liu,C.A., Wang,M.J., Chi,C.W., Wu,C.W. and Chen,J.Y.
  TITLE     Rho/Rhotekin-mediated NF-kappaB activation confers resistance to
            apoptosis
  JOURNAL   Oncogene 23 (54), 8731-8742 (2004)
   PUBMED   15480428
REFERENCE   6  (bases 1 to 2140)
  AUTHORS   Reynaud,C., Fabre,S. and Jalinot,P.
  TITLE     The PDZ protein TIP-1 interacts with the Rho effector rhotekin and
            is involved in Rho signaling to the serum response element
  JOURNAL   J Biol Chem 275 (43), 33962-33968 (2000)
   PUBMED   10940294
REFERENCE   7  (bases 1 to 2140)
  AUTHORS   Reid,T., Furuyashiki,T., Ishizaki,T., Watanabe,G., Watanabe,N.,
            Fujisawa,K., Morii,N., Madaule,P. and Narumiya,S.
  TITLE     Rhotekin, a new putative target for Rho bearing homology to a
            serine/threonine kinase, PKN, and rhophilin in the rho-binding
            domain
  JOURNAL   J Biol Chem 271 (23), 13556-13560 (1996)
   PUBMED   8662891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000148.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001415852.2.
            
            On Jan 4, 2023 this sequence version replaced XM_008763035.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR8487227.11753.1,
                                           SRR8487226.211534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               JACYVU010000148.1  12971067-12971286
            221-420             JACYVU010000148.1  12980842-12981041
            421-482             JACYVU010000148.1  12982477-12982538
            483-536             JACYVU010000148.1  12982654-12982707
            537-654             JACYVU010000148.1  12982827-12982944
            655-864             JACYVU010000148.1  12983156-12983365
            865-959             JACYVU010000148.1  12985067-12985161
            960-1066            JACYVU010000148.1  12985310-12985416
            1067-1195           JACYVU010000148.1  12985597-12985725
            1196-1364           JACYVU010000148.1  12986346-12986514
            1365-1469           JACYVU010000148.1  12986643-12986747
            1470-2140           JACYVU010000148.1  12987284-12987954
FEATURES             Location/Qualifiers
     source          1..2140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q34"
     gene            1..2140
                     /gene="Rtkn"
                     /note="rhotekin"
                     /db_xref="GeneID:297383"
                     /db_xref="RGD:727874"
     exon            1..220
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1795
                     /gene="Rtkn"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="rhotekin isoform 2"
                     /protein_id="NP_001402781.1"
                     /db_xref="GeneID:297383"
                     /db_xref="RGD:727874"
                     /translation="MFSRNHRSRVTVARGSALEMEFKRGRFRLSVLSDLPEDTELQRK
                     LDHEIRMREGACKLLAACSQREQALEATKSLLVCNSRILSYMGELQRRKEAQVLGKTG
                     RRPSDSVQPPERSPCRGRVCISDLRIPLMWKDTEYFKNKGDLHRWAVFLLLQLGEQIQ
                     DTEMVLVDRTLTDISFQNNAIFAEAGPDFELRLELYGACVEEEGALAGAPKRLATKLS
                     SSLGRSSGKRVRASLDSAGGSGNSPILLPTPAVGGPRYHLLAHTTLTLAAVQDGFRTH
                     DLTLTSHEENPAWLPLYGSMCCRLVAQPLCMTQPTASGTLRVQQAGELQSGTLVHGVL
                     KGTNLFCYWRSEDADSGQEPLFTILINKETRVRAGELEQAPEWPFTLSISNRYGDDEV
                     TNTLQVQSRDALQSWMEALWQLFLDMSQWKHCCDEVMKIETPAPRKPPQALAKQGSLY
                     HEMAIEPLEDIAAVTDILAQREGTRLEPPPPWLAMFTDQPALRSSCSPASVPTWTQPL
                     PWGRPRTFSLDAVPADHSLGPSRSVAPLPPQRSPQSRGFYSKSQLSTWLQSPV"
     exon            221..420
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            421..482
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            483..536
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            537..654
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            655..864
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            865..959
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1066
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1195
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1364
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1469
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
     exon            1470..2140
                     /gene="Rtkn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcccggct gcactggtag gagggcggcc gtcgagggac cggagcccaa gcccgcgaga
       61 gactgatccc aggagcgcag ggagcgcact gagcaagggg gctgcaagca tgttctcgcg
      121 aaaccatcgg agccgggtca cagtggccag gggctccgcc ctggagatgg agttcaaacg
      181 cggccgcttt cgacttagtg tactcagcga cctgccggag gacacagagt tgcagaggaa
      241 actagatcat gagatccgga tgagggaagg ggcctgcaag ctgttggcgg cctgctccca
      301 gcgagagcag gctctggaag ccaccaagag cctgctggtg tgcaatagcc ggattctcag
      361 ctacatgggc gagctgcagc ggcgcaagga ggcccaggtg ctgggaaaga caggccggcg
      421 accttccgac agtgtgcagc cccctgagcg ctctccttgc cgaggccggg tctgcatctc
      481 tgacctccgg atcccactca tgtggaagga cacagagtat ttcaagaaca aaggcgatct
      541 gcaccgctgg gctgtgtttc tactgctgca gcttggggaa cagattcagg atactgagat
      601 ggtcctggtg gacaggaccc tcacagacat ctcctttcag aacaatgcga tttttgctga
      661 ggcagggcct gactttgaat tgcggctgga gctgtatggg gcctgtgtgg aagaggaggg
      721 agccctagct ggtgccccca agaggcttgc caccaaactc agtagctccc tgggccggtc
      781 ctcagggaag cgtgtcagag catcactgga cagtgctggg ggctccggga acagtcccat
      841 cctgctccct accccagctg tgggaggtcc tcgataccac ctcttggccc acaccactct
      901 cactctagcg gcagtgcaag atggattccg tacacatgac ctcactctca ccagtcatga
      961 ggagaaccct gcctggctgc ccctttatgg tagcatgtgt tgccgcctgg tggctcagcc
     1021 tctctgcatg actcagccta ctgcaagtgg taccctcagg gtgcagcaag ccggggagct
     1081 ccagagtggg acacttgtac atggagtcct gaaaggcaca aacctctttt gctactggag
     1141 atctgaggat gcagattctg ggcaggagcc actgttcact atcctcatca acaaggagac
     1201 tagggtccgg gcaggggagt tggagcaggc cccggagtgg cctttcaccc tcagtatcag
     1261 caaccggtat ggagatgatg aggtgacaaa cacgctccag gtgcagagca gggatgccct
     1321 gcagagctgg atggaggcgc tgtggcagct gttccttgac atgagccagt ggaaacactg
     1381 ttgtgatgaa gttatgaaga tcgaaactcc tgctccccgg aaaccacccc aagcactggc
     1441 caagcagggg tccttatacc acgagatggc cattgagcca ctagaggaca tcgcagcagt
     1501 gacagacatc ctggcccagc gggagggcac aaggctggag ccgcccccac cctggctagc
     1561 aatgtttacc gaccagcctg ccttgcgtag ctcctgctcg cctgcctcag tcccaacctg
     1621 gacgcaaccc ctgccctggg gaagaccccg caccttttcc ctggatgctg tccctgcaga
     1681 ccactccctt gggccttctc gctcggttgc accccttccc ccacagcgat ccccacaatc
     1741 cagaggtttc tacagcaaaa gtcagctcag cacatggctc cagtccccag tgtgagaggc
     1801 accagcaaga ggatggccaa gagagaaaat gacccaagga caactggact ctagggccag
     1861 ctggccagct tgggctcctc ttcctccact ggacaaggac agaaggctgg ggaggggtga
     1921 cacaaaccct tcttaagttg tggttagatg gtactgaggg gaccattccc ggagctggct
     1981 aggacccccc ccccccaagc gcttcctggg agaaaactgg aacaactctg ccctacctcc
     2041 ctacactaac cagcctccag ggctgcactg gagagcggag aggaaagcac ctcccttgtg
     2101 acccctacat caaccattaa aagttattta acagctcgaa
//
