LOCUS       NM_001191857            4237 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus regulator of telomere elongation helicase 1
            (Rtel1), mRNA.
ACCESSION   NM_001191857 XM_342602
VERSION     NM_001191857.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4237)
  AUTHORS   Gu,C.Y., Jin,S.M., Qin,X.J., Zhu,Y., Bo,D., Lin,G.W., Shi,G.H. and
            Ye,D.W.
  TITLE     Genetic variants in RTEL1 influencing telomere length are
            associated with prostate cancer risk
  JOURNAL   J Cancer 10 (24), 6170-6174 (2019)
   PUBMED   31762827
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4237)
  AUTHORS   Girard,E., Eon-Marchais,S., Olaso,R., Renault,A.L., Damiola,F.,
            Dondon,M.G., Barjhoux,L., Goidin,D., Meyer,V., Le Gal,D.,
            Beauvallet,J., Mebirouk,N., Lonjou,C., Coignard,J., Marcou,M.,
            Cavaciuti,E., Baulard,C., Bihoreau,M.T., Cohen-Haguenauer,O.,
            Leroux,D., Penet,C., Fert-Ferrer,S., Colas,C., Frebourg,T.,
            Eisinger,F., Adenis,C., Fajac,A., Gladieff,L., Tinat,J.,
            Floquet,A., Chiesa,J., Giraud,S., Mortemousque,I., Soubrier,F.,
            Audebert-Bellanger,S., Limacher,J.M., Lasset,C.,
            Lejeune-Dumoulin,S., Dreyfus,H., Bignon,Y.J., Longy,M., Pujol,P.,
            Venat-Bouvet,L., Bonadona,V., Berthet,P., Luporsi,E., Maugard,C.M.,
            Nogues,C., Delnatte,C., Fricker,J.P., Gesta,P., Faivre,L.,
            Lortholary,A., Buecher,B., Caron,O., Gauthier-Villars,M.,
            Coupier,I., Servant,N., Boland,A., Mazoyer,S., Deleuze,J.F.,
            Stoppa-Lyonnet,D., Andrieu,N. and Lesueur,F.
  TITLE     Familial breast cancer and DNA repair genes: Insights into known
            and novel susceptibility genes from the GENESIS study, and
            implications for multigene panel testing
  JOURNAL   Int J Cancer 144 (8), 1962-1974 (2019)
   PUBMED   30303537
REFERENCE   3  (bases 1 to 4237)
  AUTHORS   Lu,S., Zhong,J., Wu,M., Huang,K., Zhou,Y., Zhong,Z., Li,Q. and
            Zhou,H.
  TITLE     Genetic analysis of the relation of telomere length-related gene
            (RTEL1) and coronary heart disease risk
  JOURNAL   Mol Genet Genomic Med 7 (3), e550 (2019)
   PUBMED   30623606
REFERENCE   4  (bases 1 to 4237)
  AUTHORS   Namgoong,S., Cheong,H.S., Kim,J.H., Kim,L.H., Seo,J.Y., Kang,S.G.,
            Yoon,S.J., Kim,S.H., Chang,J.H. and Shin,H.D.
  TITLE     Association analysis of RTEL1 variants with risk of adult gliomas
            in a Korean population
  JOURNAL   PLoS One 13 (11), e0207660 (2018)
   PUBMED   30462709
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4237)
  AUTHORS   Shoeb,M., Joseph,P., Kodali,V., Mustafa,G., Farris,B.Y.,
            Umbright,C., Roberts,J.R., Erdely,A. and Antonini,J.M.
  TITLE     Silica inhalation altered telomere length and gene expression of
            telomere regulatory proteins in lung tissue of rats
  JOURNAL   Sci Rep 7 (1), 17284 (2017)
   PUBMED   29230030
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4237)
  AUTHORS   Seki,M., Takeda,Y., Iwai,K. and Tanaka,K.
  TITLE     IOP1 protein is an external component of the human cytosolic
            iron-sulfur cluster assembly (CIA) machinery and functions in the
            MMS19 protein-dependent CIA pathway
  JOURNAL   J Biol Chem 288 (23), 16680-16689 (2013)
   PUBMED   23585563
REFERENCE   7  (bases 1 to 4237)
  AUTHORS   Walne,A.J., Vulliamy,T., Kirwan,M., Plagnol,V. and Dokal,I.
  TITLE     Constitutional mutations in RTEL1 cause severe dyskeratosis
            congenita
  JOURNAL   Am J Hum Genet 92 (3), 448-453 (2013)
   PUBMED   23453664
REFERENCE   8  (bases 1 to 4237)
  AUTHORS   Vannier,J.B., Pavicic-Kaltenbrunner,V., Petalcorin,M.I., Ding,H.
            and Boulton,S.J.
  TITLE     RTEL1 dismantles T loops and counteracts telomeric G4-DNA to
            maintain telomere integrity
  JOURNAL   Cell 149 (4), 795-806 (2012)
   PUBMED   22579284
REFERENCE   9  (bases 1 to 4237)
  AUTHORS   Barber,L.J., Youds,J.L., Ward,J.D., McIlwraith,M.J., O'Neil,N.J.,
            Petalcorin,M.I., Martin,J.S., Collis,S.J., Cantor,S.B., Auclair,M.,
            Tissenbaum,H., West,S.C., Rose,A.M. and Boulton,S.J.
  TITLE     RTEL1 maintains genomic stability by suppressing homologous
            recombination
  JOURNAL   Cell 135 (2), 261-271 (2008)
   PUBMED   18957201
REFERENCE   10 (bases 1 to 4237)
  AUTHORS   Ding,H., Schertzer,M., Wu,X., Gertsenstein,M., Selig,S.,
            Kammori,M., Pourvali,R., Poon,S., Vulto,I., Chavez,E., Tam,P.P.,
            Nagy,A. and Lansdorp,P.M.
  TITLE     Regulation of murine telomere length by Rtel: an essential gene
            encoding a helicase-like protein
  JOURNAL   Cell 117 (7), 873-886 (2004)
   PUBMED   15210109
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            [WARNING] On Oct 26, 2024 this sequence was replaced by
            NM_001191857.2.
            
            On Jul 17, 2010 this sequence version replaced XM_342602.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760433,
                              SAMN06680416 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000003.1  188807998-188808089
            93-345              JAXUCZ010000003.1  188809042-188809294
            346-544             JAXUCZ010000003.1  188810344-188810542
            545-638             JAXUCZ010000003.1  188810854-188810947
            639-720             JAXUCZ010000003.1  188811461-188811542
            721-781             JAXUCZ010000003.1  188811670-188811730
            782-857             JAXUCZ010000003.1  188813560-188813635
            858-942             JAXUCZ010000003.1  188816009-188816093
            943-1008            JAXUCZ010000003.1  188821433-188821498
            1009-1162           JAXUCZ010000003.1  188822419-188822572
            1163-1201           JAXUCZ010000003.1  188826199-188826237
            1202-1280           JAXUCZ010000003.1  188826306-188826384
            1281-1378           JAXUCZ010000003.1  188827589-188827686
            1379-1434           JAXUCZ010000003.1  188828592-188828647
            1435-1509           JAXUCZ010000003.1  188833134-188833208
            1510-1591           JAXUCZ010000003.1  188833315-188833396
            1592-1724           JAXUCZ010000003.1  188835611-188835743
            1725-1838           JAXUCZ010000003.1  188835908-188836021
            1839-1879           JAXUCZ010000003.1  188836112-188836152
            1880-1965           JAXUCZ010000003.1  188836335-188836420
            1966-2043           JAXUCZ010000003.1  188836568-188836645
            2044-2121           JAXUCZ010000003.1  188837089-188837166
            2122-2268           JAXUCZ010000003.1  188837491-188837637
            2269-2384           JAXUCZ010000003.1  188837716-188837831
            2385-2508           JAXUCZ010000003.1  188838029-188838152
            2509-2659           JAXUCZ010000003.1  188838259-188838409
            2660-2799           JAXUCZ010000003.1  188838493-188838632
            2800-2895           JAXUCZ010000003.1  188839199-188839294
            2896-3094           JAXUCZ010000003.1  188840264-188840462
            3095-3235           JAXUCZ010000003.1  188840633-188840773
            3236-3352           JAXUCZ010000003.1  188841266-188841382
            3353-3577           JAXUCZ010000003.1  188841605-188841829
            3578-3739           JAXUCZ010000003.1  188841927-188842088
            3740-3886           JAXUCZ010000003.1  188842206-188842352
            3887-3987           JAXUCZ010000003.1  188842430-188842530
            3988-4237           JAXUCZ010000003.1  188842628-188842877
FEATURES             Location/Qualifiers
     source          1..4237
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q43"
     gene            1..4237
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /note="regulator of telomere elongation helicase 1"
                     /db_xref="GeneID:362288"
                     /db_xref="RGD:1306721"
     exon            1..92
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            93..345
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..4068
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /EC_number="3.6.4.12"
                     /note="helicase-like protein NHL"
                     /codon_start=1
                     /product="regulator of telomere elongation helicase 1"
                     /protein_id="NP_001178786.1"
                     /db_xref="GeneID:362288"
                     /db_xref="RGD:1306721"
                     /translation="MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPT
                     GTGKTLCLLCTTLAWREHLRDAVSSLKIAERVQGELFASRTLSSWRSAADANGDSIDC
                     YTDIPKIIYASRTHSQLTQVIGELRNTSYRPKVCVLGSREQLCIHPEVKKQESNHMQI
                     SLCRKKVASRSCHFYNNVEEKSLEQELATPILDIEDLVKNGSKHKVCPYYLSRNLKQQ
                     ADIIFMPYNYLLDAKSRKAHNIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGL
                     EVINQVLEEQARVAQHGELQQEFIIDTSSSGLNMELEDIAKLKMILLHLEEAIDAVQL
                     PGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLTGRTGVFTNTAGLQKL
                     MDIIQIVFSVDPLEGSPGSQVGLGSSHFYKVHIHPETSHRRAAQRSDAWSTTASRKQG
                     KVLSYWCFSPSHSMRELVQQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDK
                     NQLWVGVIPRGPDGVQLSSAYDKRFSEECLSSLGKALGNIARVVPHGLLVFFPSYPVM
                     EKSLEFWQAQGMSKKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPGSNGATFLAVCR
                     GKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVILKMQFLDEMKGRSRVGGQCLSGQEW
                     YQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRFAYADARAHLPSWVRPYLKVYDNFGR
                     VIRDVAQFFRVAQKAMPLPVPQAVTSSVSEGEAAVKEATLSSHSLSTRKAMSLDVHVP
                     SLRRRPVGLPTAGDSESSVCVEYEQQTFSAQKRPMGLLAALEYNEQKAGASEEQALSS
                     STPSLRCEKRLSVEQRGGKKKVRLVNHPEEPVAGTQAGRAKMFMVAVKQALSQANFDT
                     FTQALQHYKSSDDFEALVASLTCLFAEDPKKHTLLKGFYQFVRPHHKQQFEDICFQLT
                     GQRCSYQPGNSLPFGEQAQSTASKQGRRELESKLTLSEGADRQLDPGEHLNQGWPHLS
                     THLTSKGDTSNCPKVGCVGEKPGQPAVNDYLSDVHKALGSASCNQLTAALRAYKQDDD
                     LDKVLAVVAALTTAKPEHLSLLQRFGMFIRRHHKPRFVQTCADLMGLPTIGKGLELPC
                     PRDESTTVPSELTHEDMKPGPSTSKKPEKTQSKISSFLRQRPDQSARSDDTIMQLPPR
                     LPPEHTTSQWNFVCPACATEDTVLFQCPSCDFCRCRACWQRQLQASRLCPACGAVNRK
                     QSIAQVIWPKPQ"
     exon            346..544
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            545..638
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            639..720
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            721..781
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            782..857
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            858..942
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1008
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1162
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1201
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1280
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1378
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1434
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1509
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1591
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1724
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1838
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1879
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1965
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2043
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2121
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2268
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2384
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2508
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            2509..2659
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2799
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2895
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3094
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3235
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            3236..3352
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3577
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3739
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3886
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            3887..3987
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
     exon            3988..4237
                     /gene="Rtel1"
                     /gene_synonym="RGD1306721"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagttccaat cagcagactg cggagcacgc gggggtcggc gtctttacaa ttgattgact
       61 tcggattttg caaggcaccc ccaccgagac aaggaattcc tgcagagaga aacctggtgc
      121 cacatgctgc cagcacttaa cctggagcgg ctgaaacact gagatgttca gaggggtttc
      181 tctgacagac ccaaacagcc tgcatcttgg cctaccaccg tgtcttcctc agtataggct
      241 gatatgccca gggtagtcct gaatggtgtg acagtggatt tccctttcca gccctaccca
      301 tgccagcagg aatatatgac caaggtgcta gaatgtctcc agaagaaagt gaatggcatc
      361 ctcgagagcc ccactggcac tgggaagacg ctatgcctcc tctgcactac attggcctgg
      421 cgggaacatc tccgagatgc cgtttcttcc ctaaagattg ctgagagagt tcaaggggaa
      481 ctctttgcca gtcggacctt gtcatcctgg aggagtgctg ctgatgccaa tggagactca
      541 atagattgct acacagatat cccaaagatc atctatgctt ctagaactca ctcacagcta
      601 actcaggtca tcggtgagct tcggaatact tcctaccggc ccaaggtgtg tgtgctgggc
      661 tcccgggagc agctgtgtat tcatcccgaa gtgaagaagc aagagagtaa ccacatgcag
      721 atcagtttgt gccgtaagaa ggtggcaagt cgctcctgtc atttctacaa caatgtggaa
      781 gagaaaagcc tggagcaaga gctggctacc cccatcttgg atattgagga ccttgtgaag
      841 aacggaagca aacacaaagt gtgcccatac tacctctctc gaaacctgaa gcagcaagct
      901 gatatcatct ttatgccata caattacttg ttggatgcta agagtcgtaa ggcacacaac
      961 attgacctga agggaacggt tgtaatcttt gatgaagctc acaatgtgga aaagatatgt
     1021 gaggagtcag cctcctttga cttgactccc cgagatgtgg cttcaggact ggaggttatc
     1081 aaccaggttt tggaggagca agcccgggtg gctcagcatg gtgaactcca acaggagttc
     1141 attatagaca cgtccagctc aggtctcaac atggagctgg aagacatcgc aaagttgaag
     1201 atgatcctgc tgcacctgga ggaggctatt gatgctgttc agctgcctgg ggatgacaga
     1261 ggagtcacca aacctggaag ctacatcttc gagctgtttg ctgaagcaca aataacattt
     1321 caaaccaaag gctgcatttt ggagtcgctg gaccagataa tccagcacct gacaggacgc
     1381 actggtgtgt tcaccaacac ggctgggttg cagaagctca tggacattat ccagattgtg
     1441 ttcagcgtgg accctctgga aggcagccct ggttctcagg tggggctggg tagctcacat
     1501 ttctataagg tacacataca ccctgaaacc agccaccgga gagcagctca gcggtcagat
     1561 gcctggagta ccactgcatc caggaaacaa gggaaggtgc tgagctattg gtgcttcagt
     1621 cccagccaca gcatgcgtga actggtccag caaggagtcc gtacccttat cctcaccagt
     1681 ggtacactgg ctccgctgtc ttcctttgct ctggagatgc aaattccatt cccagtctgt
     1741 ctggagaatc cacacatcat tgacaagaac cagctctggg taggggttat ccccagagga
     1801 cctgatggtg ttcagctaag ctctgcctat gacaaaaggt tttctgaaga gtgcttatct
     1861 tccctgggga aggctctggg caacattgct cgtgtggtgc cccatgggct tctggtcttc
     1921 ttcccttcct accctgtcat ggagaaaagc ctggagttct ggcaggcgca aggcatgtcc
     1981 aaaaaggtag aggcactgaa gcctctattc gtggaaccca ggaacaaagg cagcttctca
     2041 gaggtcattg atgcctacta ccagcaagtt gcctcccctg ggtctaatgg ggccaccttc
     2101 ttagcagtgt gtcgaggaaa ggccagtgaa gggctggact tctcagacat gaatggtcgt
     2161 ggtgtgattg tcacgggcct cccatatccc ccacgcatgg atccccgtgt tatcctcaag
     2221 atgcagttct tggatgagat gaaaggccgg agtagggttg gaggccagtg cctctctgga
     2281 caggaatggt accagcaaca agcatccagg gctgtgaacc aggctattgg gagggttatc
     2341 cgacaccgcc atgactatgg ggccatcttc ttatgtgacc acaggtttgc ctatgctgat
     2401 gccagggccc atctgccctc ctgggtgcgc ccctacctca aggtgtatga caactttggc
     2461 cgtgtcatcc gagatgtggc ccagttcttc cgtgttgctc agaaagctat gcctttgcca
     2521 gttcctcagg ctgtgacctc aagtgtgagt gagggagaag ctgctgtcaa ggaggccaca
     2581 ttgtccagcc actccctctc caccaggaaa gccatgagct tggatgtgca tgtgcccagc
     2641 ctgaggcgga ggcccgtagg attaccgact gctggagact ccgagagcag cgtatgtgtg
     2701 gagtatgagc agcagacatt ttctgcccag aagagaccca tggggctgct agctgcctta
     2761 gagtacaacg agcagaaggc tggggcatct gaggagcagg cactcagctc ctccacccca
     2821 tctctccggt gtgaaaagag gctgtccgtt gagcaaagag gaggaaagaa gaaagtcagg
     2881 ctggtcaacc atccggagga accagtggct ggcacacagg caggcagagc caagatgttc
     2941 atggtggccg tgaagcaagc actgagccaa gctaactttg acacctttac ccaggccctg
     3001 cagcactata agagttctga tgactttgaa gccctagtgg cctctctcac ctgcctcttt
     3061 gctgaagacc ccaagaaaca caccctactt aaaggtttct accagtttgt acgaccccac
     3121 cacaagcagc agtttgagga catctgcttc cagctaacag gccaacgatg tagctaccag
     3181 ccaggaaaca gccttccctt tggagagcaa gcacagtcaa ctgccagtaa gcaaggaagg
     3241 agagagctgg aatctaaact gaccttgtct gaaggtgcag ataggcagct ggatcctgga
     3301 gagcacctga atcaggggtg gcctcacctg tctacccatc taacctccaa aggagacacc
     3361 agcaattgtc caaaagtggg atgtgtggga gaaaaacctg gccagcctgc tgtgaatgac
     3421 tacctatctg acgtccacaa agctctggga tctgcaagct gcaaccagct tacggcagct
     3481 ctgagggcat acaaacagga tgatgacctg gacaaagtgc tggctgtggt ggcagcattg
     3541 accactgcaa aacctgaaca cttatctttg ctacagagat ttggcatgtt tatacgtcgg
     3601 catcataagc ctcggtttgt acagacctgt gcagacctaa tgggcctacc taccataggc
     3661 aagggcttgg agctcccatg tcccagggat gagagtacaa ctgtgccttc tgagcttact
     3721 catgaggaca tgaaaccagg gccctcgacg tccaagaaac ctgagaagac ccagagtaag
     3781 atctcatcct tccttagaca gaggccagac cagagtgcga ggtctgatga taccataatg
     3841 cagcttcctc ccagactacc ccctgaacac acgacgtctc agtggaattt tgtatgccca
     3901 gcctgtgcaa ctgaggatac agtgcttttc cagtgccctt cctgtgactt ctgccgctgc
     3961 cgggcctgct ggcaacgtca actccaggcc tctagactgt gtccagcttg tggtgctgtt
     4021 aacaggaagc agagcattgc acaggtcatc tggccgaagc cccagtgaac acagatgatg
     4081 gcctttgctg gcccagatgc ggctaaatcc actgtagctc tcatgctcag ctgtccaatg
     4141 gaatctactt gtgaagtctt aaaacttcaa atatattggc atcgcacaca tattactgaa
     4201 ggtatagact gttcaataaa attaacagtt gtcagga
//
