LOCUS       NM_001100990            1006 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus R-spondin 3 (Rspo3), mRNA.
ACCESSION   NM_001100990 XM_001059176 XM_574288
VERSION     NM_001100990.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1006)
  AUTHORS   Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lefevre C, Khatoo
            M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C,
            de Sousa SB, Karaman B, Latypova X, Basaran S, Yucel EB, Tan TT,
            Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C,
            Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H and
            Reversade B.
  TITLE     RSPO2 inhibition of RNF43 and ZNRF3 governs limb development
            independently of LGR4/5/6
  JOURNAL   Nature 557 (7706), 564-569 (2018)
   PUBMED   29769720
  REMARK    Erratum:[Nature. 2018 Sep;561(7722):E7. PMID: 29977062]
REFERENCE   2  (bases 1 to 1006)
  AUTHORS   Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M,
            Niehrs C and Augustin HG.
  TITLE     Endothelial RSPO3 Controls Vascular Stability and Pruning through
            Non-canonical WNT/Ca(2+)/NFAT Signaling
  JOURNAL   Dev Cell 36 (1), 79-93 (2016)
   PUBMED   26766444
REFERENCE   3  (bases 1 to 1006)
  AUTHORS   Li JY, Chai B, Zhang W, Fritze DM, Zhang C and Mulholland MW.
  TITLE     LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food
            intake in the hypothalamus of male rats
  JOURNAL   Endocrinology 155 (2), 429-440 (2014)
   PUBMED   24280058
  REMARK    GeneRIF: These data indicate that Rspo1 and Rspo3 and their
            receptor LGR4 form novel circuits in the brain to regulate energy
            homeostasis.
REFERENCE   4  (bases 1 to 1006)
  AUTHORS   Niehrs C.
  TITLE     The complex world of WNT receptor signalling
  JOURNAL   Nat Rev Mol Cell Biol 13 (12), 767-779 (2012)
   PUBMED   23151663
  REMARK    Review article
REFERENCE   5  (bases 1 to 1006)
  AUTHORS   Gong X, Carmon KS, Lin Q, Thomas A, Yi J and Liu Q.
  TITLE     LGR6 is a high affinity receptor of R-spondins and potentially
            functions as a tumor suppressor
  JOURNAL   PLoS One 7 (5), e37137 (2012)
   PUBMED   22615920
REFERENCE   6  (bases 1 to 1006)
  AUTHORS   Kazanskaya O, Ohkawara B, Heroult M, Wu W, Maltry N, Augustin HG
            and Niehrs C.
  TITLE     The Wnt signaling regulator R-spondin 3 promotes angioblast and
            vascular development
  JOURNAL   Development 135 (22), 3655-3664 (2008)
   PUBMED   18842812
REFERENCE   7  (bases 1 to 1006)
  AUTHORS   Aoki M, Mieda M, Ikeda T, Hamada Y, Nakamura H and Okamoto H.
  TITLE     R-spondin3 is required for mouse placental development
  JOURNAL   Dev Biol 301 (1), 218-226 (2007)
   PUBMED   16963017
REFERENCE   8  (bases 1 to 1006)
  AUTHORS   Nam JS, Turcotte TJ, Smith PF, Choi S and Yoon JK.
  TITLE     Mouse cristin/R-spondin family proteins are novel ligands for the
            Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent
            gene expression
  JOURNAL   J Biol Chem 281 (19), 13247-13257 (2006)
   PUBMED   16543246
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EU030376.1.
            
            On or before Aug 13, 2007 this sequence version replaced
            XM_574288.2, XM_001059176.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU030376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1006
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WKY"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..1006
                     /gene="Rspo3"
                     /gene_synonym="RGD1563246"
                     /note="R-spondin 3"
                     /db_xref="GeneID:498997"
                     /db_xref="RGD:1563246"
     exon            1..193
                     /gene="Rspo3"
                     /gene_synonym="RGD1563246"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..927
                     /gene="Rspo3"
                     /gene_synonym="RGD1563246"
                     /note="R-spondin 3-like protein"
                     /codon_start=1
                     /product="R-spondin-3 precursor"
                     /protein_id="NP_001094460.1"
                     /db_xref="GeneID:498997"
                     /db_xref="RGD:1563246"
                     /translation="MHLRLISWFFIILNFMEYIGSQNATRGRRQRRMHPNVSQGCQGG
                     CATCSDYNGCLSCKPRLFFVLERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADC
                     DTCFNKNFCTKCKSGFYLHLGKCLDSCPEGLEASNHTMECVSIVHCEASDWSSWSPCM
                     KKGKTCGFKRGTETRVRDILQHPSAKGNLCPPTSETRTCIVQRKKCSKGERGKKGRER
                     KRKKLNKEDKKETSSSDSKGLESSRETSEQHESKERQQQQKRRAREKQQKSVSVSTVH
                     "
     exon            194..385
                     /gene="Rspo3"
                     /gene_synonym="RGD1563246"
                     /inference="alignment:Splign:2.1.0"
     exon            386..532
                     /gene="Rspo3"
                     /gene_synonym="RGD1563246"
                     /inference="alignment:Splign:2.1.0"
     exon            533..730
                     /gene="Rspo3"
                     /gene_synonym="RGD1563246"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1006
                     /gene="Rspo3"
                     /gene_synonym="RGD1563246"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgcctaac acctacatac agatttttaa gaacattaaa tataactaac agtgaaagaa
       61 aaaggagaaa gagaagggta acattactgg gttactatgc acttgcgact gatttcttgg
      121 ttttttatca ttttgaactt tatggaatac atcggcagcc aaaacgccac ccgaggaagg
      181 cggcagcgaa gaatgcatcc taacgtcagc caaggctgcc aaggaggctg cgcgacgtgt
      241 tcagattaca atggatgttt gtcatgtaag cccagactat tttttgttct ggaaagaatt
      301 ggcatgaagc agataggcgt gtgtctctct tcgtgtccaa gtggatatta tggaactcga
      361 tatccagata taaataagtg tacaaaatgc aaagctgact gtgatacctg tttcaacaaa
      421 aatttctgca caaaatgtaa aagtggattt tacttacacc ttggaaagtg ccttgacagt
      481 tgcccagaag ggttagaagc cagcaaccat accatggaat gtgtcagtat tgtacactgt
      541 gaggccagtg actggagttc atggagccca tgcatgaaga aaggaaaaac atgtggcttc
      601 aaaagaggga ctgaaacacg ggtccgagat atactgcagc atccttcagc caaggggaac
      661 ctgtgtcccc caaccagcga gacaagaacg tgtatagtac aaagaaagaa gtgttcaaag
      721 ggagagcgag ggaaaaaggg aagagagcga aaacgaaaaa aactcaataa agaagataaa
      781 aaggaaacaa gctcctctga cagcaaaggt ttggagtcca gcagagagac ctcagagcag
      841 cacgaaagca aagagagaca gcagcaacag aagagaagag cccgagagaa acaacagaaa
      901 tcggtatcag tcagcactgt acactagagg gtcctgtgag gtcactgtag actcatgatg
      961 ctgctatctc aaccagatgt ccaggacact gttctggcca ttagga
//
