LOCUS       NM_001130575            3223 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus R-spondin 2 (Rspo2), mRNA.
ACCESSION   NM_001130575 XM_001062232 XM_576261
VERSION     NM_001130575.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3223)
  AUTHORS   Szenker-Ravi,E., Altunoglu,U., Leushacke,M., Bosso-Lefevre,C.,
            Khatoo,M., Thi Tran,H., Naert,T., Noelanders,R., Hajamohideen,A.,
            Beneteau,C., de Sousa,S.B., Karaman,B., Latypova,X., Basaran,S.,
            Yucel,E.B., Tan,T.T., Vlaminck,L., Nayak,S.S., Shukla,A.,
            Girisha,K.M., Le Caignec,C., Soshnikova,N., Uyguner,Z.O.,
            Vleminckx,K., Barker,N., Kayserili,H. and Reversade,B.
  TITLE     RSPO2 inhibition of RNF43 and ZNRF3 governs limb development
            independently of LGR4/5/6
  JOURNAL   Nature 557 (7706), 564-569 (2018)
   PUBMED   29769720
  REMARK    Erratum:[Nature. 2018 Sep;561(7722):E7. doi:
            10.1038/s41586-018-0296-7. PMID: 29977062]
REFERENCE   2  (bases 1 to 3223)
  AUTHORS   Hsu,P.J., Wu,F.J., Kudo,M., Hsiao,C.L., Hsueh,A.J. and Luo,C.W.
  TITLE     A naturally occurring Lgr4 splice variant encodes a soluble
            antagonist useful for demonstrating the gonadal roles of Lgr4 in
            mammals
  JOURNAL   PLoS One 9 (9), e106804 (2014)
   PUBMED   25188337
  REMARK    GeneRIF: The endogenously expressed Lgr4 may act as an antagonist
            molecule that helps to fine-tune the R-spondin/norrin-mediated
            Lgr4-Wnt signaling during gonadal development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3223)
  AUTHORS   Kawasaki,M., Porntaveetus,T., Kawasaki,K., Oommen,S.,
            Otsuka-Tanaka,Y., Hishinuma,M., Nomoto,T., Maeda,T., Takubo,K.,
            Suda,T., Sharpe,P.T. and Ohazama,A.
  TITLE     R-spondins/Lgrs expression in tooth development
  JOURNAL   Dev Dyn 243 (6), 844-851 (2014)
   PUBMED   24616052
REFERENCE   4  (bases 1 to 3223)
  AUTHORS   Hoekstra,E.J., von Oerthel,L., van der Heide,L.P.,
            Kouwenhoven,W.M., Veenvliet,J.V., Wever,I., Jin,Y.R., Yoon,J.K.,
            van der Linden,A.J., Holstege,F.C., Groot Koerkamp,M.J. and
            Smidt,M.P.
  TITLE     Lmx1a encodes a rostral set of mesodiencephalic dopaminergic
            neurons marked by the Wnt/B-catenin signaling activator R-spondin 2
  JOURNAL   PLoS One 8 (9), e74049 (2013)
   PUBMED   24066094
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3223)
  AUTHORS   Niehrs,C.
  TITLE     The complex world of WNT receptor signalling
  JOURNAL   Nat Rev Mol Cell Biol 13 (12), 767-779 (2012)
   PUBMED   23151663
  REMARK    Review article
REFERENCE   6  (bases 1 to 3223)
  AUTHORS   Gong,X., Carmon,K.S., Lin,Q., Thomas,A., Yi,J. and Liu,Q.
  TITLE     LGR6 is a high affinity receptor of R-spondins and potentially
            functions as a tumor suppressor
  JOURNAL   PLoS One 7 (5), e37137 (2012)
   PUBMED   22615920
REFERENCE   7  (bases 1 to 3223)
  AUTHORS   Friedman,M.S., Oyserman,S.M. and Hankenson,K.D.
  TITLE     Wnt11 promotes osteoblast maturation and mineralization through
            R-spondin 2
  JOURNAL   J Biol Chem 284 (21), 14117-14125 (2009)
   PUBMED   19213727
REFERENCE   8  (bases 1 to 3223)
  AUTHORS   Bell,S.M., Schreiner,C.M., Wert,S.E., Mucenski,M.L., Scott,W.J. and
            Whitsett,J.A.
  TITLE     R-spondin 2 is required for normal laryngeal-tracheal, lung and
            limb morphogenesis
  JOURNAL   Development 135 (6), 1049-1058 (2008)
   PUBMED   18256198
REFERENCE   9  (bases 1 to 3223)
  AUTHORS   Nam,J.S., Turcotte,T.J., Smith,P.F., Choi,S. and Yoon,J.K.
  TITLE     Mouse cristin/R-spondin family proteins are novel ligands for the
            Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent
            gene expression
  JOURNAL   J Biol Chem 281 (19), 13247-13257 (2006)
   PUBMED   16543246
REFERENCE   10 (bases 1 to 3223)
  AUTHORS   Hatanaka,Y. and Jones,E.G.
  TITLE     Early region-specific gene expression during tract formation in the
            embryonic rat forebrain
  JOURNAL   J Comp Neurol 395 (3), 296-309 (1998)
   PUBMED   9596525
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_001062232.1, XM_576261.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3223
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..3223
                     /gene="Rspo2"
                     /gene_synonym="RGD1562331"
                     /note="R-spondin 2"
                     /db_xref="GeneID:500863"
                     /db_xref="RGD:1562331"
     exon            1..1096
                     /gene="Rspo2"
                     /gene_synonym="RGD1562331"
                     /inference="alignment:Splign:2.1.0"
     CDS             1003..1683
                     /gene="Rspo2"
                     /gene_synonym="RGD1562331"
                     /codon_start=1
                     /product="R-spondin-2 precursor"
                     /protein_id="NP_001124047.1"
                     /db_xref="GeneID:500863"
                     /db_xref="RGD:1562331"
                     /translation="MRFCLFSFALIILNCMDYSQCQGNRWRRSKRASYVSNPICKGCL
                     SCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCD
                     SCFSKDFCTKCKAGFYLHRGRCFDECPEGFAPLDETMECVEGCEVGHWSEWGTCSRNN
                     RTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRRCKMAMRHCPGGGSKQSCSYAACL
                     PKAPSSTQ"
     exon            1097..1285
                     /gene="Rspo2"
                     /gene_synonym="RGD1562331"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1429
                     /gene="Rspo2"
                     /gene_synonym="RGD1562331"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..3223
                     /gene="Rspo2"
                     /gene_synonym="RGD1562331"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttgtgtgc atctccatcg gaaagtgcgc tggccacatc ccttcggcct cccgggcagt
       61 gttctgtctc ccctagctca agcagcgaga aacttcagct gtgaagtggt ggtggagaga
      121 gcactgggag cagcgactgg acccggacgc caagagaaga gcggactcgc ccctcgcctg
      181 gaatcgctct cgaaggtgga gacccagcat cccagcgctt gcggttgtgc ttgcccggcc
      241 gcgcgctttt gctacgcgcc gctagccccg aagacccttg gggtccgggg acccttctgc
      301 agccggcgga ttcccaaagc tgccaagagc tccgggcggg tgtccgcaaa ctttttccga
      361 gcccacgtgc tgaccaaaca gcccggctcg cttcccgagc ctgggatgga gcgccgcgcc
      421 taggcacgcc gtgcagcccg agacacgagc gcacggtagg cgatccacac ctggtgccgc
      481 ggctctggga tagcccgtct ggggagcgaa gggcgtcaga acgccccttt aaagccctgc
      541 gcgcggctgc ttctagagct ccttcccttc cgcagagctc gcacaacgcc ctttccccag
      601 ggtcagaagc cactgctcgg cagaggttgc taattcactg attgtaatca ccttcctctc
      661 caagtcgcct gcagctgtgt catctgcgtt aaactgctgc gtgggtcctg ccagtgagtt
      721 cgcgtcctcc ctccctcctt tctttaaacc aagaggcgcg aaggtgcagg tacctcctcc
      781 gggttctctc ggtcctccac ccacccagct tctcttttcc tcatctccca ggttcaccgc
      841 ggagggagag atgcccatca agccaaattg atcattgcag cccctgggca gtggcatttg
      901 tctctgagtc ctccctagga gcgcgacccg cacagtctcc ttgcaggagc ccagcatttc
      961 ctcgactttt gagaggtgtc tctccccagc ccgaccgtcc agatgcgttt ttgcctcttc
     1021 tcatttgctc tcatcattct gaactgtatg gattacagcc agtgccaagg caaccgatgg
     1081 agacgcagta agcgagctag ttatgtatca aatcccattt gcaagggttg tttgtcttgt
     1141 tcgaaggaca atggctgcag ccgatgtcag cagaagttgt tctttttcct tcggagagaa
     1201 gggatgcgcc agtatggaga gtgtctgcat tcctgcccat cagggtacta tggacaccga
     1261 gccccagata tgaacagatg tgcaagatgc agaatagaaa actgtgattc ttgctttagc
     1321 aaagactttt gtaccaagtg caaagcaggc ttttatttgc atagaggccg ctgctttgat
     1381 gaatgtccag agggttttgc accactagat gagaccatgg agtgtgtaga aggttgtgaa
     1441 gttggtcatt ggagcgaatg gggaacgtgt agcagaaaca accgcacgtg tggatttaaa
     1501 tggggtctgg aaaccagaac acggcagatt gttaaaaagc cagcgaaaga cacaatacca
     1561 tgtccaacca ttgcagaatc caggagatgc aagatggcca tgaggcactg tccaggaggt
     1621 gggtctaaac aatcatgctc atatgctgcc tgccttccga aagctccctc ctccacacaa
     1681 taaatgctgt ttatccatga tagaaacccg atactaacat tggacatgag ataaaattct
     1741 acctttttgt tttaagaaac aaatgcttaa gttgtgattt atatacagtg gacatttcat
     1801 ttgcttttat aatagttttg aaataatttg aaggagtatc aatatgcttt caaacatgag
     1861 atttataaaa gtatgggttt gtgtgtgtgt gtggtgtgtg tgtgtgtgtg tgtgtgtgtg
     1921 tgtgtgtgtt ctcaaatgtg ccataataaa ggcttcttgt gaaatttggc ctttgcagat
     1981 gttgctcagg agaaggggcc aactttcagt tgagaagagt ttagattaga aaggtttata
     2041 gaatctgtaa aattatctgc atcattacta gttgaatatg acagcttaaa ataaacttac
     2101 ccaaacactg ggaggaaaaa accctgtgtt aatgttacca caattagccc tttctctttg
     2161 ttttgataat aatttgtaga aaacagctac tggtatgtgt gtgcttaact ctttgtaata
     2221 attatactga tttgcagtca ttattctgta atagccggat taggctcatt tggaaactag
     2281 gagaggagta cttagtgagg tgttagacaa tacagaacca ggaggtcaaa atgcagttct
     2341 tgggtacatg tgtttgtgtg ttgtgattac atgtgtgttt gtgacatgga tgtgtatgtg
     2401 tacatgtgtg tgcatgtgga gaccagatga cattaggcat ttccctttat tgttgtcaac
     2461 ctttttaaga catggtccct tactgacctg gaactcacta atttgactag actggttggc
     2521 cagtaaggcc ctaggaccct gtgtctctgt gcatcttacc caggggtgga gttattggca
     2581 tacttgacat gtatgtagat gctgggtata tgaactttgg tcttcctaac agtgcagcaa
     2641 gcctattaca gactgaacca tctcaccagt gtattcatgt ggaatatgca caatattcat
     2701 gtgctgctta aagcagtaat cacttattga cacttacagt atcactggcc aaagccatat
     2761 tgccacagag gaaaccgaga tttttttttt aggtgcacag attaaaaaca aaaaaaaaaa
     2821 gcaataagta agttgttttt ggaagagcga ctttaaaaca atccaaactt ttgtttgccc
     2881 tcttccccct cactcactgt tgctgtgtaa cttctcaacc ttttaactca agcccagaaa
     2941 gagaccacat agttacttaa agtgggtttg catcctcatt ctgctgcccc agagacagtg
     3001 tctatgatcc atggagaaag acgagactct gaagactgga agactccggc tggcctctga
     3061 ggactattag atccagattc agaagctcgt gtggaggagc cagcttttcc tcttaaatta
     3121 gtcttgcttt tccttactgg gcctttgaaa caaattttct ttgggggtct gcttttcact
     3181 aacaaggatg gttttgttca ctttaagtgg gtatttttca gtc
//
