LOCUS       NM_001107980            1705 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Rattus norvegicus R-spondin 1 (Rspo1), mRNA.
ACCESSION   NM_001107980 XM_001056937 XM_233520
VERSION     NM_001107980.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1705)
  AUTHORS   Li,J.Y., Wu,X., Lee,A., Zhou,S.Y. and Owyang,C.
  TITLE     Altered R-spondin 1/CART neurocircuit in the hypothalamus
            contributes to hyperphagia in diabetes
  JOURNAL   J Neurophysiol 121 (3), 928-939 (2019)
   PUBMED   30649980
REFERENCE   2  (bases 1 to 1705)
  AUTHORS   Szenker-Ravi,E., Altunoglu,U., Leushacke,M., Bosso-Lefevre,C.,
            Khatoo,M., Thi Tran,H., Naert,T., Noelanders,R., Hajamohideen,A.,
            Beneteau,C., de Sousa,S.B., Karaman,B., Latypova,X., Basaran,S.,
            Yucel,E.B., Tan,T.T., Vlaminck,L., Nayak,S.S., Shukla,A.,
            Girisha,K.M., Le Caignec,C., Soshnikova,N., Uyguner,Z.O.,
            Vleminckx,K., Barker,N., Kayserili,H. and Reversade,B.
  TITLE     RSPO2 inhibition of RNF43 and ZNRF3 governs limb development
            independently of LGR4/5/6
  JOURNAL   Nature 557 (7706), 564-569 (2018)
   PUBMED   29769720
  REMARK    Erratum:[Nature. 2018 Sep;561(7722):E7. doi:
            10.1038/s41586-018-0296-7. PMID: 29977062]
REFERENCE   3  (bases 1 to 1705)
  AUTHORS   Li,J.Y., Chai,B., Zhang,W., Fritze,D.M., Zhang,C. and
            Mulholland,M.W.
  TITLE     LGR4 and its ligands, R-spondin 1 and R-spondin 3, regulate food
            intake in the hypothalamus of male rats
  JOURNAL   Endocrinology 155 (2), 429-440 (2014)
   PUBMED   24280058
  REMARK    GeneRIF: These data indicate that Rspo1 and Rspo3 and their
            receptor LGR4 form novel circuits in the brain to regulate energy
            homeostasis.
REFERENCE   4  (bases 1 to 1705)
  AUTHORS   Niehrs,C.
  TITLE     The complex world of WNT receptor signalling
  JOURNAL   Nat Rev Mol Cell Biol 13 (12), 767-779 (2012)
   PUBMED   23151663
  REMARK    Review article
REFERENCE   5  (bases 1 to 1705)
  AUTHORS   Ruffner,H., Sprunger,J., Charlat,O., Leighton-Davies,J.,
            Grosshans,B., Salathe,A., Zietzling,S., Beck,V., Therier,M.,
            Isken,A., Xie,Y., Zhang,Y., Hao,H., Shi,X., Liu,D., Song,Q.,
            Clay,I., Hintzen,G., Tchorz,J., Bouchez,L.C., Michaud,G., Finan,P.,
            Myer,V.E., Bouwmeester,T., Porter,J., Hild,M., Bassilana,F.,
            Parker,C.N. and Cong,F.
  TITLE     R-Spondin potentiates Wnt/beta-catenin signaling through orphan
            receptors LGR4 and LGR5
  JOURNAL   PLoS One 7 (7), e40976 (2012)
   PUBMED   22815884
REFERENCE   6  (bases 1 to 1705)
  AUTHORS   Carmon,K.S., Gong,X., Lin,Q., Thomas,A. and Liu,Q.
  TITLE     R-spondins function as ligands of the orphan receptors LGR4 and
            LGR5 to regulate Wnt/beta-catenin signaling
  JOURNAL   Proc Natl Acad Sci U S A 108 (28), 11452-11457 (2011)
   PUBMED   21693646
REFERENCE   7  (bases 1 to 1705)
  AUTHORS   de Lau,W., Barker,N., Low,T.Y., Koo,B.K., Li,V.S., Teunissen,H.,
            Kujala,P., Haegebarth,A., Peters,P.J., van de Wetering,M.,
            Stange,D.E., van Es,J.E., Guardavaccaro,D., Schasfoort,R.B.,
            Mohri,Y., Nishimori,K., Mohammed,S., Heck,A.J. and Clevers,H.
  TITLE     Lgr5 homologues associate with Wnt receptors and mediate R-spondin
            signalling
  JOURNAL   Nature 476 (7360), 293-297 (2011)
   PUBMED   21727895
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1705)
  AUTHORS   Binnerts,M.E., Kim,K.A., Bright,J.M., Patel,S.M., Tran,K., Zhou,M.,
            Leung,J.M., Liu,Y., Lomas,W.E. 3rd, Dixon,M., Hazell,S.A.,
            Wagle,M., Nie,W.S., Tomasevic,N., Williams,J., Zhan,X., Levy,M.D.,
            Funk,W.D. and Abo,A.
  TITLE     R-Spondin1 regulates Wnt signaling by inhibiting internalization of
            LRP6
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14700-14705 (2007)
   PUBMED   17804805
REFERENCE   9  (bases 1 to 1705)
  AUTHORS   Nam,J.S., Turcotte,T.J., Smith,P.F., Choi,S. and Yoon,J.K.
  TITLE     Mouse cristin/R-spondin family proteins are novel ligands for the
            Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent
            gene expression
  JOURNAL   J Biol Chem 281 (19), 13247-13257 (2006)
   PUBMED   16543246
REFERENCE   10 (bases 1 to 1705)
  AUTHORS   Kamata,T., Katsube,K., Michikawa,M., Yamada,M., Takada,S. and
            Mizusawa,H.
  TITLE     R-spondin, a novel gene with thrombospondin type 1 domain, was
            expressed in the dorsal neural tube and affected in Wnts mutants
  JOURNAL   Biochim Biophys Acta 1676 (1), 51-62 (2004)
   PUBMED   14732490
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_233520.4, XM_001056937.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC168963.1 [ECO:0000331]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1705
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1705
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /note="R-spondin 1"
                     /db_xref="GeneID:313589"
                     /db_xref="RGD:1565558"
     exon            1..105
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            106..450
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1145
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /codon_start=1
                     /product="R-spondin-1 precursor"
                     /protein_id="NP_001101450.1"
                     /db_xref="GeneID:313589"
                     /db_xref="RGD:1565558"
                     /translation="MRLGLCVVALVLSWTHLAVGSRGIKGKRQRRISAEGSQSCAKGC
                     ELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHC
                     EACFSHNFCTKCQEGLYLHKGRCYPACPEGSTAANSTMECGSPAQCEMSEWSPWGPCS
                     KKRKLCGFRKGSEERTRRVLHAPGGDQTNCSDTKETRKCTVRRTPCPEGQKRKKASQG
                     RRENANRHPTRKNSKEPGSNSRRHKGQQQPQPGTAGPLTSVGPT"
     exon            451..642
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            643..792
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            793..981
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1705
                     /gene="Rspo1"
                     /gene_synonym="RGD1565558"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggattccctc cctcgtgcga gccggggacc ggcccctctc cgggcgcggg gcgcagagcc
       61 cgggcggcgg actgcggggc ccgcgcgggc cgccccagca ccaatgtctg tcttgagggt
      121 ggttctctgc tggcgtgaga agacttctca tgtgaccctc tgaggtggct tcaagcagga
      181 caggacctcc ctttggaccg atggagaacc tggctccatt ccccctcaga tcccagctga
      241 ggttatggtg gatctggcct gcagcctggg cctgggtccc ctgccactga cccagcctca
      301 gagcctatag caagagacca cccctcctgc aaggggcccg gggctggcca gtgactatgc
      361 ggcttgggct gtgtgtggtg gccctggttc tgagctggac acacctcgct gtgggcagcc
      421 gggggatcaa gggcaagaga cagaggcgga tcagtgctga ggggagccaa tcttgtgcca
      481 agggctgtga gctctgttca gaagtcaacg gttgcctcaa atgctcgccc aagctcttca
      541 ttctgctgga gaggaacgac atccgccagg tgggcgtctg cctgccgtcc tgcccgcctg
      601 gatactttga tgcccgcaac cccgacatga acaaatgcat caaatgcaag attgagcact
      661 gtgaggcctg cttcagccac aacttctgca ccaagtgtca ggagggcttg tacttacaca
      721 agggccgctg ctatccagcc tgtcccgagg gttccacagc agccaacagc accatggagt
      781 gcggcagtcc tgcacaatgt gaaatgagcg agtggtcacc gtggggcccc tgctccaaga
      841 agaggaagct gtgtggtttc cggaagggat cggaagagcg gacacgcagg gtgctccatg
      901 ctcctggagg agaccaaacc aactgctcag acaccaaaga gacccggaag tgtaccgtgc
      961 gcaggacgcc ctgccctgag gggcagaaga ggaagaaggc gagccagggc cggagggaga
     1021 atgccaatag gcacccgacc aggaagaaca gcaaggagcc aggctccaac tctcggagac
     1081 acaaaggcca gcagcagcca cagccaggga cagcagggcc actcacatca gtaggcccca
     1141 cctaggcaca gtgaccagtc tccagttacg tgtggaagaa tccagtgctg tgagaacttt
     1201 ccagaactgg agcatctggg aaagaaagtc cacacatacc ccattcaccc acccatccat
     1261 ctatccatgc atccatgcac acatatggcc acatctgaaa acttccacac acgcgcgcac
     1321 acacacacac acacacacac acacacacac acacacacac acacacacac actcttgagg
     1381 tcacagaaga tatttccatt ctgtggccca gctgtatatt cagcctagga tgctcttaga
     1441 aggcgtaact gagagaacct ttcccagcac ctgaagctaa acttcaatgc gtggaacctt
     1501 ctggaggaac ttctgggaca gcatctgcca gatggacggc agattggaac caaaactgga
     1561 gcagctgccg aggggaagaa tgctctccct gtcctgagag gcactcccag cttcgagact
     1621 tgattgttgg agaatcatta cacatccggg gtgcacgtca cggctgacct gacttggaaa
     1681 ctgcgtaaag gtttatttca aatta
//
