LOCUS       NM_001107629            2339 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus radial spoke head component 4A (Rsph4a), mRNA.
ACCESSION   NM_001107629 XM_001057335 XM_003751961 XM_017588068 XM_228162
VERSION     NM_001107629.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2339)
  AUTHORS   Shinohara,K., Chen,D., Nishida,T., Misaki,K., Yonemura,S. and
            Hamada,H.
  TITLE     Absence of Radial Spokes in Mouse Node Cilia Is Required for
            Rotational Movement but Confers Ultrastructural Instability as a
            Trade-Off
  JOURNAL   Dev Cell 35 (2), 236-246 (2015)
   PUBMED   26506310
REFERENCE   2  (bases 1 to 2339)
  AUTHORS   Antony,D., Becker-Heck,A., Zariwala,M.A., Schmidts,M.,
            Onoufriadis,A., Forouhan,M., Wilson,R., Taylor-Cox,T., Dewar,A.,
            Jackson,C., Goggin,P., Loges,N.T., Olbrich,H., Jaspers,M.,
            Jorissen,M., Leigh,M.W., Wolf,W.E., Daniels,M.L., Noone,P.G.,
            Ferkol,T.W., Sagel,S.D., Rosenfeld,M., Rutman,A., Dixit,A.,
            O'Callaghan,C., Lucas,J.S., Hogg,C., Scambler,P.J., Emes,R.D.,
            Chung,E.M., Shoemark,A., Knowles,M.R., Omran,H. and Mitchison,H.M.
  CONSRTM   Uk10k
  TITLE     Mutations in CCDC39 and CCDC40 are the major cause of primary
            ciliary dyskinesia with axonemal disorganization and absent inner
            dynein arms
  JOURNAL   Hum Mutat 34 (3), 462-472 (2013)
   PUBMED   23255504
REFERENCE   3  (bases 1 to 2339)
  AUTHORS   Castleman,V.H., Romio,L., Chodhari,R., Hirst,R.A., de Castro,S.C.,
            Parker,K.A., Ybot-Gonzalez,P., Emes,R.D., Wilson,S.W., Wallis,C.,
            Johnson,C.A., Herrera,R.J., Rutman,A., Dixon,M., Shoemark,A.,
            Bush,A., Hogg,C., Gardiner,R.M., Reish,O., Greene,N.D.,
            O'Callaghan,C., Purton,S., Chung,E.M. and Mitchison,H.M.
  TITLE     Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause
            primary ciliary dyskinesia with central-microtubular-pair
            abnormalities
  JOURNAL   Am J Hum Genet 84 (2), 197-209 (2009)
   PUBMED   19200523
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Aug 10, 2019 this sequence version replaced
            XM_003751961.4, XM_017588068.1, NM_001107629.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.78779.1,
                                           SRR26643429.57946.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-822               JAXUCZ010000020.1  31307102-31307923
            823-1057            JAXUCZ010000020.1  31310454-31310688
            1058-1795           JAXUCZ010000020.1  31315181-31315918
            1796-1931           JAXUCZ010000020.1  31320176-31320311
            1932-2049           JAXUCZ010000020.1  31321016-31321133
            2050-2339           JAXUCZ010000020.1  31322974-31323263
FEATURES             Location/Qualifiers
     source          1..2339
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..2339
                     /gene="Rsph4a"
                     /gene_synonym="Rshl3"
                     /note="radial spoke head component 4A"
                     /db_xref="GeneID:309767"
                     /db_xref="RGD:1307229"
     exon            1..822
                     /gene="Rsph4a"
                     /gene_synonym="Rshl3"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..2275
                     /gene="Rsph4a"
                     /gene_synonym="Rshl3"
                     /note="radial spokehead-like 3; radial spoke head 4
                     homolog A"
                     /codon_start=1
                     /product="radial spoke head protein 4 homolog A"
                     /protein_id="NP_001101099.2"
                     /db_xref="GeneID:309767"
                     /db_xref="RGD:1307229"
                     /translation="MENSTSLKQEKENQEPEGAERSWQGESEVSPPDPALASPEYREE
                     EQRSDTEPSPKRSPSWGSQPRASLSLGHLTAGLGVSSSPPPPPLEFHSTPLQTTTTQD
                     PVTASHAERAPSGITDTGTPYSDPWEPSSAARKSTSHYTSHTEESAFPLSQPPHPDLG
                     GRRDAAWNKPKYKGLRFDLLQEEDSNSNCDPDQPEVGASEAAPSMLEVAVQNAKAYLL
                     STSSKSGLNLYDHLSKVLTKILDERPVDAVDVVENISQDVKMSHFDKKLDTLHNENEM
                     LPAYELAETQKALFLQGHLEGADSELEEEIAESSLPNVMESAYYFEQAGVGLGTDETY
                     RIFLALKQLTDTHPIQRCRFWGKILGLEMNYIVAEVEFRDGEDEEEVEEEGIAEERDN
                     GGSEAGDSEEDELPKPLYKAPQAIPKEESRTGANKYVYFVCSEPGRPWVRLPSVTPAQ
                     IVTARKIKKFFTGRLDAAIVSYPPFPGNESNYLRAQIARISAGTHVSPLGFYQFGEEE
                     GEEEEVEGGRDSYEENSDFEGIQVIDLVESLSNWVHHAQYILPQGRCNWFNPTQKDEE
                     EEEEDEEKGEEPDYVEQEVGPPLLTPISEDLEIQNIPSWTTRLSSNLVPQYAIAVLRS
                     NLWPGAYAFSNGKKFENLYIGWGHKYSVENYTPPGPPPVYQEYPSGPEIAEMDDPSVE
                     EEQAFRITQEAAALSAEENEETEDEDNDD"
     exon            823..1057
                     /gene="Rsph4a"
                     /gene_synonym="Rshl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1795
                     /gene="Rsph4a"
                     /gene_synonym="Rshl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1931
                     /gene="Rsph4a"
                     /gene_synonym="Rshl3"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2049
                     /gene="Rsph4a"
                     /gene_synonym="Rshl3"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2339
                     /gene="Rsph4a"
                     /gene_synonym="Rshl3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggttgttatg gaaacaggac gcttgcaacc tgtggaggca ggtcgatcca gaaattgatc
       61 acttagatct caacaaagcc cggtgttgct ttcttccata tccgcacgct cccttcagag
      121 gaattttttt ttgacactta tggaaaattc tacctctctg aaacaagaaa aggaaaatca
      181 agagccagag ggagcagaga gatcatggca aggagagtcc gaagtttctc ccccggatcc
      241 tgctctcgca tcacctgagt accgggaaga ggagcaaagg tcagacaccg aaccctcacc
      301 caaaaggagc ccctcttggg gcagccagcc tagagccagc ctgtctctgg gacacctcac
      361 cgctggacta ggagtgtcat cctcccctcc cccacctcct ctggagtttc attccacgcc
      421 tctccaaact acaactactc aggatcctgt gactgcatca cacgcagaga gggcccctag
      481 tgggattact gacaccggga cgccttattc tgatccttgg gaaccatctt ctgctgcaag
      541 aaaatcaact tctcactaca caagccacac agaggaaagt gccttcccgc tgtcacagcc
      601 accccaccct gacctgggtg ggagaaggga tgccgcctgg aacaagccca agtacaaagg
      661 gctgagattt gaccttttac aagaggaaga ctcaaacagt aactgtgatc cagaccagcc
      721 tgaggttggt gccagcgaag cagcccccag tatgcttgag gtggccgtcc agaatgcaaa
      781 agcctacctg ctgagtacca gcagcaagtc tggcttaaac ctatatgatc atctttctaa
      841 agtgttgacc aagatactag atgagcgtcc tgtggatgct gttgacgtcg ttgagaatat
      901 aagccaggat gtgaaaatgt cacattttga taaaaaatta gacaccctcc acaatgaaaa
      961 cgagatgctt ccagcgtatg agctagcaga gacacagaag gcccttttcc tgcagggaca
     1021 tttggaagga gctgattcag aattggagga ggaaattgca gaaagctctc tgcccaatgt
     1081 gatggaatcg gcttattatt tcgagcaagc tggagtcggt ttgggaacag atgagactta
     1141 tcgaatattt cttgccctca agcaacttac tgacacacac ccaatccaaa gatgccgctt
     1201 ctggggcaag atcttggggc tggaaatgaa ctacattgtt gccgaggtgg aatttcgtga
     1261 cggcgaagac gaagaggagg tggaagagga agggatagct gaagagaggg acaatggagg
     1321 aagtgaagcc ggtgacagcg aggaagatga attaccgaag cccttgtaca aggccccaca
     1381 ggctatacct aaggaagaga gtagaactgg tgccaacaag tatgtctatt tcgtttgcag
     1441 tgagcctggg aggccgtggg taaggttgcc atcagttaca cccgcgcaaa ttgtcactgc
     1501 aagaaaaatc aagaagtttt tcacggggcg actagacgca gccatcgtaa gctacccacc
     1561 cttcccaggg aatgagagca attacttaag agcacaaatt gcccgcattt cggcagggac
     1621 gcacgtcagc cctctgggat tctatcagtt tggtgaagag gaaggagagg aagaggaggt
     1681 ggaaggtggt cgggacagct atgaggaaaa ctctgacttt gaaggcatcc aagtgattga
     1741 cctggtggag tctctctcca actgggttca tcacgcgcag tacattcttc ctcagggtcg
     1801 ctgtaattgg ttcaacccta cacaaaaaga tgaagaggaa gaggaagaag atgaagaaaa
     1861 gggggaagag cctgactacg tagagcagga agtggggcct cctcttttga caccaatctc
     1921 tgaagaccta gagattcaga atataccctc ttggacgaca cggctgtcct caaatctcgt
     1981 tccacagtac gccatcgctg tccttcgatc caatctttgg cctggagcat atgccttttc
     2041 caacggcaag aagtttgaaa acttgtacat aggctggggt cataagtaca gtgtggagaa
     2101 ttacacacct ccaggcccac caccagttta tcaagaatat cccagtggac cagaaattgc
     2161 agaaatggat gatcccagtg tggaggagga acaggctttc agaattacac aagaggcagc
     2221 tgcactttca gccgaggaga atgaagaaac tgaagacgag gacaatgacg actaatataa
     2281 aactagccca accttttatg gcaccaacac acgcaagtgt tttatggggg actgttctt
//
