LOCUS       NM_138881               3608 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus radical S-adenosyl methionine domain containing 2
            (Rsad2), mRNA.
ACCESSION   NM_138881 XM_346761
VERSION     NM_138881.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3608)
  AUTHORS   Teng,T.S., Foo,S.S., Simamarta,D., Lum,F.M., Teo,T.H., Lulla,A.,
            Yeo,N.K., Koh,E.G., Chow,A., Leo,Y.S., Merits,A., Chin,K.C. and
            Ng,L.F.
  TITLE     Viperin restricts chikungunya virus replication and pathology
  JOURNAL   J Clin Invest 122 (12), 4447-4460 (2012)
   PUBMED   23160199
REFERENCE   2  (bases 1 to 3608)
  AUTHORS   Wang,S., Wu,X., Pan,T., Song,W., Wang,Y., Zhang,F. and Yuan,Z.
  TITLE     Viperin inhibits hepatitis C virus replication by interfering with
            binding of NS5A to host protein hVAP-33
  JOURNAL   J Gen Virol 93 (Pt 1), 83-92 (2012)
   PUBMED   21957124
REFERENCE   3  (bases 1 to 3608)
  AUTHORS   Szretter,K.J., Brien,J.D., Thackray,L.B., Virgin,H.W., Cresswell,P.
            and Diamond,M.S.
  TITLE     The interferon-inducible gene viperin restricts West Nile virus
            pathogenesis
  JOURNAL   J Virol 85 (22), 11557-11566 (2011)
   PUBMED   21880757
REFERENCE   4  (bases 1 to 3608)
  AUTHORS   Seo,J.Y., Yaneva,R., Hinson,E.R. and Cresswell,P.
  TITLE     Human cytomegalovirus directly induces the antiviral protein
            viperin to enhance infectivity
  JOURNAL   Science 332 (6033), 1093-1097 (2011)
   PUBMED   21527675
REFERENCE   5  (bases 1 to 3608)
  AUTHORS   Saitoh,T., Satoh,T., Yamamoto,N., Uematsu,S., Takeuchi,O., Kawai,T.
            and Akira,S.
  TITLE     Antiviral protein Viperin promotes Toll-like receptor 7- and
            Toll-like receptor 9-mediated type I interferon production in
            plasmacytoid dendritic cells
  JOURNAL   Immunity 34 (3), 352-363 (2011)
   PUBMED   21435586
REFERENCE   6  (bases 1 to 3608)
  AUTHORS   Rivieccio,M.A., Suh,H.S., Zhao,Y., Zhao,M.L., Chin,K.C., Lee,S.C.
            and Brosnan,C.F.
  TITLE     TLR3 ligation activates an antiviral response in human fetal
            astrocytes: a role for viperin/cig5
  JOURNAL   J Immunol 177 (7), 4735-4741 (2006)
   PUBMED   16982913
REFERENCE   7  (bases 1 to 3608)
  AUTHORS   Helbig,K.J., Lau,D.T., Semendric,L., Harley,H.A. and Beard,M.R.
  TITLE     Analysis of ISG expression in chronic hepatitis C identifies
            viperin as a potential antiviral effector
  JOURNAL   Hepatology 42 (3), 702-710 (2005)
   PUBMED   16108059
REFERENCE   8  (bases 1 to 3608)
  AUTHORS   Chin,K.C. and Cresswell,P.
  TITLE     Viperin (cig5), an IFN-inducible antiviral protein directly induced
            by human cytomegalovirus
  JOURNAL   Proc Natl Acad Sci U S A 98 (26), 15125-15130 (2001)
   PUBMED   11752458
  REMARK    Erratum:[Proc Natl Acad Sci U S A 2002 Feb 19;99(4):2460]
REFERENCE   9  (bases 1 to 3608)
  AUTHORS   Grewal,T.S., Genever,P.G., Brabbs,A.C., Birch,M. and Skerry,T.M.
  TITLE     Best5: a novel interferon-inducible gene expressed during bone
            formation
  JOURNAL   FASEB J 14 (3), 523-531 (2000)
   PUBMED   10698968
REFERENCE   10 (bases 1 to 3608)
  AUTHORS   Zhu,H., Cong,J.P. and Shenk,T.
  TITLE     Use of differential display analysis to assess the effect of human
            cytomegalovirus infection on the accumulation of cellular RNAs:
            induction of interferon-responsive RNAs
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13985-13990 (1997)
   PUBMED   9391139
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_138881.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y07704.1, SRR26643295.25044.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               JAXUCZ010000006.1  48787773-48788120   c
            349-510             JAXUCZ010000006.1  48786129-48786290   c
            511-740             JAXUCZ010000006.1  48782714-48782943   c
            741-890             JAXUCZ010000006.1  48780787-48780936   c
            891-923             JAXUCZ010000006.1  48779246-48779278   c
            924-3608            JAXUCZ010000006.1  48774985-48777669   c
FEATURES             Location/Qualifiers
     source          1..3608
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..3608
                     /gene="Rsad2"
                     /gene_synonym="Best5; SAND; Vig1"
                     /note="radical S-adenosyl methionine domain containing 2"
                     /db_xref="GeneID:65190"
                     /db_xref="RGD:620495"
     exon            1..348
                     /gene="Rsad2"
                     /gene_synonym="Best5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..1088
                     /gene="Rsad2"
                     /gene_synonym="Best5; SAND; Vig1"
                     /note="radical S-adenosyl methionine domain-containing
                     protein 2; viperin; bone-expressed sequence tag 5 protein;
                     virus inhibitory protein, endoplasmic
                     reticulum-associated, interferon-inducible"
                     /codon_start=1
                     /product="S-adenosylmethionine-dependent nucleotide
                     dehydratase RSAD2"
                     /protein_id="NP_620236.1"
                     /db_xref="GeneID:65190"
                     /db_xref="RGD:620495"
                     /translation="MLVPTALAARLLSLFQQQLGSLWSGLAMLFCWLRIALGWPDPGK
                     GQPRVRGEPKETQETHEDPGSAQPTTPVSVNYHFTRQCNYKCGFCFHTAKTSFVLPLE
                     EAKRGLLLLKQAGMEKINFSGGEPFLQDRGEYLGKLVRFCKEELALPSVSIVSNGSLI
                     RERWFKDYGDYLDILAISCDSFDEQVNVLIGRGQGKKNHVENLQKLRKWCRDYKVAFK
                     INSVINRFNVDEDMNEHIKALSPVRWKVFQCLLIEGENSGEDALREAERFLISNEEFE
                     AFLQRHKDVSCLVPESNQKMKDSYLILDEYMRFLNCTGGRKDPSRSILDVGVEEAIKF
                     SGFDEKMFLKRGGKYVWSKADLKLDW"
     exon            349..510
                     /gene="Rsad2"
                     /gene_synonym="Best5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..740
                     /gene="Rsad2"
                     /gene_synonym="Best5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..890
                     /gene="Rsad2"
                     /gene_synonym="Best5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..923
                     /gene="Rsad2"
                     /gene_synonym="Best5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..3608
                     /gene="Rsad2"
                     /gene_synonym="Best5; SAND; Vig1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggggatgct agtgcctact gcgctggctg ctcggctgct gagcctgttc cagcaacagc
       61 tgggttccct ctggagtggc ctggccatgc tgttctgctg gctgagaata gcattggggt
      121 ggccagatcc tggaaaggga cagccacggg tccggggtga gcccaaggag actcaggaga
      181 cccacgaaga tccaggcagt gctcagccca caacccccgt tagtgtcaac taccacttca
      241 cgcgtcagtg caactacaaa tgtggcttct gcttccacac ggccaagaca tccttcgtgc
      301 tgcccctgga ggaggccaag cgaggactgc ttctgctcaa acaggctggt atggagaaga
      361 tcaacttttc aggaggagaa cccttcctac aggacagggg tgaatacttg ggcaagctcg
      421 tgagattctg caaggaggag ctagccctgc cctctgtgag catagtgagc aatggcagcc
      481 ttatccgaga gagatggttc aaggactatg gagactattt ggacattctt gctatctcct
      541 gtgacagctt tgatgagcag gttaatgttc tcattggtcg tggccaaggg aaaaagaacc
      601 atgtggaaaa ccttcaaaag ctgcggaagt ggtgcaggga ttacaaggtg gctttcaaga
      661 tcaattccgt cattaatcgc ttcaacgtgg acgaagatat gaatgagcac atcaaggcgc
      721 tgagccctgt ccgctggaag gttttccaat gcctcctgat tgagggtgag aactcaggag
      781 aagatgccct gagggaagca gaaagatttc ttataagcaa tgaagaattt gaagcattct
      841 tacagcgtca caaagatgtg tcctgcttgg tgcctgaatc taaccagaag atgaaagact
      901 cctaccttat cctggatgaa tatatgcgct ttctgaactg taccggtggc cggaaggacc
      961 cttccaggtc catcctggat gttggcgtgg aggaagcgat caaattcagt gggtttgatg
     1021 agaagatgtt tctgaagcgc ggggggaagt atgtatggag taaggctgac ctgaagctag
     1081 actggtgagg tgagattgga cggagactct aaccagctac gaggagtcca cgagcagccg
     1141 ctcgccacca cgcacatctg gctgtctacg gactgttgct actgagaatg cactctatgt
     1201 tctttctttc agtttgactg aactaagaaa ggagtaaaac cattctgtga acccttatac
     1261 agccgataag ggtcctccac agggaaggag ttcagttcac agaggaacaa ggtccagcga
     1321 tctcaaagaa ctcacatttt atttgtattc gaatttttgt atggatcgtt actgtgaatc
     1381 ccatgtttcc ttttcccttt ctgttccccc atgagaaact gggttatttt ctgctaacta
     1441 tgccagtttt gtcaacagga aggatcacaa aacacaccct gcgattactg ctgactgttc
     1501 taatgctttt ctgctttgga atctcggact ttttgctcag aaatatagaa tcaagaagtg
     1561 tgttatagag ccgtacgtga gaaccttact cttttgcaag gagcatatgg aaggaggtac
     1621 ttccgaggac gtgtgttcat ggcctcagcc tctgctgctg ctgctgcttc aaggatggct
     1681 gttctatatc gtaccaattc cttcaaggtt ctggacaaag ccaaggtaca ctttaccttt
     1741 catggcatgg ccgtgaagat ggcactgaca gccgcaacca ccccagcact gaggctgcct
     1801 gagtctgtca ggctaaaagg ttgtcccact tttctgaaaa gctacaaggg ctcttctgca
     1861 catccagcag aatcatgaca ggatgggcat ggaggactct tcaggagtat gaaatgtggc
     1921 tgctgctcct taccatattt ctcatgaaac tctgaaataa gacctagtag tctaggtcac
     1981 catgagaaaa taatttcttc tctacatcaa ataagcaaaa gagagaacat gaactagccc
     2041 aaatcttctt cctgtggaaa cattgcctga gtttattcaa cctagacagc ctcactgctt
     2101 ggaaaataat tccctggaaa ttaaataaat accatggaaa attttgtttt gtccaagaaa
     2161 ttgaactcct ctgcaatccc actgtggcca ctagagggca ccaggaagtc agacttcatt
     2221 aagtgtctca gagacttttc ttcagtctgt ttttaggatt tggtgaattt taattctgtt
     2281 ccttatctgt tttgtctttg ttttttgttt tggtgcctat tactaaaatt aatgctaaac
     2341 attttccaag gaactggaat tttggccatt tacaaaaggt cttcattctt tagtgaggtc
     2401 actataattc aactaagaca tactctgtct cattaaaaat aggtcaggtt ttctgtgttt
     2461 tctgtcttgt ttgtgtgtgt gtgtgtttac ctatttttgc ttgaatatag atataactat
     2521 gtatcccagg ctagcctgga actcatgata cctctgcctt aacctccccc tcttaagtgc
     2581 cagggattac ccaactcctg tacagagatt tttaagagaa gtttgagtca cattcccccc
     2641 tgcagattgt gatttttttt taagttaagt cctgtgtact tagttcacct gggaaaccat
     2701 gacatccccg aggacatggg cagacaccca cttggtcaca cgacagaggg aagctgcatg
     2761 tctctttccc taattaaagt agagcatgaa gaaagtatga ttggaaagtg agccatcatt
     2821 ctacatgtac ccccaacccc ttgtgcatgc accggaggtg ggagatctct gtgcttaaaa
     2881 tattgaaaag tcccctttcc ttaaagggaa aaattacgat attttactat catagtaaaa
     2941 atcaaacttg gattagatca tacattggtt tgctttttca gtgttaaatc tgggtgttca
     3001 ttttgtaaag catacgctcc ctgctgggga aacgaggagt gatctagttg acatttgtta
     3061 agtgtgacca gcagatacct tgtgtcccat gattgattta tgcagagcag taatactggg
     3121 aagggggatt tacttaagaa catcgaaggg taggacatcc cacactgatt tcaaagtttt
     3181 ggcgtcttta ttataatgtg ttcaacggta aaaaaaaaag tcatgggttg ttttctttga
     3241 agctgaaagt ctcatggtgt tatttaccta aattatctga aaaatttaaa aggggcccag
     3301 gtttcattct gcgttggagt ttgggggtct aattgttgca taaataagca ggcaaccaat
     3361 catcagaggt tgactcctcc catcaataat tcagctcgtg ttttaccctt ttgatggact
     3421 gatgttgttt cataagctat tagtcgtcca agaacaatca tgcaggcctc atgtgaatgt
     3481 gttcagatga ggtttgatgt tcgggataca tgtgcatgta tctccctgta gaatgacact
     3541 gtattttgag gcattgctct aatgtatgga aacgtgatct gtgtattaaa atgttctatg
     3601 catgacct
//
