LOCUS       NM_001104643            1980 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus retinoschisin 1 (Rs1), mRNA.
ACCESSION   NM_001104643
VERSION     NM_001104643.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1980)
  AUTHORS   Ye EA, Zeng Y, Thomas S, Sun N, Smit-McBride Z and Sieving PA.
  TITLE     XLRS Rat with Rs1-/Y Exon-1-Del Shows Failure of Early Postnatal
            Outer Retina Development
  JOURNAL   Genes (Basel) 13 (11), 1995 (2022)
   PUBMED   36360232
  REMARK    GeneRIF: XLRS Rat with Rs1[-/Y] Exon-1-Del Shows Failure of Early
            Postnatal Outer Retina Development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1980)
  AUTHORS   Zeng Y, Qian H, Campos MM, Li Y, Vijayasarathy C and Sieving PA.
  TITLE     Rs1h-/y exon 3-del rat model of X-linked retinoschisis with early
            onset and rapid phenotype is rescued by RS1 supplementation
  JOURNAL   Gene Ther 29 (7-8), 431-440 (2022)
   PUBMED   34548657
  REMARK    GeneRIF: Rs1h(-/y) exon 3-del rat model of X-linked retinoschisis
            with early onset and rapid phenotype is rescued by RS1
            supplementation.
REFERENCE   3  (bases 1 to 1980)
  AUTHORS   Yi J, Li S, Jia X, Xiao X, Wang P, Guo X and Zhang Q.
  TITLE     Novel RS1 mutations associated with X-linked juvenile retinoschisis
  JOURNAL   Int J Mol Med 29 (4), 644-648 (2012)
   PUBMED   22245991
REFERENCE   4  (bases 1 to 1980)
  AUTHORS   Friedrich U, Stohr H, Hilfinger D, Loenhardt T, Schachner M,
            Langmann T and Weber BH.
  TITLE     The Na/K-ATPase is obligatory for membrane anchorage of
            retinoschisin, the protein involved in the pathogenesis of X-linked
            juvenile retinoschisis
  JOURNAL   Hum Mol Genet 20 (6), 1132-1142 (2011)
   PUBMED   21196491
REFERENCE   5  (bases 1 to 1980)
  AUTHORS   Kotova S, Vijayasarathy C, Dimitriadis EK, Ikonomou L, Jaffe H and
            Sieving PA.
  TITLE     Retinoschisin (RS1) interacts with negatively charged lipid
            bilayers in the presence of Ca2+: an atomic force microscopy study
  JOURNAL   Biochemistry 49 (33), 7023-7032 (2010)
   PUBMED   20677810
REFERENCE   6  (bases 1 to 1980)
  AUTHORS   Reid SN, Yamashita C and Farber DB.
  TITLE     Retinoschisin, a photoreceptor-secreted protein, and its
            interaction with bipolar and muller cells
  JOURNAL   J Neurosci 23 (14), 6030-6040 (2003)
   PUBMED   12853421
REFERENCE   7  (bases 1 to 1980)
  AUTHORS   Weber BH, Schrewe H, Molday LL, Gehrig A, White KL, Seeliger MW,
            Jaissle GB, Friedburg C, Tamm E and Molday RS.
  TITLE     Inactivation of the murine X-linked juvenile retinoschisis gene,
            Rs1h, suggests a role of retinoschisin in retinal cell layer
            organization and synaptic structure
  JOURNAL   Proc Natl Acad Sci U S A 99 (9), 6222-6227 (2002)
   PUBMED   11983912
REFERENCE   8  (bases 1 to 1980)
  AUTHORS   Mashima Y, Shinoda K, Ishida S, Ozawa Y, Kudoh J, Iwata T, Oguchi Y
            and Shimizu N.
  TITLE     Identification of four novel mutations of the XLRS1 gene in
            Japanese patients with X-linked juvenile retinoschisis. Mutation in
            brief no. 234. Online
  JOURNAL   Hum Mutat 13 (4), 338 (1999)
   PUBMED   10220153
REFERENCE   9  (bases 1 to 1980)
  AUTHORS   .
  TITLE     Functional implications of the spectrum of mutations found in 234
            cases with X-linked juvenile retinoschisis. The Retinoschisis
            Consortium
  JOURNAL   Hum Mol Genet 7 (7), 1185-1192 (1998)
   PUBMED   9618178
REFERENCE   10 (bases 1 to 1980)
  AUTHORS   Sauer CG, Gehrig A, Warneke-Wittstock R, Marquardt A, Ewing CC,
            Gibson A, Lorenz B, Jurklies B and Weber BH.
  TITLE     Positional cloning of the gene associated with X-linked juvenile
            retinoschisis
  JOURNAL   Nat Genet 17 (2), 164-170 (1997)
   PUBMED   9326935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000385.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001104643.3.
            
            On Aug 31, 2022 this sequence version replaced NM_001104643.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU074986.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               JACYVU010000385.1  511918-512057       c
            141-166             JACYVU010000385.1  500336-500361       c
            167-272             JACYVU010000385.1  496532-496637       c
            273-414             JACYVU010000385.1  486732-486873       c
            415-610             JACYVU010000385.1  486088-486283       c
            611-1980            JACYVU010000385.1  482294-483663       c
FEATURES             Location/Qualifiers
     source          1..1980
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq14"
     gene            1..1980
                     /gene="Rs1"
                     /note="retinoschisin 1"
                     /db_xref="GeneID:100125595"
                     /db_xref="RGD:1642515"
     exon            1..140
                     /gene="Rs1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..763
                     /gene="Rs1"
                     /codon_start=1
                     /product="retinoschisin precursor"
                     /protein_id="NP_001098113.1"
                     /db_xref="GeneID:100125595"
                     /db_xref="RGD:1642515"
                     /translation="MPHKIEGFFLLLLFGYEATLGLSSTEDEGEDPWYQKACKCDCQG
                     GANALWSAGAASLDCIPECPYHKPLGFESGEVTPDQITCSNPEQYVGWYSSWTANKAR
                     LNSQGFGCAWLSKYQDSSQWLQIDLKEIKVISGILTQGRCDIDEWMTKYSVQYRTDER
                     LNWIYYKDQTGNNRVFYGNSDRSSTVQNLLRPPIISRFIRLIPLGWHVRIAIRMELLE
                     CASKCA"
     exon            141..166
                     /gene="Rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..272
                     /gene="Rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..414
                     /gene="Rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            415..610
                     /gene="Rs1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..1980
                     /gene="Rs1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaggccag tggctcaagt taatcacctg ctccaaggcc agctttctac ttcatttagg
       61 gagtgctgtg accaaggaca aggagaaaat gccacacaag attgaaggct tcttcttatt
      121 gcttctcttt ggctatgaag ccacattggg attgtcttcg acagaggatg agggtgagga
      181 cccttggtac cagaaagcgt gcaagtgtga ttgccaggga ggagccaatg ctctgtggtc
      241 tgctggagcc gcctccttag actgtattcc agaatgccca tatcacaagc ccctgggttt
      301 cgagtcaggg gaagtcacac cagatcagat cacttgctcc aacccagagc agtatgtggg
      361 ctggtattcc tcatggactg caaacaaggc ccggctcaac agtcaaggtt ttgggtgtgc
      421 ttggctttcc aagtatcagg acagtagcca gtggttacag atagatttga aggagatcaa
      481 ggtgatttcg gggatcctta cccaaggacg ctgtgacata gatgagtgga tgaccaagta
      541 cagtgtgcaa tataggactg atgaacgcct gaactggatt tactataagg atcagactgg
      601 aaacaatcgg gtcttctatg gaaactccga ccggagttct acagtccaga acttactgag
      661 gccccccatt atttcccgct tcatccgact gatccctcta ggctggcatg tccgaattgc
      721 catccggatg gagctgcttg agtgtgccag caagtgtgcc tgatgcctag ttcagctcag
      781 tcctgccact tgcagggaaa gcttggggga gaggagagtc accttgaaat accactttga
      841 tgaatggggc tagatcttat aagcacttta caaatgtaga tctggtagac aatattttac
      901 tttttaaaag atagtttcaa atttcaacaa gagagacaga gggaaaggga gagagggaga
      961 gagagagaga gagagagaga gagagagaga gagagagaga gagagagaag cttttcctca
     1021 actcagcgcc aaagaaaata agagcaaaga aaatatccct caaaccaatt ttcttacaca
     1081 aacccaaata gcaggggtaa tttgcacttc tggctccgtg tctttttctc tttgtctcag
     1141 tgatactgtc aaaggtacag acccagggga acacaaagca gctctgataa tttgaaaatt
     1201 ctttttggct cttagcacat tcagaagagg aacatactct tctgcaaagc ttcacttgaa
     1261 cacgttcatg aaatccccac tagagaggcc tggagacaag aacatgggca tgaagacagc
     1321 agaaggaagc ctggtgtgtg gcccaagagt ctgtaaacac taaccaacta accaatcaac
     1381 taactaacta accaatcaac taaccaacta accaagcagt caaggcttcc ccttcctgga
     1441 attgcttttg ccttgaaggg gtttgggctt ttatccacag gattgaggga atgtgggcca
     1501 gttggagctc cttttgcata aactccattc tacagccttt ccccaatgtg cccttctgtg
     1561 gttgccagga gatgaatgca aggggcagac tatatgtgtg tgggtagtga ggtttccctt
     1621 atactgagga agcccaaatg actagaatac atcacacctt ctttatcttt ggctacagtt
     1681 ttccagaaat taaacaggct tggaaatcag tggagacaaa ccacctatct ggctactggg
     1741 aagagatcat gctttggggg aaggggtcag ggctcctatc atacagaact atatagggat
     1801 ggctcagtag gcagagtttc tgctgtgcaa gcatagggac ttgaatttat atttctagaa
     1861 tgcatgtgaa aagctagcta tggacaggta tggaacatgc ctttaatctc agtatttaga
     1921 aggcagaggc aagcagatct aaattcaggg ccagcctggt ctatatacca gttccaagct
//
