LOCUS       NP_001073167             365 aa            linear   ROD 04-JUN-2024
DEFINITION  ribosome biogenesis regulatory protein homolog [Rattus norvegicus].
ACCESSION   NP_001073167 XP_001066738 XP_232622
VERSION     NP_001073167.1
DBSOURCE    REFSEQ: accession NM_001079699.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 365)
  AUTHORS   Sloan,K.E., Bohnsack,M.T. and Watkins,N.J.
  TITLE     The 5S RNP couples p53 homeostasis to ribosome biogenesis and
            nucleolar stress
  JOURNAL   Cell Rep 5 (1), 237-247 (2013)
   PUBMED   24120868
REFERENCE   2  (residues 1 to 365)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   3  (residues 1 to 365)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (residues 1 to 365)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (residues 1 to 365)
  AUTHORS   Carnemolla,A., Fossale,E., Agostoni,E., Michelazzi,S.,
            Calligaris,R., De Maso,L., Del Sal,G., MacDonald,M.E. and
            Persichetti,F.
  TITLE     Rrs1 is involved in endoplasmic reticulum stress response in
            Huntington disease
  JOURNAL   J Biol Chem 284 (27), 18167-18173 (2009)
   PUBMED   19433866
REFERENCE   6  (residues 1 to 365)
  AUTHORS   Gambe,A.E., Matsunaga,S., Takata,H., Ono-Maniwa,R., Baba,A.,
            Uchiyama,S. and Fukui,K.
  TITLE     A nucleolar protein RRS1 contributes to chromosome congression
  JOURNAL   FEBS Lett 583 (12), 1951-1956 (2009)
   PUBMED   19465021
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128746.1.
            
            On or before Dec 10, 2006 this sequence version replaced
            XP_232622.3, XP_001066738.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC128746.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     Protein         1..365
                     /product="ribosome biogenesis regulatory protein homolog"
                     /note="RRS1 ribosome biogenesis regulator homolog"
                     /calculated_mol_wt=41406
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:Q15050; propagated from
                     UniProtKB/Swiss-Prot (A1A5P2.1)"
     Site            5
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15050; propagated from
                     UniProtKB/Swiss-Prot (A1A5P2.1)"
     Region          31..193
                     /region_name="RRS1"
                     /note="Ribosome biogenesis regulatory protein (RRS1);
                     pfam04939"
                     /db_xref="CDD:461494"
     Region          200..255
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A1A5P2.1)"
     Region          272..365
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (A1A5P2.1)"
     CDS             1..365
                     /gene="Rrs1"
                     /coded_by="NM_001079699.1:90..1187"
                     /db_xref="GeneID:297784"
                     /db_xref="RGD:1311403"
ORIGIN      
        1 megqsveell akakqeeaek lqritvhkel elefdlgnll asdrnpptvl rqagpspeae
       61 lralardntq llvnqlwqlp terveeavva rlpepatrlp rekplprprp ltrwqqfarl
      121 kgirpkkktn lvwdevsgqw rrrwgykrar ddtkewliev pgsadpmedq fakrirakke
      181 rvaknelnrl rnlarahkmq mpssaglhpt ghqskeelgr amqvakvsta svgrfqerlp
      241 kekaprgsgk krkfqplfgd faaekknqle llrvmnskkp qldvtratnk qmreedqeea
      301 akrrkmsqkg kkkggrqgps grrkggppsq gekrkgvlgg kkhsrppalg gkkkgvphhg
      361 gkrrk
//
