LOCUS       NM_001135846            3445 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus RRN3 homolog, RNA polymerase I transcription
            factor (Rrn3), mRNA.
ACCESSION   NM_001135846 XM_001053401 XM_001075799 XM_001075816 XM_222526
VERSION     NM_001135846.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3445)
  AUTHORS   Lewinska,A., Bednarz,D., Adamczyk-Grochala,J. and Wnuk,M.
  TITLE     Phytochemical-induced nucleolar stress results in the inhibition of
            breast cancer cell proliferation
  JOURNAL   Redox Biol 12, 469-482 (2017)
   PUBMED   28334682
REFERENCE   2  (bases 1 to 3445)
  AUTHORS   Knutson,B.A. and Hahn,S.
  TITLE     TFIIB-related factors in RNA polymerase I transcription
  JOURNAL   Biochim Biophys Acta 1829 (3-4), 265-273 (2013)
   PUBMED   22960599
  REMARK    Review article
REFERENCE   3  (bases 1 to 3445)
  AUTHORS   Zhai,N., Zhao,Z.L., Cheng,M.B., Di,Y.W., Yan,H.X., Cao,C.Y.,
            Dai,H., Zhang,Y. and Shen,Y.F.
  TITLE     Human PIH1 associates with histone H4 to mediate the
            glucose-dependent enhancement of pre-rRNA synthesis
  JOURNAL   J Mol Cell Biol 4 (4), 231-241 (2012)
   PUBMED   22368283
REFERENCE   4  (bases 1 to 3445)
  AUTHORS   Schneider,D.A.
  TITLE     RNA polymerase I activity is regulated at multiple steps in the
            transcription cycle: recent insights into factors that influence
            transcription elongation
  JOURNAL   Gene 493 (2), 176-184 (2012)
   PUBMED   21893173
  REMARK    Review article
REFERENCE   5  (bases 1 to 3445)
  AUTHORS   Gomes,C., Smith,S.C., Youssef,M.N., Zheng,J.J., Hagg,T. and
            Hetman,M.
  TITLE     RNA polymerase 1-driven transcription as a mediator of BDNF-induced
            neurite outgrowth
  JOURNAL   J Biol Chem 286 (6), 4357-4363 (2011)
   PUBMED   21098478
REFERENCE   6  (bases 1 to 3445)
  AUTHORS   Cavanaugh,A.H., Evans,A. and Rothblum,L.I.
  TITLE     Mammalian Rrn3 is required for the formation of a transcription
            competent preinitiation complex containing RNA polymerase I
  JOURNAL   Gene Expr 14 (3), 131-147 (2008)
   PUBMED   18590050
  REMARK    GeneRIF: Data demonstrate that Rrn3 must be present when the
            committed template complex is forming for transcription to occur.
REFERENCE   7  (bases 1 to 3445)
  AUTHORS   Yuan,X., Zhou,Y., Casanova,E., Chai,M., Kiss,E., Grone,H.J.,
            Schutz,G. and Grummt,I.
  TITLE     Genetic inactivation of the transcription factor TIF-IA leads to
            nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis
  JOURNAL   Mol Cell 19 (1), 77-87 (2005)
   PUBMED   15989966
REFERENCE   8  (bases 1 to 3445)
  AUTHORS   Schnapp,A., Schnapp,G., Erny,B. and Grummt,I.
  TITLE     Function of the growth-regulated transcription initiation factor
            TIF-IA in initiation complex formation at the murine ribosomal gene
            promoter
  JOURNAL   Mol Cell Biol 13 (11), 6723-6732 (1993)
   PUBMED   8413268
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166485.1.
            
            On or before Oct 17, 2008 this sequence version replaced
            XM_001053401.1, XM_222526.4, XM_001075816.1, XM_001075799.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166485.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3445
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..3445
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /note="RRN3 homolog, RNA polymerase I transcription
                     factor"
                     /db_xref="GeneID:304714"
                     /db_xref="RGD:1305001"
     exon            1..89
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..1992
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /note="RRN3 RNA polymerase I transcription factor homolog;
                     RNA polymerase I-specific transcription initiation factor
                     RRN3-like"
                     /codon_start=1
                     /product="RNA polymerase I-specific transcription
                     initiation factor RRN3"
                     /protein_id="NP_001129318.1"
                     /db_xref="GeneID:304714"
                     /db_xref="RGD:1305001"
                     /translation="MAAPLLHTRLSSDVAATGSATLSASRTGLSNMLALESDFFSSPP
                     RKTVRFGGTVTDVLLKYKKGETNDLELLKNQLSDPDIKDDQIINWLLEFRSSVMYLTK
                     DFEQLINIILRLPWLNRSQTVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIV
                     KEGGIDVSESEDEDDNLPANFDTCHKALQIITRYVPSTPWFLMPILVEKFPFVRKSER
                     TLECYVHNLLRISLYFPTLRREILELIIEKSLKLDVSVSRQDIDDAEETAAQTYGGTD
                     AAEGLFNMDEDEETDPEKKAEQERPGRMAHPTAERLDILLSLLLSYIDDVCHVQGKID
                     NNKTKDLYRDLISIFDKLVLPTHASCHVQFFMFFLCSFKLSLLLQGFAEAFLEHLWKK
                     LQDPNNPVIIRQAAANYIGSFLARAKFIPLITVKSCLDLLVNWLHLYLNSQDSGTKAF
                     CDVALHGPFYSACQAVFYTVVFRHKQLLSGNLKEGLRYLQSLNFERIVLSQLNPLKIC
                     LPRVVNFFAAITNKYQLVFCYTIMERNNRQMLPVIRSTAGGDSVQTCTNPLDTFFPFD
                     PCMLKRSKKFIDPVYQAWEDMSDEELQELRKPTRKELVEDEDDDFLKGEVPQSDTVAG
                     LTPNSFDTHFRSPSSSVGSPPVLFMPDQSSLLSRICD"
     exon            90..195
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            196..252
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            253..342
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            343..472
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            473..532
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            533..596
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            597..666
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            667..765
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            766..858
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            859..997
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1128
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1274
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1459
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1568
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1721
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1809
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..3402
                     /gene="Rrn3"
                     /gene_synonym="RGD1305001"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggccgaatgg cggccccgct gctccacacg cgcttgtcga gcgacgtggc ggctacgggc
       61 tctgccacgc tgagtgcgtc gcggactggg ctttcaaaca tgcttgcatt agagagtgat
      121 ttcttcagtt ctcccccaag aaaaactgtt cggtttggtg gaactgtgac agacgtctta
      181 ctgaagtaca aaaagggtga aacaaatgac ttagagttgt tgaagaacca gctgtctgat
      241 cctgatataa aggatgatca gatcattaac tggctgctgg aatttcgttc ctctgtcatg
      301 tacttgacaa aagactttga gcaacttata aacatcatat tgagattgcc ctggttgaat
      361 agaagtcaga cggtggtgga ggagtatttg gcttttcttg gtaatcttgt gtcagcacag
      421 actgtcttcc ttagaccatg tctcagcatg attgcttctc attttgtacc tccccgagtt
      481 attgtcaagg aaggtggcat tgatgtttca gagtctgagg atgaagatga caatcttcct
      541 gcaaattttg acacatgtca caaagccttg caaataataa caagatatgt cccttcgaca
      601 ccatggtttc taatgccaat actggtagaa aaatttccat ttgtgaggaa atcagagaga
      661 acactggaat gctatgttca taacctatta aggataagtt tatatttccc aacgttgagg
      721 cgtgaaattc tcgagcttat tattgaaaag tcactcaagt tagatgtgag tgtgtcgcgg
      781 caggatattg acgatgctga agagacagca gctcagactt atggtgggac agacgccgca
      841 gaaggactgt ttaatatgga tgaagatgag gaaactgacc ctgagaagaa agctgagcag
      901 gagcggcctg gccggatggc tcatcccact gcagagcgcc tggacatcct gctgtccttg
      961 ctgctctcct acattgacga tgtctgccat gtgcaaggta aaattgataa caataaaaca
     1021 aaggatttat atcgtgatct gatatctatc tttgacaaac ttgtgttgcc cacacatgcc
     1081 tcctgccatg tacagttctt catgtttttc ctttgcagct tcaaattgtc tctcttgtta
     1141 caggggtttg cagaagcatt tttggaacat ctctggaaaa agttgcagga tccaaataac
     1201 cctgtcatca tcaggcaagc tgctgcaaat tacattggaa gctttttggc aagagctaaa
     1261 tttattcctc ttatcactgt gaagtcatgc ctggatcttt tggttaactg gctgcacctg
     1321 taccttaata gccaggattc gggaacaaag gctttttgtg atgttgcact ccatggacca
     1381 ttttattcag cctgccaagc tgtgttctac actgttgttt ttagacacaa gcaacttttg
     1441 agtggcaacc tgaaggaagg tctacggtat cttcagagtc taaattttga acgcattgtg
     1501 ctgagccagc tgaacccact gaagatctgc ctgccacgtg tggttaattt ctttgctgcc
     1561 ataacaaata aataccagct tgtgttctgc tacaccatca tggagaggaa caatcgccag
     1621 atgctccctg ttattcgaag tacagctggt ggagactctg tgcagacctg caccaaccca
     1681 ttggacactt tctttccctt tgacccttgt atgcttaaga ggtcaaagaa gttcatcgat
     1741 cctgtctatc aggcttggga agacatgagt gatgaagagc tgcaggagct taggaaaccc
     1801 actagaaagg agctagtgga ggatgaagac gatgactttt tgaaaggcga agtgccccag
     1861 agtgacacag tggctggcct taccccgaac tcctttgaca cccactttcg aagtccttcc
     1921 agtagtgtgg gctcccctcc tgtgctgttt atgccagacc aatcttcgct cctctcaagg
     1981 atctgtgatt gagctacgct gttctcccca gggcactgtg ccccaccact gatcccgcat
     2041 tgaactagtc tatgcctcgt gtccagcctc catgttggac ttcagccagc atctgaaggg
     2101 ccccaggttg tgtgtgtttg cagtttgctc cctgtggaca taaggaaaga ttgagtgtca
     2161 tgtgcaatat ttcacagtga acagagcaat ctgtgcctac agccttctaa ttgctggctc
     2221 catgctacat cagcctcacc tggcaggtgg ccttctgaca ggttcctttt tgttagaccc
     2281 acaatcacat gactttgttg gtcttgtttt ggggacatat cctccaggat cagcactgcc
     2341 tgtgaatact tttaactgtg tcctgcttac agtggcatga tggtttcctt ttgactagaa
     2401 gtctatttgt gttgtagggt gcatggggag aggccagcca gaggtggggc tgaactttac
     2461 caaggggaca caaaggactg cagagaagcc aggtgggcag agagcattca gagaatcaca
     2521 aaaaggcact tattcaggat tccacgtcag cacagctgca gcagccatgg ttcaggctga
     2581 ctgaagcgga cctgggtgtc tgtcaacatt cattccacag tttgcacaac atggactcaa
     2641 gccagaagag ctgtcttata ctaaacagcc agccttgctc tgtagcaggt gtgtttgagg
     2701 actgtggaag ttgccttccc ttgtatcctt acatgtaaac ttgtgtattt gtgaaaatat
     2761 ccctttaagt atatttaatt ttttgccact tatatttatt taaagggaag tgatattttc
     2821 ttggtcacaa tattttttaa tggaattctt ctcaaggttt atatactcct gtgtaatgag
     2881 actgatgcag agccctggat tttagtctgc ctatgaatac ctttttgaat caggaaaact
     2941 ttattgcttt aaaaagcttt tataagaggc aggcaaatcc ctgagtccca ggccagcttt
     3001 ggtggcaagt cactaggaaa cctcaagatt ctatatgtct ttcttttaca gtgtagtcct
     3061 ggctatcctg gaaatcacta tgtagctcag gctggccttg aactcagaga tctagttgcc
     3121 tccaactctg gagtgcaggg aatttgcacc accactgcct ggttcaaggt tcttacttaa
     3181 ctgctgacag aaaatgcaat gaaattgcat ctgtagattc tgacgggatg tcaggtttgg
     3241 acagtagcta gaatgtagaa ggtatgttga caaataagcc tcttggagta taaaggagtt
     3301 tgaggggaaa aatctattgt gaaaatgaaa gaacagccta gctcacctga ggcctccctg
     3361 ttcacagcca atgcaggctt taataaaaag actcagccat gcaaaaaaaa aaaaaaaaaa
     3421 aaaaaaaaaa aaaaaaaaaa aaaaa
//
