LOCUS       NM_001130543            1204 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ribonucleotide reductase regulatory TP53
            inducible subunit M2B (Rrm2b), mRNA.
ACCESSION   NM_001130543 XM_001061249 XM_235367
VERSION     NM_001130543.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1204)
  AUTHORS   Fragoza R, Das J, Wierbowski SD, Liang J, Tran TN, Liang S, Beltran
            JF, Rivera-Erick CA, Ye K, Wang TY, Yao L, Mort M, Stenson PD,
            Cooper DN, Wei X, Keinan A, Schimenti JC, Clark AG and Yu H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1204)
  AUTHORS   Wei X, Das J, Fragoza R, Liang J, Bastos de Oliveira FM, Lee HR,
            Wang X, Mort M, Stenson PD, Cooper DN, Lipkin SM, Smolka MB and Yu
            H.
  TITLE     A massively parallel pipeline to clone DNA variants and examine
            molecular phenotypes of human disease mutations
  JOURNAL   PLoS Genet 10 (12), e1004819 (2014)
   PUBMED   25502805
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1204)
  AUTHORS   Bourdon A, Minai L, Serre V, Jais JP, Sarzi E, Aubert S, Chretien
            D, de Lonlay P, Paquis-Flucklinger V, Arakawa H, Nakamura Y,
            Munnich A and Rotig A.
  TITLE     Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase
            (p53R2), causes severe mitochondrial DNA depletion
  JOURNAL   Nat Genet 39 (6), 776-780 (2007)
   PUBMED   17486094
REFERENCE   4  (bases 1 to 1204)
  AUTHORS   Tudzarova-Trajkovska S and Wesierska-Gadek J.
  TITLE     Strong induction of p73 protein in vivo coincides with the onset of
            apoptosis in rat liver after treatment with the hepatocarcinogen
            N-nitrosomorpholine (NNM)
  JOURNAL   J Cell Biochem 90 (4), 837-855 (2003)
   PUBMED   14587038
REFERENCE   5  (bases 1 to 1204)
  AUTHORS   Kimura T, Takeda S, Sagiya Y, Gotoh M, Nakamura Y and Arakawa H.
  TITLE     Impaired function of p53R2 in Rrm2b-null mice causes severe renal
            failure through attenuation of dNTP pools
  JOURNAL   Nat Genet 34 (4), 440-445 (2003)
   PUBMED   12858174
REFERENCE   6  (bases 1 to 1204)
  AUTHORS   Guittet O, Hakansson P, Voevodskaya N, Fridd S, Graslund A, Arakawa
            H, Nakamura Y and Thelander L.
  TITLE     Mammalian p53R2 protein forms an active ribonucleotide reductase in
            vitro with the R1 protein, which is expressed both in resting cells
            in response to DNA damage and in proliferating cells
  JOURNAL   J Biol Chem 276 (44), 40647-40651 (2001)
   PUBMED   11517226
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_235367.4, XM_001061249.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760494 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1204
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..1204
                     /gene="Rrm2b"
                     /note="ribonucleotide reductase regulatory TP53 inducible
                     subunit M2B"
                     /db_xref="GeneID:299976"
                     /db_xref="RGD:1306045"
     exon            1..179
                     /gene="Rrm2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1187
                     /gene="Rrm2b"
                     /EC_number="1.17.4.1"
                     /note="ribonucleotide reductase M2 B (TP53 inducible)"
                     /codon_start=1
                     /product="ribonucleoside-diphosphate reductase subunit M2
                     B"
                     /protein_id="NP_001124015.1"
                     /db_xref="GeneID:299976"
                     /db_xref="RGD:1306045"
                     /translation="MGDPERPEAARPEEGEQLCPETKENEVRSNEEPLLRKSSRRFVI
                     FPIQYPDIWKMYKQAQASFWTAEEVDLSKDLPHWNKLKSEEKYFISHILAFFAASDGI
                     VNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIE
                     TMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGIFFSGSFAAIFWLKKRGLMPGLT
                     FSNELISRDEGLHCDFACLMFQYLVNKPSEERVMEIIVDAVKIEQEFLTEALPVGLIG
                     MNCVLMKQYIEFVADRLLGELGFSKIFQAENPFDFMENISLEGKTNFFEKRVSEYQRF
                     AVMAETTDNVFTLDADF"
     exon            180..335
                     /gene="Rrm2b"
                     /inference="alignment:Splign:2.1.0"
     exon            336..452
                     /gene="Rrm2b"
                     /inference="alignment:Splign:2.1.0"
     exon            453..586
                     /gene="Rrm2b"
                     /inference="alignment:Splign:2.1.0"
     exon            587..681
                     /gene="Rrm2b"
                     /inference="alignment:Splign:2.1.0"
     exon            682..815
                     /gene="Rrm2b"
                     /inference="alignment:Splign:2.1.0"
     exon            816..920
                     /gene="Rrm2b"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1034
                     /gene="Rrm2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1204
                     /gene="Rrm2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtgcagctg ggcgggcccg gagcaggagg aggttcacac agtgcagact tgttggctac
       61 ctcggtatta ctcggatttg ccctgccgct ctcagttcct cagctcgggt ggctctggca
      121 gagtctgcgc gatgggcgac ccggaaaggc cggaagcggc caggccggag gagggtgagc
      181 aattgtgtcc agagacaaaa gaaaacgagg tgaggtcaaa tgaagagcca ctcctcagaa
      241 agagttcccg acggtttgtc atctttccaa tccagtaccc tgatatttgg aagatgtata
      301 agcaagcaca ggcatctttc tggacagcag aggaggttga cttgtccaag gacctccctc
      361 attggaacaa gcttaagtcg gaagagaagt attttatctc ccacatctta gcatttttcg
      421 cagccagcga tggaattgta aatgaaaact tggtggagcg ttttagtcaa gaggtgcagg
      481 ttccagaggc tcgctgcttc tatggctttc agattctcat cgagaatgtt cactcagaga
      541 tgtacagttt actaatagac acttacatca gagatccaaa gaagagggaa tttttattta
      601 atgcaattga aacaatgccg tatgttaaga aaaaagcaga ttgggctctg cgctggatag
      661 cagataggaa atctactttt ggggaaagag tggtggcctt cgctgctgta gaagggattt
      721 tcttctctgg atcatttgct gctatattct ggctaaagaa gagaggcctc atgcctgggc
      781 tgactttttc aaatgaactg atcagcaggg atgaaggact tcactgtgac tttgcctgcc
      841 tgatgtttca gtacctggta aacaagcctt cagaagaaag ggtcatggaa atcattgttg
      901 atgctgttaa aattgagcag gagtttttaa cagaagcctt gcctgttggc ctcattggaa
      961 tgaactgtgt tttgatgaaa caatatattg agtttgtagc tgacagatta cttggagaac
     1021 ttggattctc aaagattttt caggcagaaa atccctttga ttttatggag aacatttcgt
     1081 tagaagggaa aacaaatttc tttgagaaac gagtttctga gtatcagcga tttgcagtca
     1141 tggcagaaac cacagataat gtcttcacct tggatgcaga tttctaaagc cctcctcata
     1201 aaaa
//
