LOCUS       NM_001025740            2538 bp    mRNA    linear   ROD 16-FEB-2024
DEFINITION  Rattus norvegicus ribonucleotide reductase regulatory subunit M2
            (Rrm2), mRNA.
ACCESSION   NM_001025740 XM_343040
VERSION     NM_001025740.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2538)
  AUTHORS   Yu,H., Tang,H., Deng,C., Lin,Q., Yu,P., Chen,S. and Ruan,J.
  TITLE     RRM2 Improves Cardiomyocyte Proliferation after Myocardial Ischemia
            Reperfusion Injury through the Hippo-YAP Pathway
  JOURNAL   Dis Markers 2021, 5089872 (2021)
   PUBMED   34868394
  REMARK    GeneRIF: RRM2 Improves Cardiomyocyte Proliferation after Myocardial
            Ischemia Reperfusion Injury through the Hippo-YAP Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2538)
  AUTHORS   Yu,C., Ji,S.Y., Dang,Y.J., Sha,Q.Q., Yuan,Y.F., Zhou,J.J.,
            Yan,L.Y., Qiao,J., Tang,F. and Fan,H.Y.
  TITLE     Oocyte-expressed yes-associated protein is a key activator of the
            early zygotic genome in mouse
  JOURNAL   Cell Res 26 (3), 275-287 (2016)
   PUBMED   26902285
REFERENCE   3  (bases 1 to 2538)
  AUTHORS   Korte,F.S., Dai,J., Buckley,K., Feest,E.R., Adamek,N., Geeves,M.A.,
            Murry,C.E. and Regnier,M.
  TITLE     Upregulation of cardiomyocyte ribonucleotide reductase increases
            intracellular 2 deoxy-ATP, contractility, and relaxation
  JOURNAL   J Mol Cell Cardiol 51 (6), 894-901 (2011)
   PUBMED   21925507
  REMARK    GeneRIF: overexpression of the ribonucleotide reductase (Rrm1 and
            Rrm2) complex would increase contractility of adult rat
            cardiomyocytes.
REFERENCE   4  (bases 1 to 2538)
  AUTHORS   Lu,Y., Liu,P., Wen,W., Grubbs,C.J., Townsend,R.R., Malone,J.P.,
            Lubet,R.A. and You,M.
  TITLE     Cross-species comparison of orthologous gene expression in human
            bladder cancer and carcinogen-induced rodent models
  JOURNAL   Am J Transl Res 3 (1), 8-27 (2010)
   PUBMED   21139803
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2538)
  AUTHORS   Fan,H., Villegas,C. and Wright,J.A.
  TITLE     A link between ferritin gene expression and ribonucleotide
            reductase R2 protein, as demonstrated by retroviral vector mediated
            stable expression of R2 cDNA
  JOURNAL   FEBS Lett 382 (1-2), 145-148 (1996)
   PUBMED   8612737
REFERENCE   6  (bases 1 to 2538)
  AUTHORS   Saeki,T., Takahashi,T., Okabe,M., Furuya,A., Hanai,N., Yamagami,K.,
            Mandai,K., Moriwaki,S., Doihara,H., Takashima,S. and Salomon,D.
  TITLE     Immunohistochemical detection of ribonucleotide reductase in human
            breast-tumors
  JOURNAL   Int J Oncol 6 (3), 523-529 (1995)
   PUBMED   21556566
REFERENCE   7  (bases 1 to 2538)
  AUTHORS   Lycksell,P.O., Ingemarson,R., Davis,R., Graslund,A. and
            Thelander,L.
  TITLE     1H NMR studies of mouse ribonucleotide reductase: the R2 protein
            carboxyl-terminal tail, essential for subunit interaction, is
            highly flexible but becomes rigid in the presence of protein R1
  JOURNAL   Biochemistry 33 (10), 2838-2842 (1994)
   PUBMED   8130196
REFERENCE   8  (bases 1 to 2538)
  AUTHORS   Sikorska,M., Brewer,L.M., Youdale,T., Richards,R., Whitfield,J.F.,
            Houghten,R.A. and Walker,P.R.
  TITLE     Evidence that mammalian ribonucleotide reductase is a nuclear
            membrane associated glycoprotein
  JOURNAL   Biochem Cell Biol 68 (5), 880-888 (1990)
   PUBMED   2205248
REFERENCE   9  (bases 1 to 2538)
  AUTHORS   Thelander,M. and Thelander,L.
  TITLE     Molecular cloning and expression of the functional gene encoding
            the M2 subunit of mouse ribonucleotide reductase: a new dominant
            marker gene
  JOURNAL   EMBO J 8 (9), 2475-2479 (1989)
   PUBMED   2684652
REFERENCE   10 (bases 1 to 2538)
  AUTHORS   Youdale,T., Frappier,L., Whitfield,J.F. and Rixon,R.H.
  TITLE     Changes in the cytoplasmic and nuclear activities of the
            ribonucleotide reductase holoenzyme and its subunits in
            regenerating liver cells in normal and thyroparathyroidectomized
            rats
  JOURNAL   Can J Biochem Cell Biol 62 (9), 914-919 (1984)
   PUBMED   6388757
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000164.1.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by
            NM_001025740.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001025740.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099082.1, SRR8487230.20177.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               JACYVU010000164.1  17628732-17628881
            151-225             JACYVU010000164.1  17628985-17629059
            226-372             JACYVU010000164.1  17629342-17629488
            373-489             JACYVU010000164.1  17629778-17629894
            490-623             JACYVU010000164.1  17630754-17630887
            624-718             JACYVU010000164.1  17631536-17631630
            719-852             JACYVU010000164.1  17631752-17631885
            853-1071            JACYVU010000164.1  17633149-17633367
            1072-2538           JACYVU010000164.1  17633471-17634937
FEATURES             Location/Qualifiers
     source          1..2538
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..2538
                     /gene="Rrm2"
                     /note="ribonucleotide reductase regulatory subunit M2"
                     /db_xref="GeneID:362720"
                     /db_xref="RGD:1598310"
     exon            1..150
                     /gene="Rrm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1224
                     /gene="Rrm2"
                     /EC_number="1.17.4.1"
                     /note="ribonucleotide reductase small chain;
                     ribonucleotide reductase small subunit; Ribonucleotide
                     reductase 2; ribonucleotide reductase M2 polypeptide"
                     /codon_start=1
                     /product="ribonucleoside-diphosphate reductase subunit M2"
                     /protein_id="NP_001020911.1"
                     /db_xref="GeneID:362720"
                     /db_xref="RGD:1598310"
                     /translation="MLSVRAPLATIADQQQLHLSPLKRLSLADKENTPPTLSSARVLA
                     SKAARRIFQDSAELESKAPTKPSIEEEPLLRENPRRFVVFPIEYHDIWQMYKKAEASF
                     WTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEAR
                     CFYGFQIAMENIHSEMYSLLIDTYIKDSKEREYLFNAIETMPCVKKKADWALRWIGDK
                     EATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACL
                     MFKHLVHKPSEQRVKEIITNSVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLML
                     ELGFNKIFKVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSNSTENSFTLDADF"
     exon            151..225
                     /gene="Rrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            226..372
                     /gene="Rrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            373..489
                     /gene="Rrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            490..623
                     /gene="Rrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            624..718
                     /gene="Rrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..852
                     /gene="Rrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1071
                     /gene="Rrm2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..2538
                     /gene="Rrm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccagctgtt ccctcttctc ctcgtcctct ccacctctgc cttcgttcgc catgctctcg
       61 gtccgcgccc cgctcgccac catcgctgac cagcagcagc tgcacttgtc gcccctgaag
      121 cgactcagtc tggctgacaa ggagaacacg cccccaaccc tcagcagcgc ccgcgtcctg
      181 gctagcaagg ctgcaaggag aatcttccag gactctgccg agctggaaag taaagcaccc
      241 actaagccca gcattgagga agagccgtta ctgagagaaa atccccgccg tttcgttgtc
      301 tttcccatcg aataccatga tatctggcag atgtacaaga aagctgaggc ctccttttgg
      361 actgccgagg aggtggacct ttccaaggat attcagcact gggaagctct gaaaccagat
      421 gagagacatt ttatatctca tgttctggcc ttctttgcgg cgagtgacgg catagtcaat
      481 gagaacttgg tggagcgatt tagccaagaa gttcaagtca cagaggcccg ctgtttctat
      541 ggcttccaaa ttgccatgga gaacatacac tccgaaatgt acagtctcct tattgacact
      601 tacattaaag attccaaaga aagagaatat ctcttcaacg ccattgagac aatgccttgt
      661 gtgaagaaga aggctgactg ggccttgcgt tggattgggg acaaagaggc tacgtatgga
      721 gaacgagttg tggccttcgc tgcggtagaa ggaatcttct tttctggttc ttttgcatca
      781 atattctggc tcaagaaacg gggactgatg ccgggcctta cattttccaa tgagcttatt
      841 agcagagatg agggtctgca ctgtgacttt gcctgcctga tgttcaagca cctggtacac
      901 aagccctcgg agcagagagt aaaagaaata attaccaact cggtcaggat agagcaggag
      961 ttcctcacag aggccctgcc tgtgaagctc atcgggatga attgcacctt gatgaagcag
     1021 tacatcgagt ttgtggccga caggcttatg ctggagctgg gttttaacaa gattttcaaa
     1081 gtagaaaatc catttgactt catggagaat atttcactag aaggaaaaac aaacttcttt
     1141 gagaagcgag taggcgagta ccagaggatg ggagtaatgt caaattcgac agaaaattct
     1201 ttcaccttgg atgctgactt ctaagcaacc gatccgtgtg ctctttgctg attattctcc
     1261 ccttgtcatt aaaagaaatc agcaaaacca aacaactggc tacaccacga attgtcgtta
     1321 aatttgctaa ctggtgtcta aaagccgtgt agctacctcg gtcctgcttg ctaggtttgc
     1381 cactagaagg aagcatactt aaaacaatgg ctacttggat cctcagggag atcctgtctg
     1441 caagtcgcgt ggtcaccctt agcttcatca aagcactaac agctcacccg gccaggcttc
     1501 atgagcactg accctcaagc aagcaggttt attaaacatt tagatgccaa cctcacttac
     1561 tgtttcctgc agtcatggag agtttactta acaagtttgt aaataataaa actggcactt
     1621 tgcacacaga cttggtacta tcctagggga aggcctgctt tatttggttt ctagaccgag
     1681 taggaagtga tccatttacc actgagggca gccccattca gagtcttaag tgactaagcc
     1741 agtgttgaac aagcaatttc caggctttgt tcttcaggga acttcccatc agctttgaag
     1801 tcggtcctgt gcaccctagg cacatggatc agttcacaag tggggttcag tggagagaac
     1861 ttccccctca gaagtcactt gaaacttaga tgagatttgg gacacttgct ggttgactct
     1921 gtctcatttg tgtaaaaagt agtttttttt tttttttttt ttccaagtta tactttgtcc
     1981 cattcctagt tagtacaaag tcttgaaagg gcctttgtag ggctttttaa gtcagggtct
     2041 taactatgta actctggctt ggcctggaac ttgctatgta gaccaggtta ccctcaaact
     2101 tgcctgtctt cccaaatact gggattaagg tttctgtgac catacctggc tttacctgat
     2161 taattcctaa acaccagaaa accagtactg tatgagatgt taatgtgtgt tcctttcaga
     2221 ctggagtaca gaccagtaga taacagataa cagctggttc accttaatct gcctttttgt
     2281 gtattaatct gtgtttagag aacggaacaa tagccagaat tcacctagcg agttcgaggc
     2341 cagttggtgt atatgtggga ctcttaacca aaacagcaag cgttccctgg ggtagttcac
     2401 aatgatctcc agcttccttg ttaaccagat aactgcaagt cagatgtatg accctggttg
     2461 gtttattgta ttgatatgtt tctgtaatat gagtaaatta ttgttactta aaagtaataa
     2521 attcaagttt caaaattg
//
