LOCUS       NM_001013236            3038 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus ribonucleotide reductase catalytic subunit M1
            (Rrm1), mRNA.
ACCESSION   NM_001013236
VERSION     NM_001013236.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3038)
  AUTHORS   Korte FS, Dai J, Buckley K, Feest ER, Adamek N, Geeves MA, Murry CE
            and Regnier M.
  TITLE     Upregulation of cardiomyocyte ribonucleotide reductase increases
            intracellular 2 deoxy-ATP, contractility, and relaxation
  JOURNAL   J Mol Cell Cardiol 51 (6), 894-901 (2011)
   PUBMED   21925507
  REMARK    GeneRIF: overexpression of the ribonucleotide reductase (Rrm1 and
            Rrm2) complex would increase contractility of adult rat
            cardiomyocytes
REFERENCE   2  (bases 1 to 3038)
  AUTHORS   Fairman JW, Wijerathna SR, Ahmad MF, Xu H, Nakano R, Jha S,
            Prendergast J, Welin RM, Flodin S, Roos A, Nordlund P, Li Z, Walz T
            and Dealwis CG.
  TITLE     Structural basis for allosteric regulation of human ribonucleotide
            reductase by nucleotide-induced oligomerization
  JOURNAL   Nat Struct Mol Biol 18 (3), 316-322 (2011)
   PUBMED   21336276
REFERENCE   3  (bases 1 to 3038)
  AUTHORS   Daino K, Ugolin N, Altmeyer-Morel S, Guilly MN and Chevillard S.
  TITLE     Gene expression profiling of alpha-radiation-induced rat
            osteosarcomas: identification of dysregulated genes involved in
            radiation-induced tumorigenesis of bone
  JOURNAL   Int J Cancer 125 (3), 612-620 (2009)
   PUBMED   19444910
REFERENCE   4  (bases 1 to 3038)
  AUTHORS   Zahedi Avval F and Holmgren A.
  TITLE     Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen
            donors for Mammalian s phase ribonucleotide reductase
  JOURNAL   J Biol Chem 284 (13), 8233-8240 (2009)
   PUBMED   19176520
REFERENCE   5  (bases 1 to 3038)
  AUTHORS   Boukovinas I, Papadaki C, Mendez P, Taron M, Mavroudis D,
            Koutsopoulos A, Sanchez-Ronco M, Sanchez JJ, Trypaki M,
            Staphopoulos E, Georgoulias V, Rosell R and Souglakos J.
  TITLE     Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical
            response to first-line gemcitabine plus docetaxel in non-small-cell
            lung cancer patients
  JOURNAL   PLoS One 3 (11), e3695 (2008)
   PUBMED   19002265
REFERENCE   6  (bases 1 to 3038)
  AUTHORS   Lycksell PO, Ingemarson R, Davis R, Graslund A and Thelander L.
  TITLE     1H NMR studies of mouse ribonucleotide reductase: the R2 protein
            carboxyl-terminal tail, essential for subunit interaction, is
            highly flexible but becomes rigid in the presence of protein R1
  JOURNAL   Biochemistry 33 (10), 2838-2842 (1994)
   PUBMED   8130196
REFERENCE   7  (bases 1 to 3038)
  AUTHORS   Sikorska M, Brewer LM, Youdale T, Richards R, Whitfield JF,
            Houghten RA and Walker PR.
  TITLE     Evidence that mammalian ribonucleotide reductase is a nuclear
            membrane associated glycoprotein
  JOURNAL   Biochem Cell Biol 68 (5), 880-888 (1990)
   PUBMED   2205248
REFERENCE   8  (bases 1 to 3038)
  AUTHORS   Hansson HA, Billig H and Isgaard J.
  TITLE     Insulin-like growth factor I in the developing and mature rat
            testis: immunohistochemical aspects
  JOURNAL   Biol Reprod 40 (6), 1321-1328 (1989)
   PUBMED   2775821
REFERENCE   9  (bases 1 to 3038)
  AUTHORS   Hansson HA, Holmgren A, Norstedt G and Rozell B.
  TITLE     Changes in the distribution of insulin-like growth factor I,
            thioredoxin, thioredoxin reductase and ribonucleotide reductase
            during the development of the retina
  JOURNAL   Exp Eye Res 48 (3), 411-420 (1989)
   PUBMED   2647502
REFERENCE   10 (bases 1 to 3038)
  AUTHORS   Youdale,T., Frappier,L., Whitfield,J.F. and Rixon,R.H.
  TITLE     Changes in the cytoplasmic and nuclear activities of the
            ribonucleotide reductase holoenzyme and its subunits in
            regenerating liver cells in normal and thyroparathyroidectomized
            rats
  JOURNAL   Can J Biochem Cell Biol 62 (9), 914-919 (1984)
   PUBMED   6388757
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085906.1.
            
            On Apr 20, 2005 this sequence version replaced XM_344927.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085906.1, SRR8487227.51542.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3038
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3038
                     /gene="Rrm1"
                     /note="ribonucleotide reductase catalytic subunit M1"
                     /db_xref="GeneID:685579"
                     /db_xref="RGD:1592569"
     exon            1..224
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..2584
                     /gene="Rrm1"
                     /EC_number="1.17.4.1"
                     /note="ribonucleotide reductase M1"
                     /codon_start=1
                     /product="ribonucleoside-diphosphate reductase large
                     subunit"
                     /protein_id="NP_001013254.1"
                     /db_xref="GeneID:685579"
                     /db_xref="RGD:1592569"
                     /translation="MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVI
                     QGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLY
                     NYINPHNGRHSPMVASSTLEIVMAHKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKIN
                     GKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSC
                     FLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPML
                     RVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWI
                     PDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLWYA
                     IIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLA
                     LNMYVTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGL
                     ADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCDLAKEYGPYETYEGSPVSKGIL
                     QYDMWNVTPTDLWDWKLLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNI
                     YTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPEDLKQLYKT
                     VWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLR
                     TRPAANPIQFTLNKEKLKDKEKALKEEEEKERNTAAMVCSLENREECLMCGS"
     exon            225..313
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            314..491
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..592
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..652
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..692
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..855
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..997
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1081
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1243
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1323
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1525
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1675
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1897
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..1974
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2110
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2206
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2395
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2396..3011
                     /gene="Rrm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggtggcgg gagcgggaag gagttcgtaa tttggttcgt cccttctgga ggagaaagtg
       61 ctgtctgtcc ggcagtttca acctctcggt ctgagcggcc cctaaggagt ccaacccttc
      121 acatctgaca gtcgtctcta tcctatcttc gcctcggagc tgctaactgg tctcgaaccc
      181 ctcagcactt cagcttctag cggcgatgca tgtgatcaag cgagatggcc gccaagagcg
      241 agttatgttt gacaaaatta catcccgaat ccagaaactc tgttatggac tcaatatgga
      301 ctttgtggat cctgctcaga tcaccatgaa agtaatccaa ggcctataca gtggggtcac
      361 cacagtggaa ctggacaccc tggctgctga gacagctgcc accttgacta cgaagcaccc
      421 tgactatgcc atcctggcag caaggatcgc tgtctctaac ttgcacaagg aaacaaagaa
      481 agtgttcagt gacgtgatgg aggatctcta caactacata aatccacaca acggcagaca
      541 ttctcccatg gtggccagct caacactcga gattgttatg gcccataagg atcgcctgaa
      601 ttctgccatt atctatgacc gggatttctc ttacaactac tttggtttta agacactgga
      661 acggtcatat ttgttgaaga tcaatggaaa agtggctgaa agaccacagc acatgttgat
      721 gagggtatct gtggggattc acaaagaaga tattgatgct gcaattgaaa catacaatct
      781 actttctgag aagtggttta ctcacgcctc tccgactctc ttcaatgctg ggaccaaccg
      841 cccacagttg tccagctgtt tcctcttgag tatgaaagat gacagcattg aggggattta
      901 tgatactctg aagcagtgtg ccttgatttc taagtctgct ggaggaattg gtgttgccgt
      961 gagttgtatt cgggccactg gcagctacat tgctgggact aatggcaatt ctaatggcct
     1021 tgtgccaatg ctgagagtct ataacaacac agctcgttat gtggatcaag gtggaaacaa
     1081 gcgcccaggg gcatttgcta tttacctgga gccttggcac ctggacatct ttgagtttct
     1141 tgacttgaag aagaacacag gcaaggaaga acagcgcgcg cgggatctct tctttgcact
     1201 gtggatccca gatctcttca tgaagcgagt ggagaccaac caggactggt cactgatgtg
     1261 tcccaatgag tgtcctggtc tggacgaggt ctggggagag gagtttgaga agttatatga
     1321 aagttacgag aagcagggcc gtgtccgaaa agttgtgaag gctcagcagc tttggtacgc
     1381 catcattgag tctcagacgg agacgggcac cccatacatg ctctacaaag actcctgtaa
     1441 ccggaagagc aaccagcaga acctgggaac catcaagtgc agcaacctgt gcacagagat
     1501 agtagagtac accagtaaag atgaggttgc ggtttgtaac ttggcttctc tggctctgaa
     1561 catgtatgtc acaccagaac acacgtatga ctttgagaaa ctggcagaag tcactaaagt
     1621 cattgtccga aatctgaata aaataattga tataaactac tatcctattc cagaggcaca
     1681 cttatcaaat aaacgccatc ggcccattgg aattggggta caaggtctag cagatgcttt
     1741 catcctgatg aggtatccct ttgagagccc agaagcccag ctactaaata agcaaatctt
     1801 tgaaaccatc tattatggag ccctggaagc cagctgtgac ctagccaagg agtatggccc
     1861 ctacgaaacg tatgagggat ctccagtcag caagggtatt cttcagtatg atatgtggaa
     1921 tgttactcct acagacctgt gggactggaa gcttctcaag gagaagattg caaagtacgg
     1981 tataagaaac agtttactta ttgccccaat gcctactgct tcaactgctc agattctggg
     2041 gaataatgag tccattgagc cttacaccag taacatctac actcgcagag tcttgtcagg
     2101 agaatttcag attgtgaatc ctcacttact gaaagatctt actgagcggg gcttgtggaa
     2161 tgaagagatg aaaaatcaga ttattgcctg caatggctcc attcagagca taccagaaat
     2221 tcctgaggac ctgaagcagc tctataagac cgtgtgggaa atctctcaga agactgttct
     2281 caagatggca gccgagagag gtgctttcat cgatcaaagc cagtctttaa acatccatat
     2341 cgctgagccc aactatggca aactcactag tatgcacttc tacggttgga agcagggttt
     2401 aaagactggg atgtattatt taaggacaag acctgccgct aatccaatcc agttcactct
     2461 gaacaaggaa aagctgaaag ataaggaaaa ggcactgaag gaggaagaag agaaggagag
     2521 gaacacagca gccatggtgt gctctttgga gaacagagag gagtgtctga tgtgtggatc
     2581 ctgagacaag gcctagaaga gccagcgtct ttccgccata gcagaccatg tgacatagat
     2641 aggcatagtg ggtttgcttg attaagggaa agctttgccg gacatttctg ccaggagaag
     2701 aatccttgat ttgcagtact gtttctctat agtgtaaagg tcattttaaa caaaacaaaa
     2761 aaccaaagcc agctttgata ttaggaatca aagtacaggt tttgggaatg cagaagagcc
     2821 ttcctggaaa tagtgatgtt gtttaggaag tctcttctcc ctccagcttt ccctgtctga
     2881 ctgtctcagt ttgggcaaag agctttagtt cgctttgacc gatggcctag aagtaaaatc
     2941 aagcaataag tcaccagctg gagatctaga caaacttcca tagttgtttt gaaataaaaa
     3001 tttctaagtg aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
