LOCUS       NM_001108481             950 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus RAS related (Rras), mRNA.
ACCESSION   NM_001108481 XM_001080661 XM_341851
VERSION     NM_001108481.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 950)
  AUTHORS   Flex,E., Jaiswal,M., Pantaleoni,F., Martinelli,S., Strullu,M.,
            Fansa,E.K., Caye,A., De Luca,A., Lepri,F., Dvorsky,R., Pannone,L.,
            Paolacci,S., Zhang,S.C., Fodale,V., Bocchinfuso,G., Rossi,C.,
            Burkitt-Wright,E.M., Farrotti,A., Stellacci,E., Cecchetti,S.,
            Ferese,R., Bottero,L., Castro,S., Fenneteau,O., Brethon,B.,
            Sanchez,M., Roberts,A.E., Yntema,H.G., Van Der Burgt,I., Cianci,P.,
            Bondeson,M.L., Cristina Digilio,M., Zampino,G., Kerr,B., Aoki,Y.,
            Loh,M.L., Palleschi,A., Di Schiavi,E., Care,A., Selicorni,A.,
            Dallapiccola,B., Cirstea,I.C., Stella,L., Zenker,M., Gelb,B.D.,
            Cave,H., Ahmadian,M.R. and Tartaglia,M.
  TITLE     Activating mutations in RRAS underlie a phenotype within the
            RASopathy spectrum and contribute to leukaemogenesis
  JOURNAL   Hum Mol Genet 23 (16), 4315-4327 (2014)
   PUBMED   24705357
REFERENCE   2  (bases 1 to 950)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
REFERENCE   3  (bases 1 to 950)
  AUTHORS   Sandri,C., Caccavari,F., Valdembri,D., Camillo,C., Veltel,S.,
            Santambrogio,M., Lanzetti,L., Bussolino,F., Ivaska,J. and Serini,G.
  TITLE     The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and
            morphogenesis via active integrin endocytosis and Rac signaling
  JOURNAL   Cell Res 22 (10), 1479-1501 (2012)
   PUBMED   22825554
REFERENCE   4  (bases 1 to 950)
  AUTHORS   Wilson,L.S., Baillie,G.S., Pritchard,L.M., Umana,B., Terrin,A.,
            Zaccolo,M., Houslay,M.D. and Maurice,D.H.
  TITLE     A phosphodiesterase 3B-based signaling complex integrates exchange
            protein activated by cAMP 1 and phosphatidylinositol 3-kinase
            signals in human arterial endothelial cells
  JOURNAL   J Biol Chem 286 (18), 16285-16296 (2011)
   PUBMED   21393242
REFERENCE   5  (bases 1 to 950)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 950)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 950)
  AUTHORS   Willard,F.S., Willard,M.D., Kimple,A.J., Soundararajan,M.,
            Oestreich,E.A., Li,X., Sowa,N.A., Kimple,R.J., Doyle,D.A.,
            Der,C.J., Zylka,M.J., Snider,W.D. and Siderovski,D.P.
  TITLE     Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras
            effector
  JOURNAL   PLoS One 4 (3), e4884 (2009)
   PUBMED   19319189
REFERENCE   8  (bases 1 to 950)
  AUTHORS   Carta,C., Pantaleoni,F., Bocchinfuso,G., Stella,L., Vasta,I.,
            Sarkozy,A., Digilio,C., Palleschi,A., Pizzuti,A., Grammatico,P.,
            Zampino,G., Dallapiccola,B., Gelb,B.D. and Tartaglia,M.
  TITLE     Germline missense mutations affecting KRAS Isoform B are associated
            with a severe Noonan syndrome phenotype
  JOURNAL   Am J Hum Genet 79 (1), 129-135 (2006)
   PUBMED   16773572
REFERENCE   9  (bases 1 to 950)
  AUTHORS   Oinuma,I., Ishikawa,Y., Katoh,H. and Negishi,M.
  TITLE     The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein
            for R-Ras
  JOURNAL   Science 305 (5685), 862-865 (2004)
   PUBMED   15297673
  REMARK    GeneRIF: Plexin-B1 mediates Sema4D-induced repulsive axon guidance
            signaling by acting as a GTPase activating protein for R-Ras
REFERENCE   10 (bases 1 to 950)
  AUTHORS   Huang,Y., Rangwala,F., Fulkerson,P.C., Ling,B., Reed,E., Cox,A.D.,
            Kamholz,J. and Ratner,N.
  TITLE     Role of TC21/R-Ras2 in enhanced migration of
            neurofibromin-deficient Schwann cells
  JOURNAL   Oncogene 23 (2), 368-378 (2004)
   PUBMED   14724565
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473979.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341851.3, XM_001080661.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ211166.1, BG662693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..950
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..950
                     /gene="Rras"
                     /gene_synonym="p23"
                     /note="RAS related"
                     /db_xref="GeneID:361568"
                     /db_xref="RGD:1311443"
     exon            1..164
                     /gene="Rras"
                     /gene_synonym="p23"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..668
                     /gene="Rras"
                     /gene_synonym="p23"
                     /EC_number="3.6.5.2"
                     /note="Harvey rat sarcoma oncogene, subgroup R;
                     Ras-related protein R-RAS (P23); Harvey rat sarcoma virus
                     oncogene, subgroup R; related RAS viral (r-ras) oncogene
                     homolog; RAS-related viral oncoprotein"
                     /codon_start=1
                     /product="ras-related protein R-Ras"
                     /protein_id="NP_001101951.1"
                     /db_xref="GeneID:361568"
                     /db_xref="RGD:1311443"
                     /translation="MSSGAASGTGRGRPRGGGPGPRDPPPGETHKLVVVGGGGVGKSA
                     LTIQFIQSYFVSDYDPTIEDSYTKICTVDGIPARLDILDTAGQEEFGAMREQYMRAGN
                     GFLLVFAINDRQSFIEVSKLFTQILRVKDRDDFPIVLVGNKADLETQRQVLRSEASSF
                     SASHHMTYFEASAKLRLNVDEAFEQLVRTVRKYQEQELPPSPPSAPRKKDGRCPCVLL
                     "
     exon            165..252
                     /gene="Rras"
                     /gene_synonym="p23"
                     /inference="alignment:Splign:2.1.0"
     exon            253..355
                     /gene="Rras"
                     /gene_synonym="p23"
                     /inference="alignment:Splign:2.1.0"
     exon            356..464
                     /gene="Rras"
                     /gene_synonym="p23"
                     /inference="alignment:Splign:2.1.0"
     exon            465..583
                     /gene="Rras"
                     /gene_synonym="p23"
                     /inference="alignment:Splign:2.1.0"
     exon            584..950
                     /gene="Rras"
                     /gene_synonym="p23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggtggcga catgagcagc ggggcggcgt ccgggactgg gcgggggcgg ccccggggcg
       61 gggggccggg acccagggac cccccgcccg gcgagactca caagctggtg gtcgtaggcg
      121 gcggcggcgt gggcaagagc gcgctgacca tccagttcat ccagtcctac tttgtgtctg
      181 actatgaccc caccattgag gattcctaca caaagatctg cacggtggac ggcatccctg
      241 cacggctgga catcctggac actgcggggc aagaggaatt cggcgccatg cgggagcagt
      301 acatgcgtgc tggcaatggc ttcttgctgg tgtttgccat taacgacagg cagagtttca
      361 ttgaagtaag caagctcttc actcagatcc tcagggtcaa ggaccgcgat gacttcccca
      421 ttgtgctggt tgggaacaag gcagatctgg agacacagcg ccaggtcctt cgatcagagg
      481 cctcctcctt tagtgcttcc caccatatga cttactttga ggcctcagcc aaactgcgtc
      541 taaatgtcga tgaggcattt gagcagctgg tgcggactgt ccggaaatac caggagcaag
      601 aactccctcc tagcccaccc agtgccccta ggaagaagga tgggaggtgc ccctgtgtcc
      661 tgctgtagcc tcaagtgacc agcacaagct ctcgggacca gctgcctcac acttgctgtg
      721 tggcccaagg ctctctctga ctgagcctct gtttcaacct ctgggttccc caggacacac
      781 tacaccctct tacctttact tctggcctcc tggggctacc accatgtgcc ttctgtcaat
      841 acctcctcct ttcccccaca agaccctggt agggtgaggg gcatcttgtc actgctgtat
      901 ataactccca tctgtcagta taataaatat cactgccaac aactgaagac
//
