LOCUS       NM_001048184            2548 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus Ras-related GTP binding C (Rragc), mRNA.
ACCESSION   NM_001048184 XM_001055506 XM_216515
VERSION     NM_001048184.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2548)
  AUTHORS   Larsen M, Kress W, Schoser B, Hehr U, Muller CR and Rost S.
  TITLE     Identification of variants in MBNL1 in patients with a myotonic
            dystrophy-like phenotype
  JOURNAL   Eur J Hum Genet 24 (10), 1467-1472 (2016)
   PUBMED   27222292
REFERENCE   2  (bases 1 to 2548)
  AUTHORS   Bar-Peled L and Sabatini DM.
  TITLE     Regulation of mTORC1 by amino acids
  JOURNAL   Trends Cell Biol 24 (7), 400-406 (2014)
   PUBMED   24698685
  REMARK    Review article
REFERENCE   3  (bases 1 to 2548)
  AUTHORS   Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA,
            Grabiner BC, Spear ED, Carter SL, Meyerson M and Sabatini DM.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   4  (bases 1 to 2548)
  AUTHORS   Han JM, Jeong SJ, Park MC, Kim G, Kwon NH, Kim HK, Ha SH, Ryu SH
            and Kim S.
  TITLE     Leucyl-tRNA synthetase is an intracellular leucine sensor for the
            mTORC1-signaling pathway
  JOURNAL   Cell 149 (2), 410-424 (2012)
   PUBMED   22424946
REFERENCE   5  (bases 1 to 2548)
  AUTHORS   Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S and Sabatini
            DM.
  TITLE     Ragulator-Rag complex targets mTORC1 to the lysosomal surface and
            is necessary for its activation by amino acids
  JOURNAL   Cell 141 (2), 290-303 (2010)
   PUBMED   20381137
REFERENCE   6  (bases 1 to 2548)
  AUTHORS   Ma XM and Blenis J.
  TITLE     Molecular mechanisms of mTOR-mediated translational control
  JOURNAL   Nat Rev Mol Cell Biol 10 (5), 307-318 (2009)
   PUBMED   19339977
  REMARK    Review article
REFERENCE   7  (bases 1 to 2548)
  AUTHORS   Sekiguchi T, Hirose E, Nakashima N, Ii M and Nishimoto T.
  TITLE     Novel G proteins, Rag C and Rag D, interact with GTP-binding
            proteins, Rag A and Rag B
  JOURNAL   J Biol Chem 276 (10), 7246-7257 (2001)
   PUBMED   11073942
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105622.1.
            
            On or before Sep 17, 2006 this sequence version replaced
            XM_216515.4, XM_001055506.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2548
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2548
                     /gene="Rragc"
                     /note="Ras-related GTP binding C"
                     /db_xref="GeneID:298514"
                     /db_xref="RGD:1311760"
     exon            1..277
                     /gene="Rragc"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1240
                     /gene="Rragc"
                     /codon_start=1
                     /product="ras-related GTP-binding protein C"
                     /protein_id="NP_001041649.1"
                     /db_xref="GeneID:298514"
                     /db_xref="RGD:1311760"
                     /translation="MSLQYGAEETPLAGSYGAADSFPKDFGYGVEEEEEEAAAGGGGG
                     AGAGGGCGPGGGDSSKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKIYKDD
                     ISNSSFVNFQIWDFPGQMDFFDPTFDYEMIFRGTGALIYVIDAQDDYMEALTRLHITV
                     SKAYKVNPDMNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKLHLSFYLTS
                     IYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSSPV
                     DMQSYELCCDMIDVVIDVSCIYGLKEDGSGSAYDKESMAIIKLNNTTVLYLKEVTKFL
                     ALVCILREESFERKGLIDYNFHCFRKAIHEVFEVGVTSHRSCSHQTSAPSLKALAHNG
                     TPRNAI"
     exon            278..481
                     /gene="Rragc"
                     /inference="alignment:Splign:2.1.0"
     exon            482..681
                     /gene="Rragc"
                     /inference="alignment:Splign:2.1.0"
     exon            682..796
                     /gene="Rragc"
                     /inference="alignment:Splign:2.1.0"
     exon            797..939
                     /gene="Rragc"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1088
                     /gene="Rragc"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..2526
                     /gene="Rragc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggcctggc ctgtcagggc gcgggcggtg gtggtccagc accatgtccc tgcaatacgg
       61 ggcggaggag acgcccctgg ccggcagtta cggcgcagcc gactcattcc ccaaggactt
      121 cggctacggc gtggaggagg aggaagaaga ggcagcggcg ggtggcggcg gaggcgcggg
      181 ggccggcggc ggctgcggcc cgggaggcgg tgacagctcc aagccaagga tcttgcttat
      241 gggactacgg cgcagcggca agtcctccat tcagaaggtg gtgtttcata agatgtcacc
      301 caatgagact ctctttttgg aaagtaccaa caagatttat aaagatgaca tttccaacag
      361 ctcctttgtc aacttccaga tttgggattt tcctgggcag atggacttct tcgacccaac
      421 ctttgactat gaaatgatct tcagggggac aggagcattg atatatgtca ttgatgcaca
      481 ggatgactac atggaggctt taactcgact tcacatcact gtatctaagg cctacaaagt
      541 gaacccagac atgaactttg aggtttttat tcacaaagtt gatggtctgt ctgatgatca
      601 caagatagaa acacagaggg acattcatca aagggccaat gatgacctgg cagatgctgg
      661 gctggaaaag ctccatctta gcttttattt gactagcatc tatgaccact caatatttga
      721 agctttcagt aaggtggtac agaaactcat cccgcaactg cccactttgg aaaacctatt
      781 aaatatcttt atatcaaatt caggtattga aaaagctttt ctctttgatg ttgtcagcaa
      841 aatctacatt gcaacagaca gctcccctgt ggatatgcag tcttacgagc tctgctgtga
      901 catgattgat gttgtaattg atgtgtcctg tatatatgga ttaaaggaag atggaagtgg
      961 aagtgcttat gacaaagaat cgatggccat tatcaagctg aacaatacaa ctgtccttta
     1021 tttaaaggaa gtcactaaat ttttggcact ggtttgcatt cttagggaag agagctttga
     1081 acgaaaaggt ttgatagact acaacttcca ctgtttccga aaagctatcc atgaggtgtt
     1141 tgaggtgggt gtgacttctc acagaagctg tagtcatcag accagtgctc caagcctgaa
     1201 agccttggca cacaatggca cacctcggaa tgccatctag tctgaatctc agcagtggag
     1261 gctcagtgct ggcttactcc tcactccagg gtcagacgcc atgtgctgca ggactcgaga
     1321 gccgctgccc atgggagttg gagacgatgg tggagcttct ctcttgatga aggcccctca
     1381 gccagccatg tgcaactgaa gctactctct aaataacatc gcaaaagaat ggcagagacc
     1441 ccagaactcg gtgtgtcttt tcttctcttt cgagtcctac tttaaatagt tggactattt
     1501 tggacctgga catgatacca gttatccatc tttaccggtg aatgtcgctg tcagttccag
     1561 cctgaaacag taggaaactg agttttatat gcttccctag gccttcactt gagtagtgtc
     1621 taaagactcg ctttgcttac gttctaacac tgcctttcag agctcagatc tcactgtacc
     1681 tctaggacct cgaaagtgca ttagcttgct gactcagaag acaaagcaaa ggatgtttct
     1741 atttgtcctg aagaaaagag gaagtttctg tgcggcactg gggagagcca ggctcggcaa
     1801 gggctgcatc agttccctgg atgtgttgag gaaaaaactt tgaaacagaa gtgatttttc
     1861 acacctgggg tttgggtagc agatggatgt actctcctca tttgatcttg atcatgcaca
     1921 atgtaacaaa gggaattcga cagaagggct ttccccagag tccccacagt gagggggcaa
     1981 actcattatg tcactgaagt acttcgctca cttttcttta gtcctggtgc catggctgtc
     2041 actctatgct gtgtaggctc tttaagaatt gtttttgacc acagatgacc ctgaggctct
     2101 ggcagactgt ctgtcctctg ggggttggag gaggcctgtg gtggtacagc gtgctctgca
     2161 gtcttctgac accaagtgtc agctgtggta ctttgctttg ctgaggtatg aattcatagc
     2221 tgttcctgtt gttcatggct gatacccttt ccccgttgat ttaggctttc acattttctt
     2281 tactacacat gcccagtagt cacattccaa agccactggg ccccttgagt gcgtcagtgc
     2341 cgctggtgag ggatgtactc aggtctgtta cccagcagtg agacttggag cacttcctgc
     2401 agatgactga ctgttgagta tttacttgga ccacggtgat agccaaagga aaaatgcttt
     2461 tatatttata gattatttca ttgaactata tgtaaaatgg gtatcaataa atgtatttac
     2521 tccaaaaaaa aaaaaaaaaa aaaaaaaa
//
