LOCUS       NM_053973               1596 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus Ras-related GTP binding A (Rraga), mRNA.
ACCESSION   NM_053973
VERSION     NM_053973.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1596)
  AUTHORS   Deng,L., Jiang,C., Chen,L., Jin,J., Wei,J., Zhao,L., Chen,M.,
            Pan,W., Xu,Y., Chu,H., Wang,X., Ge,X., Li,D., Liao,L., Liu,M.,
            Li,L. and Wang,P.
  TITLE     The ubiquitination of rag A GTPase by RNF152 negatively regulates
            mTORC1 activation
  JOURNAL   Mol Cell 58 (5), 804-818 (2015)
   PUBMED   25936802
REFERENCE   2  (bases 1 to 1596)
  AUTHORS   Bar-Peled,L. and Sabatini,D.M.
  TITLE     Regulation of mTORC1 by amino acids
  JOURNAL   Trends Cell Biol 24 (7), 400-406 (2014)
   PUBMED   24698685
  REMARK    Review article
REFERENCE   3  (bases 1 to 1596)
  AUTHORS   Bar-Peled,L., Chantranupong,L., Cherniack,A.D., Chen,W.W.,
            Ottina,K.A., Grabiner,B.C., Spear,E.D., Carter,S.L., Meyerson,M.
            and Sabatini,D.M.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   4  (bases 1 to 1596)
  AUTHORS   Han,J.M., Jeong,S.J., Park,M.C., Kim,G., Kwon,N.H., Kim,H.K.,
            Ha,S.H., Ryu,S.H. and Kim,S.
  TITLE     Leucyl-tRNA synthetase is an intracellular leucine sensor for the
            mTORC1-signaling pathway
  JOURNAL   Cell 149 (2), 410-424 (2012)
   PUBMED   22424946
REFERENCE   5  (bases 1 to 1596)
  AUTHORS   Sancak,Y., Bar-Peled,L., Zoncu,R., Markhard,A.L., Nada,S. and
            Sabatini,D.M.
  TITLE     Ragulator-Rag complex targets mTORC1 to the lysosomal surface and
            is necessary for its activation by amino acids
  JOURNAL   Cell 141 (2), 290-303 (2010)
   PUBMED   20381137
REFERENCE   6  (bases 1 to 1596)
  AUTHORS   Sekiguchi,T., Todaka,Y., Wang,Y., Hirose,E., Nakashima,N. and
            Nishimoto,T.
  TITLE     A novel human nucleolar protein, Nop132, binds to the G proteins,
            RRAG A/C/D
  JOURNAL   J Biol Chem 279 (9), 8343-8350 (2004)
   PUBMED   14660641
REFERENCE   7  (bases 1 to 1596)
  AUTHORS   Sekiguchi,T., Hirose,E., Nakashima,N., Ii,M. and Nishimoto,T.
  TITLE     Novel G proteins, Rag C and Rag D, interact with GTP-binding
            proteins, Rag A and Rag B
  JOURNAL   J Biol Chem 276 (10), 7246-7257 (2001)
   PUBMED   11073942
REFERENCE   8  (bases 1 to 1596)
  AUTHORS   Hirose,E., Nakashima,N., Sekiguchi,T. and Nishimoto,T.
  TITLE     RagA is a functional homologue of S. cerevisiae Gtr1p involved in
            the Ran/Gsp1-GTPase pathway
  JOURNAL   J Cell Sci 111 (Pt 1), 11-21 (1998)
   PUBMED   9394008
REFERENCE   9  (bases 1 to 1596)
  AUTHORS   Li,Y., Kang,J. and Horwitz,M.S.
  TITLE     Interaction of an adenovirus 14.7-kilodalton protein inhibitor of
            tumor necrosis factor alpha cytolysis with a new member of the
            GTPase superfamily of signal transducers
  JOURNAL   J Virol 71 (2), 1576-1582 (1997)
   PUBMED   8995684
REFERENCE   10 (bases 1 to 1596)
  AUTHORS   Schurmann,A., Brauers,A., Massmann,S., Becker,W. and Joost,H.G.
  TITLE     Cloning of a novel family of mammalian GTP-binding proteins (RagA,
            RagBs, RagB1) with remote similarity to the Ras-related GTPases
  JOURNAL   J Biol Chem 270 (48), 28982-28988 (1995)
   PUBMED   7499430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 27, 2020 this sequence version replaced NM_053973.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: X85183.1, BC061850.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1596              JAXUCZ010000005.1  106159335-106160930
FEATURES             Location/Qualifiers
     source          1..1596
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q31"
     gene            1..1596
                     /gene="Rraga"
                     /gene_synonym="Raga"
                     /note="Ras-related GTP binding A"
                     /db_xref="GeneID:117044"
                     /db_xref="RGD:619804"
     exon            1..1596
                     /gene="Rraga"
                     /gene_synonym="Raga"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1170
                     /gene="Rraga"
                     /gene_synonym="Raga"
                     /note="rag A; Ras-related GTP-binding protein ragA"
                     /codon_start=1
                     /product="ras-related GTP-binding protein A"
                     /protein_id="NP_446425.1"
                     /db_xref="GeneID:117044"
                     /db_xref="RGD:619804"
                     /translation="MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATID
                     VEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKD
                     MHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACF
                     RTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQ
                     CKEQRDVHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVM
                     SDPSIPSAATLINIRNARKHFEKLERVDGPKHSLLMR"
ORIGIN      
        1 taggctggag ctgatcgcat cactagtttg gtctccctag ctccgagctg ctgtggccat
       61 tgcctccagc gctgttttct gaggcctcgc ctccgccgtc tttcctgccc gagctccggt
      121 gcaaggcctc cgctgccaga cggtgcctgg tgtcccgccg ttcccatcct cggttggtcc
      181 gccgttaggc cgtgcctcag gcccaatccg cggcgacgcc ggcaggtgat gccaaataca
      241 gccatgaaga aaaaggtgct gttgatggga aagagcgggt cggggaagac cagcatgagg
      301 tcgatcatct ttgcaaatta tattgcgcgc gacaccaggc gcctgggtgc caccatcgac
      361 gtggagcact cccacgtccg attcttgggg aacctggtgc tgaacctgtg ggactgtggc
      421 ggccaggaca cctttatgga aaattacttc accagccagc gggacaacat cttccgtaat
      481 gtggaggttc tgatctacgt gtttgacgta gagagccgcg aactggaaaa agatatgcat
      541 tattatcagt cgtgtctgga agccatcctc cagaattcac ctgatgccaa aatcttctgc
      601 ctggtgcaca aaatggatct ggttcaggaa gatcaacgtg acctgatttt taaagagcga
      661 gaagaagacc tgaggcgttt gtctcgcccg ctggagtgcg cttgttttcg aacgtccatc
      721 tgggatgaga cgctctacaa agcctggtcc agcatcgtct atcagctgat ccccaacgtt
      781 cagcagctgg agatgaacct aaggaatttt gcccagatta ttgaggctga tgaagttctg
      841 ctgttcgaga gagctacgtt cttggtgatt tcccactacc agtgcaaaga gcagcgagat
      901 gtacaccgct ttgagaagat cagcaacatc atcaagcagt ttaagctaag ctgcagtaaa
      961 ttggccgctt ctttccagag catggaagtg aggaattcta acttcgctgc cttcatcgac
     1021 atctttacat caaacacgta tgtgatggtg gtcatgtcag atccatccat cccttctgca
     1081 gctactctga tcaacattcg taatgccagg aaacactttg agaagctaga gagagtagat
     1141 ggccccaagc acagcctcct catgcgctga cataatgcca aatgctcttt agtaaatgct
     1201 gaattatggt ggggtttttt tttgcatcat ttgtttttaa tattcataat gtcatgtgct
     1261 taaaagtggg ctttgaaacg tgtgcttact atctcatctc ttccctagtc ttagtattgg
     1321 acgctattta ctcagctatc cagtagagat cctcaagacg gcctttatga aaagttagtg
     1381 tggtgttaac actaaagtag gtggtgtgta tgggtgtgtg tgtgtgtggg tgtgttatgg
     1441 ttacctggtt ataatagagt attaaagcag ttatcttctg tattatcaga tcacaaaggt
     1501 ggaatgttac tattttatca gcaagatatt aaaatgtatt tctaaatcct ccttggtttc
     1561 aatcatgaat aaacatttat tattagcaat ttaaaa
//
