LOCUS       NM_053972               2249 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus Ras-related GTP binding B (RragB), mRNA.
ACCESSION   NM_053972 XM_346870
VERSION     NM_053972.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2249)
  AUTHORS   Bar-Peled,L. and Sabatini,D.M.
  TITLE     Regulation of mTORC1 by amino acids
  JOURNAL   Trends Cell Biol 24 (7), 400-406 (2014)
   PUBMED   24698685
  REMARK    Review article
REFERENCE   2  (bases 1 to 2249)
  AUTHORS   Bar-Peled,L., Chantranupong,L., Cherniack,A.D., Chen,W.W.,
            Ottina,K.A., Grabiner,B.C., Spear,E.D., Carter,S.L., Meyerson,M.
            and Sabatini,D.M.
  TITLE     A Tumor suppressor complex with GAP activity for the Rag GTPases
            that signal amino acid sufficiency to mTORC1
  JOURNAL   Science 340 (6136), 1100-1106 (2013)
   PUBMED   23723238
REFERENCE   3  (bases 1 to 2249)
  AUTHORS   Kim,Y.M., Stone,M., Hwang,T.H., Kim,Y.G., Dunlevy,J.R.,
            Griffin,T.J. and Kim,D.H.
  TITLE     SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1
            signaling
  JOURNAL   Mol Cell 46 (6), 833-846 (2012)
   PUBMED   22575674
REFERENCE   4  (bases 1 to 2249)
  AUTHORS   Han,J.M., Jeong,S.J., Park,M.C., Kim,G., Kwon,N.H., Kim,H.K.,
            Ha,S.H., Ryu,S.H. and Kim,S.
  TITLE     Leucyl-tRNA synthetase is an intracellular leucine sensor for the
            mTORC1-signaling pathway
  JOURNAL   Cell 149 (2), 410-424 (2012)
   PUBMED   22424946
REFERENCE   5  (bases 1 to 2249)
  AUTHORS   Sancak,Y., Bar-Peled,L., Zoncu,R., Markhard,A.L., Nada,S. and
            Sabatini,D.M.
  TITLE     Ragulator-Rag complex targets mTORC1 to the lysosomal surface and
            is necessary for its activation by amino acids
  JOURNAL   Cell 141 (2), 290-303 (2010)
   PUBMED   20381137
REFERENCE   6  (bases 1 to 2249)
  AUTHORS   Ma,X.M. and Blenis,J.
  TITLE     Molecular mechanisms of mTOR-mediated translational control
  JOURNAL   Nat Rev Mol Cell Biol 10 (5), 307-318 (2009)
   PUBMED   19339977
  REMARK    Review article
REFERENCE   7  (bases 1 to 2249)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   8  (bases 1 to 2249)
  AUTHORS   Hirose,E., Nakashima,N., Sekiguchi,T. and Nishimoto,T.
  TITLE     RagA is a functional homologue of S. cerevisiae Gtr1p involved in
            the Ran/Gsp1-GTPase pathway
  JOURNAL   J Cell Sci 111 (Pt 1), 11-21 (1998)
   PUBMED   9394008
REFERENCE   9  (bases 1 to 2249)
  AUTHORS   Schurmann,A., Brauers,A., Massmann,S., Becker,W. and Joost,H.G.
  TITLE     Cloning of a novel family of mammalian GTP-binding proteins (RagA,
            RagBs, RagB1) with remote similarity to the Ras-related GTPases
  JOURNAL   J Biol Chem 270 (48), 28982-28988 (1995)
   PUBMED   7499430
REFERENCE   10 (bases 1 to 2249)
  AUTHORS   Chevalier,C., Bourgeois,E., Pradet,A. and Raymond,P.
  TITLE     Molecular cloning and characterization of six cDNAs expressed
            during glucose starvation in excised maize (Zea mays L.) root tips
  JOURNAL   Plant Mol Biol 28 (3), 473-485 (1995)
   PUBMED   7632917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC087698.1.
            
            On Mar 17, 2021 this sequence version replaced NM_053972.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087698.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2249              BC087698.1         1-2249
FEATURES             Location/Qualifiers
     source          1..2249
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..2249
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /note="Ras-related GTP binding B"
                     /db_xref="GeneID:117043"
                     /db_xref="RGD:619805"
     exon            1..612
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /inference="alignment:Splign:2.1.0"
     exon            613..646
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /inference="alignment:Splign:2.1.0"
     exon            647..746
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /inference="alignment:Splign:2.1.0"
     exon            747..830
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /inference="alignment:Splign:2.1.0"
     exon            831..897
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1120
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1216
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1339
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1431
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1547
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..2249
                     /gene="RragB"
                     /gene_synonym="Ragb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcctgcagt agcgtggttg cagtgaggtt cttgcgctcc tgaagggcgg gcgcggaagt
       61 aagagcatcc tcaggcggtc tgtgactggc agcgaggtcg agaggagcca ccaggcagtg
      121 accgctttgc ttctgcagct cggctcagct cattccgtta tctcagcctt tgcagtctgc
      181 acagaagctg accaagttac ctttgggtct tgagacctgg gagagtgagg cccaaactcg
      241 ggaccaactc ctcatctacc ttgccctccc tctcctccat ctcttccttt gcatgcacga
      301 atcgcttgct cctttgggct ggcttgctcg gctgtgcctg gagactaagt tcgggtcggt
      361 aaaggtaact gtgggaaaag cggcccccca gtggacaaag gcggaggcag ggatagagca
      421 ggccccgcgg gccctgggcg ctgagcatag gcagtagaga aggtgagcca gaagaacagt
      481 actgcggatt tagaaggcac tgtgaaggac ttgttgcgcg atggaagaat ctgactccga
      541 gaaaaagacg gagaaagaga atgtgggccc aaaagtggag cctcctctag gggagccgga
      601 aggatcgctt gggtgggcaa tgccaaatgc agccatgaag aaaaaggtgc tgttgatggg
      661 taaaagtgga tctggtaaga ccagcatgag gtctattatc tttgcaaatt atattgccag
      721 agacacacgt cgtcttggtg caacaatact agaccgtata catagtcttc aaattaatag
      781 cagtttgagc acctactctc tcgtagactc tgttggaaat acaaagacat ttgatgtaga
      841 acattctcat gttcgatttc tgggaaacct ggttttgaac ctgtgggatt gtggtggaca
      901 agacaccttc atggaaaatt acttcactag ccagcgtgac aacatcttcc gaaatgtgga
      961 ggttctgatt tatgtctttg acgtggagag ccgtgaactc gagaaagaca tgcactacta
     1021 tcagtcatgc cttgaggcta ttctgcagaa ttccccagaa gccaaaatct tttgcttggt
     1081 acacaaaatg gatttggtcc aggaggatca gcgagacttg atttttaaag aacgagaaga
     1141 agacttaagg cgtttatcgc gtccgttaga atgttcttgt ttccgaacat ctatctggga
     1201 tgaaactctg tataaggctt ggtccagcat tgtttatcag ctgattccca atgttcagca
     1261 actggaaatg aacctgcgca attttgctga aattattgag gctgatgaag tacttctgtt
     1321 tgagagagct acctttctgg tgatttctca ctatcagtgt aaagaacagc gagatgccca
     1381 ccgatttgag aaaatcagca acattattaa gcagttcaag ctgagctgta gcaagctggc
     1441 tgcctctttc cagagtatgg aagtcaggaa ttctaacttt gctgctttca ttgacatatt
     1501 cacatccaac acttacgtca tggtcgtgat gtctgatcca tccattcctt ctgcagctac
     1561 tctgatcaac atccgcaatg ccagaaaaca ctttgaaaag ctggagagag tggatggacc
     1621 aaaacagtgt cttctcatgc gctaaacatt gccgaatatt gtttcacaca aaataattga
     1681 aacactgttt cttaatttta ttgtattcat atatgtaggc tctgaaatat tgtgatgctc
     1741 actgcttctg tatttcttct ctactctcca gtcttaacat ttatctttga atgctattta
     1801 ttcaaatagc ttgaggagtt agaagatgag gtgtctatga agttgatgta acgtatacgt
     1861 aggcgatata tgtaagtgtt ctgataacat gattctaatg gtgttttaag tgttctgata
     1921 acctgctttt aatagttgtg tatgccaaag tctttcccag aacctcttgt attcactatc
     1981 aaatatatac atgtaagttt taagtattac tgttttctca gcatgaatta aaaatattcc
     2041 gtaactcaac caggcaacgt agctcatgcc tgtgacccca gcagttgaga agcagagaca
     2101 agaggattgc tgcaagtttg aggccagcct gtctacatag ggaggtccag gccaagtata
     2161 tatcaagatc ttgtttcaaa aacaagatac acacacacac acacacacac cacttaactt
     2221 cgatgtaaat aaacttctgc tgttaggga
//
