LOCUS       NM_001134499            6699 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus regulatory associated protein of MTOR, complex 1
            (Rptor), mRNA.
ACCESSION   NM_001134499 XM_001081775 XM_213539
VERSION     NM_001134499.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6699)
  AUTHORS   Yang,C., Tsaih,S.W., Lemke,A., Flister,M.J., Thakar,M.S. and
            Malarkannan,S.
  TITLE     mTORC1 and mTORC2 differentially promote natural killer cell
            development
  JOURNAL   Elife 7, e35619 (2018)
   PUBMED   29809146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6699)
  AUTHORS   Aghamohammadzadeh,R., Zhang,Y.Y., Stephens,T.E., Arons,E.,
            Zaman,P., Polach,K.J., Matar,M., Yung,L.M., Yu,P.B., Bowman,F.P.,
            Opotowsky,A.R., Waxman,A.B., Loscalzo,J., Leopold,J.A. and
            Maron,B.A.
  TITLE     Up-regulation of the mammalian target of rapamycin complex 1
            subunit Raptor by aldosterone induces abnormal pulmonary artery
            smooth muscle cell survival patterns to promote pulmonary arterial
            hypertension
  JOURNAL   FASEB J 30 (7), 2511-2527 (2016)
   PUBMED   27006450
  REMARK    GeneRIF: Up-regulation of mTORC1 via raptor by aldosterone is a
            critical pathobiologic mechanism that controls pulmonary artery
            smooth muscle cell survival to promote hypertrophic vascular
            remodeling and pulmonary arterial hypertension.
            Erratum:[FASEB J. 2024 Jan 31;38(2):e23438. PMID: 38252126]
REFERENCE   3  (bases 1 to 6699)
  AUTHORS   Fonseca,B.D., Zakaria,C., Jia,J.J., Graber,T.E., Svitkin,Y.,
            Tahmasebi,S., Healy,D., Hoang,H.D., Jensen,J.M., Diao,I.T.,
            Lussier,A., Dajadian,C., Padmanabhan,N., Wang,W., Matta-Camacho,E.,
            Hearnden,J., Smith,E.M., Tsukumo,Y., Yanagiya,A., Morita,M.,
            Petroulakis,E., Gonzalez,J.L., Hernandez,G., Alain,T. and
            Damgaard,C.K.
  TITLE     La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine
            (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)
  JOURNAL   J Biol Chem 290 (26), 15996-16020 (2015)
   PUBMED   25940091
REFERENCE   4  (bases 1 to 6699)
  AUTHORS   Kamano,Y., Saeki,M., Egusa,H., Kakihara,Y., Houry,W.A., Yatani,H.
            and Kamisaki,Y.
  TITLE     PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA
            transcription
  JOURNAL   FEBS Lett 587 (20), 3303-3308 (2013)
   PUBMED   24036451
REFERENCE   5  (bases 1 to 6699)
  AUTHORS   Le Bacquer,O., Queniat,G., Gmyr,V., Kerr-Conte,J., Lefebvre,B. and
            Pattou,F.
  TITLE     mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1
            cells
  JOURNAL   J Endocrinol 216 (1), 21-29 (2013)
   PUBMED   23092880
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6699)
  AUTHORS   Takei,N., Inamura,N., Kawamura,M., Namba,H., Hara,K., Yonezawa,K.
            and Nawa,H.
  TITLE     Brain-derived neurotrophic factor induces mammalian target of
            rapamycin-dependent local activation of translation machinery and
            protein synthesis in neuronal dendrites
  JOURNAL   J Neurosci 24 (44), 9760-9769 (2004)
   PUBMED   15525761
REFERENCE   7  (bases 1 to 6699)
  AUTHORS   Jacinto,E., Loewith,R., Schmidt,A., Lin,S., Ruegg,M.A., Hall,A. and
            Hall,M.N.
  TITLE     Mammalian TOR complex 2 controls the actin cytoskeleton and is
            rapamycin insensitive
  JOURNAL   Nat Cell Biol 6 (11), 1122-1128 (2004)
   PUBMED   15467718
REFERENCE   8  (bases 1 to 6699)
  AUTHORS   Kim,D.H., Sarbassov,D.D., Ali,S.M., Latek,R.R., Guntur,K.V.,
            Erdjument-Bromage,H., Tempst,P. and Sabatini,D.M.
  TITLE     GbetaL, a positive regulator of the rapamycin-sensitive pathway
            required for the nutrient-sensitive interaction between raptor and
            mTOR
  JOURNAL   Mol Cell 11 (4), 895-904 (2003)
   PUBMED   12718876
REFERENCE   9  (bases 1 to 6699)
  AUTHORS   Hara,K., Maruki,Y., Long,X., Yoshino,K., Oshiro,N., Hidayat,S.,
            Tokunaga,C., Avruch,J. and Yonezawa,K.
  TITLE     Raptor, a binding partner of target of rapamycin (TOR), mediates
            TOR action
  JOURNAL   Cell 110 (2), 177-189 (2002)
   PUBMED   12150926
REFERENCE   10 (bases 1 to 6699)
  AUTHORS   Kim,D.H., Sarbassov,D.D., Ali,S.M., King,J.E., Latek,R.R.,
            Erdjument-Bromage,H., Tempst,P. and Sabatini,D.M.
  TITLE     mTOR interacts with raptor to form a nutrient-sensitive complex
            that signals to the cell growth machinery
  JOURNAL   Cell 110 (2), 163-175 (2002)
   PUBMED   12150925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Oct 1, 2009 this sequence version replaced NM_001134499.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.65529.1,
                                           SRR26643295.42006.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1075              JAXUCZ010000010.1  105376943-105378017
            1076-1178           JAXUCZ010000010.1  105437487-105437589
            1179-1261           JAXUCZ010000010.1  105448040-105448122
            1262-1420           JAXUCZ010000010.1  105494070-105494228
            1421-1567           JAXUCZ010000010.1  105511959-105512105
            1568-1743           JAXUCZ010000010.1  105523843-105524018
            1744-1803           JAXUCZ010000010.1  105549601-105549660
            1804-1904           JAXUCZ010000010.1  105573826-105573926
            1905-2049           JAXUCZ010000010.1  105574355-105574499
            2050-2125           JAXUCZ010000010.1  105588290-105588365
            2126-2227           JAXUCZ010000010.1  105594135-105594236
            2228-2311           JAXUCZ010000010.1  105598038-105598121
            2312-2422           JAXUCZ010000010.1  105599725-105599835
            2423-2497           JAXUCZ010000010.1  105622568-105622642
            2498-2563           JAXUCZ010000010.1  105624989-105625054
            2564-2755           JAXUCZ010000010.1  105625391-105625582
            2756-2896           JAXUCZ010000010.1  105629792-105629932
            2897-3014           JAXUCZ010000010.1  105634004-105634121
            3015-3155           JAXUCZ010000010.1  105634878-105635018
            3156-3314           JAXUCZ010000010.1  105635398-105635556
            3315-3433           JAXUCZ010000010.1  105642194-105642312
            3434-3537           JAXUCZ010000010.1  105648995-105649098
            3538-3721           JAXUCZ010000010.1  105649652-105649835
            3722-3832           JAXUCZ010000010.1  105651510-105651620
            3833-3938           JAXUCZ010000010.1  105660681-105660786
            3939-4053           JAXUCZ010000010.1  105663908-105664022
            4054-4178           JAXUCZ010000010.1  105665167-105665291
            4179-4283           JAXUCZ010000010.1  105667654-105667758
            4284-4390           JAXUCZ010000010.1  105669056-105669162
            4391-4518           JAXUCZ010000010.1  105670679-105670806
            4519-4605           JAXUCZ010000010.1  105671156-105671242
            4606-4722           JAXUCZ010000010.1  105672220-105672336
            4723-4852           JAXUCZ010000010.1  105672696-105672825
            4853-6699           JAXUCZ010000010.1  105673567-105675413
FEATURES             Location/Qualifiers
     source          1..6699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.3"
     gene            1..6699
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /note="regulatory associated protein of MTOR, complex 1"
                     /db_xref="GeneID:287871"
                     /db_xref="RGD:1311784"
     exon            1..1075
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     CDS             914..4921
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /note="raptor"
                     /codon_start=1
                     /product="regulatory-associated protein of mTOR"
                     /protein_id="NP_001127971.2"
                     /db_xref="GeneID:287871"
                     /db_xref="RGD:1311784"
                     /translation="MESEMLQSPLMGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKS
                     LAQSWRMKDRMKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETI
                     GANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHYNGHGVPRPTV
                     NGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSFKQFALQREQELE
                     VAAINPNHPLAQMPLPPSMKNCIQLAACEAHELLPMIPDLPADLFTSCLTTPIKIALR
                     WFCMQKCVSLVPGVTLDLIEKIPGRLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQ
                     KLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYMHAMWQAWDLAVDICLSQ
                     LPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRSPPEQLPIVLQVLLSQVHRLRAL
                     DLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSCQAD
                     LVKDNGHKYFLSVLADPYMPAEHRTMTAFILAVIVNSYTTGQEACLQGNLIAICLEQL
                     SDPHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALG
                     TFVGNSAERTDHSTTIDHNVAMMLAQLINDGSPMVRKELVVALSHLVVQYESNFCTVA
                     LQFMEEEKNYPLPSPAATEGGSLTPVRDSPCTPRLRSVSSYGNIRAVTTARNLNKSLQ
                     NLSLTEESGSSVAFSPGNLSTSSSASSTLGSPENEEYILSFETIDKMRRVSSYSALNS
                     LIGVSFNSVYTQIWRVLLHLAADPYPDVSDLAMKVLNSIAYKATVNARPQRILDTSSL
                     TQSAPASPTNKGMHIHQVGGSPPASSTSSCSLTNDVAKQTVSRDLPSSRPGTAGPTGA
                     QYTPHSHQFPRTRKMFDKGPDQTTDDADDAAGHKSFICATMQTGFCDWSARYFAQPVM
                     KIPEEHDLESQIRKEREWRFLRNTRVRKQAQQVIQKGITRLDDQIFLNRNPGVPSVVK
                     FHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMEYLNGQDCSLLLTAT
                     DDGAIRVWKNFADLEKNPEMVTAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRI
                     VRIWDTDRETKVQDIPTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRMALSECRV
                     MTYREHTAWVVKAYLQKHPEGHIVSVSVNGDVRFFDPRMPESVNVMQIVKGLTALDIH
                     PQANLIACGSMNQFTAIYNGNGELINNIKYYDGFMGQRVGAISCLAFHPHWPHLAVGS
                     NDYYISVYSVEKRVR"
     exon            1076..1178
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1261
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1420
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1567
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1743
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1803
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1904
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2049
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2125
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2227
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2311
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2422
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2497
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2563
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..2755
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            2756..2896
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3014
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3155
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3314
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3433
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3537
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            3538..3721
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3832
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..3938
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            3939..4053
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4178
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            4179..4283
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            4284..4390
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4518
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            4519..4605
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            4606..4722
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            4723..4852
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
     exon            4853..6699
                     /gene="Rptor"
                     /gene_synonym="RGD1311784"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggacggaac gccgaactct ccgccctagc ctgggtagag cggtgagaac gcttgaagag
       61 gtttggctta ttggacacac cgtagacagc ggtgcatgct gggccttggt aatatggcgt
      121 cctccttgat gtgctgatga gaggagtttt cactgtggct ccagagcaga gggcaaaact
      181 cccctgacct aataagccca gtattcccgt gtggtccgct ggcccgtgtc gcgcgtgtat
      241 caggactcgt tcccgggcag gagagagcca cgaagccgaa ggccagcacc ggccaggccg
      301 cgcggacccg gggctgagga gccgactgcg gacgggcacg atgggccggt cctggctcag
      361 gttgcagccc ctcaggcgag tgcgggaccc gcagggctga gagccgctgg acgagccccg
      421 aagccccctg agcgcgatcc cctgacgcct cagccgagcc agcgcaatca gagaacccgc
      481 actgcgagcg ggacggcctg cctgccctgg gatccactga ggcgttggag gccgagagca
      541 gggtcatccc cgggcctgaa gtctttcccg cctctgacag tccggcttgc agtcctccag
      601 acgacctcct gggctgcggg tggcttgcga ctgggcgcga gtgtcggcgc agctcctggg
      661 gctgcggggt tggttaccca ccgattcttc accccacccc accccgccct ctccgacttc
      721 ccgctcagag ttcgagataa agatctccga gtttttacct gaataaggac cttcgtgcac
      781 tctgccgtca tctctattcc caacttcccg ctttcctgta tttcctttta ccagttctgg
      841 tacacactag tttttaaggc tggaggttct cgagcgcttg ctgccaagga ctccccctcc
      901 ccctcctccc ctgatggagt cggagatgct gcagtcgcct cttatgggac tcggggagga
      961 agatgaggca gaccttacag attggaactt gcctttggcg tttatgaaaa agagacattg
     1021 tgagaaaatt gaaggctcca aatctttagc acagagctgg agaatgaagg atcggatgaa
     1081 gaccgtcagt gtggccttgg tcctgtgcct gaatgtgggt gtggatcctc cagatgtggt
     1141 gaagaccaca ccttgtgctc gattggaatg ctggattgat cctctgtcta tgggtcctca
     1201 gaaagctctg gaaaccatcg gtgcaaatct acagaagcag tatgagaact ggcagccaag
     1261 ggctcggtac aagcagagcc ttgaccccac tgtggatgaa gtcaagaaac tttgcacatc
     1321 tctgcgtcgg aacgccaagg aggaacgggt cctcttccac tataatggcc atggggtgcc
     1381 caggcctacg gtgaatggag aggtctgggt cttcaacaag aactacactc agtacatccc
     1441 actgtccata tatgacctgc agacgtggat gggcagccca tccatctttg tctacgactg
     1501 ctccaatgct ggcctcatcg tcaagtcctt caaacagttc gcactgcaga gggagcagga
     1561 actagaggta gctgcaatta acccaaacca tccacttgcc cagatgccct tgcctccctc
     1621 aatgaaaaac tgcatccagc tggcagcctg tgaggcccac gagctcctgc cgatgatccc
     1681 tgacctccca gccgacctgt tcacatcctg cctcaccact cccatcaaga ttgctttgcg
     1741 ctggttttgc atgcagaagt gtgttagtct ggtgcctgga gtcacactgg atttgataga
     1801 aaagatccct ggccggctga atgaccggag aacccctctg ggtgaactga actggatctt
     1861 cacagccatc acagacacca tcgcctggaa tgtgctccct cgggatctct ttcaaaagct
     1921 tttccgacag gacctgctgg tggcaagttt gtttagaaat tttttattgg cagaaagaat
     1981 catgaggtcg tataactgca ccccagtaag cagcccacga cttcccccaa catacatgca
     2041 tgccatgtgg caggcctggg accttgctgt ggacatttgc ctctctcaac tgccaaccat
     2101 catcgaagag ggaactgcct tcaggcacag cccattcttt gctgagcagc tgacggcatt
     2161 ccaggtgtgg ctcaccatgg gtgtggaaaa caggagcccc cccgagcagc tgcccatcgt
     2221 cctacaggtg ctgctaagcc aggtgcaccg gctgagagcc ttggacttgc tgggacgatt
     2281 tttggacttg ggcccttggg cggtgagctt ggccctgtcg gtgggcatct tcccctatgt
     2341 actgaagctg cttcagagct cggcccgaga gctgcggcca ctccttgtct tcatctgggc
     2401 caaaatcctc gctgtggaca gttcatgcca ggctgacctc gtgaaggaca acggtcacaa
     2461 gtacttcctg tccgtcttgg cagacccata catgccagct gaacacagga ccatgacagc
     2521 cttcattctt gctgtaatcg tcaacagcta cacaacaggg caagaagcct gcctgcaggg
     2581 gaacctgatt gccatctgtt tggagcagct cagtgaccca caccccttgc tacgccagtg
     2641 ggtggccatt tgcctgggaa ggatctggca gaactttgat tctgcaaggt ggtgtggggt
     2701 gagagacagc gcccacgaaa aactctatag cctcctctcc gaccccatcc ctgaggtacg
     2761 atgtgcagct gtgtttgccc ttggtacctt tgtgggaaac tctgctgaga ggacagacca
     2821 ctctactacc attgaccaca atgtggccat gatgctggct cagctgatta atgatggaag
     2881 ccccatggtc cggaaggagc tggtggtggc tctgagtcac cttgtagtcc aatatgagag
     2941 caatttctgc actgtggccc tgcagttcat ggaagaggaa aagaactacc ccttgccttc
     3001 tccagcagcc acagagggag ggagcttgac tccagttcga gacagcccgt gcacccccag
     3061 actccggtca gtgagctcct atgggaacat ccgagccgtc accacagcta ggaacctgaa
     3121 caaatctttg cagaacctga gcttgacgga agaatcgggc agctcagtgg ccttctctcc
     3181 cgggaacctc agtacaagta gtagtgccag cagcaccttg ggaagccctg agaacgagga
     3241 gtatatcctg tccttcgaga ccatcgacaa gatgcggcgt gtgagctcct attcagcgct
     3301 caactccctc ataggagtct cctttaatag tgtctacact cagatttgga gagtcttact
     3361 gcatttggcc gctgatccct acccagatgt ttctgactta gccatgaaag tcctcaacag
     3421 cattgcttac aaggccacag tcaacgcccg gccccagcga atcctcgaca catcctctct
     3481 cacacagtcg gccccagcca gcccaaccaa caagggcatg cacatccacc aggtgggagg
     3541 ctccccgcca gcatctagca ccagcagctg cagcctgacc aatgatgtgg ccaagcagac
     3601 ggtcagccgt gacctgccct ccagccgccc gggtactgcc ggccccacag gggcacagta
     3661 cacccctcac tcccaccagt tccctcgtac acgaaagatg tttgacaaag gccctgatca
     3721 gaccacagac gatgcagatg atgctgccgg acacaagagc ttcatttgtg ccactatgca
     3781 gacggggttc tgtgactgga gtgcccgcta ctttgcccag ccggtcatga agatccctga
     3841 agagcatgac ctagagagtc agatccgcaa ggagcgtgag tggcggttcc tgaggaacac
     3901 tcgagtcagg aagcaggcac agcaggtcat ccagaagggc atcaccagac tggatgatca
     3961 gatatttctg aacaggaacc ccggcgttcc ctctgtggtc aaattccacc cctttacacc
     4021 atgcatagct gttgctgaca aggacagcat ctgtttttgg gactgggaga aaggagagaa
     4081 actggactac ttccacaatg gtaaccctcg gtacaccaga gtcactgcta tggagtacct
     4141 gaatgggcag gactgctcct tgctgctgac agccacagac gatggagcca tcagggtctg
     4201 gaaaaatttt gctgatttgg aaaagaatcc agagatggtg actgcgtggc aagggctctc
     4261 agacatgctt ccaacaacac gaggagctgg gatggtggtg gactgggaac aagaaactgg
     4321 cctcctcatg agctcagggg acgtgcgcat tgtccggatc tgggataccg accgggagac
     4381 gaaggtccag gacatcccca cgggggccga cagctgtgtg acaagtttat cttgtgattc
     4441 gcaccgctca ctcattgtag ctggcctggg tgatggctcg atccgtgtct acgacaggag
     4501 gatggcactc agtgaatgcc gggtcatgac ttaccgagag cacacagcat gggtggtaaa
     4561 ggcctacctg cagaagcacc ctgagggcca catcgtgagt gtgagtgtca atggagatgt
     4621 gcgattcttc gatcctcgga tgcctgagtc tgtgaatgta atgcagattg tgaaggggct
     4681 gacagccctc gacatccacc cccaggcaaa cctgatcgcc tgtggctcca tgaaccagtt
     4741 cacagccatc tacaacggca atggggagct gatcaacaac atcaaatact acgatggctt
     4801 catgggccag cgagtcgggg ccatcagctg cctggctttc cacccacact ggcctcatct
     4861 ggccgtcgga agcaatgact actacatttc tgtatattcg gtggagaagc gtgtcagata
     4921 gcggcacctc ggactcgtgc caggctgcag ccaccctctg ctgtacatag cgaaccagcc
     4981 tgcactgctc aggatcagtg cccacctccc acccacctgc aaaccctggc tcctggcctg
     5041 gcgtggccag ctgaggaggg gcttgcacat cctcccttct gtcttcactg taatgtgcag
     5101 gtccagagca ggggagggtt tgacatggct tcccatcgag aaccaggacc caggcaccaa
     5161 gggcctcctc agtacagcat ggtcctttcc tgccctgttt ccttctgagg ttttacaaag
     5221 gaacacattt gatttttcca tgcgatcaaa gcattagtca cagaacagac agcaccctgg
     5281 agaaaagcta tgttggggct tctgagggct gtggcccagc ccctcagagt aggaaagtag
     5341 atggaagcaa ttgagggaag aagagggggg aggcctctcc tgctactcaa ggtatggaag
     5401 tgtgagcctg gccctcctag agcactgagg cagtccaaca cactggctat gtcatggtgg
     5461 tatgaggaaa gggatccccg tcctgcacag ctagaactct gaggtccagt ctggttccct
     5521 cacatgagct ggtgcaggag agggtctggt tctgggcaga tgaggcagat ctgtagtcag
     5581 cggctgccta cctctgccag gcacattctg aagtgcttct ctcccacagg ccagtaacag
     5641 tggccacagc cctgtctcct gcttgtgcca cacacaggca cacacacatg caggcacaca
     5701 gcgttcctat ccatgcttac atgggtgtcc tggtcttcct gcctgtgcac acttgggtgt
     5761 gcattcgtgc aggcccacag tctcccctcc tgcacatata tgggcactgt ggccggccat
     5821 atgcacacgc atgctggcct caccaggttc agagactacg ctggacccag aggctcgagg
     5881 gcagcatcag ctgtgttggt gtgactgagg ttgcatgatg cagtctgtgt tgtggaggag
     5941 ttcagcagtg tcctggtgtg cctgacacgt gtctgtgcac atgcaagtga gggacactgc
     6001 attgctgagc agttgcacac aaacaggaca caacacaatg atgttttgaa aagcatttta
     6061 cgttttccct gggaatcagg atctttcaga ggaggacaag cgcccacagg agcccgggac
     6121 acaggttggg acagctgtgg cagaggctgg gtccctgtgc tgtgcttggt ggacctgttt
     6181 tagccaagag catcttccct gtggaaggat ccctacaggc caagcagggc aagcaggacg
     6241 ggtaggcgct ggtgctgccc tggagatgca ctctcccaac atggaggagc ttagaggaag
     6301 tcatcccctc agttgggcca gacagcagtg tggcgtcagg acggccctag aaccacctga
     6361 cttgccacct tctcagttct gcagagtgct ccagggggtg ggtatccttg tccaactggt
     6421 gattcagttc agcagcgaag ggccctggtg ggctgggtcg cttccctgcc cagtggagcc
     6481 agcgtttgca tcttgcccag aggctgggcc ttcacaagcc tgatgcgaaa attcaatcat
     6541 gaagctaacc aaggctcgag agagcgctga cctagagttc attgtctcta tttattttac
     6601 caaaatgaga gttgaaaagg actgacaaga cacaggactg caatggtgtc cagagcagtg
     6661 acagcagcag agtgttaata aagaataaag ccgtgagaa
//
