LOCUS       NM_017138               1017 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ribosomal protein SA (Rpsa), mRNA.
ACCESSION   NM_017138
VERSION     NM_017138.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1017)
  AUTHORS   Kim,J.E., Park,H., Lee,J.E. and Kang,T.C.
  TITLE     Blockade of 67-kDa Laminin Receptor Facilitates AQP4
            Down-Regulation and BBB Disruption via ERK1/2-and p38 MAPK-Mediated
            PI3K/AKT Activations
  JOURNAL   Cells 9 (7), 1670 (2020)
   PUBMED   32664509
  REMARK    GeneRIF: Blockade of 67-kDa Laminin Receptor Facilitates AQP4
            Down-Regulation and BBB Disruption via ERK1/2-and p38 MAPK-Mediated
            PI3K/AKT Activations.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1017)
  AUTHORS   Park,H. and Kang,T.C.
  TITLE     The Regional Specific Alterations in BBB Permeability are Relevant
            to the Differential Responses of 67-kDa LR Expression in
            Endothelial Cells and Astrocytes Following Status Epilepticus
  JOURNAL   Int J Mol Sci 20 (23), 6025 (2019)
   PUBMED   31795399
  REMARK    GeneRIF: These findings suggested that 67-kDa laminin receptor
            expression level might be involved in Blood-Brain Barrier integrity
            in regional specific manners, which might affect the susceptibility
            to Status Epilepticus induction.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1017)
  AUTHORS   Voorhees,R.M., Fernandez,I.S., Scheres,S.H. and Hegde,R.S.
  TITLE     Structure of the mammalian ribosome-Sec61 complex to 3.4 A
            resolution
  JOURNAL   Cell 157 (7), 1632-1643 (2014)
   PUBMED   24930395
REFERENCE   4  (bases 1 to 1017)
  AUTHORS   Gundimeda,U., McNeill,T.H., Fan,T.K., Deng,R., Rayudu,D., Chen,Z.,
            Cadenas,E. and Gopalakrishna,R.
  TITLE     Green tea catechins potentiate the neuritogenic action of
            brain-derived neurotrophic factor: role of 67-kDa laminin receptor
            and hydrogen peroxide
  JOURNAL   Biochem Biophys Res Commun 445 (1), 218-224 (2014)
   PUBMED   24508265
  REMARK    GeneRIF: Data indicate that green tea polyphenols (GTPP)-induced
            potentiation of brain-derived neurotrophic factor (BDNF) action
            required the cell-surface associated 67 kDa laminin receptor
            (67LR).
REFERENCE   5  (bases 1 to 1017)
  AUTHORS   Anger,A.M., Armache,J.P., Berninghausen,O., Habeck,M., Subklewe,M.,
            Wilson,D.N. and Beckmann,R.
  TITLE     Structures of the human and Drosophila 80S ribosome
  JOURNAL   Nature 497 (7447), 80-85 (2013)
   PUBMED   23636399
REFERENCE   6  (bases 1 to 1017)
  AUTHORS   Rao,M., Manishen,W.J., Maheshwari,Y., Sykes,D.E., Siyanova,E.Y.,
            Tyner,A.L. and Weiser,M.M.
  TITLE     Laminin receptor expression in rat intestine and liver during
            development and differentiation
  JOURNAL   Gastroenterology 107 (3), 764-772 (1994)
   PUBMED   8076763
REFERENCE   7  (bases 1 to 1017)
  AUTHORS   Tohgo,A., Takasawa,S., Munakata,H., Yonekura,H., Hayashi,N. and
            Okamoto,H.
  TITLE     Structural determination and characterization of a 40 kDa protein
            isolated from rat 40 S ribosomal subunit
  JOURNAL   FEBS Lett 340 (1-2), 133-138 (1994)
   PUBMED   8119397
REFERENCE   8  (bases 1 to 1017)
  AUTHORS   Fulcher,K.D., Welch,J.E., Davis,C.M., O'Brien,D.A. and Eddy,E.M.
  TITLE     Characterization of laminin receptor messenger ribonucleic acid and
            protein expression in mouse spermatogenic cells
  JOURNAL   Biol Reprod 48 (3), 674-682 (1993)
   PUBMED   8452943
REFERENCE   9  (bases 1 to 1017)
  AUTHORS   McCaffery,P., Neve,R.L. and Drager,U.C.
  TITLE     A dorso-ventral asymmetry in the embryonic retina defined by
            protein conformation
  JOURNAL   Proc Natl Acad Sci U S A 87 (21), 8570-8574 (1990)
   PUBMED   2146686
REFERENCE   10 (bases 1 to 1017)
  AUTHORS   Collatz,E., Ulbrich,N., Tsurugi,K., Lightfoot,H.N., MacKinlay,W.,
            Lin,A. and Wool,I.G.
  TITLE     Isolation of eukaryotic ribosomal proteins. Purification and
            characterization of the 40 S ribosomal subunit proteins Sa, Sc,
            S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18,
            S19, S20, S21, S26, S27', and S29
  JOURNAL   J Biol Chem 252 (24), 9071-9080 (1977)
   PUBMED   925037
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D25224.1.
            
            On Aug 31, 2012 this sequence version replaced NM_017138.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D25224.1, FQ209667.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1017              D25224.1           2-1018
FEATURES             Location/Qualifiers
     source          1..1017
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1017
                     /gene="Rpsa"
                     /gene_synonym="Lamr1"
                     /note="ribosomal protein SA"
                     /db_xref="GeneID:29236"
                     /db_xref="RGD:71026"
     exon            1..30
                     /gene="Rpsa"
                     /gene_synonym="Lamr1"
                     /inference="alignment:Splign:2.1.0"
     exon            31..197
                     /gene="Rpsa"
                     /gene_synonym="Lamr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..952
                     /gene="Rpsa"
                     /gene_synonym="Lamr1"
                     /function="a constituent of 40S ribosome"
                     /note="laminin receptor 1 (67kD, ribosomal protein SA);
                     laminin receptor 1 (ribosomal protein SA)"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS2"
                     /protein_id="NP_058834.1"
                     /db_xref="GeneID:29236"
                     /db_xref="RGD:71026"
                     /translation="MSGGLDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSD
                     GIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGR
                     FTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIA
                     IPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAA
                     EKAVTKEEFQGEWTAPAPEFTAAQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDW
                     SAAPTAQATEWVGATTEWS"
     exon            198..316
                     /gene="Rpsa"
                     /gene_synonym="Lamr1"
                     /inference="alignment:Splign:2.1.0"
     exon            317..562
                     /gene="Rpsa"
                     /gene_synonym="Lamr1"
                     /inference="alignment:Splign:2.1.0"
     exon            563..691
                     /gene="Rpsa"
                     /gene_synonym="Lamr1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..857
                     /gene="Rpsa"
                     /gene_synonym="Lamr1"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1017
                     /gene="Rpsa"
                     /gene_synonym="Lamr1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1017
                     /gene="Rpsa"
                     /gene_synonym="Lamr1"
ORIGIN      
        1 ctggaacggg tccgtacggc gttgttcttg gttcccatcg taacttaaaa gggaaactta
       61 cacaatgtcc ggaggccttg acgtcctgca gatgaaggag gaggatgtcc tcaaattcct
      121 tgctgcagga acccacttag gtggcaccaa ccttgacttt cagatggagc agtacatcta
      181 caaaaggaaa agtgacggta tctacatcat caacctgaag aggacttggg agaagctgtt
      241 gttagccgct cgagctattg ttgccattga gaaccctgct gatgtcagcg tcatctcctc
      301 caggaacact ggccagcgag ctgtgctgaa gtttgccgct gccacaggag ccactccaat
      361 tgctggccgc ttcacacctg ggaccttcac taaccagatc caagcagcct tcagggagcc
      421 ccggcttcta gtggtgactg atccccgggc tgaccaccag cccctcacag aggcctctta
      481 cgtcaacctg cccaccattg ctctttgtaa cacagattct cccctgcgct atgtggacat
      541 tgccatccca tgcaacaaca agggagctca ctcagtgggt ctcatgtggt ggatgctggc
      601 cagggaagta ctccgcatgc gaggaaccat ctcccgggag cacccatggg aggttatgcc
      661 tgatctttac ttctacaggg acccagagga gattgagaag gaggagcagg ctgccgctga
      721 gaaggctgtg accaaggagg aattccaggg tgaatggacg gcaccagcgc ctgagttcac
      781 tgctgctcag cctgaggtgg ccgactggtc tgagggtgtg caggtgccct ctgtgcccat
      841 tcagcagttc cccacagaag actggagtgc acagccggcc actgaggact ggtcagcagc
      901 tcccacagca caggctactg agtgggttgg agccaccact gagtggtcct gagctcctct
      961 gcaggtgcct gagcgaaggg aaaaaaggtg gaaggaaaat aaagttcctg aaagctg
//
