LOCUS       NM_001010962            1769 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ribosomal protein S6 kinase B2 (Rps6kb2), mRNA.
ACCESSION   NM_001010962 XM_341979
VERSION     NM_001010962.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1769)
  AUTHORS   Nguyen JT, Ray C, Fox AL, Mendonca DB, Kim JK and Krebsbach PH.
  TITLE     Mammalian EAK-7 activates alternative mTOR signaling to regulate
            cell proliferation and migration
  JOURNAL   Sci Adv 4 (5), eaao5838 (2018)
   PUBMED   29750193
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1769)
  AUTHORS   Ma XM and Blenis J.
  TITLE     Molecular mechanisms of mTOR-mediated translational control
  JOURNAL   Nat Rev Mol Cell Biol 10 (5), 307-318 (2009)
   PUBMED   19339977
  REMARK    Review article
REFERENCE   3  (bases 1 to 1769)
  AUTHORS   Katta A, Karkala SK, Wu M, Meduru S, Desai DH, Rice KM and Blough
            ER.
  TITLE     Lean and obese Zucker rats exhibit different patterns of p70s6
            kinase regulation in the tibialis anterior muscle in response to
            high-force muscle contraction
  JOURNAL   Muscle Nerve 39 (4), 503-511 (2009)
   PUBMED   19296503
  REMARK    GeneRIF: insulin resistance is associated with alterations in the
            ability of muscle to activate p70S6k signaling following an acute
            bout of exercise
REFERENCE   4  (bases 1 to 1769)
  AUTHORS   Zeniou-Meyer M, Begle A, Bader MF and Vitale N.
  TITLE     The Coffin-Lowry syndrome-associated protein RSK2 controls
            neuroendocrine secretion through the regulation of phospholipase D1
            at the exocytotic sites
  JOURNAL   Ann N Y Acad Sci 1152, 201-208 (2009)
   PUBMED   19161391
  REMARK    GeneRIF: RSK2 is a critical upstream signaling element in the
            activation of PLD1 to produce the lipids required for exocytosis
REFERENCE   5  (bases 1 to 1769)
  AUTHORS   Zeniou-Meyer M, Liu Y, Begle A, Olanich ME, Hanauer A, Becherer U,
            Rettig J, Bader MF and Vitale N.
  TITLE     The Coffin-Lowry syndrome-associated protein RSK2 is implicated in
            calcium-regulated exocytosis through the regulation of PLD1
  JOURNAL   Proc Natl Acad Sci U S A 105 (24), 8434-8439 (2008)
   PUBMED   18550821
  REMARK    GeneRIF: RSK2 is an essential modulator of PLD1 activity in
            calcium-regulated exocytosis.
            Erratum:[Proc Natl Acad Sci U S A. 2009 May 19;106(20):8398.
            Olanish, Mary [corrected to Olanich, Mary E]]
REFERENCE   6  (bases 1 to 1769)
  AUTHORS   Yutsudo Y, Kido Y, Okabayashi Y, Matsumoto M, Ogawa W, Ohba M,
            Kuroki T and Kasuga M.
  TITLE     Protein kinase Calpha is implicated in cholecystokinin-induced
            activation of 70-kd S6 kinase in AR42J cells
  JOURNAL   Pancreas 30 (1), 50-53 (2005)
   PUBMED   15632699
  REMARK    GeneRIF: PKCalpha is implicated in CCK-induced activation of p70 S6
            kinase in pancreatic acinar AR42J cells.
REFERENCE   7  (bases 1 to 1769)
  AUTHORS   Xu T, Shen Y, Pink H, Triantafillou J, Stimpson SA, Turnbull P and
            Han B.
  TITLE     Phosphorylation of p70s6 kinase is implicated in androgen-induced
            levator ani muscle anabolism in castrated rats
  JOURNAL   J Steroid Biochem Mol Biol 92 (5), 447-454 (2004)
   PUBMED   15698549
  REMARK    GeneRIF: phosphorylation of p70(s6k), likely via the Insulin-Like
            Growth Factor I pathway, may play an important role in
            androgen-induced skeletal muscle hypertrophy
REFERENCE   8  (bases 1 to 1769)
  AUTHORS   Harrington LS, Findlay GM, Gray A, Tolkacheva T, Wigfield S,
            Rebholz H, Barnett J, Leslie NR, Cheng S, Shepherd PR, Gout I,
            Downes CP and Lamb RF.
  TITLE     The TSC1-2 tumor suppressor controls insulin-PI3K signaling via
            regulation of IRS proteins
  JOURNAL   J Cell Biol 166 (2), 213-223 (2004)
   PUBMED   15249583
REFERENCE   9  (bases 1 to 1769)
  AUTHORS   Boylan JM, Anand P and Gruppuso PA.
  TITLE     Ribosomal protein S6 phosphorylation and function during late
            gestation liver development in the rat
  JOURNAL   J Biol Chem 276 (48), 44457-44463 (2001)
   PUBMED   11574531
REFERENCE   10 (bases 1 to 1769)
  AUTHORS   Wang L, Gout I and Proud CG.
  TITLE     Cross-talk between the ERK and p70 S6 kinase (S6K) signaling
            pathways. MEK-dependent activation of S6K2 in cardiomyocytes
  JOURNAL   J Biol Chem 276 (35), 32670-32677 (2001)
   PUBMED   11431469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY315655.1, DY561917.1, AW144793.1 and CK843568.1.
            
            On Jan 25, 2008 this sequence version replaced NM_001010962.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-635               DY315655.1         53-687
            636-1291            DY561917.1         11-666
            1292-1748           AW144793.1         153-609
            1749-1769           CK843568.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..1769
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1769
                     /gene="Rps6kb2"
                     /note="ribosomal protein S6 kinase B2"
                     /db_xref="GeneID:361696"
                     /db_xref="RGD:1305144"
     exon            1..150
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1530
                     /gene="Rps6kb2"
                     /EC_number="2.7.11.1"
                     /note="ribosomal protein S6 kinase, 70kDa, polypeptide 2;
                     ribosomal protein S6 kinase, polypeptide 2"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase beta-2"
                     /protein_id="NP_001010962.2"
                     /db_xref="GeneID:361696"
                     /db_xref="RGD:1305144"
                     /translation="MAAVFDLDLETEEGSEGEGEPEFNPADVCPLGELRAAGLETVGH
                     YEEVELTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLR
                     KAKIVCSAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHL
                     EREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLNSQGHIKLTDFGLCKE
                     SIHEGAITHTFCGTIEYMAPEILVRIGHNRAVDWWSLGALMYDMLTGSPPFTAENRKK
                     TMDKIIKGKLVLPPYLTPDARDLAKKFLKRNPTHRIGGGPGDAADVQRHPFFRHINWD
                     DLLAHRVDPPFRPSLQSEEDVSQFDVRFTRQTPVDSPDDTALSESANQAFLGFTYVAP
                     SVLDSIKEGFSFQPKLRSPRRLNSSPRTPISPLKFSPFEGFRPSPGPPEPMEPSLPPL
                     LPPPSSPPPTSTAPLPIRPPSGTKKSKKGRGRPGR"
     exon            151..191
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            192..312
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..381
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..529
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..587
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..688
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            689..779
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            780..870
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            871..978
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1041
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1119
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1227
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1340
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1752
                     /gene="Rps6kb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcacaagcc tagggctgtc agtcagagcg ctgcctggtc cgggccaagg gtcccgcggg
       61 accggcgggg ccatggcggc cgtgtttgat ttagacttgg agaccgagga aggaagtgag
      121 ggcgagggcg agccggagtt caaccctgcg gacgtgtgtc cccttggcga gttaagggct
      181 gctggcctgg agacagtggg acactatgag gaggtggaac tgacagagag cagcgtcaac
      241 ctgggtcctg agcgcatcgg accccactgc tttgagctac tgagtgttct gggcaagggg
      301 ggttatggca aggtgttcca ggtgagaaaa gtgcaaggca ccaacttggg caaaatatat
      361 gccatgaaag tcttgagaaa ggccaagatt gtatgcagtg ccaaggacac agcacatacc
      421 cgggctgagc ggaacattct agaatcggtg aagcacccct tcattgtaga actggcctat
      481 gctttccaga caggtggcaa actctacctc atcctggagt gcctcagtgg tggtgagctc
      541 ttcacacatc ttgagcgaga aggcatcttc ctggaagaca cagcctgctt ctacctggca
      601 gagatcacac tagccctggg ccatctccat tcccaaggca tcatctaccg ggatctcaag
      661 cccgagaaca tcatgctcaa cagccagggc catatcaaac tgacagactt tggactctgc
      721 aaagagtcca ttcatgaggg tgctatcact cacaccttct gtggcaccat tgagtacatg
      781 gccccagaga ttctagtgcg catcggtcac aaccgggcag tggactggtg gagcctggga
      841 gccctgatgt acgacatgct cactggatcg ccgcccttca ccgcagagaa ccggaagaaa
      901 actatggata aaatcattaa agggaagctg gtgctgcccc cctacctcac cccggatgcc
      961 cgggaccttg ccaaaaagtt tctgaagcgg aatcccactc atcgaattgg gggtggccca
     1021 ggagatgctg ctgatgtgca gaggcacccg tttttccggc acatcaattg ggatgacctc
     1081 ttggcccatc gtgtagaccc tcccttcaga ccgagtctgc aatcagaaga ggacgtgagc
     1141 cagtttgatg tgcgattcac acggcagacg ccagtagata gtccagatga cacagccctc
     1201 agtgagagtg ccaaccaagc cttcctgggc ttcacgtatg tggcaccttc tgtactggac
     1261 agcatcaaag agggcttctc cttccagcct aagctgcgct cccccagacg ccttaacagc
     1321 agtccccgca cccctatcag ccccctcaag ttctctccct ttgaggggtt ccggcccagt
     1381 cctggcccac cagagcccat ggagccatct ctacctccac tcctgccacc accatcatca
     1441 ccaccaccca caagtactgc cccacttccc atccgtcccc cctcaggaac caagaagtcc
     1501 aagaagggac ggggccgccc tgggcgctag gagaatagaa gagacagctg tgagaacctg
     1561 actggctccg acctgtggat gagatgagag tgtgcttgtg tggggggagg gtgagcctta
     1621 caatcgtgta caggagggct gcaggctgca gccactggag gtgttcccac cccccatccc
     1681 atcagaaggg acttggcctg tctttggacc tgtgccctca taggattaaa ggactgaatc
     1741 atggcagagt gaaaaaaaaa aaaaaaaaa
//
