LOCUS       NM_031985               2287 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus ribosomal protein S6 kinase B1 (Rps6kb1), mRNA.
ACCESSION   NM_031985
VERSION     NM_031985.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2287)
  AUTHORS   Huang,Y., Yue,S., Yan,Z., Liu,Y., Qiao,J., Zhang,M., Dong,Y. and
            Zheng,J.
  TITLE     Lactate-upregulated ARG2 expression induces cellular senescence in
            fibroblast-like synoviocytes of osteoarthritis via activating the
            mTOR/S6K1 signaling pathway
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113071 (2024)
   PUBMED   39236462
  REMARK    GeneRIF: Lactate-upregulated ARG2 expression induces cellular
            senescence in fibroblast-like synoviocytes of osteoarthritis via
            activating the mTOR/S6K1 signaling pathway.
REFERENCE   2  (bases 1 to 2287)
  AUTHORS   Chi,O.Z., Liu,X., Fortus,H., Werlen,G., Jacinto,E. and Weiss,H.R.
  TITLE     Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood
            Flow in a Rat Model of Autism-Tuberous Sclerosis
  JOURNAL   Neuromolecular Med 26 (1), 10 (2024)
   PUBMED   38570425
  REMARK    GeneRIF: Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces
            Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2287)
  AUTHORS   Chen,J., Yu,J., Yuan,R., Li,N., Li,C. and Zhang,X.
  TITLE     mTOR inhibitor improves testosterone-induced myocardial hypertrophy
            in hypertensive rats
  JOURNAL   J Endocrinol 252 (3), 179-193 (2022)
   PUBMED   34874016
  REMARK    GeneRIF: mTOR inhibitor improves testosterone-induced myocardial
            hypertrophy in hypertensive rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2287)
  AUTHORS   Wolff,M., Rauschner,M., Reime,S., Riemann,A. and Thews,O.
  TITLE     Role of the mTOR Signalling Pathway During Extracellular Acidosis
            in Tumour Cells
  JOURNAL   Adv Exp Med Biol 1395, 281-285 (2022)
   PUBMED   36527650
  REMARK    GeneRIF: Role of the mTOR Signalling Pathway During Extracellular
            Acidosis in Tumour Cells.
REFERENCE   5  (bases 1 to 2287)
  AUTHORS   Yalcin,M. and Kacar,M.
  TITLE     Investigation of the hepatic mTOR/S6K1/SREBP1 signalling pathway in
            rats at different ages: from neonates to adults
  JOURNAL   Mol Biol Rep 48 (11), 7415-7422 (2021)
   PUBMED   34655015
  REMARK    GeneRIF: Investigation of the hepatic mTOR/S6K1/SREBP1 signalling
            pathway in rats at different ages: from neonates to adults.
REFERENCE   6  (bases 1 to 2287)
  AUTHORS   Long,W., Saffer,L., Wei,L. and Barrett,E.J.
  TITLE     Amino acids regulate skeletal muscle PHAS-I and p70 S6-kinase
            phosphorylation independently of insulin
  JOURNAL   Am J Physiol Endocrinol Metab 279 (2), E301-E306 (2000)
   PUBMED   10913029
REFERENCE   7  (bases 1 to 2287)
  AUTHORS   Burnett,P.E., Blackshaw,S., Lai,M.M., Qureshi,I.A., Burnett,A.F.,
            Sabatini,D.M. and Snyder,S.H.
  TITLE     Neurabin is a synaptic protein linking p70 S6 kinase and the
            neuronal cytoskeleton
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8351-8356 (1998)
   PUBMED   9653190
REFERENCE   8  (bases 1 to 2287)
  AUTHORS   Lane,H.A., Morley,S.J., Doree,M., Kozma,S.C. and Thomas,G.
  TITLE     Identification and early activation of a Xenopus laevis p70s6k
            following progesterone-induced meiotic maturation
  JOURNAL   EMBO J 11 (5), 1743-1749 (1992)
   PUBMED   1374712
REFERENCE   9  (bases 1 to 2287)
  AUTHORS   Banerjee,P., Ahmad,M.F., Grove,J.R., Kozlosky,C., Price,D.J. and
            Avruch,J.
  TITLE     Molecular structure of a major insulin/mitogen-activated 70-kDa S6
            protein kinase
  JOURNAL   Proc Natl Acad Sci U S A 87 (21), 8550-8554 (1990)
   PUBMED   2236064
REFERENCE   10 (bases 1 to 2287)
  AUTHORS   Kozma,S.C., Ferrari,S., Bassand,P., Siegmann,M., Totty,N. and
            Thomas,G.
  TITLE     Cloning of the mitogen-activated S6 kinase from rat liver reveals
            an enzyme of the second messenger subfamily
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7365-7369 (1990)
   PUBMED   1699226
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M58340.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M58340.1, SRR8487230.75648.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2287
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..2287
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /note="ribosomal protein S6 kinase B1"
                     /db_xref="GeneID:83840"
                     /db_xref="RGD:620683"
     exon            1..162
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1599
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /EC_number="2.7.11.1"
                     /note="ribosomal protein S6 kinase, polypeptide 1; S6K;
                     S6K1; P70S6K; p70(S6K)-alpha; p70 S6 kinase alpha;
                     ribosomal protein S6 kinase I; 70 kDa ribosomal protein S6
                     kinase 1; P70S6K1; p70 S6KA; p70-S6K 1; S6K-beta-1; p70
                     ribosomal S6 kinase alpha; ribosomal protein S6 kinase,
                     70kDa, polypeptide 1"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase beta-1"
                     /protein_id="NP_114191.1"
                     /db_xref="GeneID:83840"
                     /db_xref="RGD:620683"
                     /translation="MRRRRRRDGFYPAPDFRHREAEDMAGVFDIDLDQPEDAGSEDEL
                     EEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGY
                     GKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIY
                     AFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRD
                     LKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDW
                     WSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAAS
                     RLGAGPGDAGEVQAHPFFRHINWEELLARKVERPFKPLLQSEEDVSQFDSKFTRQTPV
                     DSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVK
                     FSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTTSGEASAPLPIRQPNSGPYKK
                     QAFPMISKRPEHLRMNL"
     exon            163..212
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            213..333
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            334..402
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            403..550
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            551..608
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            609..709
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            710..800
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            801..891
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            892..999
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1062
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1140
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1248
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1361
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..2283
                     /gene="Rps6kb1"
                     /gene_synonym="p70 S6K-alpha"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgcggcg ggtccgggcc catgaggcga cgacggaggc gggacggctt ttacccagcg
       61 cctgacttcc gacacaggga agctgaggac atggcaggag tgtttgacat agacctggac
      121 cagccagagg atgcaggctc tgaggatgag ctggaggagg ggggtcagtt aaatgaaagc
      181 atggaccatg ggggagttgg accatatgaa cttggcatgg aacattgtga gaaatttgaa
      241 atctcagaaa ctagtgtgaa cagagggcca gaaaaaatca gaccagaatg ttttgagcta
      301 cttcgggtac ttggtaaagg gggctatgga aaggtttttc aagtacgaaa agtaacagga
      361 gcaaatactg ggaagatatt tgccatgaag gtgcttaaaa aggcaatgat agtaagaaat
      421 gctaaagata cagctcatac aaaagcagag cggaatattc tggaggaagt aaagcatccc
      481 ttcattgtgg atttaattta tgcctttcag accggtggaa aactctacct catccttgag
      541 tatctcagtg gaggagaact atttatgcag ttagaaagag aggggatatt catggaagat
      601 acagcttgct tttacttggc tgaaatctcc atggctttgg ggcatttaca tcaaaagggg
      661 attatctaca gagacctgaa gccggagaac atcatgctta atcaccaagg tcacgtgaag
      721 ctgacagact ttggactatg caaagaatct attcatgatg gaacagtcac gcacacattt
      781 tgtggaacaa tagaatacat ggcccctgaa atcttgatga gaagcggcca caaccgtgct
      841 gtggattggt ggagtctggg agcattaatg tatgacatgc tgactggagc acctccattc
      901 actggggaga atagaaagaa gacaattgac aaaatcctca aatgtaaact taatttgcct
      961 ccctacctca cacaagaagc tcgagatctg cttaaaaagc tgctgaagag aaatgctgct
     1021 tctcgtcttg gagctggccc tggggatgct ggagaagtcc aagcgcatcc attttttaga
     1081 cacattaact gggaagagct tttggctcgg aaggtggagc gcccctttaa gcctctgttg
     1141 caatctgaag aggatgtgag tcagtttgat tcaaagttta ctcgtcagac acctgttgac
     1201 agccccgatg actcaactct cagtgaaagt gccaaccagg tctttctggg ttttacatat
     1261 gtggctccat ctgtacttga aagtgtgaaa gaaaagtttt cttttgaacc aaaaatccga
     1321 tcgcctcgaa gatttattgg tagcccacga acgcctgtca gcccagtcaa attctctcct
     1381 ggggatttct ggggacgagg tgcttcagcc agcacagcaa atcctcagac acctgtggaa
     1441 tacccaatgg aaacaagtgg aatagagcag atggatgtga caacgagcgg ggaagcttca
     1501 gcgccacttc caatccgaca gcccaactct gggccataca aaaaacaagc ttttcctatg
     1561 atctccaaac ggccagagca cctgcgtatg aatctatgat gaaacaatgc ttttattaat
     1621 gcaaatgcaa aaaggaaaca aatcctggaa gggcatgtgt gaggatcctg caagataaaa
     1681 atgagaaaat ggcagtctca aagagtcagt gtcattacct ggaatgcttt cgatggagga
     1741 aaaaataaac atggattttt aaaaaaatca atcaatggtg caaaaaataa acccacaaaa
     1801 aactcaaaca aaatagtatt gtggaaccca cagacacatc aactgactgg ttcctaccct
     1861 agcaacatct cagcgttcgt aaggattctc atgctgatgg ccgtaaactg acagtattaa
     1921 gggtaggatg ttgcttctga atcactggta aagtctgatg atgtcacata agggttatcc
     1981 taataggcaa agtacaagat tgcctgtaat acttgcaact aaggacaaat tagcatgcaa
     2041 gctttgtcaa actttttcca gcaacacaga atcaaagaca aaagaaactt atcgattgat
     2101 gttttacgtg caaacaacct gaatcttttt tttatataaa tatatatttt tcaaatagat
     2161 ttttgattca gctcattatg aaaaacatcc caaactttaa aatgcgaagt tattggttgg
     2221 tgtgaagaaa gccagcttct gttcttctct tgatgaaata aaatgcaaat ggatcattgt
     2281 taaaaaa
//
