LOCUS       NM_001191721            4230 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus ribosomal protein S6 kinase A6 (Rps6ka6), mRNA.
ACCESSION   NM_001191721 XM_228473
VERSION     NM_001191721.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4230)
  AUTHORS   Gaestel,M.
  TITLE     MAPKAP kinases - MKs - two's company, three's a crowd
  JOURNAL   Nat Rev Mol Cell Biol 7 (2), 120-130 (2006)
   PUBMED   16421520
  REMARK    Review article
REFERENCE   2  (bases 1 to 4230)
  AUTHORS   Myers,A.P., Corson,L.B., Rossant,J. and Baker,J.C.
  TITLE     Characterization of mouse Rsk4 as an inhibitor of fibroblast growth
            factor-RAS-extracellular signal-regulated kinase signaling
  JOURNAL   Mol Cell Biol 24 (10), 4255-4266 (2004)
   PUBMED   15121846
REFERENCE   3  (bases 1 to 4230)
  AUTHORS   Berns,K., Hijmans,E.M., Mullenders,J., Brummelkamp,T.R., Velds,A.,
            Heimerikx,M., Kerkhoven,R.M., Madiredjo,M., Nijkamp,W., Weigelt,B.,
            Agami,R., Ge,W., Cavet,G., Linsley,P.S., Beijersbergen,R.L. and
            Bernards,R.
  TITLE     A large-scale RNAi screen in human cells identifies new components
            of the p53 pathway
  JOURNAL   Nature 428 (6981), 431-437 (2004)
   PUBMED   15042092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Aug 29, 2022 this sequence version replaced NM_001191721.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               JAXUCZ010000021.1  80638779-80638910   c
            133-387             JAXUCZ010000021.1  80618591-80618845   c
            388-450             JAXUCZ010000021.1  80600919-80600981   c
            451-510             JAXUCZ010000021.1  80595279-80595338   c
            511-627             JAXUCZ010000021.1  80588286-80588402   c
            628-709             JAXUCZ010000021.1  80584750-80584831   c
            710-790             JAXUCZ010000021.1  80584488-80584568   c
            791-870             JAXUCZ010000021.1  80582792-80582871   c
            871-977             JAXUCZ010000021.1  80572494-80572600   c
            978-1015            JAXUCZ010000021.1  80571932-80571969   c
            1016-1158           JAXUCZ010000021.1  80569091-80569233   c
            1159-1229           JAXUCZ010000021.1  80566000-80566070   c
            1230-1318           JAXUCZ010000021.1  80565704-80565792   c
            1319-1377           JAXUCZ010000021.1  80564893-80564951   c
            1378-1480           JAXUCZ010000021.1  80562650-80562752   c
            1481-1611           JAXUCZ010000021.1  80561963-80562093   c
            1612-1734           JAXUCZ010000021.1  80561445-80561567   c
            1735-1824           JAXUCZ010000021.1  80560758-80560847   c
            1825-1983           JAXUCZ010000021.1  80559603-80559761   c
            1984-2145           JAXUCZ010000021.1  80557422-80557583   c
            2146-2222           JAXUCZ010000021.1  80546399-80546475   c
            2223-2340           JAXUCZ010000021.1  80544777-80544894   c
            2341-2472           JAXUCZ010000021.1  80540539-80540670   c
            2473-4230           JAXUCZ010000021.1  80537723-80539480   c
FEATURES             Location/Qualifiers
     source          1..4230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq31"
     gene            1..4230
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /note="ribosomal protein S6 kinase A6"
                     /db_xref="GeneID:317203"
                     /db_xref="RGD:1560817"
     exon            1..132
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2601
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /EC_number="2.7.11.1"
                     /note="ribosomal protein S6 kinase polypeptide 6"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-6"
                     /protein_id="NP_001178650.1"
                     /db_xref="GeneID:317203"
                     /db_xref="RGD:1560817"
                     /translation="MLNFRRTRHTPSGHRSNSSLNLFCCFPFFGCRRQSRSRQRAGTP
                     VVPLLRYPPLARSAVTQRESWSYEEDHEPAQQAGCMLVLGTSSFFSSVPEAAMLPFAP
                     VEDPWDEEMEVFGSGSTSSSEPQIVFTMKTAAMVIRQHEHKEVNDLKMVDEPMDEGEP
                     VFCRREDLVKEIPITQHVKEGYEKADPAQFDLLKVLGQGSFGKVFLVRKKTGPDAGQL
                     YAMKVLRKASLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGD
                     VFTRLSKEVLFTEEDVKFYLAELALALDHLHRLGIVYRDLKPENILLDEIGHIKLTDF
                     GLSKESVDQEKKAYSFCGTVEYMAPEVVNRRGHSQSADWWSYGVLMFEMLTGTLPFQG
                     KDRNETMNMILKAKLGMPQFLSAEAQSLLRMLFKRNPANRLGSEGVEEVKRHAFFSSI
                     DWNKLYKREVQPPFRPASGKPDDTFCFDPEFTAKTPKDSPGLPASANAHQLFKGFSFV
                     ATSIAEEYKITPVTSSNVLPIVQINGNAAQFSEAYELKEDIGIGSYSVCKRCIHSASN
                     MEFAVKIIDKNKRDPSEEIEILMRYGQHPNIISLKEVFDDGKYVYLVTDLMKGGELLD
                     RILKKKCFSEQEASNVLYVITKTVEYLHSQGVVHRDLKPSNILYMDESGHPDSIKICD
                     FGFAKQLRGENGLLLTPCYTANFVAPEVLTQQGYDAACDIWSLGVLLYTMLAGYTPFS
                     NGPNDTPEEILLRIGNGRFSLSGGIWDNISRGAKDLLSHMLHMDPHQRYTAEQVLKHP
                     WITQREQLPRHQPTSDDPPQEAVAAAYSVLARNQNRHPILEPVAASRLAQRRNMKKRT
                     STGL"
     exon            133..387
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            388..450
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            451..510
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            511..627
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            628..709
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            710..790
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            791..870
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            871..977
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1015
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1158
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1229
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1318
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1377
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1480
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1611
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1734
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1824
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1983
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2145
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2222
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2340
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2472
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..4230
                     /gene="Rps6ka6"
                     /gene_synonym="RGD1560817"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataaatccac tttgaatcat gctgaatttt agaaggacac gacacacacc atctggccac
       61 aggtccaact ctagcttgaa cctgttctgt tgctttccgt tttttggatg tcgtcgacaa
      121 tccaggagtc ggcagcgggc ggggacccct gtggtccctc ttttgaggta cccgcctttg
      181 gcgaggtcag cagtcaccca gcgcgagtcc tggtcctacg aagaagacca cgagccagct
      241 cagcaggcgg gatgcatgct ggtgctgggg acaagcagct tcttttcgag tgttcctgaa
      301 gcggcgatgc taccattcgc tcctgtggag gatccctggg acgaagaaat ggaggtgttc
      361 ggcagtggca gcacgagcag tagcgagcca cagattgtgt ttaccatgaa gactgcggcg
      421 atggttattc gacagcatga acacaaagag gtaaatgatc ttaaaatggt tgatgaacca
      481 atggatgagg gagagccagt tttttgccgg cgggaagatt tggttaaaga aatccctatt
      541 acacagcatg ttaaagaagg atatgagaaa gcagatcccg cacagttcga cttgctcaag
      601 gttcttggtc agggatcttt tggaaaggtt tttcttgtta gaaagaagac tggtcctgat
      661 gctgggcagc tctatgcaat gaaggtgtta agaaaagctt ctttgaaggt tcgagaccgt
      721 gttcgcacaa agatggagag ggatatactg gtagaagtaa atcatccttt tatcgtcaaa
      781 ctgcactatg cttttcagac tgaagggaag ctgtacttaa tattggattt cctcagggga
      841 ggagatgtct tcacaagatt atccaaagag gttcttttta cagaggaaga tgtgaaattc
      901 taccttgcgg aattggccct agctttggat catctgcatc gattaggaat tgtgtataga
      961 gacctgaagc cagagaacat cttgcttgac gaaataggac atatcaagtt aacagatttt
     1021 gggctgagca aagagtcagt ggatcaagaa aagaaagcct actccttctg tggtactgta
     1081 gaatacatgg cccccgaagt agtaaatcga agaggccatt ctcagagtgc tgattggtgg
     1141 tcatatggtg tacttatgtt tgaaatgctt actggcacat tgccatttca agggaaagac
     1201 agaaatgaga ccatgaatat gatactgaaa gcaaaacttg gaatgcccca attccttagt
     1261 gctgaagcac aaagcctttt aaggatgtta ttcaaaagga atccagcaaa tagattggga
     1321 tcagaaggag ttgaagaagt caaaagacat gcttttttct cttccattga ctggaataaa
     1381 ttatataaaa gagaagttca gcctcctttc agacctgctt ctggaaaacc agatgatact
     1441 ttttgttttg atcctgaatt tactgccaaa acacctaaag attctcctgg tttgccagcc
     1501 agcgcaaatg ctcatcaact cttcaaagga ttcagttttg ttgcgacttc tatcgcagaa
     1561 gaatataaaa tcactcctgt tacaagttca aatgtattgc caatcgttca gataaatgga
     1621 aatgctgctc aatttagtga agcgtatgag ttgaaagagg atattggtat tggatcttac
     1681 tctgtttgca agcgatgcat acattcagct tccaacatgg aatttgcagt taagatcatt
     1741 gataaaaata agagagaccc ctcagaagaa attgaaattc tgatgcgcta tggacaacat
     1801 cccaacatta tctctttaaa ggaggtcttt gatgatggga aatatgttta ccttgttacg
     1861 gacttgatga aaggaggaga acttctggat cgcattctca aaaagaaatg tttctcagag
     1921 caggaagcta gtaatgtgct gtatgtaatt accaagacag ttgaatacct tcattctcaa
     1981 ggagtcgttc atcgtgatct taagcccagt aatattttgt acatggatga atcaggccat
     2041 ccagattcaa tcaagatctg tgactttgga tttgcaaaac agcttcgagg agaaaatgga
     2101 cttctgttaa ctccatgcta cactgcaaac tttgtagccc ctgaggttct cactcaacag
     2161 ggatatgatg ctgcctgtga tatttggagc ttaggagtcc ttttgtacac aatgttggct
     2221 ggctacactc cattttcaaa tggacccaat gatactcctg aggaaatact tctgcgcata
     2281 ggcaatggga ggttctcttt gagtggtgga atctgggata atatttcacg tggagcaaag
     2341 gatttgcttt ctcatatgct tcacatggac ccacatcagc gttatactgc tgaacaagta
     2401 ttaaagcacc cttggataac ccaaagagaa caactgccgc gtcatcagcc aacctcagat
     2461 gacccgccac aggaagcagt ggctgcagca tattctgttt tggctcggaa ccagaacagg
     2521 catccaatcc tggagcctgt tgctgcttca cgtttagctc agagacgtaa catgaaaaag
     2581 cgaacatcaa ctggcttatg agttctagtg ttcctcagct aactggatga agagaaaatt
     2641 aaatgtgttg tgggttggct tttttgttgt tgttgttgtt ttgttttgtt tttgtctaat
     2701 ctcatatcaa aggtattttg tttcctgcca tattacttga atattctgtt aagcctcttt
     2761 tggagaggtt ggaattttaa acaaacatgc ataggtccgt aatattcata ctatgtcata
     2821 ttgcagtagt gtccaaatgt ttgactatgt aattgatgtc tacaaggtct tgtcttctct
     2881 gcacattaac ttcccaaatt cctttcaaag ttaacctata tttattattt tacataaata
     2941 tgggttagga attcattaac actaatcaaa atgcttttca tatgttataa tgctaaataa
     3001 tatcagtgtt ttaccatcat ttcctaaaaa gtaacttttc ttcttaaaag aacaacagaa
     3061 gtattctaat agcttgtgca tagccaaagc actcgtctga gtccatttag atactaaatg
     3121 tagtaaaata gtttggtgcc tgagcaaaat acattcgtgc taatatatga attcctgata
     3181 tggttggtgc caaagttttg atagaataat taaatcacta ataatttgtg cggacagatt
     3241 tgtatattat ccataagtgg cttcatctag agaaagtttc catgaggctt ctaatgtttt
     3301 acagctaatg aagttgtagt gaaagtgaag atgtttttat ccaaaggttt catgttggtg
     3361 ttgtaatctc ctaaaaatgt catagttaag cctttgaata tgcacttcat ggtgttgatg
     3421 cgatcttggt gttacctaag ctgactttga agttaaccat tgaatgaatc atctttcccc
     3481 tgtatacgtg aagctacact gtgttattcc tgatttccat gtggtttgag ctacagtgta
     3541 gcagcatatt gatctacctt gaatcctatg gtgatgtagt tgaagtttta ctatagtgga
     3601 cttgtgcact tagcacatat gataccgtat aatgtatttc agtaagcatc agacaattct
     3661 acatacttca agaaaataat ttctcatttt aaataggaaa caatattgat gattgacaca
     3721 gaaatttgag tacatttaaa aaacatttat aataaactgg ccaaattggc attattaaat
     3781 ttatgattca gaaccagtgt gtaatgtgta ttgttttcat caaatgctga aaatttaaaa
     3841 agtcatttta tattgttaag gaaaatacca ttaactacta ctactgacag aaaaaattca
     3901 tgaatgtaaa ctggagagta tcagctttgt ttagtgacta gaaatgtatc acttgtgtgt
     3961 gctaggtgta ctgtttgctg tgcatttttt tttgcttagt tcagagagag ctgattactg
     4021 agtatgtgat ttaggctagg agacatgtaa cattggaatt taataaaacc aactgtatgt
     4081 attctcttga aaatgtaagt gatctttatc catgcacaaa tatctgtttc ctacatgtga
     4141 tatataaatt ctgtattctt atttgagatg tcttttttaa aatgattgga caatattaaa
     4201 caacagctga tctgatatcg cacaacagca
//
