LOCUS       NM_001395592            5518 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ribosomal protein S6 kinase A5 (Rps6ka5), mRNA.
ACCESSION   NM_001395592 XM_006240437
VERSION     NM_001395592.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5518)
  AUTHORS   Zhong,Z.X., Feng,S.S., Chen,S.Z., Chen,Z.M. and Chen,X.W.
  TITLE     Inhibition of MSK1 Promotes Inflammation and Apoptosis and Inhibits
            Functional Recovery After Spinal Cord Injury
  JOURNAL   J Mol Neurosci 68 (2), 191-203 (2019)
   PUBMED   30919247
  REMARK    GeneRIF: MSK1 knockdown promotes inflammation and apoptosis and
            inhibits functional recovery after spinal cord injury.
REFERENCE   2  (bases 1 to 5518)
  AUTHORS   Gong,P., Jiang,R., Yao,J., Yao,Q., Xu,X., Chen,J., Shen,J. and
            Shi,W.
  TITLE     Novel Insights into MSK1 Phosphorylation by MRKbeta in
            Intracerebral Hemorrhage-Induced Neuronal Apoptosis
  JOURNAL   Cell Transplant 28 (6), 783-795 (2019)
   PUBMED   30744416
  REMARK    GeneRIF: Novel Insights into MSK1 Phosphorylation by MRKbeta in
            Intracerebral Hemorrhage-Induced Neuronal Apoptosis.
REFERENCE   3  (bases 1 to 5518)
  AUTHORS   Zhu,P., Zhan,L., Zhu,T., Liang,D., Hu,J., Sun,W., Hou,Q., Zhou,H.,
            Wu,B., Wang,Y. and Xu,E.
  TITLE     The roles of p38 MAPK/MSK1 signaling pathway in the neuroprotection
            of hypoxic postconditioning against transient global cerebral
            ischemia in adult rats
  JOURNAL   Mol Neurobiol 49 (3), 1338-1349 (2014)
   PUBMED   24352802
  REMARK    GeneRIF: Hypoxic postconditioning induced a significant increase of
            phosphorylated MSK1 in neurons of hippocampus after transient
            global cerebral ischemia.
REFERENCE   4  (bases 1 to 5518)
  AUTHORS   Gong,P., Xu,X., Shi,J., Ni,L., Huang,Q., Xia,L., Nie,D., Lu,X.,
            Chen,J. and Shi,W.
  TITLE     Phosphorylation of mitogen- and stress-activated protein kinase-1
            in astrocytic inflammation: a possible role in inhibiting
            production of inflammatory cytokines
  JOURNAL   PLoS One 8 (12), e81747 (2013)
   PUBMED   24349124
  REMARK    GeneRIF: MSK1 phosphorylation is associated with the mitigation of
            brain injury and possibly acts as a negative regulator of
            inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5518)
  AUTHORS   Li,Z., Zhao,L., Hang,H., Zhu,N., Ning,B. and Lv,Z.
  TITLE     Spatiotemporal patterns and essential role of MSK1 expression after
            rat spinal cord injury
  JOURNAL   Neurochem Res 38 (12), 2581-2587 (2013)
   PUBMED   24142296
  REMARK    GeneRIF: data suggested that MSK1 might play important roles in CNS
            pathophysiology after spinal cord injury
REFERENCE   6  (bases 1 to 5518)
  AUTHORS   Wierenga,A.T., Vogelzang,I., Eggen,B.J. and Vellenga,E.
  TITLE     Erythropoietin-induced serine 727 phosphorylation of STAT3 in
            erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent
            pathway
  JOURNAL   Exp Hematol 31 (5), 398-405 (2003)
   PUBMED   12763138
REFERENCE   7  (bases 1 to 5518)
  AUTHORS   Vermeulen,L., De Wilde,G., Van Damme,P., Vanden Berghe,W. and
            Haegeman,G.
  TITLE     Transcriptional activation of the NF-kappaB p65 subunit by mitogen-
            and stress-activated protein kinase-1 (MSK1)
  JOURNAL   EMBO J 22 (6), 1313-1324 (2003)
   PUBMED   12628924
REFERENCE   8  (bases 1 to 5518)
  AUTHORS   Markou,T. and Lazou,A.
  TITLE     Phosphorylation and activation of mitogen- and stress-activated
            protein kinase-1 in adult rat cardiac myocytes by G-protein-coupled
            receptor agonists requires both extracellular-signal-regulated
            kinase and p38 mitogen-activated protein kinase
  JOURNAL   Biochem J 365 (Pt 3), 757-763 (2002)
   PUBMED   11994045
  REMARK    GeneRIF: MSK1 activation in adult rat cardiac myocytes by
            G-protein-coupled receptor agonists requires the simultaneous
            activation of both the ERK1/2 and p38 MAPK pathways [Rps6ka5].
REFERENCE   9  (bases 1 to 5518)
  AUTHORS   New,L., Zhao,M., Li,Y., Bassett,W.W., Feng,Y., Ludwig,S.,
            Padova,F.D., Gram,H. and Han,J.
  TITLE     Cloning and characterization of RLPK, a novel RSK-related protein
            kinase
  JOURNAL   J Biol Chem 274 (2), 1026-1032 (1999)
   PUBMED   9873047
REFERENCE   10 (bases 1 to 5518)
  AUTHORS   Deak,M., Clifton,A.D., Lucocq,L.M. and Alessi,D.R.
  TITLE     Mitogen- and stress-activated protein kinase-1 (MSK1) is directly
            activated by MAPK and SAPK2/p38, and may mediate activation of CREB
  JOURNAL   EMBO J 17 (15), 4426-4441 (1998)
   PUBMED   9687510
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Jul 21, 2021 this sequence version replaced XM_006240437.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.23567.1,
                                           SRR26643292.26983.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               JAXUCZ010000006.1  125735501-125735755 c
            256-327             JAXUCZ010000006.1  125677982-125678053 c
            328-546             JAXUCZ010000006.1  125652435-125652653 c
            547-662             JAXUCZ010000006.1  125630027-125630142 c
            663-770             JAXUCZ010000006.1  125626473-125626580 c
            771-854             JAXUCZ010000006.1  125599358-125599441 c
            855-958             JAXUCZ010000006.1  125597083-125597186 c
            959-1109            JAXUCZ010000006.1  125584074-125584224 c
            1110-1271           JAXUCZ010000006.1  125580105-125580266 c
            1272-1397           JAXUCZ010000006.1  125577993-125578118 c
            1398-1531           JAXUCZ010000006.1  125577478-125577611 c
            1532-1625           JAXUCZ010000006.1  125576783-125576876 c
            1626-1796           JAXUCZ010000006.1  125573285-125573455 c
            1797-1988           JAXUCZ010000006.1  125567805-125567996 c
            1989-2148           JAXUCZ010000006.1  125563628-125563787 c
            2149-2312           JAXUCZ010000006.1  125562394-125562557 c
            2313-5518           JAXUCZ010000006.1  125558434-125561639 c
FEATURES             Location/Qualifiers
     source          1..5518
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..5518
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /note="ribosomal protein S6 kinase A5"
                     /db_xref="GeneID:314384"
                     /db_xref="RGD:1308336"
     exon            1..255
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2552
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /EC_number="2.7.11.1"
                     /note="ribosomal protein S6 kinase, 90kDa, polypeptide 5;
                     mitogen and stress-activated protein kinase 1; ribosomal
                     protein S6 kinase, polypeptide 5"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-5"
                     /protein_id="NP_001382521.1"
                     /db_xref="GeneID:314384"
                     /db_xref="RGD:1308336"
                     /translation="MEGEGGGSGGAGTSGDSGDGGEQLLTVKHELRTANLTGHAEKVG
                     IENFELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATIVQKAKTTEHTRTERQ
                     VLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEI
                     VLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADEAERAYSFCGTIEY
                     MAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPP
                     YPQGMSSVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFFEKINWDDLAAKKVPAPF
                     KPVIRDELDVSNFAEEFTEMDPTYSPAALPQSSERLFQGYSFVAPSILFKRNAAVIDP
                     LQFHMGVDRPGVTNVARSAMMKDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKTNQA
                     FAVKIISKRMEANTQKEITALKLCEGHPNVVKLHEVFHDQLHTFLVMELLNGGELFER
                     IKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKVIDFG
                     FARLKPPDNQPLKTPCFTLHYAAPELLTHNGYDESCDLWSLGVILYTMLSGQVPFQSH
                     DRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRY
                     NEWLQDGSQLSSNPLMTPDILGSSGAAVHTCVKATFHAFNKYKREGFCLQNVDKAPLA
                     KRRKMKRTSTSTETRSSSSESSRSSSSHSHGKTTPTKTLQPSNPTEGSNPDTLFQFSD
                     "
     exon            256..327
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..546
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..662
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..770
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            771..854
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..958
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1109
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1271
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1397
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1531
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1625
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1796
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..1988
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2148
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2312
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..5518
                     /gene="Rps6ka5"
                     /gene_synonym="Msk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggagctccg cggccagagc gggaaagaga ctcgcctcag tgtcggagtt gtggcgctgc
       61 ggcagcttgg ctcctggagc tgtgaagaga cagggcgtct gctgtcccat caggttccca
      121 tcagagcgac ccgcgcggtc ggaaagaggg tgaagatgga gggggagggc ggcggcagcg
      181 gcggcgcggg caccagcggg gacagtggcg acggcggcga gcagctcctt actgtcaagc
      241 atgagctgcg gaccgccaac ttaacaggac atgcagagaa ggtgggaatt gaaaattttg
      301 agctgctgaa ggtcctagga actggagctt atgggaaagt atttctagtt cgtaaaataa
      361 gcggccatga tgctggaaag ctgtatgcca tgaaagtttt aaaaaaagca acaatcgttc
      421 agaaggctaa aactacggag catacgagga cagaacggca ggttctggag cacattagac
      481 agtcgccatt tctggtgacg ttgcactatg ctttccagac agagaccaag cttcatctca
      541 tcttagatta tataaatggt ggagaacttt ttactcatct ttctcaaaga gagcgtttca
      601 cagagcacga agtgcagatc tatgttggag agatcgtgct tgccctggaa cacctgcaca
      661 agttggggat tatataccgt gacattaagc tggaaaatat tctacttgat tctaatggcc
      721 atgtggtgct gacagatttt ggtctgagta aggagtttgt ggctgatgaa gccgaaagag
      781 cgtattcttt ctgtgggact attgagtaca tggcgccaga tattgtcaga gggggcgatt
      841 ccggacatga caaggcagtt gactggtgga gtttaggtgt tctaatgtat gagctactaa
      901 ctggagcatc tcctttcact gttgatggag aaaaaaattc ccaggctgag atatctagga
      961 gaatcttaaa gagtgagcct ccgtatcccc agggaatgag ctcagtagct aaagacctcc
     1021 ttcagcgtct tttgatgaaa gatcccaaga agcgattggg atgtggccca cgggatgcag
     1081 aagaaatcaa agaacatctc ttctttgaga agataaattg ggatgactta gctgccaaaa
     1141 aagtgcctgc gccctttaaa ccagtgatcc gggacgagtt agacgtgagt aactttgctg
     1201 aagagttcac tgagatggac cccacctact ctcctgcagc tctgccccag agctctgagc
     1261 gactgttcca gggctactcc ttcgttgctc cttccatcct cttcaagcgt aacgcggcgg
     1321 tcatagatcc ccttcagttc catatgggag tagaccgccc tggagtgaca aacgttgcca
     1381 ggagcgcaat gatgaaggac tcaccattct accaacacta tgacctagat ctgaaggaca
     1441 aacctttggg agaaggaagt ttttcaatct gtcggaagtg tgtacacaaa aaaactaacc
     1501 aagcctttgc cgtcaaaata atcagcaaaa ggatggaagc caatactcag aaagaaataa
     1561 cagctctgaa actctgcgaa ggccacccca atgttgtgaa gctgcatgaa gtttttcatg
     1621 accagcttca tacatttctt gtgatggagc ttctgaatgg gggagagctg tttgagcgca
     1681 tcaagaaaaa gaagcacttc agcgagactg aggccagcta cattatgcgg aagcttgtgt
     1741 cggctgtgag ccacatgcac gatgttggag tggtgcacag agacctgaag ccggagaatt
     1801 tattgttcac tgatgaaaac gacaatttgg agattaaagt gattgacttt gggtttgcac
     1861 gcctcaagcc gcctgacaat cagcccctca agaccccatg cttcacgctt cactacgcag
     1921 caccggagct cttgacgcac aatggctacg atgagtcctg cgacctgtgg agcttgggtg
     1981 tcatcctgta tacaatgctg tcagggcagg taccgttcca gtcccatgac agaagtttaa
     2041 catgtaccag tgcagtggaa atcatgaaga aaattaaaaa gggagatttc tcctttgaag
     2101 gggaagcatg gaaaaatgta tcccaagagg ctaaagactt gattcaagga cttcttacag
     2161 ttgatccaaa taaaaggctg aaaatgtctg gcttgaggta caatgaatgg cttcaggatg
     2221 gcagtcagct gtcctccaat cctctgatga ctccagacat tctgggatct tcaggagcag
     2281 ctgtacacac ctgtgtgaaa gcaaccttcc atgcctttaa caaatataag agagaagggt
     2341 tctgccttca gaatgtcgat aaggcccctt tggctaagag gaggaaaatg aagaggacca
     2401 gcaccagcac agagactcgc agcagctcca gtgagagctc ccgctcctcc tcctcccatt
     2461 cccatggcaa gacaacgcct accaagacac tgcagccaag caaccccacc gaaggcagca
     2521 acccagacac cctcttccag ttctcagact gagtgctgca ggaatggtag gctgtcctcg
     2581 ctgacccttg cacctcagct ccctcagcat gtgcctgagg tatgttctgt gctttaaaag
     2641 atgtgtccca ttgttctcat tggactctgc ctcgtaatga atatttcttg gggaactcta
     2701 cttggttatc cttgtccaaa agcactggac agacagcatt actgtgaata gaggacacgt
     2761 gatagatact ttttagcaga ctaacatgat gccagctcaa gattcttctt gaaacagcaa
     2821 aggtttctgt aactttggtg actagttaga taagtcacag attttcacat gtctgccaag
     2881 aagacttgaa aatttcgcca tgcctggtgg acaaggaagg tttttaagag acttgcacct
     2941 tttgggtagt gatttactag agaaaaaggt ctgttttcca aaaagatata atgaatttta
     3001 tgtgtgactt gtttcttaaa agagaattta acttattgtt tttattttat ggtcatatat
     3061 gctgataacc tgctattatt aatctttttc taaaaagtaa aaaaaaaaat atttaagaat
     3121 ttagggtcct atgctttgca cctggggccc atctgagacg catgctaagc tatgtttgtt
     3181 tttaattttg cactgctctt tcctgacagt ttgttttaat ggttattgtg ggagttaagg
     3241 tacatgtctc ttggttttat gtaacatggc actttatgaa atagtgtgag tattgcagtc
     3301 tgtcttagaa ggtgcactgt tccaagcatc tgtgctgatt taccattcgt actctacctt
     3361 ctttcatctg tccccacctc tctcttctgc tttctgtgca gcaagtagaa agggacatgt
     3421 tgtctcatga gtcattagcc acttatgcac caatctgagg aaaagtaaag ggaattgtac
     3481 tcaacactgt gctccacatc tgtacactgt gtcgcactac agcgagccgc cccctcctgt
     3541 aggcagagac tatgtacata gtattttaga accacagcca tgcttgaccc acaccgcatt
     3601 ttataaactt atgcagagca cttttattgc tccaaagttc tgaattcata cagacaagca
     3661 ctatgccatg aagatatttc actgaaagac tgctgcattt taaagtacaa actagttaat
     3721 tccctatgca aaaaagaaat catggatttg tatgtgtttt tctttaaagc cattacatgg
     3781 aatgtcagga ctgagaaaag ggtcttcact atgtctacaa gaactgcgtt taaaagggta
     3841 cctcccgaca tgttgatctt acagttttgt taatgataac ctccttagca ttagtttggg
     3901 atttggacac gatacctatt tatctctttc ttaaggtaat agcagcatta atgtcaacca
     3961 gtgatgaata ctgaaggtaa ctgcattctg tgtaatggta atatatttat tactaagtca
     4021 atgtatatat taataatagt ataggaaaca aaatggcaaa tattaaaata ttttcaaaat
     4081 aatatattat cctgctcact ttttgttcac agtagttact ggggatattt tttgatattc
     4141 tgactggcca aatgagtata tgattctaat tgagtcaata aaaattttat actcctagct
     4201 ttcagtcatt tctagtaatg ataggaaact gtgtgaatta ctaataaact ctagctattt
     4261 cacaaaaatg tgatgccctt gggcagaggt ttttaataag aatatgtcca ctcattttta
     4321 cactgggtta tatttggaaa tgtttaagtt agtttttgaa gttatttgta aatgtctgtc
     4381 ctgtaggaaa tatgagttac acagtacaaa ctaaggagac tgttgccaaa agaaagtaat
     4441 ccagaaaagg ggttcagtgc cctcatgatt gattagtgca ttgtagatat tggaattgat
     4501 gggttctaaa tttcttcacc tggtatcttc tggaagaatc aatagtcact agaacgggca
     4561 aaagacaggt agagtaagaa gaaagcctaa ctgaatcttc taccgggagc ttgtgaaagg
     4621 cctcaggaaa cttaagatgc tgtcagtaac acccaattta taagtgcttg aaaggcagta
     4681 cgtaatgatt ccttgcaggt tgtgttagga aagttctttt agaaatcaca tttagtcaca
     4741 tcaaaactaa acgataaaaa tgctacgtac aaaagcactg agaggggctg gagaaatagg
     4801 agcagttaag aacagacact gttcttggcc aaaggatagg agttccattc ccagcatgca
     4861 tggctcacag ctcacagcaa gcctggaact ccagctccag agcatcccat gctgtcttct
     4921 ggtgcacaga aatgttaagt gagatgactt ttgattttag gagtaaaata gaagtagatc
     4981 aaagaaacat aaataatctg ctttaagttc cctctatgac aatggttctg gctgtcaagt
     5041 caaattatcc tacccttctt tatggattac attgtatgta atttatccca ctgtatatcg
     5101 ggagtcacac attgtataat tgtgtctgtc taatatatcg aaaggcaaag atatgctagg
     5161 agaacaaaac taaagcagag gggtttcctg taattacgat gccagatcct gttgctgaat
     5221 gaactaattt agctctcttg aagtccatca gttatcccaa acctctataa aaaccattta
     5281 actattggaa tgaagtgaat ttcaacatga ttatctgtct tgaggttgcg ggctcatttg
     5341 tgcatgaaaa ctgctttttt tcttttgaga ttactgctaa ttaagtatgc aaatggcttt
     5401 gttttaaatg taaggtggtt attttgaaga gttctactag ggtaacaatg agtgatttgt
     5461 ttgttcattt gttttttaat aaagaaaatt ctttatctaa atatgaactc aaatatta
//
