LOCUS       NM_001108517            3119 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus ribosomal protein S6 kinase A4 (Rps6ka4), mRNA.
ACCESSION   NM_001108517 XM_342004
VERSION     NM_001108517.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3119)
  AUTHORS   Wang B, Chen J, Santiago FS, Janes M, Kavurma MM, Chong BH, Pimanda
            JE and Khachigian LM.
  TITLE     Phosphorylation and acetylation of histone H3 and autoregulation by
            early growth response 1 mediate interleukin 1beta induction of
            early growth response 1 transcription
  JOURNAL   Arterioscler Thromb Vasc Biol 30 (3), 536-545 (2010)
   PUBMED   20018936
REFERENCE   2  (bases 1 to 3119)
  AUTHORS   Gaestel M.
  TITLE     MAPKAP kinases - MKs - two's company, three's a crowd
  JOURNAL   Nat Rev Mol Cell Biol 7 (2), 120-130 (2006)
   PUBMED   16421520
  REMARK    Review article
REFERENCE   3  (bases 1 to 3119)
  AUTHORS   Soloaga A, Thomson S, Wiggin GR, Rampersaud N, Dyson MH, Hazzalin
            CA, Mahadevan LC and Arthur JS.
  TITLE     MSK2 and MSK1 mediate the mitogen- and stress-induced
            phosphorylation of histone H3 and HMG-14
  JOURNAL   EMBO J 22 (11), 2788-2797 (2003)
   PUBMED   12773393
REFERENCE   4  (bases 1 to 3119)
  AUTHORS   Tomas-Zuber M, Mary JL, Lamour F, Bur D and Lesslauer W.
  TITLE     C-terminal elements control location, activation threshold, and p38
            docking of ribosomal S6 kinase B (RSKB)
  JOURNAL   J Biol Chem 276 (8), 5892-5899 (2001)
   PUBMED   11035004
REFERENCE   5  (bases 1 to 3119)
  AUTHORS   Pierrat B, Correia JS, Mary JL, Tomas-Zuber M and Lesslauer W.
  TITLE     RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase
            under dominant control of p38alpha mitogen-activated protein kinase
            (p38alphaMAPK)
  JOURNAL   J Biol Chem 273 (45), 29661-29671 (1998)
   PUBMED   9792677
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN932052.1, BU671341.1, FM059731.1, CB700259.1, FM035808.1,
            BF407559.1, CB737401.1, AW251264.1 and BQ194971.1.
            
            On Jun 23, 2009 this sequence version replaced NM_001108517.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                DN932052.1         33-46
            15-393              BU671341.1         1-379
            394-830             DN932052.1         262-698
            831-1160            FM059731.1         106-435
            1161-1559           CB700259.1         1-399
            1560-1799           FM035808.1         253-492
            1800-2164           BF407559.1         103-467             c
            2165-2267           CB737401.1         7-109               c
            2268-2816           AW251264.1         8-556
            2817-3119           BQ194971.1         1-303               c
FEATURES             Location/Qualifiers
     source          1..3119
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..3119
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /note="ribosomal protein S6 kinase A4"
                     /db_xref="GeneID:361715"
                     /db_xref="RGD:1307277"
     exon            1..103
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..2370
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /EC_number="2.7.11.1"
                     /note="coiled-coil domain containing 88B; ribosomal
                     protein S6 kinase, polypeptide 4"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-4"
                     /protein_id="NP_001101987.2"
                     /db_xref="GeneID:361715"
                     /db_xref="RGD:1307277"
                     /translation="MGDEDEDEGCAVELQITEANLTGHEEKVSVENFALLKVLGTGAY
                     GKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLH
                     YAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYR
                     DLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKAGHGKA
                     VDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRL
                     LCKDPKKRLGAGPQGAQEVKSHLFFQGLDWVALAARKIPAPFRPQIRSELDVGNFAEE
                     FTRLEPVYSPAGSPPPGDPRIFQGYSFVAPSILFDHNNAVMADVLAAPGAGYRPGRAA
                     VARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRLEENT
                     QREVAALRLCQSHPNVVNLHEVLHDQLHTYLVLELLRGGELLEHIRKKRLFSESEASQ
                     ILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQSPAGPM
                     QTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQAAEI
                     MCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRSSSWLQDGSARSS
                     PPLRTPDVLESSGPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQKLRSAAA
                     SRRGSPVPASSGRLPASASKGTTRRANGPLSPS"
     exon            104..175
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            176..394
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            395..510
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            511..618
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            619..699
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            700..803
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            804..954
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1119
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1248
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1382
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1476
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1650
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1845
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..2005
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2169
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..3102
                     /gene="Rps6ka4"
                     /gene_synonym="Ccdc88b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgccgccc ggagccccag ccgcgcgggc cccagcgacc ggcccgccat gggagacgag
       61 gatgaggatg agggctgcgc cgtggagctg cagatcaccg aagccaacct gaccgggcat
      121 gaggagaagg tgagcgtgga gaacttcgcg ctgctcaagg tgctgggcac gggagcctac
      181 gggaaggtgt tcctggtgcg gaaggcgggt gggcacgatg cgggcaagct ctatgccatg
      241 aaggtgcttc gcaaggcggc gttggtgcag cgcgccaaga cgcaggagca tacccgcacc
      301 gaacgctcag tgctggagct ggtacgccag gcacccttcc tggtcacact gcactacgcc
      361 ttccagacgg acgccaaact gcacctcatc ctggactatg tgagcggtgg tgagatgttc
      421 actcacctgt accagcgcca gtacttcaag gaggctgagg tgcgagtgta cgggggagag
      481 attgtgctgg ccctagagca cctgcacaag ttgggcatca tctacaggga cctgaagctg
      541 gagaacgtct tacttgactc tgaaggtcac attgtcctca cagactttgg tttgagcaag
      601 gagttcctga ctgaggagaa agagcgaacc ttctccttct gtggcaccat cgagtacatg
      661 gctcccgaaa tcatccgaag caaggctgga catggcaagg ctgtggactg gtggagcctg
      721 ggtatcctgc tcttcgagct gctgacagga gcctcaccct tcacactgga gggagaaagg
      781 aacactcagg ctgaggtgtc tcgacggatc ttgaagtgct cccctccctt ccctccccgg
      841 attgggcctg tggcacagga cctgctacag cgcctgctgt gcaaggaccc taagaagagg
      901 ttgggcgcag gtccccaggg tgcacaggaa gtcaagagtc acctcttttt ccagggtctg
      961 gattgggttg ctctggctgc cagaaagatc ccagccccat tccggcccca gatccgctca
     1021 gagctggatg tggggaattt tgcagaggaa ttcactcggc tggagcctgt ctactcccct
     1081 gctggcagcc ctccacctgg ggaccctagg atctttcagg gatactcctt cgtggctcct
     1141 tccatactct ttgaccacaa caacgcagtg atggctgatg tgctggcggc acctggtgct
     1201 ggatacaggc ctggcagggc agcagttgcc aggagtgcca tgatgcagga ctcgcctttc
     1261 ttccagcagt atgagctgga ccttcgggag ccagcgctgg ggcagggcag cttctctgtg
     1321 tgtaggcgat gtcgccagcg ccagagtggt caggaatttg ccgtcaagat cctcagccgc
     1381 aggctggagg agaacactca gcgcgaggta gctgcccttc gcttgtgcca gtcacacccc
     1441 aacgtggtga acctgcatga ggtgcttcac gaccagttac acacttatct ggtcctggag
     1501 ttgctgcggg gcggggagct gctggagcac atccgcaaga agcgactctt cagcgagtcc
     1561 gaggctagcc agatccttcg gagcttggtg tcagccgtga gcttcatgca tgaggaggcg
     1621 ggcgtggtgc accgtgacct gaaacccgag aacatcttgt acgcagacga cactcctggg
     1681 gccccggtga agatcatcga ctttgggttc gcgagactgc ggccccagag cccggcgggg
     1741 cccatgcaga cgccttgctt caccctgcag tacgctgcac ccgagctgct ggcacagcag
     1801 gggtacgacg agtcctgtga tctttggagc ctgggtgtca ttctgtacat gatgctgtct
     1861 ggacaggttc ccttccaagg ggcctctggc cagggtggac agagccaggc agctgagatc
     1921 atgtgcaaga tccgtgaagg gcgcttctct ctggacgggg aagcctggca aggtgtttcg
     1981 gaggaagcca aggagctggt ccgagggcta ctgacagtgg accccgccaa gcggctgaag
     2041 ctggaggggc tgcgtagcag ctcgtggctt caggacggca gtgcgcgctc ctcgcccccg
     2101 ctccgcacgc cggatgtgct ggagtcctct gggccagcag tgcgctccgg gctcaatgcc
     2161 actttcatgg cgtttaaccg aggaaagcgc gagggcttct ttttgaagag tgtggagaac
     2221 gcgccgctgg ccaaaaggcg caagcagaag ctccggagcg cggccgcctc ccgccgcggc
     2281 tccccggtgc ctgcctcctc gggtcgccta ccagcctctg cctccaaggg gacaactcgc
     2341 cgagccaacg gccccttgtc cccttcttag ctcccgccac tgtgaccccc ttccctttag
     2401 gagttctgac ccgggagcct ggtgtttcca ccagactttg ggtagcagct cccactctga
     2461 tccccaggaa ttgccctccc ctccccaccc acttctagac agagcagaag tatttttata
     2521 agcagagatt ttttaaaaat gtcttaccag ataagaattg gggacacagg gaagcaagtg
     2581 tcatcagcaa agtggggttt gggcttcctc tccccgctcc cgatgctgcc tcatcaggag
     2641 agagaaagcc ccttccaggg gctactctgc ttaggaaggc atcctatcct gtccctaagt
     2701 acacagttgc catggggtag agatcaggag cccccgtcct gtgcttccct gggactttgc
     2761 tcctaggagg gggtacccat caatgtcact ttatggaccg tgtgcaatga tgtccaccaa
     2821 agacctgtgt tggggatgag aaagagacca tgggggcctc tagacatttc tgagatacat
     2881 cacttttatg tcactggctt ctccccagtg ggggtaagaa aggaggtagg tgcccctaca
     2941 aggggagccc ctttctcact cacccttcct cattggcaca gctgcttcta gctgcaggtg
     3001 gacccatggg gttctgtact gggcatccac agtcactgcc tcagcccctc gaggctgtgc
     3061 ctttgacttt aaaataaaac tccatccagt gctgcacgtg gaaaaaaaaa aaaaaaaaa
//
