LOCUS       NM_057128               5396 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus ribosomal protein S6 kinase A2 (Rps6ka2), mRNA.
ACCESSION   NM_057128 XM_001058582 XM_001064184 XM_001064230 XM_001064287
            XM_001064346 XM_001064394 XM_001064450 XM_341758
VERSION     NM_057128.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5396)
  AUTHORS   Li,J., Kritzer,M.D., Michel,J.J., Le,A., Thakur,H., Gayanilo,M.,
            Passariello,C.L., Negro,A., Danial,J.B., Oskouei,B., Sanders,M.,
            Hare,J.M., Hanauer,A., Dodge-Kafka,K. and Kapiloff,M.S.
  TITLE     Anchored p90 ribosomal S6 kinase 3 is required for cardiac myocyte
            hypertrophy
  JOURNAL   Circ Res 112 (1), 128-139 (2013)
   PUBMED   22997248
  REMARK    GeneRIF: Anchored RSK3 transduces signals that modulate pathologic
            myocyte growth in cardiac hypertrophy.
REFERENCE   2  (bases 1 to 5396)
  AUTHORS   Hoxhaj,G., Najafov,A., Toth,R., Campbell,D.G., Prescott,A.R. and
            MacKintosh,C.
  TITLE     ZNRF2 is released from membranes by growth factors and, together
            with ZNRF1, regulates the Na+/K+ATPase
  JOURNAL   J Cell Sci 125 (Pt 19), 4662-4675 (2012)
   PUBMED   22797923
  REMARK    Erratum:[J Cell Sci. 2022 Mar 15;135(6):. PMID: 35267011]
REFERENCE   3  (bases 1 to 5396)
  AUTHORS   Sung,J.H., Kim,M.O. and Koh,P.O.
  TITLE     Nicotinamide prevents the down-regulation of MEK/ERK/p90RSK
            signaling cascade in brain ischemic injury
  JOURNAL   J Vet Med Sci 74 (1), 35-41 (2012)
   PUBMED   21891976
  REMARK    GeneRIF: These findings suggest that nicotinamide protects neuronal
            cells against cerebral ischemic injury and that MEK-ERK-p90RSK
            cascade activation by nicotinamide contributes to these
            neuroprotective effects.
REFERENCE   4  (bases 1 to 5396)
  AUTHORS   Yang,M.F., Xie,J., Gu,X.Y., Zhang,X.H., Davey,A.K., Zhang,S.J.,
            Wang,J.P. and Zhu,R.M.
  TITLE     Involvement of 90-kuD ribosomal S6 kinase in collagen type I
            expression in rat hepatic fibrosis
  JOURNAL   World J Gastroenterol 15 (17), 2109-2115 (2009)
   PUBMED   19418583
  REMARK    GeneRIF: Data show that p90RSK is over-expressed in activated
            hepatic stellate cells (HSCs) and is involved in regulating the
            abnormal expression of collagen type I through initiating the
            proliferation of HSCs.
REFERENCE   5  (bases 1 to 5396)
  AUTHORS   Bignone,P.A., Lee,K.Y., Liu,Y., Emilion,G., Finch,J., Soosay,A.E.,
            Charnock,F.M., Beck,S., Dunham,I., Mungall,A.J. and Ganesan,T.S.
  TITLE     RPS6KA2, a putative tumour suppressor gene at 6q27 in sporadic
            epithelial ovarian cancer
  JOURNAL   Oncogene 26 (5), 683-700 (2007)
   PUBMED   16878154
REFERENCE   6  (bases 1 to 5396)
  AUTHORS   Fingar,D.C., Salama,S., Tsou,C., Harlow,E. and Blenis,J.
  TITLE     Mammalian cell size is controlled by mTOR and its downstream
            targets S6K1 and 4EBP1/eIF4E
  JOURNAL   Genes Dev 16 (12), 1472-1487 (2002)
   PUBMED   12080086
  REMARK    GeneRIF: Mammalian cell size is controlled by mTOR and its
            downstream targets S6K1 and 4EBP1/eIF4E
REFERENCE   7  (bases 1 to 5396)
  AUTHORS   Buck,M., Poli,V., Hunter,T. and Chojkier,M.
  TITLE     C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase
            inhibitory box critical for cell survival
  JOURNAL   Mol Cell 8 (4), 807-816 (2001)
   PUBMED   11684016
REFERENCE   8  (bases 1 to 5396)
  AUTHORS   Buck,M., Poli,V., van der Geer,P., Chojkier,M. and Hunter,T.
  TITLE     Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP
            beta is required for hepatocyte proliferation induced by TGF alpha
  JOURNAL   Mol Cell 4 (6), 1087-1092 (1999)
   PUBMED   10635333
REFERENCE   9  (bases 1 to 5396)
  AUTHORS   Kim,Y.B., Inoue,T., Nakajima,R., Shirai-Morishita,Y., Tokuyama,K.
            and Suzuki,M.
  TITLE     Effect of long-term exercise on gene expression of insulin
            signaling pathway intermediates in skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 254 (3), 720-727 (1999)
   PUBMED   9920808
REFERENCE   10 (bases 1 to 5396)
  AUTHORS   Yin,T. and Yang,Y.C.
  TITLE     Mitogen-activated protein kinases and ribosomal S6 protein kinases
            are involved in signaling pathways shared by interleukin-11,
            interleukin-6, leukemia inhibitory factor, and oncostatin M in
            mouse 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (5), 3731-3738 (1994)
   PUBMED   7508917
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Dec 17, 2009 this sequence version replaced
            XM_001064450.1, XM_001064184.1, XM_001064346.1, XM_001064230.1,
            XM_001064394.1, XM_001064287.1, XM_341758.3, XM_001058582.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.816.1, SRR26643295.694.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               JAXUCZ010000001.1  55318811-55319136
            327-443             JAXUCZ010000001.1  55373773-55373889
            444-525             JAXUCZ010000001.1  55382189-55382270
            526-606             JAXUCZ010000001.1  55392619-55392699
            607-686             JAXUCZ010000001.1  55394836-55394915
            687-793             JAXUCZ010000001.1  55397024-55397130
            794-831             JAXUCZ010000001.1  55399831-55399868
            832-974             JAXUCZ010000001.1  55401616-55401758
            975-1045            JAXUCZ010000001.1  55407306-55407376
            1046-1134           JAXUCZ010000001.1  55408574-55408662
            1135-1199           JAXUCZ010000001.1  55419934-55419998
            1200-1302           JAXUCZ010000001.1  55426519-55426621
            1303-1433           JAXUCZ010000001.1  55432937-55433067
            1434-1559           JAXUCZ010000001.1  55433877-55434002
            1560-1649           JAXUCZ010000001.1  55440324-55440413
            1650-1808           JAXUCZ010000001.1  55442248-55442406
            1809-1970           JAXUCZ010000001.1  55444649-55444810
            1971-2047           JAXUCZ010000001.1  55447146-55447222
            2048-2165           JAXUCZ010000001.1  55447956-55448073
            2166-2303           JAXUCZ010000001.1  55450252-55450389
            2304-5396           JAXUCZ010000001.1  55451179-55454271
FEATURES             Location/Qualifiers
     source          1..5396
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..5396
                     /gene="Rps6ka2"
                     /note="ribosomal protein S6 kinase A2"
                     /db_xref="GeneID:117269"
                     /db_xref="RGD:620676"
     exon            1..326
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..2429
                     /gene="Rps6ka2"
                     /EC_number="2.7.11.1"
                     /note="ribosomal protein S6 kinase, 90kD, polypeptide 2;
                     ribosomal protein S6 kinase polypeptide 2"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-2"
                     /protein_id="NP_476469.1"
                     /db_xref="GeneID:117269"
                     /db_xref="RGD:620676"
                     /translation="MELNMKKFTVRRFFSVYLRKKSRSKSSSLSRLEEEGIVKEIDIS
                     SHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRD
                     RVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEED
                     VKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYS
                     FCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKL
                     GMPQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFFVTIDWNKLYRKEIKPP
                     FKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLVQEPSQQDV
                     PKAPIHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSK
                     RDPSEEIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSERE
                     ASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENG
                     LLMTPCYTANFVAPEVLKRQGYDAACDVWSLGILLYTMLAGFTPFANGPDDTPEEILA
                     RIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLTAVQVLKHPWIVNREYLSQNQ
                     LSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSSLAQRRGMKRLTSTRL"
     exon            327..443
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            444..525
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..606
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            607..686
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            687..793
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..831
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..974
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1045
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1134
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1199
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1302
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1433
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1559
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1649
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1808
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1970
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2047
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2165
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            2166..2303
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
     exon            2304..5396
                     /gene="Rps6ka2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagctggta ctcctggccg gaggcaaagg cgccgcggga gtgatcctgg ggtcggggcc
       61 cggtggccgg cgcggcctgc cctttgtgct tgcagtccgc atccgcgccc agggccgccg
      121 cgtcgggctc cccggcgcgc gtgcccgcca gcgcgctgcc tagcctggga tgtgccgggg
      181 atgcgcgccc gccggccctg cggctcctgg cagctgggcg cggggcgatg gagctgaaca
      241 tgaagaagtt cacggtgcgc aggttcttct cagtgtacct gcgcaagaag tcgcgctcca
      301 agagctccag tctgagtcgc ctcgaggaag aaggcatcgt gaaggagatt gacattagca
      361 gccatgtgaa ggaaggcttc gagaaggcag acccctccca gttcgagctg ctaaaagttt
      421 taggacaagg gtcgtatgga aaggtgttct tggtgaggaa agtcacagga tcggatgctg
      481 gtcagctcta cgccatgaaa gtcctgaaga aagccacctt gaaagtgcgg gaccgggtcc
      541 ggtctaagat ggagagagat atcctggcag aggtgaatca ccctttcatc gtcaagctgc
      601 attacgcctt tcagaccgaa ggcaagctct acctgatcct ggacttcctg cggggaggag
      661 acctcttcac caggctttcc aaagaggtga tgtttacgga ggaggatgtt aagttctacc
      721 tggctgagct ggccttggct ctggaccacc tccacggcct agggatcatc tacagggatc
      781 tgaagcctga aaatatcctc ctggatgaag agggacatat taagatcaca gattttggct
      841 tgagcaagga ggccatcgac catgacaaga gagcctattc attttgtggg actattgaat
      901 acatggcgcc cgaggtggtg aaccggcgtg gacacacaca gagtgctgac tggtggtcct
      961 ttggtgtgct catgttcgag atgctcacag gatccctgcc gtttcagggg aaggacagga
     1021 aggaaacaat ggccctcatc ctcaaagcca agctgggcat gcctcagttc ctcagtgcgg
     1081 aggcacagag cctgctgaga gcccttttca agcggaatcc ctgtaaccgg ctaggtgctg
     1141 gtgttgacgg agtggaggaa attaaacgtc acccgttctt tgtcaccata gactggaata
     1201 agctgtatcg caaggaaatc aagccaccct tcaagccagc agtgggaagg cctgaggaca
     1261 ccttccactt tgaccccgag tttactgcaa ggacccccac agactctcct ggtgtccccc
     1321 caagtgcaaa cgcccaccac ctgttcaggg ggttcagctt tgtggcctcc agcctggtcc
     1381 aggagccttc acagcaagac gtgcccaagg cccccattca cccgattgtg cagcagttac
     1441 atgggaacaa tatccacttc actgatggct acgagatcaa ggaggacatc ggggtgggct
     1501 cctactcagt gtgcaagcgg tgtgtacaca aagccacgga tgccgagtac gccgtgaaga
     1561 tcatcgataa gagcaaaagg gatccctcag aggagattga gatcctcctg cggtatggcc
     1621 aacaccccaa catcatcacc ctaaaagatg tctatgatga tggaaaatac gtatacctgg
     1681 tgatggagct catgcgaggt ggggagctgc tggaccgcat cctccgccag cggtgcttct
     1741 cagagcggga ggccagtgat gtgctgtaca ccatcgccag gaccatggac tacctgcact
     1801 cccaaggggt tgttcatcgg gacctgaaac caagtaacat tctgtacatg gatgaatctg
     1861 gaaaccccga atctatccgc atctgtgact ttgggtttgc caaacagctg cgagcagaaa
     1921 atggactgct catgaccccc tgctatactg cgaacttcgt ggctcctgag gtcctgaagc
     1981 ggcaaggcta cgacgcagcg tgtgatgtct ggagcctggg aatcctgctg tacaccatgc
     2041 tggctgggtt cacccctttt gctaatgggc cagacgatac ccccgaggag attctggcga
     2101 ggattggcag tgggaagtac gccctttctg gaggaaactg ggactccata tcggatgcag
     2161 caaaggacgt cgtgtccaag atgctccacg tggacccgca gcaacgccta acagcagttc
     2221 aagtgttgaa gcacccatgg atcgtgaaca gagagtacct atcccaaaac cagctgagca
     2281 gacaggacgt ccatctagtg aagggtgcca tggcagccac ctactttgct ctgaacagga
     2341 ccccacaggc gccgaggctg gagcctgtgc tctcctctag cttggcccaa cgcagaggca
     2401 tgaagagact cacgtctacc cggttgtagt ggctagccaa gtctccagcc tcagcctccc
     2461 tgcccaacgt cctctcaggc tcacagacac cagatacagg tcctgttcac gggcccttgc
     2521 gtgcccgcga gtccagcaca aagatggatc tggccttggc tgtctctctg tttcctttgc
     2581 agccctggaa agggtcctgc ccaggatgtc tgagccttgc tgcgccgacc tcgccgcctg
     2641 ctctcctctt ctcctgagtg aaaccaaata aacttgtcac ctcacagcac cctgctggag
     2701 cctccctggg ctcactcagg gctctcggtg tctcccatgt catggcttat gctcaaagca
     2761 gagagctctt catgtcacct atgtgtccca ctgtctctct aagagtgtta gtgcatggtc
     2821 cctgccagga gactgcagag ctgctctgga aggactggat gctcctggat gttccggtgt
     2881 caccagaggc tgtgtgaagg catccagctt aaatgcctgg ttctgtccac aatcacccaa
     2941 agagtgcccc tcaccaccct ctggttcaca agtgggatgc tggctagcct ctccctgacc
     3001 tggtcactga cttggcaaga gtccaggtgg ctgagtctgt gtgagagcct gatttgtgct
     3061 ggttgagaca ggaacccaag gaaattgctg ggcagagctc agaacccact gcactgctgc
     3121 ccctctaacc ctgtggcccc agggacactg gaagaatggg ggctccgcta tggctgggtg
     3181 tgttggcagc cctgcacgcg tttgcctgag gccatgtagc atattcaccc cctgctgccc
     3241 tgggccacag agaaactgaa gaaatggaac tttgctccct ctctctccct tccttagcct
     3301 gactgaggac aggagagaca cctgagtccc ttggctgtag agagacagaa ggtgccagga
     3361 cgttgaaggt gccaggacgt tgtcagcagg agcggtgcgc ttcgtagaag ccgcggctct
     3421 gtgttgcgtc ttgtgttttc tgtttctaac ctgtgtttcc aggctgtggg ctgcacaggg
     3481 agcagtagct ccactgacca ggctgtctgt gcgcactctg gatgcagagt aaccgagtga
     3541 gaccctgcct gcgtagcatg ctccactcca agtggtcccg gaagaggggc ttgtgtgtcc
     3601 tccggtcttt ctgggggctg ctgaggatga tggactcagg ttagaggaca ctccactgtg
     3661 gctcaggacc tgccagtctg ataagcggcc cctctgcctg gtaggtgtag gaggcgcctg
     3721 ttggtcacag aaagcttgca ctaggaagac cacgggtgga tcgtggctgc ttctccaact
     3781 cctgccccag tggaatgttc ggaacataac tcctttgctc agcctaatta tttcagacct
     3841 caaaatgtaa acgtgtttca caagctttaa ttaccccact ggactctgct ctgtctcaga
     3901 gttgtaaaat acagagtggg gacagactgc ccgccatttt cagtgtcgct agggatgttc
     3961 tcgtgctttc tcagtggacc ttgctctgcc caaggctgag gtcacctccc cgttgttaat
     4021 gttctaggtc cagatccttc catttcttga tagaactcta gagggaaagt atagtgggtg
     4081 actcagtgac agattctgtc ctctgggaaa tgggctcgca tcctctgagg gcctctctgg
     4141 catgcgcagt ccagccgtcc acagcttcag gctggctttc cttgcagctt caagagtaca
     4201 tctttcgagg aaaggaaaga ataacagaat atagaaggcg tggctgagga ggcgggcaca
     4261 gcgtgccccc ctcatggtca cttagtcgca tcacctcttt taatcatgcc aggttatctg
     4321 ccttacactc agcctactct ggccaaaggg atggaggaga ccgtcacacc aaacgtatcc
     4381 tccaagtgtc tgaaaaggat gctggctcag ccatgctctg ctgagagtgg agggccccac
     4441 actcccaccc ccacctagta cttgatactt gaaatctctc gtggaatcaa cctgaggagc
     4501 acgtgacagg attattttaa tccctgttct ttaaagtctt cagtgcgaca gcaggcggct
     4561 gtggcgtgta acccagtatc ccagtgttta cctgtcctgc gaacccttta ccgaacacga
     4621 taaaagaccc tgtattctct acacaaatga ctacttgtgt agttacagaa tttgtcatgg
     4681 gaaagcccag cctacatccg ggactccttc accataacca ggagccactt ttgggctatc
     4741 ccactggcag ctcctgtcct gttcgggcta agaacatgat gagtgtccgg ctgaaggagg
     4801 tgtgggctgg gtgttggtca gattctctac ctgagagtca atggcaggca agccgtgaat
     4861 gtcccctgtc ctatggttgt gtgatttttg aactacccgt gtgcactgat ctttggatat
     4921 tgtttggctt tttaagtgag gatcttcccg atggtatcta atgtcgacag tattctttat
     4981 taaatggtgt tcttctttaa gaggcccttt gggattttcc ctgcattgtt ctgcttctct
     5041 caagcacagg aggagatcct cgtgcctctt cattctctct ggcaagttct gccgcccttc
     5101 accacccgca agactgtgag acacctgaag tggaaaagga ctctgtggtc cctatgtggc
     5161 agggacacag gtggaagggg aagccagcat ggctcatccg tgcaggtgaa acgtacctgt
     5221 ccaccctgct cccacccccg ctgcgtttac atgctcagca gttccgttta cagctcactc
     5281 cactttcaca cttcctgtct gtgtttgaga cgggcggcca ctgtacagat atttattatg
     5341 ctttccaaac tttcccatga gattttttga ataaacatgg attttatgaa gtgtaa
//
