LOCUS       NM_031107               3120 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Rattus norvegicus ribosomal protein S6 kinase A1 (Rps6ka1), mRNA.
ACCESSION   NM_031107
VERSION     NM_031107.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3120)
  AUTHORS   Takegaki,J., Sase,K. and Fujita,S.
  TITLE     Repeated bouts of resistance exercise attenuate mitogen-activated
            protein-kinase signal responses in rat skeletal muscle
  JOURNAL   Biochem Biophys Res Commun 520 (1), 73-78 (2019)
   PUBMED   31582215
  REMARK    GeneRIF: repeated bouts of resistance training desensitized ERK1/2
            and p38 MAPK, subsequently attenuating p90RSK phosphorylation in a
            rat model
REFERENCE   2  (bases 1 to 3120)
  AUTHORS   Han,J.H., Kim,S., Kim,S., Lee,H., Park,S.Y. and Woo,C.H.
  TITLE     FMK, an Inhibitor of p90RSK, Inhibits High Glucose-Induced TXNIP
            Expression via Regulation of ChREBP in Pancreatic beta Cells
  JOURNAL   Int J Mol Sci 20 (18), 4424 (2019)
   PUBMED   31505737
  REMARK    GeneRIF: FMK, an Inhibitor of p90RSK, Inhibits High Glucose-Induced
            TXNIP Expression via Regulation of ChREBP in Pancreatic beta Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3120)
  AUTHORS   Dou,X., Menkari,C., Mitsuyama,R., Foroud,T., Wetherill,L.,
            Hammond,P., Suttie,M., Chen,X., Chen,S.Y. and Charness,M.E.
  CONSRTM   Collaborative Initiative on Fetal Alcohol Spectrum Disorders
  TITLE     L1 coupling to ankyrin and the spectrin-actin cytoskeleton
            modulates ethanol inhibition of L1 adhesion and ethanol
            teratogenesis
  JOURNAL   FASEB J 32 (3), 1364-1374 (2018)
   PUBMED   29109170
REFERENCE   4  (bases 1 to 3120)
  AUTHORS   Carretero,L., Llavona,P., Lopez-Hernandez,A., Casado,P.,
            Cutillas,P.R., de la Pena,P., Barros,F. and Dominguez,P.
  TITLE     ERK and RSK are necessary for TRH-induced inhibition of r-ERG
            potassium currents in rat pituitary GH3 cells
  JOURNAL   Cell Signal 27 (9), 1720-1730 (2015)
   PUBMED   26022182
  REMARK    GeneRIF: in the native GH3 cell system, ERK and RSK are involved in
            the pathway linking TRH receptor to r-ERG channel inhibition, but
            additional components must participate to cause such inhibition.
REFERENCE   5  (bases 1 to 3120)
  AUTHORS   Seow,K.H., Zhou,L., Stephanopoulos,G. and Too,H.P.
  TITLE     c-Jun N-terminal kinase in synergistic neurite outgrowth in PC12
            cells mediated through P90RSK
  JOURNAL   BMC Neurosci 14, 153 (2013)
   PUBMED   24330599
  REMARK    GeneRIF: Our findings demonstrate a hitherto unrecognized mechanism
            of c-Jun N-terminal kinase-P90RSK in mediating synergistic neurite
            outgrowth
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3120)
  AUTHORS   Buck,M., Poli,V., van der Geer,P., Chojkier,M. and Hunter,T.
  TITLE     Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP
            beta is required for hepatocyte proliferation induced by TGF alpha
  JOURNAL   Mol Cell 4 (6), 1087-1092 (1999)
   PUBMED   10635333
REFERENCE   7  (bases 1 to 3120)
  AUTHORS   Suzuki,T., Mitake,S. and Murata,S.
  TITLE     Presence of up-stream and downstream components of a
            mitogen-activated protein kinase pathway in the PSD of the rat
            forebrain
  JOURNAL   Brain Res 840 (1-2), 36-44 (1999)
   PUBMED   10517950
REFERENCE   8  (bases 1 to 3120)
  AUTHORS   Smith,J.A., Poteet-Smith,C.E., Malarkey,K. and Sturgill,T.W.
  TITLE     Identification of an extracellular signal-regulated kinase (ERK)
            docking site in ribosomal S6 kinase, a sequence critical for
            activation by ERK in vivo
  JOURNAL   J Biol Chem 274 (5), 2893-2898 (1999)
   PUBMED   9915826
REFERENCE   9  (bases 1 to 3120)
  AUTHORS   Wong,E.V., Schaefer,A.W., Landreth,G. and Lemmon,V.
  TITLE     Involvement of p90rsk in neurite outgrowth mediated by the cell
            adhesion molecule L1
  JOURNAL   J Biol Chem 271 (30), 18217-18223 (1996)
   PUBMED   8663493
REFERENCE   10 (bases 1 to 3120)
  AUTHORS   Grove,J.R., Price,D.J., Banerjee,P., Balasubramanyam,A., Ahmad,M.F.
            and Avruch,J.
  TITLE     Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by
            phorbol ester and erk/MAP kinase
  JOURNAL   Biochemistry 32 (30), 7727-7738 (1993)
   PUBMED   7688567
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Nov 26, 2020 this sequence version replaced NM_031107.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M99169.1, SRR22582416.149335.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               JAXUCZ010000005.1  151401860-151402064 c
            206-250             JAXUCZ010000005.1  151395810-151395854 c
            251-367             JAXUCZ010000005.1  151386879-151386995 c
            368-449             JAXUCZ010000005.1  151386551-151386632 c
            450-530             JAXUCZ010000005.1  151384193-151384273 c
            531-610             JAXUCZ010000005.1  151383928-151384007 c
            611-717             JAXUCZ010000005.1  151382207-151382313 c
            718-755             JAXUCZ010000005.1  151381180-151381217 c
            756-898             JAXUCZ010000005.1  151380572-151380714 c
            899-969             JAXUCZ010000005.1  151380131-151380201 c
            970-1058            JAXUCZ010000005.1  151379783-151379871 c
            1059-1123           JAXUCZ010000005.1  151378780-151378844 c
            1124-1226           JAXUCZ010000005.1  151378439-151378541 c
            1227-1357           JAXUCZ010000005.1  151376029-151376159 c
            1358-1483           JAXUCZ010000005.1  151375381-151375506 c
            1484-1573           JAXUCZ010000005.1  151375074-151375163 c
            1574-1732           JAXUCZ010000005.1  151374227-151374385 c
            1733-1894           JAXUCZ010000005.1  151366340-151366501 c
            1895-1971           JAXUCZ010000005.1  151366074-151366150 c
            1972-2089           JAXUCZ010000005.1  151365837-151365954 c
            2090-2227           JAXUCZ010000005.1  151364117-151364254 c
            2228-3120           JAXUCZ010000005.1  151362819-151363711 c
FEATURES             Location/Qualifiers
     source          1..3120
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3120
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /note="ribosomal protein S6 kinase A1"
                     /db_xref="GeneID:81771"
                     /db_xref="RGD:620675"
     exon            1..205
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2350
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /EC_number="2.7.11.1"
                     /note="RSK-1; p90S6K; pp90RSK1; ribosomal protein S6
                     kinase polypeptide 1; MAPKAPK1A; p90-RSK 1; ribosomal S6
                     kinase 1; ribosomal protein S6 kinase, polypeptide A1; 90
                     kDa ribosomal protein S6 kinase 1; MAP kinase-activated
                     protein kinase 1a; p90RSK1; MAPKAPK-1a; S6K-alpha-1;
                     MAPKAP kinase 1a; MAPK-activated protein kinase 1a; S6
                     protein kinase (Rsk-1)"
                     /codon_start=1
                     /product="ribosomal protein S6 kinase alpha-1"
                     /protein_id="NP_112369.2"
                     /db_xref="GeneID:81771"
                     /db_xref="RGD:620675"
                     /translation="MPLAQLKEPWPLMELVPLDPENGQASGEEAGLQPSKDEGILKEI
                     SITHHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDNGHLYAMKVLKKATLK
                     VRDRVRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFT
                     EEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKK
                     AYSFCGTVEYMAPEVVNRQGHTHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILK
                     AKLGMPQFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHIFYSTIDWNKLYRREI
                     KPPFKPAVAQPDDTFYFDTEFTSRTPRDSPGIPPSAGAHQLFRGFSFVATGLMEDDSK
                     PRATQAPLHSVVQQLHGKNLVFSDGYIVKETIGVGSYSVCKRCVHKATNMEYAVKVID
                     KSKRDPSEEIEILLRYGQHPNIITLKDVYDDSKHVYLVTELMRGGELLDKILRQKFFS
                     EREASFVLYTISKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRA
                     ENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSLGVLLYTMLAGYTPFANGPSDTPEE
                     ILTRISSGKFTLNGGNWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWITQKDKLP
                     QSQLSHQDLQLVKGAMAATYSALSSSKPTPQLKPIESSILAQRRVRKLPSTTL"
     exon            206..250
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..367
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            368..449
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..530
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            531..610
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..717
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            718..755
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..898
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..969
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1058
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1123
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1226
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1357
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1483
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1573
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1732
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1894
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..1971
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2089
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2227
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..3120
                     /gene="Rps6ka1"
                     /gene_synonym="S6K-alpha 1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcggcggc ggacggccca gccagagcgc gaggggctcg ggggcgtgcg ggggtctcgg
       61 tgcagcagca aggaccccgg ggcccagagg cggcacagcc cggggccgcc cggaggagcg
      121 cgggcggtcc ggcggcggcg cgatgccgct cgcccagctc aaggaaccct ggccgctcat
      181 ggagctggtg ccgctggacc cggagaatgg acaggcttca ggggaagaag ctggacttca
      241 gccatccaag gatgagggca tcctcaagga gatctctatc acacaccacg tcaaggctgg
      301 ctctgagaag gctgatccat cccattttga gctcctcaag gttctgggcc aaggatcctt
      361 tggcaaagtc ttcctggtac gcaaggtcac ccggcctgac aatgggcact tgtatgccat
      421 gaaagtatta aagaaggcca cgctgaaagt gcgtgaccgt gttcggacca agatggagag
      481 agacatccta gctgacgtga accacccctt cgtagtgaaa ctgcactatg ccttccagac
      541 cgagggcaag ctctatctta ttctggactt tctgcgtggt ggagacctgt tcacacgact
      601 ctcaaaggag gttatgttta cagaggagga tgtgaagttt tacctggctg agctggcact
      661 gggcctggac cacctgcaca gcttgggcat catttacaga gacctcaagc ctgagaatat
      721 ccttttggat gaggagggcc acatcaaact cactgacttt ggcctgagca aggaggccat
      781 tgaccacgaa aagaaggcct attccttctg cgggacggtg gagtacatgg cccccgaggt
      841 tgtcaaccgc cagggccaca cccacagtgc agattggtgg tcctatgggg tgttgatgtt
      901 tgagatgctg acgggctccc tgcccttcca ggggaaggac cggaaggaga ccatgacctt
      961 gattttgaag gcaaagctag gcatgcccca gtttctgagc acggaagccc agagcctcct
     1021 gcgggccctg ttcaagagga atcctgccaa ccggcttggc tcaggccccg atggggctga
     1081 ggaaattaag agacatatct tctactctac cattgactgg aataagctct accgccgtga
     1141 gatcaagcca cctttcaagc ccgctgtggc ccagccggat gacaccttct actttgatac
     1201 cgagttcacg tcacgcacac ccagggattc gccgggcatc ccccccagtg ctggtgccca
     1261 tcagctcttc cgtggcttca gcttcgtggc caccggtctg atggaggatg acagcaagcc
     1321 tcgggccacc caggctccgc tgcactcggt ggtacagcaa ctccacggga agaacttggt
     1381 tttcagcgat ggctacatag taaaggagac gatcggcgtg ggctcctact ctgtgtgtaa
     1441 gcgctgtgtc cacaaggcca ccaacatgga gtacgcagtc aaagtcatcg acaaaagcaa
     1501 aagagatccc tccgaagaga tcgagattct tctgcggtat ggacagcacc ccaacatcat
     1561 caccctgaaa gatgtgtatg acgacagtaa gcacgtatac ctggtgacag agctgatgag
     1621 gggcggggag ctgctggata agatcctacg gcagaaattc ttctcagagc gggaggccag
     1681 cttcgtcctg tacaccatca gcaagactgt ggaatacttg cactcccaag gggtcgtcca
     1741 cagggacctc aaacccagta acatcctgta tgtggatgag tctgggaacc ccgaatgcct
     1801 acgaatatgc gactttggct ttgccaagca gctacgggct gagaacgggc ttctcatgac
     1861 accttgctac acagccaact ttgtggcacc tgaggtgctg aagcgtcagg gctacgatga
     1921 aggctgtgac atatggagcc tgggcgttct gctgtacacg atgctggcag gatacactcc
     1981 atttgccaat gggcccagtg ataccccaga ggagatcctc acccggatca gcagtgggaa
     2041 gttcaccctc aacgggggaa actggaacac ggtttcagag acagccaagg acttagtatc
     2101 taagatgctg catgtggacc cccaccagcg cctcacagcc aaacaggttc tgcagcaccc
     2161 gtggatcacc cagaaagaca agctccccca gagccagttg tcccaccaag acctgcagct
     2221 tgtgaagggg gccatggcag ctacatattc tgcactcagt agctccaaac ccacccccca
     2281 gctcaagcca atcgagtcgt ccatcctggc ccagcggcgg gtgaggaagc tgccatccac
     2341 caccctgtga accgcagcgc agacaaactc cttggaggca gagtccttcc cagagggagc
     2401 aagcctgagt cacaggacca agtggaatgg agtcctaaag gaagcaacta gcccagctca
     2461 cccgtgcggg tgtgaagtgc cttcctcccc aggacgggct cttctgggct caggctccat
     2521 tgtgtgaaat ccactcactg tacaaactat tttttaagaa aggaaaagaa aaatgacatc
     2581 atttaccatg gatttttttt ttacaagatc catttgcctt tttggccatt gcagtcccag
     2641 gaggaacacc cagtcccatg tgtggccaag actcccgtga tagctttggg actccgcccc
     2701 tctgttggtc aaggagccat ctgcacccgc ctccgagcag ttcggcgttg cctctcagag
     2761 ttgtcgactg gctcctcagc agaacttggt gtccccagcc atctcttttt ccattctgtt
     2821 ctggggttct cgaaccactt tctgctaaga gcccgggacc ccaccctgtc agctcttggc
     2881 tccaggcacc agcatccaca gcgcccatgc gcagtgggcc cctgcagtca gaacgggcag
     2941 ccccgtggag aggagacgga gagcactttt tgggagactt cctgtctgcc actggacaga
     3001 gttcacagga gaccagggag gtagtccacg ggggatgagg gcttttccct ttcctcctca
     3061 gctggtaact cagggttcat ctgtccaagg cctttctaat aaacctacag tccagtcaaa
//
