LOCUS       NM_017160                801 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ribosomal protein S6 (Rps6), mRNA.
ACCESSION   NM_017160
VERSION     NM_017160.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 801)
  AUTHORS   Yang,H., Wen,Y., Zhang,M., Liu,Q., Zhang,H., Zhang,J., Lu,L.,
            Ye,T., Bai,X., Xiao,G. and Wang,M.
  TITLE     MTORC1 coordinates the autophagy and apoptosis signaling in
            articular chondrocytes in osteoarthritic temporomandibular joint
  JOURNAL   Autophagy 16 (2), 271-288 (2020)
   PUBMED   31007149
REFERENCE   2  (bases 1 to 801)
  AUTHORS   Mao,B., Li,L., Yan,M., Wong,C.K.C., Silvestrini,B., Li,C., Ge,R.,
            Lian,Q. and Cheng,C.Y.
  TITLE     F5-Peptide and mTORC1/rpS6 Effectively Enhance BTB Transport
            Function in the Testis-Lesson From the Adjudin Model
  JOURNAL   Endocrinology 160 (8), 1832-1853 (2019)
   PUBMED   31157869
  REMARK    GeneRIF: a specific deletion of mTOR in Sertoli cells was found to
            cause an upregulation of p-rpS6-S240/S244 (i.e., an activation of
            rpS6), but not total rpS6, and was associated with BTB disruption,
            epithelial damage, loss of cell polarity, and infertility.
REFERENCE   3  (bases 1 to 801)
  AUTHORS   Yan,M., Li,L., Mao,B., Li,H., Li,S.Y.T., Mruk,D., Silvestrini,B.,
            Lian,Q., Ge,R. and Cheng,C.Y.
  TITLE     mTORC1/rpS6 signaling complex modifies BTB transport function: an
            in vivo study using the adjudin model
  JOURNAL   Am J Physiol Endocrinol Metab 317 (1), E121-E138 (2019)
   PUBMED   31112404
  REMARK    GeneRIF: Overexpression of this rpS6 was capable of inducing
            blood-testis barrier remodeling, making the barrier 'leaky.'
REFERENCE   4  (bases 1 to 801)
  AUTHORS   Younts,T.J., Monday,H.R., Dudok,B., Klein,M.E., Jordan,B.A.,
            Katona,I. and Castillo,P.E.
  TITLE     Presynaptic Protein Synthesis Is Required for Long-Term Plasticity
            of GABA Release
  JOURNAL   Neuron 92 (2), 479-492 (2016)
   PUBMED   27764673
REFERENCE   5  (bases 1 to 801)
  AUTHORS   Pirbhoy,P.S., Farris,S. and Steward,O.
  TITLE     Synaptic activation of ribosomal protein S6 phosphorylation occurs
            locally in activated dendritic domains
  JOURNAL   Learn Mem 23 (6), 255-269 (2016)
   PUBMED   27194793
  REMARK    GeneRIF: Synaptic activation of ribosomal protein S6
            phosphorylation occurs locally in activated dendritic domains.
            results constrain hypotheses about the possible role of rpS6
            phosphorylation in regulating postsynaptic protein synthesis during
            induction of synaptic plasticity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 801)
  AUTHORS   Macfarlane,D.E. and Gailani,D.
  TITLE     Identification of phosphoprotein NP33 as a nucleus-associated
            ribosomal S6 protein and its phosphorylation in hematopoietic cells
  JOURNAL   Cancer Res 50 (10), 2895-2900 (1990)
   PUBMED   2334893
REFERENCE   7  (bases 1 to 801)
  AUTHORS   Franco,R. and Rosenfeld,M.G.
  TITLE     Hormonally inducible phosphorylation of a nuclear pool of ribosomal
            protein S6
  JOURNAL   J Biol Chem 265 (8), 4321-4325 (1990)
   PUBMED   2106518
REFERENCE   8  (bases 1 to 801)
  AUTHORS   Chan,Y.L. and Wool,I.G.
  TITLE     The primary structure of rat ribosomal protein S6
  JOURNAL   J Biol Chem 263 (6), 2891-2896 (1988)
   PUBMED   3277962
REFERENCE   9  (bases 1 to 801)
  AUTHORS   Gressner,A.M.
  TITLE     Two-dimensional electrophoretic analysis of ribosomal proteins from
            chronically injured liver
  JOURNAL   J Clin Chem Clin Biochem 17 (8), 541-545 (1979)
   PUBMED   501300
REFERENCE   10 (bases 1 to 801)
  AUTHORS   Collatz,E., Wool,I.G., Lin,A. and Stoffler,G.
  TITLE     The isolation of eukaryotic ribosomal proteins. The purification
            and characterization of the 40 S ribosomal subunit proteins S2, S3,
            S4, S5, S6, S7, S8, S9, S13, S23/S24, S27, and S28
  JOURNAL   J Biol Chem 251 (15), 4666-4672 (1976)
   PUBMED   947902
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from M29358.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M29358.1, CD372948.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..801
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q32"
     gene            1..801
                     /gene="Rps6"
                     /note="ribosomal protein S6"
                     /db_xref="GeneID:29304"
                     /db_xref="RGD:3602"
     exon            1..21
                     /gene="Rps6"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..765
                     /gene="Rps6"
                     /note="40S ribosomal protein S6; 40S ribosomal protein
                     S6-like"
                     /codon_start=1
                     /product="small ribosomal subunit protein eS6"
                     /protein_id="NP_058856.1"
                     /db_xref="GeneID:29304"
                     /db_xref="RGD:3602"
                     /translation="MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEE
                     WKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIV
                     DANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRK
                     PLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMK
                     EAKEKRQEQIAKRRRLSSLRASTSKSESSQK"
     exon            22..153
                     /gene="Rps6"
                     /inference="alignment:Splign:2.1.0"
     exon            154..364
                     /gene="Rps6"
                     /inference="alignment:Splign:2.1.0"
     exon            365..511
                     /gene="Rps6"
                     /inference="alignment:Splign:2.1.0"
     exon            512..801
                     /gene="Rps6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcggctgtg tcaagatgaa gctgaatatc tccttccctg ccactggctg tcagaaactc
       61 atagaagtgg atgacgaacg caagcttcgt acgttctatg agaagcgcat ggccacagaa
      121 gtagctgctg atgctcttgg tgaagagtgg aagggttatg tggtccggat cagcggtggg
      181 aatgacaaac aaggttttcc catgaagcaa ggcgttttga cccatggcag agtgcgcctg
      241 cttttgagta aggggcattc ttgttataga cctaggagaa ctggagagag gaagcgcaag
      301 tctgtccgag gatgcattgt ggatgccaac ctgagtgttc tcaacttggt tattgtaaaa
      361 aaaggagaga aggatattcc aggactgaca gataccactg tgcctcgtcg gttgggacct
      421 aaaagagcta gtagaatccg aaagcttttt aatctctcca aagaagatga tgtccgccag
      481 tatgttgtta gaaagccctt aaacaaagaa ggtaagaagc ccaggaccaa agcgcccaag
      541 attcagcgtc ttgttactcc ccgtgtcctg caacacaaac gccgacgtat tgctctgaag
      601 aagcaacgca ctaagaaaaa caaggaggag gctgcagaat atgctaaact tttggccaag
      661 agaatgaagg aagccaaaga gaagcgccag gaacagattg ccaagagacg taggctgtct
      721 tcgctgagag cttctacttc taaatctgag tccagtcaaa aataagtctt taaagagtaa
      781 caaataaata atgagacctt g
//
