LOCUS       NM_001399354            1133 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus ribonuclease P/MRP subunit p40 (Rpp40),
            transcript variant 2, mRNA.
ACCESSION   NM_001399354 XM_006253790
VERSION     NM_001399354.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1133)
  AUTHORS   Wu,J., Niu,S., Tan,M., Huang,C., Li,M., Song,Y., Wang,Q., Chen,J.,
            Shi,S., Lan,P. and Lei,M.
  TITLE     Cryo-EM Structure of the Human Ribonuclease P Holoenzyme
  JOURNAL   Cell 175 (5), 1393-1404 (2018)
   PUBMED   30454648
REFERENCE   2  (bases 1 to 1133)
  AUTHORS   Lai,L.B., Vioque,A., Kirsebom,L.A. and Gopalan,V.
  TITLE     Unexpected diversity of RNase P, an ancient tRNA processing enzyme:
            challenges and prospects
  JOURNAL   FEBS Lett 584 (2), 287-296 (2010)
   PUBMED   19931535
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On Jan 6, 2022 this sequence version replaced XM_006253790.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ220078.1, SRR26643286.42844.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               JAXUCZ010000017.1  29153203-29153345
            144-288             JAXUCZ010000017.1  29155069-29155213
            289-357             JAXUCZ010000017.1  29155860-29155928
            358-453             JAXUCZ010000017.1  29157331-29157426
            454-579             JAXUCZ010000017.1  29158056-29158181
            580-778             JAXUCZ010000017.1  29160417-29160615
            779-913             JAXUCZ010000017.1  29160727-29160861
            914-1133            JAXUCZ010000017.1  29162022-29162241
FEATURES             Location/Qualifiers
     source          1..1133
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1133
                     /gene="Rpp40"
                     /note="ribonuclease P/MRP subunit p40"
                     /db_xref="GeneID:291071"
                     /db_xref="RGD:1310228"
     exon            1..143
                     /gene="Rpp40"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1112
                     /gene="Rpp40"
                     /EC_number="3.1.26.5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ribonuclease P protein subunit p40; RNaseP protein p40;
                     ribonuclease P 40 subunit; ribonuclease P/MRP 40 subunit"
                     /codon_start=1
                     /product="ribonuclease P protein subunit p40 isoform 2"
                     /protein_id="NP_001386283.1"
                     /db_xref="GeneID:291071"
                     /db_xref="RGD:1310228"
                     /translation="MATLRRLQEAPRHLLVCEKSNFGHDKSRHKHLVETHYHNYRVSF
                     LIPECGLLSKKLKDLVMEMGPYYSVKKLPLHELITHEFINTFVKKGSLSALTYNTSID
                     EDNTVALLPNGKLILSLDKDTYEETGLQGHPSRYSGRKSMRFIISIDLMDLSLNLDSK
                     KYRRISWSFKEKKPLKFDFLLAWHHTGTEESTMMSYFSKYQIREHQPKVALSTVRDLQ
                     CPVLQSSSLAGEPEEACNALEFFDWLGAVFCNADLNNEPHNFISTYCCPQPNTVAAQA
                     CLCTITGFVLPEKILVLLEQLCHYFDEPKLAPWVTLTVQGFADSPVAWREKEHGFHKG
                     GEHLYNFVVFNNQDYWLQMAVGANDDCPP"
     exon            144..288
                     /gene="Rpp40"
                     /inference="alignment:Splign:2.1.0"
     exon            289..357
                     /gene="Rpp40"
                     /inference="alignment:Splign:2.1.0"
     exon            358..453
                     /gene="Rpp40"
                     /inference="alignment:Splign:2.1.0"
     exon            454..579
                     /gene="Rpp40"
                     /inference="alignment:Splign:2.1.0"
     exon            580..778
                     /gene="Rpp40"
                     /inference="alignment:Splign:2.1.0"
     exon            779..913
                     /gene="Rpp40"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1133
                     /gene="Rpp40"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcctggaca cttccttaac atggcgacgc tgcgcaggct tcaggaggcg cctcggcact
       61 tactggtctg tgagaaatcc aactttggcc acgataagtc tcgccataag catctcgtgg
      121 agacgcacta tcataattac agggtttcat ttcttattcc tgagtgtggg ctgctatcaa
      181 aaaaactaaa agacctggtc atggaaatgg gaccctatta ctctgtgaag aagttacctc
      241 ttcatgaatt aattacacat gaattcatca acacctttgt aaagaaaggt tcactctctg
      301 cattaacgta caatacaagt attgatgagg ataatactgt tgctctccta ccaaatggga
      361 aattaatttt atcactggat aaagatactt atgaagagac tggactccaa ggccatccat
      421 ctcggtattc tggcagaaaa agtatgaggt ttatcatttc cattgatcta atggatttat
      481 cccttaacct ggattctaag aaatacagaa gaatatcttg gtccttcaaa gaaaagaagc
      541 ctttgaagtt tgatttcctt ttggcttggc atcatacagg tacagaagaa tcaacaatga
      601 tgtcatactt ttccaaatac caaattcggg agcatcagcc aaaagtggcc ttgagcacag
      661 taagagatct gcagtgccca gtgcttcaga gcagcagcct tgcaggggag ccggaggagg
      721 cctgcaatgc cctggagttc ttcgactggc ttggtgccgt cttctgcaac gcggacctaa
      781 ataatgaacc tcataatttc atatcaacct actgctgtcc acagccaaac acagtggcag
      841 cccaagcttg tctgtgtaca atcacaggtt tcgtgttgcc agagaagata cttgtccttc
      901 tggaacagct gtgtcactac tttgatgaac cgaagttggc tccatgggtc accttgacag
      961 ttcaaggctt tgcagacagc cccgttgcat ggagggagaa ggaacacggc ttccacaaag
     1021 gaggagagca cttgtacaat tttgttgttt tcaataatca ggactattgg cttcagatgg
     1081 ctgttggagc aaatgatgac tgcccaccat aaaaaatgca aagtttagag cca
//
