LOCUS       NM_031698               2234 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus ribophorin II (Rpn2), mRNA.
ACCESSION   NM_031698
VERSION     NM_031698.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2234)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 2234)
  AUTHORS   Honma,K., Iwao-Koizumi,K., Takeshita,F., Yamamoto,Y., Yoshida,T.,
            Nishio,K., Nagahara,S., Kato,K. and Ochiya,T.
  TITLE     RPN2 gene confers docetaxel resistance in breast cancer
  JOURNAL   Nat Med 14 (9), 939-948 (2008)
   PUBMED   18724378
  REMARK    Erratum:[Nat Med. 2008 Oct;14(10):1128]
REFERENCE   3  (bases 1 to 2234)
  AUTHORS   Limaye,A.M., Asangani,I., Bora,N. and Kondaiah,P.
  TITLE     Novel flutamide regulated genes in the rat ventral prostate:
            differential modulation of their expression by castration and
            flutamide treatments
  JOURNAL   Asian J Androl 9 (6), 801-808 (2007)
   PUBMED   17968466
REFERENCE   4  (bases 1 to 2234)
  AUTHORS   Farah,C.A., Liazoghli,D., Perreault,S., Desjardins,M., Guimont,A.,
            Anton,A., Lauzon,M., Kreibich,G., Paiement,J. and Leclerc,N.
  TITLE     Interaction of microtubule-associated protein-2 and p63: a new link
            between microtubules and rough endoplasmic reticulum membranes in
            neurons
  JOURNAL   J Biol Chem 280 (10), 9439-9449 (2005)
   PUBMED   15623521
REFERENCE   5  (bases 1 to 2234)
  AUTHORS   Kelleher,D.J., Karaoglu,D., Mandon,E.C. and Gilmore,R.
  TITLE     Oligosaccharyltransferase isoforms that contain different catalytic
            STT3 subunits have distinct enzymatic properties
  JOURNAL   Mol Cell 12 (1), 101-111 (2003)
   PUBMED   12887896
REFERENCE   6  (bases 1 to 2234)
  AUTHORS   Kumar,V., Heinemann,F.S. and Ozols,J.
  TITLE     Interleukin-2 induces N-glycosylation in T-cells: characterization
            of human lymphocyte oligosaccharyltransferase
  JOURNAL   Biochem Biophys Res Commun 247 (2), 524-529 (1998)
   PUBMED   9642163
REFERENCE   7  (bases 1 to 2234)
  AUTHORS   Schweizer,A., Rohrer,J., Slot,J.W., Geuze,H.J. and Kornfeld,S.
  TITLE     Reassessment of the subcellular localization of p63
  JOURNAL   J Cell Sci 108 (Pt 6), 2477-2485 (1995)
   PUBMED   7673362
REFERENCE   8  (bases 1 to 2234)
  AUTHORS   Pirozzi,G., Zhou,Z.M., D'Eustachio,P., Sabatini,D.D. and
            Kreibich,G.
  TITLE     Rat ribophorin II: molecular cloning and chromosomal localization
            of a highly conserved transmembrane glycoprotein of the rough
            endoplasmic reticulum
  JOURNAL   Biochem Biophys Res Commun 176 (3), 1482-1486 (1991)
   PUBMED   1710116
REFERENCE   9  (bases 1 to 2234)
  AUTHORS   Dunn,W.A. Jr.
  TITLE     Studies on the mechanisms of autophagy: formation of the autophagic
            vacuole
  JOURNAL   J Cell Biol 110 (6), 1923-1933 (1990)
   PUBMED   2351689
REFERENCE   10 (bases 1 to 2234)
  AUTHORS   Kreibich,G., Freienstein,C.M., Pereyra,B.N., Ulrich,B.L. and
            Sabatini,D.D.
  TITLE     Proteins of rough microsomal membranes related to ribosome binding.
            II. Cross-linking of bound ribosomes to specific membrane proteins
            exposed at the binding sites
  JOURNAL   J Cell Biol 77 (2), 488-506 (1978)
   PUBMED   418074
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X55298.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X55298.1, BC060556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2234
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2234
                     /gene="Rpn2"
                     /note="ribophorin II"
                     /db_xref="GeneID:64701"
                     /db_xref="RGD:62075"
     exon            1..22
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1905
                     /gene="Rpn2"
                     /EC_number="2.4.99.18"
                     /note="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit 2; RPN-II; ribophorin-2;
                     dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase 63 kDa subunit"
                     /codon_start=1
                     /product="dolichyl-diphosphooligosaccharide--protein
                     glycosyltransferase subunit 2 precursor"
                     /protein_id="NP_113886.1"
                     /db_xref="GeneID:64701"
                     /db_xref="RGD:62075"
                     /translation="MAPPGSSAVFLLALTITASTQALTPTHYLTKHDVERLKASLDRP
                     FTSLESAFYSIVGLNSLGAQVPDVKKACAFIKSNLDPSNVDSLFYAAQSSQVLSGCEI
                     SVSNETRDLLLAAVSEDSSVAQIYHAVAALSGFGLPLASHEALGALTARLSKEETVLA
                     TVQALHTASHLSQQADLRNIVEEIEDLVARLDELGGVYLQFEEGLELTALFVAATYKL
                     MDHVGTEPSIKEDQVIQLMNTIFSKKNFESLSEAFSVASAAAALSQNRYHVPVVVVPE
                     GSASDTQEQAILRLQVSSVLSHALAQAAVKLEHAKSVASRATVLQKMPFSLVGDVFEL
                     NFKNVKLPSGYYDFSVRVEGDNRYIANTVELRVKISTEVGITNADLSTVDKDQSIPPK
                     TTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFV
                     AEPDNKNVHKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEE
                     EAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGAN
                     VSNFTFAPTTIIFHLGHAAMLGLMYVYWTQLNMFQTLKYLAVLGTVTFLAGNRMLAQQ
                     AVKRTAH"
     exon            23..216
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..312
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            313..488
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..564
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..699
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..876
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            877..995
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1101
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1193
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1308
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1503
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1590
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1686
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1762
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1892
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2234
                     /gene="Rpn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcggaggaa tggcgccgcc gggttcaagt gctgtcttcc tgttggccct gacaatcaca
       61 gccagcaccc aggctctgac ccccacccac tacctcacca agcatgatgt ggaaagactg
      121 aaagcctcac tggatcgccc tttcacgagc ttggagtctg ccttctactc cattgtggga
      181 ctcaacagcc ttggggcaca ggtgccagat gtcaagaaag cgtgtgcctt catcaagtca
      241 aaccttgatc ccagcaacgt ggattctctc ttctatgctg cccaatccag ccaagtcctc
      301 tcaggttgtg agatatctgt ttcgaatgag accagagatc tgcttctggc agcagtcagc
      361 gaggactcct ccgttgccca aatctaccat gcagttgccg ccctcagtgg ctttggtctt
      421 cccttggcat cccatgaagc ccttggtgcc cttaccgctc gcctcagcaa ggaggagact
      481 gtgctggcaa ccgtccaggc tctgcacaca gcatcccacc tatcccagca ggctgacctg
      541 aggaacattg tagaagagat cgaggacctt gttgctcgcc tggacgaact agggggtgtg
      601 tatctccagt ttgaggaagg cctggaactt acagcattgt ttgttgctgc cacctacaag
      661 ctcatggacc atgtggggac tgaaccgtcc atcaaggagg atcaggtcat ccagctcatg
      721 aacacaatct tcagcaagaa gaactttgag tccctctcag aagccttcag tgtggcctct
      781 gctgctgctg cattgtccca gaatcgctat cacgtaccag tggtggttgt tcctgagggc
      841 tctgcttctg acactcaaga acaggctatc ctgcggttgc aagtcagcag tgttttgtct
      901 cacgctctgg ctcaagccgc agttaagctg gaacatgcta agtccgtggc ttccagagct
      961 actgtcctgc agaagatgcc cttttcactt gtaggggatg tttttgagct aaacttcaag
     1021 aatgttaaac ttcccagtgg ctactatgac ttctctgtca gagttgaagg tgacaaccgt
     1081 tacattgcaa acactgtaga gcttagagtc aagatctcca ctgaagttgg catcaccaat
     1141 gctgatcttt ccactgtgga caaggatcag agcatcccac ccaaaactac ccgggtgacc
     1201 tacccagcca aagccaaggg cacattcatc gcagacagcc atcagaactt cgccctgttt
     1261 ttccagctgg tagatgtgaa caccggtgcg gagctcaccc ctcaccagac atttgttcga
     1321 cttcataacc agaagactgg ccaggaagtg gtgtttgttg ctgagccgga taacaagaat
     1381 gtgcataagt ttgaactgga cacctctgaa aggaagattg agttcgactc tgcctctggc
     1441 acttacacac tctacctaat catcggggac gccactttga agaaccccat cctctggaac
     1501 gtggctgatg tggttatcaa gttccctgaa gaagaagctc cctccactgt gctgtcccag
     1561 aaccttttta ccccaaaaca ggaaattcag cacctgttcc gagagcctga gaagaggccc
     1621 cccactgtgg tgtccaatac attcacggcc ctcatcctct cgcccttgct cctgctcttt
     1681 gcactgtgga tccggattgg agccaatgtc tccaacttca cctttgctcc taccacgatt
     1741 atctttcacc tgggacatgc tgcaatgctg gggctcatgt atgtctactg gactcagctc
     1801 aacatgttcc agaccctgaa gtacctggcc gtcctgggca ctgtgacatt tctggctggc
     1861 aaccgaatgc tggcccagca ggcagttaag agaacagcac attagttcca gaagaagttt
     1921 gaagaccctg aactcggaaa tgaccgttta acaaagagtg gagacagttc agagtgtgga
     1981 aagaatcggg ggacagaata ggagaagagg aaatacctgt tatttaaaga gagaaaagtc
     2041 gagctatgct tacacgttta cttgtttctc actttttgct tcactgaaca gatatgtttg
     2101 gacccagatt gtctgtccct ttgttgtgat gcctggccag attctgtgaa tatcccaggt
     2161 tacccagagg ttgtatttga aaagttgaaa tctgtaattc atcagctttg gaataaagag
     2221 aatggtggac tccc
//
