LOCUS       NM_031099               1069 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus ribosomal protein L5 (Rpl5), mRNA.
ACCESSION   NM_031099
VERSION     NM_031099.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1069)
  AUTHORS   Goudarzi,K.M. and Lindstrom,M.S.
  TITLE     Role of ribosomal protein mutations in tumor development (Review)
  JOURNAL   Int J Oncol 48 (4), 1313-1324 (2016)
   PUBMED   26892688
  REMARK    Review article
REFERENCE   2  (bases 1 to 1069)
  AUTHORS   Smetanina,N.S., Mersiyanova,I.V., Kurnikova,M.A.,
            Ovsyannikova,G.S., Hachatryan,L.A., Bobrynina,V.O., Maschan,M.A.,
            Novichkova,G.A., Lipton,J.M. and Maschan,A.A.
  TITLE     Clinical and genomic heterogeneity of Diamond Blackfan anemia in
            the Russian Federation
  JOURNAL   Pediatr Blood Cancer 62 (9), 1597-1600 (2015)
   PUBMED   25946618
REFERENCE   3  (bases 1 to 1069)
  AUTHORS   Delaporta,P., Sofocleous,C., Stiakaki,E., Polychronopoulou,S.,
            Economou,M., Kossiva,L., Kostaridou,S. and Kattamis,A.
  TITLE     Clinical phenotype and genetic analysis of RPS19, RPL5, and RPL11
            genes in Greek patients with Diamond Blackfan Anemia
  JOURNAL   Pediatr Blood Cancer 61 (12), 2249-2255 (2014)
   PUBMED   25132370
REFERENCE   4  (bases 1 to 1069)
  AUTHORS   Sloan,K.E., Bohnsack,M.T. and Watkins,N.J.
  TITLE     The 5S RNP couples p53 homeostasis to ribosome biogenesis and
            nucleolar stress
  JOURNAL   Cell Rep 5 (1), 237-247 (2013)
   PUBMED   24120868
REFERENCE   5  (bases 1 to 1069)
  AUTHORS   Anger,A.M., Armache,J.P., Berninghausen,O., Habeck,M., Subklewe,M.,
            Wilson,D.N. and Beckmann,R.
  TITLE     Structures of the human and Drosophila 80S ribosome
  JOURNAL   Nature 497 (7447), 80-85 (2013)
   PUBMED   23636399
REFERENCE   6  (bases 1 to 1069)
  AUTHORS   Ogata,K., Kurahashi,A., Kenmochi,N. and Terao,K.
  TITLE     Role of 5SrRNA as a positive effector of some aminoacyl-tRNA
            synthetases in macromolecular complexes, with specific reference to
            methionyl-tRNA synthetase
  JOURNAL   J Biochem 110 (6), 1037-1044 (1991)
   PUBMED   1665486
REFERENCE   7  (bases 1 to 1069)
  AUTHORS   Tamura,S., Kuwano,Y., Nakayama,T., Tanaka,S., Tanaka,T. and
            Ogata,K.
  TITLE     Molecular cloning and nucleotide sequence of cDNA specific for rat
            ribosomal protein L5
  JOURNAL   Eur J Biochem 168 (1), 83-87 (1987)
   PUBMED   3117543
REFERENCE   8  (bases 1 to 1069)
  AUTHORS   Chan,Y.L., Lin,A., McNally,J. and Wool,I.G.
  TITLE     The primary structure of rat ribosomal protein L5. A comparison of
            the sequence of amino acids in the proteins that interact with 5 S
            rRNA
  JOURNAL   J Biol Chem 262 (26), 12879-12886 (1987)
   PUBMED   3624282
REFERENCE   9  (bases 1 to 1069)
  AUTHORS   Uchiumi,T., Kikuchi,M. and Ogata,K.
  TITLE     Cross-linking study on protein neighborhoods at the subunit
            interface of rat liver ribosomes with 2-iminothiolane
  JOURNAL   J Biol Chem 261 (21), 9663-9667 (1986)
   PUBMED   3733691
REFERENCE   10 (bases 1 to 1069)
  AUTHORS   Huber,P.W. and Wool,I.G.
  TITLE     Use of the cytotoxic nuclease alpha-sarcin to identify the binding
            site on eukaryotic 5 S ribosomal ribonucleic acid for the ribosomal
            protein L5
  JOURNAL   J Biol Chem 261 (7), 3002-3005 (1986)
   PUBMED   3949757
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X06148.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X06148.1, FQ234171.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     gene            1..1069
                     /gene="Rpl5"
                     /note="ribosomal protein L5"
                     /db_xref="GeneID:81763"
                     /db_xref="RGD:619825"
     exon            1..126
                     /gene="Rpl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1017
                     /gene="Rpl5"
                     /EC_number="3.6.5.3"
                     /note="60S ribosomal protein L5"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL18"
                     /protein_id="NP_112361.1"
                     /db_xref="GeneID:81763"
                     /db_xref="RGD:619825"
                     /translation="MGFVKVVKNKAYFKRYQVRFRRRREGKTDYYARKRLVIQDKNKY
                     NTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTG
                     LLLARRLLNRFGMDKIYEGQVEVNGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVF
                     GALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDA
                     YKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQK
                     KDRVAQKKASFLRAQERAAES"
     exon            127..196
                     /gene="Rpl5"
                     /inference="alignment:Splign:2.1.0"
     exon            197..312
                     /gene="Rpl5"
                     /inference="alignment:Splign:2.1.0"
     exon            313..650
                     /gene="Rpl5"
                     /inference="alignment:Splign:2.1.0"
     exon            651..828
                     /gene="Rpl5"
                     /inference="alignment:Splign:2.1.0"
     exon            829..917
                     /gene="Rpl5"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1069
                     /gene="Rpl5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1069
                     /gene="Rpl5"
                     /note="polyA site"
ORIGIN      
        1 tcgcttgcgt cctggaggtg ctacatactg cgcatgcgta cgcgactccg gtctttttcc
       61 ccctagcgcg gccgactctg caggtctgcg tggagccgca gttgcgggtc tctgttccgc
      121 aggatggggt tcgtgaaagt tgtcaagaat aaggcctact ttaaaagata ccaagtgaga
      181 tttagaaggc ggcgagaggg taaaactgac tactatgcac ggaaacgatt ggtgatccag
      241 gacaaaaata agtacaacac accgaaatac aggatgatag ttcgtgtaac gaacagagac
      301 atcatctgcc agattgcata tgcccgtata gaaggggata tgatcgtctg tgcagcatat
      361 gcacatgaac ttccaaaata cggtgtgaaa gttggcctga caaactatgc tgcagcctat
      421 tgcactggcc tgctgctggc ccgcaggctt ctgaataggt ttggcatgga caagatctat
      481 gaaggccaag tggaggtgaa tggagacgag tacaatgtgg aaagcataga cggtcagcct
      541 ggtgccttca cttgctatct ggatgcgggt cttgcccgaa ctacaactgg caataaagtt
      601 tttggcgccc tgaagggagc tgtggatgga ggcttatcta tcccccatag tactaaacga
      661 ttccctggct atgactctga aagcaaggag ttcaatgcag aggtgcaccg gaagcacatc
      721 atgggtcaga atgtggcaga ctacatgcgc tacctgatgg aggaggatga ggatgcgtat
      781 aagaaacagt tctctcagta catcaagaac aacgtgactc cagacatgat ggaggagatg
      841 tataagaaag ctcatgctgc tatccgagag aatccagtct acgagaagaa gcccaagaga
      901 gaagtgaaga agaagaggtg gaatcgtccc aaaatgtctc ttgcccagaa gaaagaccgg
      961 gttgctcaaa agaaggcaag cttcctcaga gctcaggaac gggctgctga aagctaaagc
     1021 cattttctat gaagattttt tcataaagac aataaacatt gatcaaagc
//
