LOCUS       NM_001108632            1812 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus ribose 5-phosphate isomerase A (Rpia), mRNA.
ACCESSION   NM_001108632 XM_001062107 XM_342707
VERSION     NM_001108632.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1812)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1812)
  AUTHORS   Huck,J.H., Verhoeven,N.M., Struys,E.A., Salomons,G.S., Jakobs,C.
            and van der Knaap,M.S.
  TITLE     Ribose-5-phosphate isomerase deficiency: new inborn error in the
            pentose phosphate pathway associated with a slowly progressive
            leukoencephalopathy
  JOURNAL   Am J Hum Genet 74 (4), 745-751 (2004)
   PUBMED   14988808
REFERENCE   3  (bases 1 to 1812)
  AUTHORS   Veech,R.L.
  TITLE     A humble hexose monophosphate pathway metabolite regulates short-
            and long-term control of lipogenesis
  JOURNAL   Proc Natl Acad Sci U S A 100 (10), 5578-5580 (2003)
   PUBMED   12721358
  REMARK    Review article
REFERENCE   4  (bases 1 to 1812)
  AUTHORS   Apel,T.W., Scherer,A., Adachi,T., Auch,D., Ayane,M. and Reth,M.
  TITLE     The ribose 5-phosphate isomerase-encoding gene is located
            immediately downstream from that encoding murine immunoglobulin
            kappa
  JOURNAL   Gene 156 (2), 191-197 (1995)
   PUBMED   7758956
REFERENCE   5  (bases 1 to 1812)
  AUTHORS   Bublitz,C. and Steavenson,S.
  TITLE     The pentose phosphate pathway in the endoplasmic reticulum
  JOURNAL   J Biol Chem 263 (26), 12849-12853 (1988)
   PUBMED   2843500
REFERENCE   6  (bases 1 to 1812)
  AUTHORS   Casazza,J.P. and Veech,R.L.
  TITLE     The interdependence of glycolytic and pentose cycle intermediates
            in ad libitum fed rats
  JOURNAL   J Biol Chem 261 (2), 690-698 (1986)
   PUBMED   3079759
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473957.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001062107.1, XM_342707.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231857.1, FQ149035.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1812
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..1812
                     /gene="Rpia"
                     /note="ribose 5-phosphate isomerase A"
                     /db_xref="GeneID:362383"
                     /db_xref="RGD:1311377"
     exon            1..295
                     /gene="Rpia"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..943
                     /gene="Rpia"
                     /EC_number="5.3.1.6"
                     /codon_start=1
                     /product="ribose-5-phosphate isomerase"
                     /protein_id="NP_001102102.1"
                     /db_xref="GeneID:362383"
                     /db_xref="RGD:1311377"
                     /translation="MQRPGPFSTLYGRVLAPLPGRAGGAASGGGGNNWGLSGSHVQLP
                     GRTQSETRGDKGGSSAGGPAPSTMSKAEEAKKLASHTAVENHVKNNQVLGIGSGSTIV
                     HAVQRIAERVKQENLDLICIPTSFQARQLILQYGLTLSDLDQHPEIDLAIDGADEVDA
                     ELNLIKGGGGCLTQEKIVAGYASRFIVIADFRKDSKNLGDRWHKGIPIEVIPMAYVPV
                     SRAVTQKFGGEVELRMAVNKAGPVVTDNGNFILDWKFDRVHKWGEVNTAIKMTPGVVD
                     TGLFINMAERVYFGMQDGSVNVREKPF"
     exon            296..356
                     /gene="Rpia"
                     /inference="alignment:Splign:2.1.0"
     exon            357..412
                     /gene="Rpia"
                     /inference="alignment:Splign:2.1.0"
     exon            413..472
                     /gene="Rpia"
                     /inference="alignment:Splign:2.1.0"
     exon            473..537
                     /gene="Rpia"
                     /inference="alignment:Splign:2.1.0"
     exon            538..606
                     /gene="Rpia"
                     /inference="alignment:Splign:2.1.0"
     exon            607..748
                     /gene="Rpia"
                     /inference="alignment:Splign:2.1.0"
     exon            749..848
                     /gene="Rpia"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1812
                     /gene="Rpia"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggccgcag aggctggagc gaggcggcgg gatgcagcgc cccgggccct tcagcaccct
       61 ctacgggcgg gtcctggccc cactgcccgg gcgggccggg ggcgcggcct cgggtggggg
      121 cgggaacaac tggggcctct cgggctccca cgtgcagttg ccggggcgta cacagtcgga
      181 gacccgcggc gacaagggag gctcgagcgc gggcggcccg gccccctcca cgatgtccaa
      241 ggccgaggag gctaagaaac tggcgagcca cacggcagtg gagaaccacg tgaagaataa
      301 ccaagtgctg ggaattggaa gtggttctac aattgtccat gctgtgcagc gaatagctga
      361 aagagtgaag caagagaacc tggacctcat ctgcatcccc acatctttcc aggccaggca
      421 gcttatccta cagtatggct taaccctcag tgacctggat caacacccgg agatcgacct
      481 tgccatcgat ggtgctgatg aagtggatgc tgagctcaat ctcatcaagg gtggtggagg
      541 ctgcctgacc caggagaaga ttgtggctgg ttatgccagt cgcttcattg tgatcgctga
      601 tttcaggaaa gattcaaaga accttgggga tcggtggcac aaggggattc ctattgaagt
      661 catcccaatg gcctatgtcc cagtgagtcg agctgtgacc cagaagtttg ggggtgaggt
      721 ggaacttcga atggctgtca acaaggcagg gcctgtggtg acagataatg ggaattttat
      781 cctggactgg aagttcgatc gggtacataa atggggtgaa gtgaacacag ctatcaagat
      841 gactccaggc gtggtggaca caggactttt catcaacatg gcagagagag tctacttcgg
      901 gatgcaggat ggctcagtga acgtgaggga gaagcccttc taaccctgcg aggagcaggg
      961 tgctcacttt gagtctccag cccaggcaca gtggacatgc ctcaccagga gcctttgcct
     1021 taatgtacct tcatgtagct gtccacagtg ccagagtgga tggctggccg tgggggtggg
     1081 gtagtcaaat ccagtcttat gaagtattgc tatgtgtctt tttaaaaaga aatttaaata
     1141 tatattttta ctattaaaat attcagtttt ttataaaata gaacttgatt ttatgtttta
     1201 tatgaaacat ttaccaaaaa caaaaaaatg tataaataaa aataagagat caggactgtc
     1261 tctgaaagct ttgactgaac ctactggttc accttctgaa gttttgggtt tgctgagaag
     1321 taacattttt ctaagctggt gaaaagtgag gagtcagcca gcaggtctcc tgatgcctta
     1381 tgggaaacct tgtttactgt ttactttctt gccacactct tctgttttga ggttgttttc
     1441 attgttacca ctcccaaatc ttagttaggt tttaagatca ggtttcagga attctgagtg
     1501 gagcagtcgg gtttgtagtg acttgggtat aaactcccag gtgagaatgc accttctctc
     1561 ggatcctggc tttgctttgg tcctgctgtt ggaagcccct ggtggaaacg ccctctggca
     1621 gcaagcacac agcattgtct gagatgtaaa gcacttactt ttgttgtttg aatgattttc
     1681 tttatgttag tattgttttg ttcctccaat aacccttgta tgatttggta tcagaagctg
     1741 tcacttcttt gtgctgtttg aaggttgaaa taaacatgat tgtgccattg tgatcctttg
     1801 tcttcactac ag
//
