LOCUS       NM_133591               2068 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus rabphilin 3A-like (without C2 domains) (Rph3al),
            mRNA.
ACCESSION   NM_133591
VERSION     NM_133591.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2068)
  AUTHORS   Koumanov,F., Pereira,V.J., Richardson,J.D., Sargent,S.L.,
            Fazakerley,D.J. and Holman,G.D.
  TITLE     Insulin regulates Rab3-Noc2 complex dissociation to promote GLUT4
            translocation in rat adipocytes
  JOURNAL   Diabetologia 58 (8), 1877-1886 (2015)
   PUBMED   26024738
  REMARK    GeneRIF: discovery of the involvement of Rab3 and Noc2 in an
            insulin-regulated step in GLUT4 translocation suggests that the
            control of this translocation process is unexpectedly similar to
            regulated secretion and particularly pancreatic insulin-vesicle
            release.
REFERENCE   2  (bases 1 to 2068)
  AUTHORS   Handley,M.T. and Burgoyne,R.D.
  TITLE     The Rab27 effector Rabphilin, unlike Granuphilin and Noc2, rapidly
            exchanges between secretory granules and cytosol in PC12 cells
  JOURNAL   Biochem Biophys Res Commun 373 (2), 275-281 (2008)
   PUBMED   18573236
  REMARK    GeneRIF: Three Rab3/27 effectors, Granuphilin, Noc2, and Rabphilin,
            in PC12 cells using fluorescence recovery after photobleaching of
            EGFP-tagged proteins.
REFERENCE   3  (bases 1 to 2068)
  AUTHORS   Imai,A., Yoshie,S., Nashida,T., Shimomura,H. and Fukuda,M.
  TITLE     Functional involvement of Noc2, a Rab27 effector, in rat parotid
            acinar cells
  JOURNAL   Arch Biochem Biophys 455 (2), 127-135 (2006)
   PUBMED   17067543
  REMARK    GeneRIF: Our results suggest that the Noc2/Rab27 complex is an
            important constituent of the early stages of IPR-stimulated amylase
            release.
            Erratum:[Arch Biochem Biophys. 2007 Sep 1;465(1):301]
REFERENCE   4  (bases 1 to 2068)
  AUTHORS   Matsumoto,M., Miki,T., Shibasaki,T., Kawaguchi,M., Shinozaki,H.,
            Nio,J., Saraya,A., Koseki,H., Miyazaki,M., Iwanaga,T. and Seino,S.
  TITLE     Noc2 is essential in normal regulation of exocytosis in endocrine
            and exocrine cells
  JOURNAL   Proc Natl Acad Sci U S A 101 (22), 8313-8318 (2004)
   PUBMED   15159548
REFERENCE   5  (bases 1 to 2068)
  AUTHORS   Fukuda,M., Kanno,E. and Yamamoto,A.
  TITLE     Rabphilin and Noc2 are recruited to dense-core vesicles through
            specific interaction with Rab27A in PC12 cells
  JOURNAL   J Biol Chem 279 (13), 13065-13075 (2004)
   PUBMED   14722103
  REMARK    GeneRIF: Rabphilin and Noc2 are recruited to dense-core vesicles
            through specific interaction with Rab27A in rat cells
REFERENCE   6  (bases 1 to 2068)
  AUTHORS   Cheviet,S., Coppola,T., Haynes,L.P., Burgoyne,R.D. and Regazzi,R.
  TITLE     The Rab-binding protein Noc2 is associated with insulin-containing
            secretory granules and is essential for pancreatic beta-cell
            exocytosis
  JOURNAL   Mol Endocrinol 18 (1), 117-126 (2004)
   PUBMED   14593078
  REMARK    GeneRIF: Noc2 is a potential partner of Munc13, a component of the
            machinery that controls vesicle priming and insulin exocytosis
REFERENCE   7  (bases 1 to 2068)
  AUTHORS   Leenders,A.G., Lopes da Silva,F.H., Ghijsen,W.E. and Verhage,M.
  TITLE     Rab3a is involved in transport of synaptic vesicles to the active
            zone in mouse brain nerve terminals
  JOURNAL   Mol Biol Cell 12 (10), 3095-3102 (2001)
   PUBMED   11598194
REFERENCE   8  (bases 1 to 2068)
  AUTHORS   Haynes,L.P., Evans,G.J., Morgan,A. and Burgoyne,R.D.
  TITLE     A direct inhibitory role for the Rab3-specific effector, Noc2, in
            Ca2+-regulated exocytosis in neuroendocrine cells
  JOURNAL   J Biol Chem 276 (13), 9726-9732 (2001)
   PUBMED   11134008
REFERENCE   9  (bases 1 to 2068)
  AUTHORS   Kotake,K., Ozaki,N., Mizuta,M., Sekiya,S., Inagaki,N. and Seino,S.
  TITLE     Noc2, a putative zinc finger protein involved in exocytosis in
            endocrine cells
  JOURNAL   J Biol Chem 272 (47), 29407-29410 (1997)
   PUBMED   9367993
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091126.1.
            
            On Mar 27, 2005 this sequence version replaced NM_133591.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091126.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2068
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..2068
                     /gene="Rph3al"
                     /gene_synonym="Noc2"
                     /note="rabphilin 3A-like (without C2 domains)"
                     /db_xref="GeneID:171123"
                     /db_xref="RGD:620342"
     exon            1..82
                     /gene="Rph3al"
                     /gene_synonym="Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            83..192
                     /gene="Rph3al"
                     /gene_synonym="Noc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1024
                     /gene="Rph3al"
                     /gene_synonym="Noc2"
                     /note="no C2 domains protein; rabphilin-3A-like protein"
                     /codon_start=1
                     /product="rab effector Noc2"
                     /protein_id="NP_598275.1"
                     /db_xref="GeneID:171123"
                     /db_xref="RGD:620342"
                     /translation="MADTIFSSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRT
                     QCLSPGEVEVILQVIQRAERLDILEQQRIGRLVERLETMQKNVMGNGVSQCLLCGEML
                     GFLGSSSVFCKDCRKKVCTKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLP
                     KYILPLKTPGRADDPHFRPLPVEPTEPQPQSAEVSRVYTWARGRVVSSDSDSDSDLSS
                     SSLEDRPMPSGIKGTKYDKPRGDSGGSMESPRMGPARPPSHLSGSQSSLGSETGAGAT
                     DPQGGTLPRPEPRVSGKRHTWATTHY"
     exon            193..336
                     /gene="Rph3al"
                     /gene_synonym="Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            337..466
                     /gene="Rph3al"
                     /gene_synonym="Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..553
                     /gene="Rph3al"
                     /gene_synonym="Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            554..728
                     /gene="Rph3al"
                     /gene_synonym="Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..842
                     /gene="Rph3al"
                     /gene_synonym="Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..989
                     /gene="Rph3al"
                     /gene_synonym="Noc2"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1994
                     /gene="Rph3al"
                     /gene_synonym="Noc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttggcaacc accacacaag agaggccctc cttttgctgg ggctccctgt aaccctcgct
       61 cgactgggcc cattgcttcc tgatgtgact cctgccctgg gctgtgctcc ccatcatggc
      121 tgacaccatc ttcagcagtg gaaatgatca gtgggtgtgc cccaacgatc ggcagcttgc
      181 tctgagagcc aagctgcaga caggctggtc tgtgcacaca taccagacgg agaagcagag
      241 gaggactcaa tgcctgagcc ctggagaggt ggaggtcatc cttcaggtca tccagagagc
      301 agagcggctg gacatcctgg agcagcagag gattgggcgg ctggtggagc ggctggagac
      361 gatgcagaag aacgtgatgg gcaatggtgt ctcccagtgt ctgctctgcg gggagatgtt
      421 gggattcctg ggcagctcct ctgtattctg caaagactgc cggaagaaag tctgcaccaa
      481 gtgtgggatc gaggcttccc ccggccagaa gcggcccctg tggctgtgta agatctgcag
      541 tgagcagaga gaggtctgga agaggtcagg ggcctggttc tacaaagggc tccccaagta
      601 catcttgccc ctgaaaaccc ctggccgggc tgatgatccc cacttccgac ctctgcctgt
      661 ggagcccaca gaaccacagc ctcagagtgc tgaagtcagc cgtgtctaca catgggcccg
      721 agggagagtg gtttctagtg acagtgacag tgactcagat ctcagctcct ccagcctgga
      781 ggacagacct atgccctctg ggatcaaggg cacaaaatat gacaagccta gaggggactc
      841 aggtggcagc atggagtcac ccaggatggg gcctgcccga ccgcccagcc atctttctgg
      901 cagccagagc agcctgggca gtgagacggg ggcaggtgct acagatccac agggaggcac
      961 cctaccccgg cctgagccca gggtatccgg caaaaggcat acctgggcaa ctacccatta
     1021 ctgaggtggc cggctgacct ccctgggctg aggcacactc tctggaggaa gattcagaga
     1081 gagacaacag ggccggccta ccggagcccc tctctgaagg ttcttgaggg ctcacaagct
     1141 ccctgatacc ttgacctgca actcaacaag ccagtgtttg gggaccgagc gtgcttgccc
     1201 ccaccctgta gtgccttctc tactatctca ctcagcaccc caccttttat ttattgcccc
     1261 tcccccatcc cagtcacatc tcgatttgct cgggccttgg gttgggttgg aaaggccttc
     1321 ctctatgcac tgaagtttgg gtgggacaca cagggctttc tttgtactaa tgatgcgcac
     1381 tctaaccctc agtgtgaccc tgcggagctg agcaacccca ccccacaccc ccacaccccc
     1441 ctccccccac cacattccca gtgtaaacct ggagcaccag gctgtcccta ttcctccaac
     1501 cggcggcgga ggccagagca aggtcctatt tgccccgagg ctggtccagg agctgagtta
     1561 aatccagctt tgaggtttcc ccgaagcccc tattggcctc tgggtttttg ttctaccctg
     1621 aaacacagct ccccctcaga cattaaaatg ctttttgttc ttcagtggaa aacaaagctc
     1681 ccaccctgcc tcatgctcgc tggcccagcc tgggagtttc aaattctaaa gccagagcaa
     1741 gcgtgaaaaa tattcaaaat acagatgctt ctggaaaacc cctccctggg gtgggggtga
     1801 ggaagtgtcc tatgcccttc cttccctgag tccagttcca tccttcccca ccaccatccc
     1861 tcccattatt attattaata atggccacca ccattattag ccttttgcct gttgctgctg
     1921 gcagaagaca aacttcacta tttccctgag atgtgtagcc atcagcacta acataataaa
     1981 cataagaatt ttcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
